JPS62174094A - α．α―トレハロース誘導体 - Google Patents

α．α―トレハロース誘導体

Info

Publication number
JPS62174094A
JPS62174094A JP60282676A JP28267685A JPS62174094A JP S62174094 A JPS62174094 A JP S62174094A JP 60282676 A JP60282676 A JP 60282676A JP 28267685 A JP28267685 A JP 28267685A JP S62174094 A JPS62174094 A JP S62174094A
Authority
JP
Japan
Prior art keywords
formula
benzyl
trehalose
alpha
fatty acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60282676A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0529235B2 (enExample
Inventor
Akihiro Shibata
柴田　晶弘
Hideaki Matsuda
松田　秀明
Hidehiko Kamiya
神谷　英彦
Tatsuhiko Katori
香取　達彦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SSP Co Ltd
Original Assignee
SSP Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SSP Co Ltd filed Critical SSP Co Ltd
Priority to JP60282676A priority Critical patent/JPS62174094A/ja
Priority to CA000524290A priority patent/CA1263649A/en
Priority to DE8686117084T priority patent/DE3674752D1/de
Priority to US06/938,883 priority patent/US4814436A/en
Priority to EP86117084A priority patent/EP0228612B1/en
Publication of JPS62174094A publication Critical patent/JPS62174094A/ja
Publication of JPH0529235B2 publication Critical patent/JPH0529235B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP60282676A 1985-12-16 1985-12-16 α．α―トレハロース誘導体 Granted JPS62174094A (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP60282676A JPS62174094A (ja) 1985-12-16 1985-12-16 α．α―トレハロース誘導体
CA000524290A CA1263649A (en) 1985-12-16 1986-12-02 DERIVATIVE OF .alpha.-.alpha.TREHALOSE AND A PROCESS FOR PREPARING THE SAME
DE8686117084T DE3674752D1 (de) 1985-12-16 1986-12-08 Alpha, alpha-trehalose-derivat und verfahren zur herstellung davon.
US06/938,883 US4814436A (en) 1985-12-16 1986-12-08 Derivative of α, α-trehalose and a process for preparing the same
EP86117084A EP0228612B1 (en) 1985-12-16 1986-12-08 A derivative of alpha, alpha-trehalose and a process for preparing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60282676A JPS62174094A (ja) 1985-12-16 1985-12-16 α．α―トレハロース誘導体

Publications (2)

Publication Number Publication Date
JPS62174094A true JPS62174094A (ja) 1987-07-30
JPH0529235B2 JPH0529235B2 (enExample) 1993-04-28

Family

ID=17655603

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60282676A Granted JPS62174094A (ja) 1985-12-16 1985-12-16 α．α―トレハロース誘導体

Country Status (5)

Country Link
US (1) US4814436A (enExample)
EP (1) EP0228612B1 (enExample)
JP (1) JPS62174094A (enExample)
CA (1) CA1263649A (enExample)
DE (1) DE3674752D1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049664A (en) * 1988-08-26 1991-09-17 Sawai Pharmaceutical Co., Ltd. Trehalose derivatives
US5529927A (en) * 1993-12-28 1996-06-25 San-Ei Gen F.F.I., Inc. "Alga species lobsphaera TM-33 (ATCC 75630) which is useful for preparing trehalase"

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2672496B3 (fr) * 1990-07-18 1993-05-28 Vacsyn France Sa Compositions a base de substances hydrophobes, solubilisables dans un solvant aqueux, leur procede d'obtention, et leurs utilisations notamment dans le domaine pharmaceutique.
FR2664813B1 (fr) * 1990-07-18 1995-01-13 Vacsyn France Sa Compositions a base de substances hydrophobes, solubilisables dans un solvant aqueux, leur procede d'obtention, et leurs utilisations notamment dans le domaine pharmaceutique.
US5095123A (en) * 1990-11-30 1992-03-10 E. I. Du Pont De Nemours And Company Process for the preparation of glycosyl phosphate triesters
US6673335B1 (en) * 1992-07-08 2004-01-06 Nektar Therapeutics Compositions and methods for the pulmonary delivery of aerosolized medicaments
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
GB9216026D0 (en) * 1992-07-28 1992-09-09 Nat Inst Biological Standards & Control Esterification process
AU688283B2 (en) * 1992-09-29 1998-03-12 Novartis Ag Pulmonary delivery of active fragments of parathyroid hormone
US5576303A (en) * 1993-03-16 1996-11-19 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Energy-supplementing saccharide source and its uses
ES2316917T3 (es) * 1994-03-07 2009-04-16 Nektar Therapeutics Metodos y composiciones para suministro pulmonar de insulina.
US20030113273A1 (en) * 1996-06-17 2003-06-19 Patton John S. Methods and compositions for pulmonary delivery of insulin
CA2190502A1 (en) * 1994-05-18 1995-11-23 Robert M. Platz Methods and compositions for the dry powder formulation of interferons
EP0688029B1 (en) * 1994-05-27 1998-05-13 Daewoo Electronics Co., Ltd Noise shielding apparatus for magnetron of microwave oven
US6586006B2 (en) 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US6632648B1 (en) * 1996-05-14 2003-10-14 Elan Drug Delivery Limited Methods of terminal sterilization of fibrinogen
US6468782B1 (en) 1996-12-05 2002-10-22 Quadrant Healthcare (Uk) Limited Methods of preserving prokaryotic cells and compositions obtained thereby
US20030035778A1 (en) * 1997-07-14 2003-02-20 Robert Platz Methods and compositions for the dry powder formulation of interferon
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6309623B1 (en) * 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US8404217B2 (en) * 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7442388B2 (en) 2000-05-10 2008-10-28 Weers Jeffry G Phospholipid-based powders for drug delivery
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US20020106368A1 (en) * 2000-07-28 2002-08-08 Adrian Bot Novel methods and compositions to upregulate, redirect or limit immune responses to peptides, proteins and other bioactive compounds and vectors expressing the same
ES2364636T3 (es) 2001-12-19 2011-09-08 Novartis Ag Administración pulmonar de aminoglucósidos.
US20070031342A1 (en) * 2005-06-22 2007-02-08 Nektar Therapeutics Sustained release microparticles for pulmonary delivery
US12064480B2 (en) 2018-04-13 2024-08-20 Glaxosmithkline Biologicals Sa Immunigenic alpha-branched trehalose-diesters

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4307229A (en) * 1979-11-07 1981-12-22 Avraham Liav 6,6'-Diesters of trehalose and process for the synthesis thereof
DE3248167A1 (de) * 1982-12-27 1984-06-28 Wintershall Ag, 3100 Celle Trehaloselipidtetraester
JPS60258195A (ja) * 1984-06-05 1985-12-20 Ss Pharmaceut Co Ltd α．α―トレハロース脂肪酸ジエステル誘導体
US4612304A (en) * 1985-06-11 1986-09-16 Ss Pharmaceutical Co., Ltd. Antitumor formulation containing lipopolysaccharide with trehalose derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049664A (en) * 1988-08-26 1991-09-17 Sawai Pharmaceutical Co., Ltd. Trehalose derivatives
US5529927A (en) * 1993-12-28 1996-06-25 San-Ei Gen F.F.I., Inc. "Alga species lobsphaera TM-33 (ATCC 75630) which is useful for preparing trehalase"

Also Published As

Publication number Publication date
EP0228612A2 (en) 1987-07-15
EP0228612A3 (en) 1988-01-13
EP0228612B1 (en) 1990-10-03
CA1263649A (en) 1989-12-05
US4814436A (en) 1989-03-21
JPH0529235B2 (enExample) 1993-04-28
DE3674752D1 (de) 1990-11-08

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