FR2672496B3 - Compositions a base de substances hydrophobes, solubilisables dans un solvant aqueux, leur procede d'obtention, et leurs utilisations notamment dans le domaine pharmaceutique. - Google Patents

Compositions a base de substances hydrophobes, solubilisables dans un solvant aqueux, leur procede d'obtention, et leurs utilisations notamment dans le domaine pharmaceutique.

Info

Publication number
FR2672496B3
FR2672496B3 FR9101497A FR9101497A FR2672496B3 FR 2672496 B3 FR2672496 B3 FR 2672496B3 FR 9101497 A FR9101497 A FR 9101497A FR 9101497 A FR9101497 A FR 9101497A FR 2672496 B3 FR2672496 B3 FR 2672496B3
Authority
FR
France
Prior art keywords
solubilizable
aqueous solvent
compositions based
pharmaceutical field
hydrophobic substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9101497A
Other languages
English (en)
Other versions
FR2672496A1 (fr
Inventor
Louis Chedid
Pierre Lefrancier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VACSYN FRANCE SA
Original Assignee
VACSYN FRANCE SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9009172A external-priority patent/FR2664813B1/fr
Application filed by VACSYN FRANCE SA filed Critical VACSYN FRANCE SA
Priority to FR9101497A priority Critical patent/FR2672496B3/fr
Priority to AU82829/91A priority patent/AU8282991A/en
Priority to JP91512552A priority patent/JPH05508653A/ja
Priority to PCT/FR1991/000595 priority patent/WO1992001475A1/fr
Priority to CA002087536A priority patent/CA2087536A1/fr
Priority to EP91913281A priority patent/EP0539457A1/fr
Publication of FR2672496A1 publication Critical patent/FR2672496A1/fr
Priority to CS924074A priority patent/CZ407492A3/cs
Publication of FR2672496B3 publication Critical patent/FR2672496B3/fr
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/5555—Muramyl dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
FR9101497A 1990-07-18 1991-02-08 Compositions a base de substances hydrophobes, solubilisables dans un solvant aqueux, leur procede d'obtention, et leurs utilisations notamment dans le domaine pharmaceutique. Expired - Lifetime FR2672496B3 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR9101497A FR2672496B3 (fr) 1990-07-18 1991-02-08 Compositions a base de substances hydrophobes, solubilisables dans un solvant aqueux, leur procede d'obtention, et leurs utilisations notamment dans le domaine pharmaceutique.
CA002087536A CA2087536A1 (fr) 1990-07-18 1991-07-18 Compositions a base de principes actifs de medicaments hydrophobes solubilisables dans un solvant aqueux
JP91512552A JPH05508653A (ja) 1990-07-18 1991-07-18 水性溶媒に可溶化し得る疎水性医薬の有効成分をベースとする組成物、その製法、及び特に医薬分野におけるその使用
PCT/FR1991/000595 WO1992001475A1 (fr) 1990-07-18 1991-07-18 Compositions a base de principes actifs de medicaments hydrophobes solubilisables dans un solvant aqueux
AU82829/91A AU8282991A (en) 1990-07-18 1991-07-18 Compositions based on active principles of hydrophobic medicaments solubilizable in an aqueous solvent
EP91913281A EP0539457A1 (fr) 1990-07-18 1991-07-18 Compositions a base de principes actifs de medicaments hydrophobes solubilisables dans un solvant aqueux
CS924074A CZ407492A3 (cs) 1990-07-18 1992-12-31 Farmaceutický prostředek

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9009172A FR2664813B1 (fr) 1990-07-18 1990-07-18 Compositions a base de substances hydrophobes, solubilisables dans un solvant aqueux, leur procede d'obtention, et leurs utilisations notamment dans le domaine pharmaceutique.
FR9101497A FR2672496B3 (fr) 1990-07-18 1991-02-08 Compositions a base de substances hydrophobes, solubilisables dans un solvant aqueux, leur procede d'obtention, et leurs utilisations notamment dans le domaine pharmaceutique.

Publications (2)

Publication Number Publication Date
FR2672496A1 FR2672496A1 (fr) 1992-08-14
FR2672496B3 true FR2672496B3 (fr) 1993-05-28

Family

ID=26228157

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9101497A Expired - Lifetime FR2672496B3 (fr) 1990-07-18 1991-02-08 Compositions a base de substances hydrophobes, solubilisables dans un solvant aqueux, leur procede d'obtention, et leurs utilisations notamment dans le domaine pharmaceutique.

Country Status (6)

Country Link
EP (1) EP0539457A1 (fr)
JP (1) JPH05508653A (fr)
AU (1) AU8282991A (fr)
CA (1) CA2087536A1 (fr)
FR (1) FR2672496B3 (fr)
WO (1) WO1992001475A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692149B1 (fr) * 1992-06-12 1995-06-09 Vacsyn France Sa Composition adjuvante de l'immunite humorale et a mediation cellulaire n'induisant pas de reponse vis-a-vis de determinants auto-antigeniques.
FR2706772A1 (en) * 1993-06-22 1994-12-30 Vacsyn Sa Prevention and treatment of septic syndrome with an immunosuppressant, in particular cyclosporin.
WO1997011092A1 (fr) * 1994-04-07 1997-03-27 Nippon Shinyaku Co., Ltd. Derives de phosphates de cyclosporine et composition medicinale
BE1008978A5 (fr) * 1994-12-27 1996-10-01 Solvay Adjuvants pour vaccins.
US6491919B2 (en) * 1997-04-01 2002-12-10 Corixa Corporation Aqueous immunologic adjuvant compostions of monophosphoryl lipid A
DK1096954T3 (da) * 1998-07-14 2005-01-31 Wyeth Corp Adjuvans- og vaccinesammensætninger indeholdende monophosphoryllipid A
US6121430A (en) * 1998-12-28 2000-09-19 University Of Iowa Research Foundation Regiospecific synthesis of glucose-based surfactants

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT709141A (fr) * 1963-11-08
US3808200A (en) * 1969-07-29 1974-04-30 Agriculture Hexitol,glucose and surcose esters of alpha-sulfo fatty acids
US4606918A (en) * 1983-08-22 1986-08-19 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
FR2564096B1 (fr) * 1984-05-11 1988-02-19 Anvar Derives lipophiles de muramylpeptides ayant des proprietes d'activation des macrophages, compositions les contenant et procede pour les obtenir
US4612304A (en) * 1985-06-11 1986-09-16 Ss Pharmaceutical Co., Ltd. Antitumor formulation containing lipopolysaccharide with trehalose derivatives
JPS62174094A (ja) * 1985-12-16 1987-07-30 Ss Pharmaceut Co Ltd α．α―トレハロース誘導体

Also Published As

Publication number Publication date
FR2672496A1 (fr) 1992-08-14
EP0539457A1 (fr) 1993-05-05
AU8282991A (en) 1992-02-18
CA2087536A1 (fr) 1992-01-19
JPH05508653A (ja) 1993-12-02
WO1992001475A1 (fr) 1992-02-06

Similar Documents

Publication Publication Date Title
FI922951A0 (fi) Reaktionsprocess av polymer och asfalt och polymerbunden asfaltprodukt.
FR2635265B1 (fr) Composition pharmaceutique intraveineuse comprenant de la cyclosporine en tant que principe actif et procede pour sa preparation
FI893958A (fi) Polymera kompositioner och foerfaranden foer deras framstaellning.
IT8521922A0 (it) Sistema di somministrazione di farmaci.
DE69010766D1 (de) Hydrophobe Membranen.
DE3580616D1 (de) Mitomycinderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen.
DE69002043D1 (de) Rotationszerstaeuber.
FI905510A0 (fi) Nya bensoxazinderivat och dessa innehaollande farmaceutiska blandningar.
FR2671086B1 (fr) Peptides opiouides, leur procede de preparation, et composition pharmaceutique contenant ces peptides.
FI910695A0 (fi) Polymera foertjockningsmedel foer vattenbaserade belaeggningar.
DE3677279D1 (de) Waessrige hilfsstoffzusammensetzungen, verfahren und polymerteilchen.
FI893314A0 (fi) Foerfarande och apparatur foer plockning av smao partiklar ur vaetsken.
DE69018580D1 (de) Zerstäubungsgerät.
FR2663326B2 (fr) Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR2672496B3 (fr) Compositions a base de substances hydrophobes, solubilisables dans un solvant aqueux, leur procede d'obtention, et leurs utilisations notamment dans le domaine pharmaceutique.
FR2697248B1 (fr) Procede de preparation du dichlorure d'acide l-5-(2-acetoxy-propionylamino)-2,4,6-triiodo-isophtalique.
FR2560195B1 (fr) Derives d'alanyl-proline, leur procede de preparation et leurs applications pharmaceutiques
DE69012263D1 (de) Flüssigkeitsentladungsvorrichtung.
NO901020D0 (no) Boerster.
NO891130L (no) Doseringspumpesystem.
FR2700956B1 (fr) Composition cosmetique et pharmaceutique et procede pour sa preparation.
FR2664813B1 (fr) Compositions a base de substances hydrophobes, solubilisables dans un solvant aqueux, leur procede d'obtention, et leurs utilisations notamment dans le domaine pharmaceutique.
FR2657872B2 (fr) Derive d'amidino-4 chromanne, procede d'obtention et compositions pharmaceutiques le contenant.
FI901752A0 (fi) Funktionaliserade polymerer av metallerade kristallina olefin-dienkopolymerer och foerfarande foer framstaellning av dessa.
FI923371A0 (fi) En farmaceutisk formulation.