JPS6312292A - Ｌ−リジンの製造法 - Google Patents
Ｌ−リジンの製造法Info
- Publication number
- JPS6312292A JPS6312292A JP15677586A JP15677586A JPS6312292A JP S6312292 A JPS6312292 A JP S6312292A JP 15677586 A JP15677586 A JP 15677586A JP 15677586 A JP15677586 A JP 15677586A JP S6312292 A JPS6312292 A JP S6312292A
- Authority
- JP
- Japan
- Prior art keywords
- lysine
- producing
- naphthoquinoline
- strain
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 title claims abstract description 62
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 239000004472 Lysine Substances 0.000 claims abstract description 37
- HCAUQPZEWLULFJ-UHFFFAOYSA-N benzo[f]quinoline Chemical compound C1=CC=C2C3=CC=CC=C3C=CC2=N1 HCAUQPZEWLULFJ-UHFFFAOYSA-N 0.000 claims abstract description 36
- 235000019766 L-Lysine Nutrition 0.000 claims abstract description 24
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 13
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 13
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- 229930195712 glutamate Natural products 0.000 claims description 8
- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 claims description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract description 8
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- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 abstract description 6
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- 229910052799 carbon Inorganic materials 0.000 abstract description 3
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- 229910000160 potassium phosphate Inorganic materials 0.000 abstract description 3
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- 150000001875 compounds Chemical class 0.000 abstract 1
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- 239000003814 drug Substances 0.000 description 6
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- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
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- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
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- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
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- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
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- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229960005337 lysine hydrochloride Drugs 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 239000004137 magnesium phosphate Substances 0.000 description 1
- 229960002261 magnesium phosphate Drugs 0.000 description 1
- 229910000157 magnesium phosphate Inorganic materials 0.000 description 1
- 235000010994 magnesium phosphates Nutrition 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 229940099596 manganese sulfate Drugs 0.000 description 1
- 239000011702 manganese sulphate Substances 0.000 description 1
- 235000007079 manganese sulphate Nutrition 0.000 description 1
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000013028 medium composition Substances 0.000 description 1
- 229960004452 methionine Drugs 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- OZIRORHUKSXTLG-UHFFFAOYSA-N naphtho[1,2-h]quinoline Chemical compound C1=CC2=CC=CN=C2C2=C1C1=CC=CC=C1C=C2 OZIRORHUKSXTLG-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 229910017464 nitrogen compound Inorganic materials 0.000 description 1
- 150000002830 nitrogen compounds Chemical class 0.000 description 1
- 239000006174 pH buffer Substances 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- AZQWKYJCGOJGHM-UHFFFAOYSA-N para-benzoquinone Natural products O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- -1 quinone compounds Chemical class 0.000 description 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 229960001153 serine Drugs 0.000 description 1
- 235000004400 serine Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 239000011686 zinc sulphate Substances 0.000 description 1
- 235000009529 zinc sulphate Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15677586A JPS6312292A (ja) | 1986-07-03 | 1986-07-03 | Ｌ−リジンの製造法 |
| MX711587A MX168303B (es) | 1986-07-03 | 1987-06-29 | Un procedimiento para producir l-lisina |
| CN 87104553 CN1022931C (zh) | 1986-07-03 | 1987-07-01 | 一种生产l-赖氨酸的方法 |
| FR8709309A FR2601035B1 (fr) | 1986-07-03 | 1987-07-01 | Procede de preparation de l-lysine |
| AU75059/87A AU597387B2 (en) | 1986-07-03 | 1987-07-02 | A process for producing L-lysine |
| HU300487A HU200797B (en) | 1986-07-03 | 1987-07-02 | Process for producing l-lysine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15677586A JPS6312292A (ja) | 1986-07-03 | 1986-07-03 | Ｌ−リジンの製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6312292A true JPS6312292A (ja) | 1988-01-19 |
| JPH0555114B2 JPH0555114B2 (zh) | 1993-08-16 |
Family
ID=15635042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15677586A Granted JPS6312292A (ja) | 1986-07-03 | 1986-07-03 | Ｌ−リジンの製造法 |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS6312292A (zh) |
| CN (1) | CN1022931C (zh) |
| AU (1) | AU597387B2 (zh) |
| FR (1) | FR2601035B1 (zh) |
| HU (1) | HU200797B (zh) |
| MX (1) | MX168303B (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6000931A (en) * | 1995-05-19 | 1999-12-14 | Matsushita Electric Industrial Co., Ltd. | Gas safety control system |
| JP2010516274A (ja) * | 2007-01-24 | 2010-05-20 | シージェイ チェイルジェダン コーポレイション | コリネバクテリアを利用してグリセロールを含む炭素源から発酵産物を生産する方法 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3006939B2 (ja) * | 1991-10-21 | 2000-02-07 | 協和醗酵工業株式会社 | Ｌ−リジンの製造法 |
| KR100830289B1 (ko) * | 2007-01-18 | 2008-05-16 | 씨제이제일제당 (주) | Ｌ－아르기닌 생산 변이주 및 이의 제조방법 |
| WO2011111073A2 (en) * | 2010-03-11 | 2011-09-15 | Anand Bhadalakar | PROCESS FOR BIOGENESIS OF L-LYSINE FROM ε-CAPROLACTAM OR ε-CAPROLACTAM DEGRADATION OR RELATED INTERMEDIATES |
| CN102399834A (zh) * | 2011-11-03 | 2012-04-04 | 中粮生物化学（安徽）股份有限公司 | 一种赖氨酸的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS594993B2 (ja) * | 1976-12-29 | 1984-02-02 | 味の素株式会社 | 発酵法によるｌ−リジンの製法 |
| ES8308357A1 (es) * | 1981-08-10 | 1983-08-16 | Kyowa Hakko Kogyo Kk | Un procedimiento para la produccion de l-lisina. |
-
1986
- 1986-07-03 JP JP15677586A patent/JPS6312292A/ja active Granted
-
1987
- 1987-06-29 MX MX711587A patent/MX168303B/es unknown
- 1987-07-01 FR FR8709309A patent/FR2601035B1/fr not_active Expired
- 1987-07-01 CN CN 87104553 patent/CN1022931C/zh not_active Expired - Lifetime
- 1987-07-02 HU HU300487A patent/HU200797B/hu not_active IP Right Cessation
- 1987-07-02 AU AU75059/87A patent/AU597387B2/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6000931A (en) * | 1995-05-19 | 1999-12-14 | Matsushita Electric Industrial Co., Ltd. | Gas safety control system |
| JP2010516274A (ja) * | 2007-01-24 | 2010-05-20 | シージェイ チェイルジェダン コーポレイション | コリネバクテリアを利用してグリセロールを含む炭素源から発酵産物を生産する方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU597387B2 (en) | 1990-05-31 |
| FR2601035A1 (fr) | 1988-01-08 |
| HU200797B (en) | 1990-08-28 |
| CN1022931C (zh) | 1993-12-01 |
| CN87104553A (zh) | 1988-05-04 |
| MX168303B (es) | 1993-05-17 |
| AU7505987A (en) | 1988-01-07 |
| HUT44080A (en) | 1988-01-28 |
| JPH0555114B2 (zh) | 1993-08-16 |
| FR2601035B1 (fr) | 1989-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EXPY | Cancellation because of completion of term |