JPS63132889A - キナゾリノン誘導体 - Google Patents

キナゾリノン誘導体

Info

Publication number
JPS63132889A
JPS63132889A JP61279421A JP27942186A JPS63132889A JP S63132889 A JPS63132889 A JP S63132889A JP 61279421 A JP61279421 A JP 61279421A JP 27942186 A JP27942186 A JP 27942186A JP S63132889 A JPS63132889 A JP S63132889A
Authority
JP
Japan
Prior art keywords
compound
salt
salts
solvent
spiro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP61279421A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0476994B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Yoshihisa Yamada
義久 山田
Yuzo Matsuoka
松岡　雄三
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP61279421A priority Critical patent/JPS63132889A/ja
Priority to US07/114,569 priority patent/US4855298A/en
Priority to KR870012999A priority patent/KR880006206A/ko
Priority to AT87310258T priority patent/ATE60334T1/de
Priority to ES198787310258T priority patent/ES2031913T3/es
Priority to EP87310258A priority patent/EP0269378B1/en
Priority to CA000552393A priority patent/CA1290756C/en
Priority to DE8787310258T priority patent/DE3767672D1/de
Publication of JPS63132889A publication Critical patent/JPS63132889A/ja
Priority to GR90400661T priority patent/GR3001362T3/el
Publication of JPH0476994B2 publication Critical patent/JPH0476994B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/48—Y being a hydrogen or a carbon atom
    • C07C275/50—Y being a hydrogen or an acyclic carbon atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP61279421A 1986-11-21 1986-11-21 キナゾリノン誘導体 Granted JPS63132889A (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP61279421A JPS63132889A (ja) 1986-11-21 1986-11-21 キナゾリノン誘導体
US07/114,569 US4855298A (en) 1986-11-21 1987-10-29 6-Halo-1,2,3,4-tetrahydroquinazoline-4-spiro-4-imidazolidine-2,2'5'-triones useful for the treatment and prophylaxis of diabetic complications
KR870012999A KR880006206A (ko) 1986-11-21 1987-11-19 퀴나졸리논 유도체 및 이의 제조방법
EP87310258A EP0269378B1 (en) 1986-11-21 1987-11-20 Quinazolinone derivative and processes for preparing the same
ES198787310258T ES2031913T3 (es) 1986-11-21 1987-11-20 Un procedimiento para preparar un derivado de quinazolinona.
AT87310258T ATE60334T1 (de) 1986-11-21 1987-11-20 Chinazolinonderivat und verfahren zu seiner herstellung.
CA000552393A CA1290756C (en) 1986-11-21 1987-11-20 Quinazolinone derivative and processes for preparing the same
DE8787310258T DE3767672D1 (de) 1986-11-21 1987-11-20 Chinazolinonderivat und verfahren zu seiner herstellung.
GR90400661T GR3001362T3 (en) 1986-11-21 1991-01-24 Quinazolinone derivative and processes for preparing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61279421A JPS63132889A (ja) 1986-11-21 1986-11-21 キナゾリノン誘導体

Publications (2)

Publication Number Publication Date
JPS63132889A true JPS63132889A (ja) 1988-06-04
JPH0476994B2 JPH0476994B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1992-12-07

Family

ID=17610847

Family Applications (1)

Application Number Title Priority Date Filing Date
JP61279421A Granted JPS63132889A (ja) 1986-11-21 1986-11-21 キナゾリノン誘導体

Country Status (9)

Country Link
US (1) US4855298A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0269378B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS63132889A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR880006206A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE60334T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1290756C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3767672D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2031913T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3001362T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR1000821B (el) * 1988-11-22 1993-01-25 Tanabe Seiyaku Co Μεθοδος παραγωγης παραγωγων κιναζολινονης.
US5081241A (en) * 1990-10-11 1992-01-14 American Home Products Corporation Spiro-pyridazines and analogs thereof useful as aldose reductase inhibitors
TW202450B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1991-06-26 1993-03-21 Dainippon Pharmaceutical Co
US5814599A (en) * 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs
US5780050A (en) 1995-07-20 1998-07-14 Theratech, Inc. Drug delivery compositions for improved stability of steroids
US5947921A (en) * 1995-12-18 1999-09-07 Massachusetts Institute Of Technology Chemical and physical enhancers and ultrasound for transdermal drug delivery
US6041253A (en) * 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
US6002961A (en) * 1995-07-25 1999-12-14 Massachusetts Institute Of Technology Transdermal protein delivery using low-frequency sonophoresis
EP2921111A1 (en) 1995-08-29 2015-09-23 Nitto Denko Corporation Microporation of human skin for drug delivery and monitoring applications
JP2002515786A (ja) 1996-06-28 2002-05-28 ソントラ メディカル，エル．ピー． 経皮輸送の超音波増強
US7066884B2 (en) 1998-01-08 2006-06-27 Sontra Medical, Inc. System, method, and device for non-invasive body fluid sampling and analysis
US8287483B2 (en) * 1998-01-08 2012-10-16 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
US20060015058A1 (en) * 1998-01-08 2006-01-19 Kellogg Scott C Agents and methods for enhancement of transdermal transport
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
CA2929300C (en) 2002-03-11 2019-04-16 Nitto Denko Corporation Transdermal drug delivery patch system, method of making same and method of using same
US8116860B2 (en) * 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
US8016811B2 (en) 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
US20060094944A1 (en) * 2004-10-28 2006-05-04 Sontra Medical Corporation System and method for analyte sampling and analysis with error correction
US7432069B2 (en) * 2005-12-05 2008-10-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
KR101433550B1 (ko) 2007-03-07 2014-08-27 에코 테라퓨틱스, 인크. 경피 피분석물 모니터링 시스템 및 피분석물 검출 방법
ATE499967T1 (de) 2007-04-27 2011-03-15 Echo Therapeutics Inc Hautpermeationsvorrichtung für analytenmessung oder transdermale arzneiabgabe
WO2012018486A2 (en) 2010-07-26 2012-02-09 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
JP6126783B2 (ja) 2009-03-02 2017-05-10 セブンス センス バイオシステムズ，インコーポレーテッド 被検体の皮膚から、および／または該皮膚の下から引き抜かれた媒体の分析用のデバイス
US20110105952A1 (en) * 2009-10-30 2011-05-05 Seventh Sense Biosystems, Inc. Relatively small devices applied to the skin, modular systems, and methods of use thereof
US9119578B2 (en) 2011-04-29 2015-09-01 Seventh Sense Biosystems, Inc. Plasma or serum production and removal of fluids under reduced pressure
US20110288389A9 (en) 2009-03-02 2011-11-24 Seventh Sense Biosystems, Inc. Oxygen sensor
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
WO2011094573A1 (en) 2010-01-28 2011-08-04 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
WO2011163347A2 (en) 2010-06-23 2011-12-29 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
US20120016308A1 (en) 2010-07-16 2012-01-19 Seventh Sense Biosystems, Inc. Low-pressure packaging for fluid devices
WO2012021801A2 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
US8808202B2 (en) 2010-11-09 2014-08-19 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
KR102237667B1 (ko) 2011-04-29 2021-04-12 세븐쓰 센스 바이오시스템즈, 인크. 유체들의 전달 및/또는 수용
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT321911B (de) * 1971-05-27 1975-04-25 Sandoz Ag Verfahren zur herstellung vonneuen 1-alkyl-4-phenyl-bzw.-4-(2-thienyl)6,7-methylendioxy-34-dihydro-2(1h)-chinazolinonen
JPS53653A (en) * 1976-06-23 1978-01-06 Matsushita Refrig Co Air conditioner
US4282229A (en) * 1977-02-11 1981-08-04 Pfizer Inc. Hydantoin derivatives as therapeutic agents
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
US4273775A (en) * 1979-06-13 1981-06-16 Pfizer Inc. Hydantoin derivatives, anti-diabetic compositions thereof, and method of use thereof
US4490381A (en) * 1979-11-13 1984-12-25 Imperial Chemical Industries Plc 1'-Substituted spiro[imidazolidine-4,3'-indoline]2,2',5-triones
JPS56104876A (en) * 1980-01-24 1981-08-20 Takeda Chem Ind Ltd Thiazolidine derivative
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
AU566869B2 (en) * 1982-05-11 1987-11-05 Imperial Chemical Industries Plc Spiro (imidazolidine-4,3'-indoline) 2,2',5-triones
US4464380A (en) * 1983-05-25 1984-08-07 Pfizer Inc. Imidazolidinedione derivatives
US4533667A (en) * 1983-05-25 1985-08-06 Pfizer Inc. Imidazolidinedione derivatives
US4617392A (en) * 1983-09-29 1986-10-14 Ortho Pharmaceutical Corporation 4-alkyl-5,6-methylenedioxy-2-1[H]-quinazolinones useful as cardiotonic agents
JPH0660152B2 (ja) * 1985-02-09 1994-08-10 日本臓器製薬株式会社 新規オキサルル酸誘導体及び該化合物を含有する血糖低下剤
US4575507A (en) * 1985-05-29 1986-03-11 Pfizer Inc. Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
US4762839A (en) * 1985-06-06 1988-08-09 Tanabe Seiyaku Co., Ltd. Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications

Also Published As

Publication number Publication date
ES2031913T3 (es) 1993-01-01
JPH0476994B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1992-12-07
US4855298A (en) 1989-08-08
KR880006206A (ko) 1988-07-22
CA1290756C (en) 1991-10-15
DE3767672D1 (de) 1991-02-28
GR3001362T3 (en) 1992-09-11
ATE60334T1 (de) 1991-02-15
EP0269378B1 (en) 1991-01-23
EP0269378A1 (en) 1988-06-01

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