JPS63297365A - ジヒドロピリジン類 - Google Patents

ジヒドロピリジン類

Info

Publication number
JPS63297365A
JPS63297365A JP63108909A JP10890988A JPS63297365A JP S63297365 A JPS63297365 A JP S63297365A JP 63108909 A JP63108909 A JP 63108909A JP 10890988 A JP10890988 A JP 10890988A JP S63297365 A JPS63297365 A JP S63297365A
Authority
JP
Japan
Prior art keywords
group
formula
compound
pharmaceutically acceptable
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63108909A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0581588B2 (https=
Inventor
シモン・フレイザー・キャンプベル
マイケル・ジョン・ハンフリー
アラン・ストービー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of JPS63297365A publication Critical patent/JPS63297365A/ja
Publication of JPH0581588B2 publication Critical patent/JPH0581588B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dental Preparations (AREA)
JP63108909A 1987-05-02 1988-04-30 ジヒドロピリジン類 Granted JPS63297365A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8710493 1987-05-02
GB878710493A GB8710493D0 (en) 1987-05-02 1987-05-02 Dihydropyridines

Publications (2)

Publication Number Publication Date
JPS63297365A true JPS63297365A (ja) 1988-12-05
JPH0581588B2 JPH0581588B2 (https=) 1993-11-15

Family

ID=10616773

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63108909A Granted JPS63297365A (ja) 1987-05-02 1988-04-30 ジヒドロピリジン類

Country Status (13)

Country Link
US (1) US4806557A (https=)
EP (1) EP0290211B1 (https=)
JP (1) JPS63297365A (https=)
AT (1) ATE66915T1 (https=)
CA (1) CA1326672C (https=)
DE (1) DE3864573D1 (https=)
DK (1) DK172094B1 (https=)
ES (1) ES2031595T3 (https=)
FI (1) FI90415C (https=)
GB (1) GB8710493D0 (https=)
GR (1) GR3002767T3 (https=)
IE (1) IE60055B1 (https=)
PT (1) PT87361B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003503408A (ja) * 1999-06-25 2003-01-28 バーテックス ファーマシューティカルズ インコーポレイテッド Ｉｍｐｄｈのカーバメート阻害剤のプロドラッグ

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270323A (en) * 1990-05-31 1993-12-14 Pfizer Inc. Method of treating impotence
US6057344A (en) 1991-11-26 2000-05-02 Sepracor, Inc. Methods for treating hypertension, and angina using optically pure (-) amlodipine
US6521647B2 (en) 2000-04-04 2003-02-18 Pfizer Inc. Treatment of renal disorders
GB0008332D0 (en) * 2000-04-04 2000-05-24 Pfizer Ltd Treament
BR0116553A (pt) 2000-12-29 2004-02-03 Pfizer Ltd Composto, composição farmacêutica para tratamento de angina ou hipertensão, processo, processo para tratamento ou prevenção de angina ou hipertensão, composição de ingredientes farmaceuticamente ativos, composição farmacêutica para tratamento ou prevenção de angina ou hipertensão e processo para tratar ou prevenir angina ou hipertensão
US6653481B2 (en) 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
MXPA03005882A (es) 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
AT5874U1 (de) 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
MXPA03005884A (es) 2000-12-29 2005-04-08 Pfizer Ltd Hemimaleato de amlodipina.
US7335380B2 (en) 2000-12-29 2008-02-26 Synthon Ip Inc. Amlodipine free base
WO2002053538A1 (en) 2000-12-29 2002-07-11 Pfizer Limited Amlodipine fumarate
BR0116554A (pt) 2000-12-29 2004-02-03 Pfizer Ltd Composto, composição farmacêutica para o tratamento da angina ou hipertensão, processo, processo para o tratamento ou prevenção da angina ou hipertensão, composição do ingrediente farmaceuticamente ativo e composição farmacêutica para o tratamento ou prevenção da angina ou hipertensão
ES2243553T3 (es) 2000-12-29 2005-12-01 Pfizer Limited Procedimiento para preparar maleato de amlodipina.
GB2371862B (en) 2000-12-29 2004-07-14 Bioorg Bv Reference standards for determining the purity or stability of amlodipine maleate and processes therefor
US6699892B2 (en) 2002-06-04 2004-03-02 Yung Shin Pharmaceutical Industrial Co., Ltd. Pharmaceutically acceptable salt of amlodipine and method of preparing the same
KR100462304B1 (ko) * 2002-07-30 2004-12-17 씨제이 주식회사 암로디핀의 유기산염
KR100538641B1 (ko) * 2002-07-30 2005-12-22 씨제이 주식회사 암로디핀의 유기산염
KR100496436B1 (ko) * 2002-07-30 2005-06-20 씨제이 주식회사 암로디핀의 유기산염
KR20040011751A (ko) * 2002-07-30 2004-02-11 씨제이 주식회사 암로디핀의 유기산염
KR100467669B1 (ko) * 2002-08-21 2005-01-24 씨제이 주식회사 암로디핀의 유기산염
WO2011137734A1 (en) 2010-05-03 2011-11-10 Tsh Biopharm Company, Limited Pharmaceutical composition and method for treating hypertension

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
US4447613A (en) * 1979-08-24 1984-05-08 Zoecon Corporation Pyridyl esters and thiolesters of aminoalkanoic acids
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8306666D0 (en) * 1983-03-10 1983-04-13 Pfizer Ltd Therapeutic agents
US4568677A (en) * 1983-07-23 1986-02-04 Pfizer Inc. 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003503408A (ja) * 1999-06-25 2003-01-28 バーテックス ファーマシューティカルズ インコーポレイテッド Ｉｍｐｄｈのカーバメート阻害剤のプロドラッグ
JP4773010B2 (ja) * 1999-06-25 2011-09-14 バーテックス ファーマシューティカルズ インコーポレイテッド Ｉｍｐｄｈのカーバメート阻害剤のプロドラッグ

Also Published As

Publication number Publication date
FI882001A7 (fi) 1988-11-03
GR3002767T3 (en) 1993-01-25
DE3864573D1 (en) 1991-10-10
ATE66915T1 (de) 1991-09-15
DK172094B1 (da) 1997-10-20
GB8710493D0 (en) 1987-06-03
DK234388D0 (da) 1988-04-28
EP0290211B1 (en) 1991-09-04
PT87361B (pt) 1992-08-31
JPH0581588B2 (https=) 1993-11-15
CA1326672C (en) 1994-02-01
FI882001A0 (fi) 1988-04-28
PT87361A (pt) 1989-05-31
IE881283L (en) 1988-11-02
DK234388A (da) 1989-01-19
IE60055B1 (en) 1994-05-18
FI90415B (fi) 1993-10-29
ES2031595T3 (es) 1992-12-16
EP0290211A1 (en) 1988-11-09
FI90415C (fi) 1994-02-10
US4806557A (en) 1989-02-21

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