JPS631319B2 - - Google Patents

Info

Publication number
JPS631319B2
JPS631319B2 JP53138402A JP13840278A JPS631319B2 JP S631319 B2 JPS631319 B2 JP S631319B2 JP 53138402 A JP53138402 A JP 53138402A JP 13840278 A JP13840278 A JP 13840278A JP S631319 B2 JPS631319 B2 JP S631319B2
Authority
JP
Japan
Prior art keywords
group
zinc
water
kanamycin
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP53138402A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5564598A (en
Inventor
Hamao Umezawa
Sumio Umezawa
Osamu Tsucha
Yasushi Takagi
Tomo Naohara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP13840278A priority Critical patent/JPS5564598A/ja
Priority to IE2026/79A priority patent/IE48972B1/en
Priority to IE1521/83A priority patent/IE48973B1/en
Priority to ZA00795691A priority patent/ZA795691B/xx
Priority to IN1104/CAL/79A priority patent/IN151454B/en
Priority to SE7908850A priority patent/SE446632B/sv
Priority to NL7907892A priority patent/NL7907892A/nl
Priority to CH184/84A priority patent/CH650005A5/de
Priority to CH9682/79A priority patent/CH650004A5/de
Priority to US06/090,591 priority patent/US4297485A/en
Priority to AT0707979A priority patent/AT367066B/de
Priority to MX798478U priority patent/MX6181E/es
Priority to FR7928015A priority patent/FR2441631A1/fr
Priority to DE2945010A priority patent/DE2945010C2/de
Priority to ES485830A priority patent/ES485830A1/es
Priority to YU2743/79A priority patent/YU44185B/xx
Priority to AU52622/79A priority patent/AU529682B2/en
Priority to PH23263A priority patent/PH16263A/en
Priority to DE2953878A priority patent/DE2953878C2/de
Priority to CA000339531A priority patent/CA1118416A/en
Priority to AR79278828A priority patent/AR241915A1/es
Priority to GB7938894A priority patent/GB2036020B/en
Priority to DK476679A priority patent/DK476679A/da
Priority to HU79ZA414A priority patent/HU183050B/hu
Priority to GB8103076A priority patent/GB2065123B/en
Priority to BE2/58198A priority patent/BE879925A/fr
Priority to LU81881A priority patent/LU81881A1/fr
Priority to IT09592/79A priority patent/IT1166021B/it
Priority to CS797711A priority patent/CS261853B2/cs
Publication of JPS5564598A publication Critical patent/JPS5564598A/ja
Priority to ES492479A priority patent/ES492479A0/es
Priority to PH25015A priority patent/PH15906A/en
Priority to FR8110968A priority patent/FR2482109A1/fr
Priority to CA386,540A priority patent/CA1131628A/en
Priority to CS829399A priority patent/CS261859B2/cs
Priority to SE8406344A priority patent/SE463264B/sv
Publication of JPS631319B2 publication Critical patent/JPS631319B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
JP13840278A 1978-11-11 1978-11-11 Preparation of aminoglycoside antibiotic having selectively protected amino group Granted JPS5564598A (en)

Priority Applications (35)

Application Number Priority Date Filing Date Title
JP13840278A JPS5564598A (en) 1978-11-11 1978-11-11 Preparation of aminoglycoside antibiotic having selectively protected amino group
IE2026/79A IE48972B1 (en) 1978-11-11 1979-10-23 The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
IE1521/83A IE48973B1 (en) 1978-11-11 1979-10-23 The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
ZA00795691A ZA795691B (en) 1978-11-11 1979-10-24 The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
IN1104/CAL/79A IN151454B (enrdf_load_stackoverflow) 1978-11-11 1979-10-24
SE7908850A SE446632B (sv) 1978-11-11 1979-10-25 Sett att framstella ett selektivt skyddat n-acylerat derivat av ett aminoglykosidantibiotikum
NL7907892A NL7907892A (nl) 1978-11-11 1979-10-26 Werkwijze voor de bereiding van een selectief beschermd n-geacyleerd derivaat van een aminoglycosidisch antibioticum.
CH184/84A CH650005A5 (de) 1978-11-11 1979-10-29 Verfahren zur herstellung eines selektiv geschuetzten n-acylierten aminoglycosid-antibiotikums.
CH9682/79A CH650004A5 (de) 1978-11-11 1979-10-29 Verfahren zur herstellung eines selektiv geschuetzten n-acylierten aminoglycosid-antibiotikums.
US06/090,591 US4297485A (en) 1978-11-11 1979-11-02 Production of a selectively protected N-acylated derivative of an aminoglycosidic antibiotic
AT0707979A AT367066B (de) 1978-11-11 1979-11-02 Verfahren zur herstellung eines selektiv geschuetzten n-acylierten derivates eines aminoglycosid-antibiotikums
PH23263A PH16263A (en) 1978-11-11 1979-11-08 The production of a selectively protected n-acylated derivatives of an aminoglycosidic antibiotic
FR7928015A FR2441631A1 (fr) 1978-11-11 1979-11-08 Procede de preparation d'un derive n-acyle selectivement protege d'un antibiotique aminoglycosidique
DE2945010A DE2945010C2 (de) 1978-11-11 1979-11-08 Verfahren zur Herstellung von durch Schutzgruppen N-acylierten Aminoglycosiden
ES485830A ES485830A1 (es) 1978-11-11 1979-11-08 Proceso para la produccion de un derivado selectivamente a- cilado n-protegido, de un antibiotico aminoglicoidico.
YU2743/79A YU44185B (en) 1978-11-11 1979-11-08 Process of a selective acylated n-protected derivatives of an amino-glycoside antibiotic
AU52622/79A AU529682B2 (en) 1978-11-11 1979-11-08 N-acylated derivatives of aminoglyosidic antibiotics
MX798478U MX6181E (es) 1978-11-11 1979-11-08 Procedimiento para la preparacion de derivados n-protegidos de antibioticos aminoglucosidicos
DE2953878A DE2953878C2 (de) 1978-11-11 1979-11-08 Verfahren zur Herstellung von durch Schutzgruppen N-acylierten Aminoglycosiden
GB8103076A GB2065123B (en) 1978-11-11 1979-11-09 Production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
AR79278828A AR241915A1 (es) 1978-11-11 1979-11-09 Procedimiento para preparar derivados 1-n- no protegidos y n-peracilados de antibioticos aminoglicocidos.
GB7938894A GB2036020B (en) 1978-11-11 1979-11-09 Production of a selectively protected n-acylated derivatives of an aminoglycosidic antibiotic
DK476679A DK476679A (da) 1978-11-11 1979-11-09 Fremgangsmaade til fremstilling af et selektivt beskyttet n-acyleret derivat af et aminoglycosidantibioticum
HU79ZA414A HU183050B (en) 1978-11-11 1979-11-09 Process for producing n-acyl-derivatives of aminoglycoside antibiotics
CA000339531A CA1118416A (en) 1978-11-11 1979-11-09 Production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
BE2/58198A BE879925A (fr) 1978-11-11 1979-11-09 Procede nouveau de preparation d'un derive n-acyle selectivement protege d'un antibiotique amino-glycosidique
LU81881A LU81881A1 (fr) 1978-11-11 1979-11-09 Procede de preparation d'un derive n-acyle selectivement protege d'un antibiotique aminoglycosidique
CS797711A CS261853B2 (en) 1978-11-11 1979-11-12 Method of aminoglycoside antibiotic's selectively acylated n-protected derivative production
IT09592/79A IT1166021B (it) 1978-11-11 1979-11-12 Procedimento per la produzione di un derivato n acilato selettivamente protetto di un antibiotico amino glicasidico
ES492479A ES492479A0 (es) 1978-11-11 1980-06-16 Proceso para la produccion de un derivado n-acilado, selec- tivamente protegido, de un antibiotico aminoglicosidico
PH25015A PH15906A (en) 1978-11-11 1980-12-22 The production of a selectively protected n-acylated derivatives of an aminoglycosidic antibiotic
FR8110968A FR2482109A1 (fr) 1978-11-11 1981-06-03 Procede de preparation d'un derive n-acyle selectivement protege d'un antibiotique aminoglycosidique
CA386,540A CA1131628A (en) 1978-11-11 1981-09-23 Production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
CS829399A CS261859B2 (cs) 1978-11-11 1982-12-20 Způsob přípravy selektivně chráněného N-acylovaného derivátu aminoglykosidového antibiotika
SE8406344A SE463264B (sv) 1978-11-11 1984-12-13 Saett att framstaella 1-n-oskyddat men i oevrigt n-acylerat derivat av ett aminoglykosidantibiotikum

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13840278A JPS5564598A (en) 1978-11-11 1978-11-11 Preparation of aminoglycoside antibiotic having selectively protected amino group

Publications (2)

Publication Number Publication Date
JPS5564598A JPS5564598A (en) 1980-05-15
JPS631319B2 true JPS631319B2 (enrdf_load_stackoverflow) 1988-01-12

Family

ID=15221109

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13840278A Granted JPS5564598A (en) 1978-11-11 1978-11-11 Preparation of aminoglycoside antibiotic having selectively protected amino group

Country Status (5)

Country Link
JP (1) JPS5564598A (enrdf_load_stackoverflow)
BE (1) BE879925A (enrdf_load_stackoverflow)
CS (1) CS261853B2 (enrdf_load_stackoverflow)
HU (1) HU183050B (enrdf_load_stackoverflow)
ZA (1) ZA795691B (enrdf_load_stackoverflow)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136254A (en) * 1976-06-17 1979-01-23 Schering Corporation Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby
DE69104092T2 (de) * 1990-03-08 1995-01-26 Opos Biochimica Srl Verfahren zur Herstellung von Amikacin-Vorläufern.
KR100450607B1 (ko) * 2002-07-11 2004-09-30 경동제약 주식회사 가라민 유도체의 제조방법

Also Published As

Publication number Publication date
CS261853B2 (en) 1989-02-10
BE879925A (fr) 1980-03-03
JPS5564598A (en) 1980-05-15
CS771179A2 (en) 1988-06-15
HU183050B (en) 1984-04-28
ZA795691B (en) 1980-11-26

Similar Documents

Publication Publication Date Title
US4297485A (en) Production of a selectively protected N-acylated derivative of an aminoglycosidic antibiotic
Tsuchiya et al. 1-N-Acylation of aminocyclitol antibiotics via zinc chelation and regiospecific N-trifluoroacetylation
JPS6127997A (ja) ３，２′，６′−トリ−ｎ−アシル−３′，４′−ジデオキシカナマイシンｂ
EP0218292B1 (en) Novel process for the synthesis of amikacin
JPS631319B2 (enrdf_load_stackoverflow)
US4547492A (en) 1-N-(ω-Amino-α-hydroxyalkanoyl-2',3'-dideoxykanamycin A and pharmaceutical composition containing same
KR840001622B1 (ko) 3-0-데메틸 이스타마이신 b의 제조방법
JPS631954B2 (enrdf_load_stackoverflow)
KR830001613B1 (ko) 아미노기를 선택적으로 보호한 아미노글리코사이드 항생물질의 제조방법
GB1589936A (en) Processes for the production of 3',4'-dideoxykanamycin b
JPS6332799B2 (enrdf_load_stackoverflow)
JPS633874B2 (enrdf_load_stackoverflow)
CA1131628A (en) Production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
JPH0134231B2 (enrdf_load_stackoverflow)
JPS6312079B2 (enrdf_load_stackoverflow)
EP0104125B1 (en) 5,2',3',4',4",6"-hexadeoxykanamycin and its 1-n-acylated derivative
CA1152063A (en) 3',4'-DIDEOXYKANAMYCIN A AND 1-N-((S)-.alpha.- HYDROXY-.omega.-AMINOALKANOLY) DERIVATIVES THEREOF
JPS6310959B2 (enrdf_load_stackoverflow)
JPS631951B2 (enrdf_load_stackoverflow)
JPS6043356B2 (ja) 耐性菌に有効なカナマイシンｃ誘導体およびそれらの製造法
JPH0631295B2 (ja) 低毒性の２′−デアミノ−２′−ヒドロキシイスタマイシンＢｏ誘導体
JPH0134232B2 (enrdf_load_stackoverflow)
IE48973B1 (en) The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
JPS631317B2 (enrdf_load_stackoverflow)
JPH0631296B2 (ja) ２′，３′−ジデオキシ−２′−フルオロカナマイシンａ誘導体、およびその製造法