JPS62289181A - 新規化合物、その製法およびそれを含む医薬組成物 - Google Patents

新規化合物、その製法およびそれを含む医薬組成物

Info

Publication number
JPS62289181A
JPS62289181A JP62080870A JP8087087A JPS62289181A JP S62289181 A JPS62289181 A JP S62289181A JP 62080870 A JP62080870 A JP 62080870A JP 8087087 A JP8087087 A JP 8087087A JP S62289181 A JPS62289181 A JP S62289181A
Authority
JP
Japan
Prior art keywords
plasminogen activator
modified
dna
sequence
residues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62080870A
Other languages
English (en)
Japanese (ja)
Inventor
マイケル・ジョセフ・ブラウン
ジェフリー・ヒュー・ロビンソン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of JPS62289181A publication Critical patent/JPS62289181A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP62080870A 1986-04-02 1987-04-01 新規化合物、その製法およびそれを含む医薬組成物 Pending JPS62289181A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8608020 1986-04-02
GB868608020A GB8608020D0 (en) 1986-04-02 1986-04-02 Compounds

Publications (1)

Publication Number Publication Date
JPS62289181A true JPS62289181A (ja) 1987-12-16

Family

ID=10595544

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62080870A Pending JPS62289181A (ja) 1986-04-02 1987-04-01 新規化合物、その製法およびそれを含む医薬組成物

Country Status (11)

Country Link
EP (1) EP0241210B1 (enExample)
JP (1) JPS62289181A (enExample)
AU (1) AU602681B2 (enExample)
DE (1) DE3780199T2 (enExample)
DK (1) DK165887A (enExample)
ES (1) ES2042553T3 (enExample)
GB (1) GB8608020D0 (enExample)
GR (1) GR3005571T3 (enExample)
NZ (1) NZ219828A (enExample)
PT (1) PT84590B (enExample)
ZA (1) ZA872334B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02215384A (ja) * 1988-10-24 1990-08-28 Boehringer Mannheim Gmbh 組織プラスミノーゲンアクチベーターミユーテイン、その製造方法および該ミユーテインを含有する凝血塊溶解剤
JP2016127839A (ja) * 1999-09-28 2016-07-14 バクスアルタ・イノベイションズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｘａｌｔａ Ｉｎｎｏｖａｔｉｏｎｓ ＧｍｂＨ 細胞の無タンパク質かつ無血清の培養のための培地

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2983997B2 (ja) * 1987-01-30 1999-11-29 アメリカン・ホーム・プロダクツ・コーポレイション 脱―表皮細胞成長因子プラスミノーゲンアクチベーター
FI882407L (fi) * 1987-05-22 1988-11-23 Zymogenetics Inc Fibrinolytiska proteiner.
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
EP0340573A3 (de) * 1988-04-30 1990-05-30 BASF Aktiengesellschaft Neue Proteine, ihre Herstellung und Verwendung
DE4123845A1 (de) * 1991-07-18 1993-01-21 Boehringer Mannheim Gmbh Pharmazeutische verpackungseinheit enthaltend plasminogenaktivatoren zur mehrfachbolusgabe

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
AU7090787A (en) * 1986-02-19 1987-10-08 Beecham Group Plc Tissue plasminogen activator
PT84587B (pt) * 1986-04-02 1989-11-30 Beecham Group Plc Processo para preparacao de uma enzima fibrinolitica
PT84588B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02215384A (ja) * 1988-10-24 1990-08-28 Boehringer Mannheim Gmbh 組織プラスミノーゲンアクチベーターミユーテイン、その製造方法および該ミユーテインを含有する凝血塊溶解剤
JP2016127839A (ja) * 1999-09-28 2016-07-14 バクスアルタ・イノベイションズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｘａｌｔａ Ｉｎｎｏｖａｔｉｏｎｓ ＧｍｂＨ 細胞の無タンパク質かつ無血清の培養のための培地
JP2017212977A (ja) * 1999-09-28 2017-12-07 バクスアルタ・イノベイションズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｘａｌｔａ Ｉｎｎｏｖａｔｉｏｎｓ ＧｍｂＨ 細胞の無タンパク質かつ無血清の培養のための培地

Also Published As

Publication number Publication date
EP0241210A1 (en) 1987-10-14
NZ219828A (en) 1990-08-28
AU602681B2 (en) 1990-10-25
GB8608020D0 (en) 1986-05-08
ZA872334B (en) 1987-12-30
DE3780199T2 (de) 1993-01-21
PT84590A (en) 1987-04-01
GR3005571T3 (enExample) 1993-06-07
DK165887A (da) 1987-10-02
DK165887D0 (da) 1987-04-01
DE3780199D1 (de) 1992-08-13
ES2042553T3 (es) 1993-12-16
EP0241210B1 (en) 1992-07-08
PT84590B (pt) 1989-11-30
AU7090587A (en) 1987-10-08

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