FI882001A7 - Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 2-(2-aminoetoksimetyyli)-4-(2-kloorifenyyli)-3-etoksikarbonyyli-5-metoksikarbonyyli-6-metyyli-1,4-dihydropyridiinien valmistamiseksi - Google Patents
Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 2-(2-aminoetoksimetyyli)-4-(2-kloorifenyyli)-3-etoksikarbonyyli-5-metoksikarbonyyli-6-metyyli-1,4-dihydropyridiinien valmistamiseksiInfo
- Publication number
- FI882001A7 FI882001A7 FI882001A FI882001A FI882001A7 FI 882001 A7 FI882001 A7 FI 882001A7 FI 882001 A FI882001 A FI 882001A FI 882001 A FI882001 A FI 882001A FI 882001 A7 FI882001 A7 FI 882001A7
- Authority
- FI
- Finland
- Prior art keywords
- aminoethoxymethyl
- dihydropyridines
- ethoxycarbonyl
- methoxycarbonyl
- chlorophenyl
- Prior art date
Links
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical class CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Dental Preparations (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8710493 | 1987-05-02 | ||
| GB878710493A GB8710493D0 (en) | 1987-05-02 | 1987-05-02 | Dihydropyridines |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI882001A0 FI882001A0 (fi) | 1988-04-28 |
| FI882001A7 true FI882001A7 (fi) | 1988-11-03 |
| FI90415B FI90415B (fi) | 1993-10-29 |
| FI90415C FI90415C (fi) | 1994-02-10 |
Family
ID=10616773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI882001A FI90415C (fi) | 1987-05-02 | 1988-04-28 | Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 2-(2-aminoetoksimetyyli)-4-(2-kloorifenyyli)-3-etoksikarbonyyli-5-metoksikarbonyyli-6-metyyli-1,4-dihydropyridiinien valmistamiseksi |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4806557A (fi) |
| EP (1) | EP0290211B1 (fi) |
| JP (1) | JPS63297365A (fi) |
| AT (1) | ATE66915T1 (fi) |
| CA (1) | CA1326672C (fi) |
| DE (1) | DE3864573D1 (fi) |
| DK (1) | DK172094B1 (fi) |
| ES (1) | ES2031595T3 (fi) |
| FI (1) | FI90415C (fi) |
| GB (1) | GB8710493D0 (fi) |
| GR (1) | GR3002767T3 (fi) |
| IE (1) | IE60055B1 (fi) |
| PT (1) | PT87361B (fi) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5270323A (en) * | 1990-05-31 | 1993-12-14 | Pfizer Inc. | Method of treating impotence |
| US6057344A (en) | 1991-11-26 | 2000-05-02 | Sepracor, Inc. | Methods for treating hypertension, and angina using optically pure (-) amlodipine |
| DK1196414T3 (da) * | 1999-06-25 | 2003-11-24 | Vertex Pharma | Prolægemiddel af carbamathæmmer for IMPDH |
| GB0008332D0 (en) * | 2000-04-04 | 2000-05-24 | Pfizer Ltd | Treament |
| US6521647B2 (en) | 2000-04-04 | 2003-02-18 | Pfizer Inc. | Treatment of renal disorders |
| EP1309555B1 (en) | 2000-12-29 | 2005-07-27 | Pfizer Limited | Process for making amlodipine maleate |
| WO2002054062A2 (en) | 2000-12-29 | 2002-07-11 | Pfizer Limited | Reference standards and processes for determining the purity or stability of amlodipine maleate |
| DE60116514T2 (de) | 2000-12-29 | 2006-08-17 | Pfizer Ltd., Sandwich | Amlodipinhemimaleat |
| BR0116553A (pt) | 2000-12-29 | 2004-02-03 | Pfizer Ltd | Composto, composição farmacêutica para tratamento de angina ou hipertensão, processo, processo para tratamento ou prevenção de angina ou hipertensão, composição de ingredientes farmaceuticamente ativos, composição farmacêutica para tratamento ou prevenção de angina ou hipertensão e processo para tratar ou prevenir angina ou hipertensão |
| US6653481B2 (en) | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
| AT5874U1 (de) | 2000-12-29 | 2003-01-27 | Bioorg Bv | Pharmazeutische zubereitungen enthaltend amlodipinmaleat |
| CA2433181C (en) | 2000-12-29 | 2005-11-22 | Pfizer Limited | Amlodipine hemifumarate |
| US7335380B2 (en) | 2000-12-29 | 2008-02-26 | Synthon Ip Inc. | Amlodipine free base |
| MXPA03005882A (es) | 2000-12-29 | 2005-04-19 | Pfizer Ltd | Derivado amida de amlodipina. |
| BR0116554A (pt) | 2000-12-29 | 2004-02-03 | Pfizer Ltd | Composto, composição farmacêutica para o tratamento da angina ou hipertensão, processo, processo para o tratamento ou prevenção da angina ou hipertensão, composição do ingrediente farmaceuticamente ativo e composição farmacêutica para o tratamento ou prevenção da angina ou hipertensão |
| US6699892B2 (en) | 2002-06-04 | 2004-03-02 | Yung Shin Pharmaceutical Industrial Co., Ltd. | Pharmaceutically acceptable salt of amlodipine and method of preparing the same |
| KR100462304B1 (ko) * | 2002-07-30 | 2004-12-17 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR20040011751A (ko) * | 2002-07-30 | 2004-02-11 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR100496436B1 (ko) * | 2002-07-30 | 2005-06-20 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR100538641B1 (ko) * | 2002-07-30 | 2005-12-22 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR100467669B1 (ko) * | 2002-08-21 | 2005-01-24 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| RU2571284C2 (ru) | 2010-05-03 | 2015-12-20 | Тсх Биофарм Корпорейшн, Лимитед | Фармацевтическая композиция и способ лечения гипертензии |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
| US4447613A (en) * | 1979-08-24 | 1984-05-08 | Zoecon Corporation | Pyridyl esters and thiolesters of aminoalkanoic acids |
| CS228917B2 (en) * | 1981-03-14 | 1984-05-14 | Pfizer | Method of preparing substituted derivatives of 1,4-dihydropyridine |
| DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
| GB8306666D0 (en) * | 1983-03-10 | 1983-04-13 | Pfizer Ltd | Therapeutic agents |
| US4568677A (en) * | 1983-07-23 | 1986-02-04 | Pfizer Inc. | 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents |
-
1987
- 1987-05-02 GB GB878710493A patent/GB8710493D0/en active Pending
-
1988
- 1988-04-28 FI FI882001A patent/FI90415C/fi not_active IP Right Cessation
- 1988-04-28 DK DK264388A patent/DK172094B1/da not_active IP Right Cessation
- 1988-04-28 US US07/187,116 patent/US4806557A/en not_active Expired - Lifetime
- 1988-04-29 AT AT88303940T patent/ATE66915T1/de not_active IP Right Cessation
- 1988-04-29 IE IE128388A patent/IE60055B1/en not_active IP Right Cessation
- 1988-04-29 PT PT87361A patent/PT87361B/pt not_active IP Right Cessation
- 1988-04-29 ES ES198888303940T patent/ES2031595T3/es not_active Expired - Lifetime
- 1988-04-29 DE DE8888303940T patent/DE3864573D1/de not_active Expired - Lifetime
- 1988-04-29 EP EP88303940A patent/EP0290211B1/en not_active Expired - Lifetime
- 1988-04-29 CA CA000565483A patent/CA1326672C/en not_active Expired - Fee Related
- 1988-04-30 JP JP63108909A patent/JPS63297365A/ja active Granted
-
1991
- 1991-09-20 GR GR91401379T patent/GR3002767T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS63297365A (ja) | 1988-12-05 |
| DK172094B1 (da) | 1997-10-20 |
| FI90415B (fi) | 1993-10-29 |
| US4806557A (en) | 1989-02-21 |
| FI90415C (fi) | 1994-02-10 |
| IE881283L (en) | 1988-11-02 |
| GR3002767T3 (en) | 1993-01-25 |
| PT87361B (pt) | 1992-08-31 |
| CA1326672C (en) | 1994-02-01 |
| JPH0581588B2 (fi) | 1993-11-15 |
| DK234388A (da) | 1989-01-19 |
| DK234388D0 (da) | 1988-04-28 |
| GB8710493D0 (en) | 1987-06-03 |
| PT87361A (pt) | 1989-05-31 |
| ATE66915T1 (de) | 1991-09-15 |
| EP0290211A1 (en) | 1988-11-09 |
| EP0290211B1 (en) | 1991-09-04 |
| DE3864573D1 (en) | 1991-10-10 |
| FI882001A0 (fi) | 1988-04-28 |
| ES2031595T3 (es) | 1992-12-16 |
| IE60055B1 (en) | 1994-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed |
Owner name: PFIZER LIMITED |