JPS6215546B2 - - Google Patents

Info

Publication number
JPS6215546B2
JPS6215546B2 JP52150384A JP15038477A JPS6215546B2 JP S6215546 B2 JPS6215546 B2 JP S6215546B2 JP 52150384 A JP52150384 A JP 52150384A JP 15038477 A JP15038477 A JP 15038477A JP S6215546 B2 JPS6215546 B2 JP S6215546B2
Authority
JP
Japan
Prior art keywords
piperazine
ethyl
fluorophenyl
propenyl
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP52150384A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5382789A (en
Inventor
Gotsutoetsusu Yohan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Publication of JPS5382789A publication Critical patent/JPS5382789A/ja
Publication of JPS6215546B2 publication Critical patent/JPS6215546B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP15038477A 1976-12-14 1977-12-14 Novel piperadine derivative and method for its production Granted JPS5382789A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB52223/76A GB1545094A (en) 1976-12-14 1976-12-14 Piperazine derivatives

Publications (2)

Publication Number Publication Date
JPS5382789A JPS5382789A (en) 1978-07-21
JPS6215546B2 true JPS6215546B2 (en, 2012) 1987-04-08

Family

ID=10463103

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15038477A Granted JPS5382789A (en) 1976-12-14 1977-12-14 Novel piperadine derivative and method for its production

Country Status (22)

Country Link
US (2) US4202896A (en, 2012)
JP (1) JPS5382789A (en, 2012)
AT (1) AT363090B (en, 2012)
AU (1) AU516920B2 (en, 2012)
BE (1) BE861853A (en, 2012)
DE (1) DE2755752A1 (en, 2012)
DK (1) DK147421C (en, 2012)
ES (6) ES465047A1 (en, 2012)
FI (1) FI69839C (en, 2012)
GB (1) GB1545094A (en, 2012)
HU (1) HU177999B (en, 2012)
IE (1) IE46278B1 (en, 2012)
IL (1) IL53597A0 (en, 2012)
IT (1) IT1093045B (en, 2012)
LU (1) LU78686A1 (en, 2012)
NL (1) NL7713817A (en, 2012)
NO (1) NO148150C (en, 2012)
NZ (1) NZ185981A (en, 2012)
PT (1) PT67400B (en, 2012)
SE (1) SE435378B (en, 2012)
YU (1) YU295877A (en, 2012)
ZA (1) ZA777452B (en, 2012)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0061453A1 (en) * 1980-06-16 1982-10-06 AB Ferrosan Diphenylbutyl-1-acylpiperazines
NL8202636A (nl) * 1982-06-29 1984-01-16 Gist Brocades Nv Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten.
DE3600390A1 (de) * 1986-01-09 1987-07-16 Hoechst Ag Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel
US5162537A (en) * 1986-04-17 1992-11-10 Monsanto Company Benzhydryl compounds as herbicide antidotes
HU196194B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new 1-4 disubstituted piperazines and pharmaceuticals comprising the compounds
HU196195B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing 1,4-disubstituted piperazine derivatives and pharmaceuticals comprising the compounds
HU196196B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds
FR2601366B1 (fr) * 1986-07-10 1988-11-25 Andre Buzas Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
FR2636946B1 (fr) * 1988-09-23 1990-11-02 Lipha ((diarylmethoxy)alcoyl)-1 pyrrolidines et piperidines, procedes de preparation et medicaments les contenant
US5087627A (en) * 1989-03-15 1992-02-11 Santen Pharmaceutical Co., Ltd. Agent for treatment of disorders of the cerebro-neural transmission system
US5153198A (en) * 1989-03-15 1992-10-06 Santen Pharmaceutical Co., Ltd. Agent for treatment of disorders of the cerebro-neural transmission system
FR2661176B1 (fr) * 1990-04-20 1992-06-12 Adir Nouveau procede de preparation de la 1-(2,3,4-trimethoxybenzyl) piperazine en amination reductive.
DK178490D0 (da) * 1990-07-26 1990-07-26 Novo Nordisk As 1,4-disubstituerede piperaziner
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
WO1993000811A1 (en) * 1991-07-01 1993-01-21 The General Hospital Corporation Invertebrate phenylethanolamine transporter and the use thereof
DE69426771T2 (de) * 1993-06-25 2001-06-13 Pola Chemical Industries, Inc. Dopaminreinkorporationshemmer zur behandlung des parkinsonschen syndroms
DK1257541T3 (da) * 2000-01-11 2009-01-19 Molecular Insight Pharm Inc Farmakoforiske stoffer
US6743797B2 (en) * 2002-02-22 2004-06-01 Chantest, Inc. Methods for treating cardiac arrhythmia
US7211407B2 (en) * 2003-07-15 2007-05-01 Chan Test, Inc. High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins
US20050054010A1 (en) * 2003-07-15 2005-03-10 Brown Arthur M. High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins
US20050208595A1 (en) * 2004-03-19 2005-09-22 Brown Arthur M High throughput assay systems and methods for identifying agents that alter expression of cellular proteins
FR2884712B1 (fr) * 2005-04-21 2007-06-15 Oreal Compositions cosmetiques comprenant des derives de piperazine
CA2614116A1 (en) * 2005-07-04 2007-01-11 Novo Nordisk A/S Novel medicaments
US8318927B2 (en) * 2006-05-23 2012-11-27 High Point Pharmaceuticals, Llc 6-(4-cyclopropylpiperazin-1-yl)-2′-methyl-[3, 4′]-bipyridine and its uses as a medicament
DK2079732T3 (da) * 2006-05-29 2012-01-23 High Point Pharmaceuticals Llc 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)-pyridazin, dets salte og solvater og dets anvendelse som histamin H3-receptorantagonister
EP2014656A3 (en) * 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
US20120028992A1 (en) * 2010-08-02 2012-02-02 Brown Arthur M Pharmaceutical compositions for terminating acute episodes of cardiac arrhythmia, restoring sinus rhythm, preventing recurrence of cardiac arrhythmia and/or maintaining normal sinus rhythm in mammals
CN104529942B (zh) * 2014-12-10 2018-05-15 天津孚音生物科技发展有限公司 一种伐诺司林的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB837986A (en) 1956-07-10 1960-06-22 Henri Morren New piperazine derivatives and process for the preparation thereof
US2953568A (en) * 1958-03-03 1960-09-20 Ciba Pharm Prod Inc Derivatives of piperazine
CH410961A (de) * 1961-02-22 1966-04-15 Yoshitomi Pharmaceutical Verfahren zur Herstellung N-substituierter Piperazinderivate
DE1445692A1 (de) 1963-03-25 1969-03-20 Egyt Gyogyszervegyeszeti Gyar Verfahren zur Herstellung von Piperazinderivaten
DE1795375A1 (de) * 1968-09-21 1972-01-05 Boehringer Mannheim Gmbh Basische AEther und Verfahren zur Herstellung derselben
JPS504086A (en, 2012) * 1973-01-18 1975-01-16

Also Published As

Publication number Publication date
SE435378B (sv) 1984-09-24
US4202896A (en) 1980-05-13
DE2755752A1 (de) 1978-06-15
NL7713817A (nl) 1978-06-16
NZ185981A (en) 1980-02-21
IE46278L (en) 1978-06-14
NO148150B (no) 1983-05-09
ES465047A1 (es) 1979-01-01
ATA891177A (de) 1980-12-15
SE7714184L (sv) 1978-06-15
LU78686A1 (en, 2012) 1978-04-17
ZA777452B (en) 1978-10-25
NO148150C (no) 1983-08-24
AT363090B (de) 1981-07-10
AU3157377A (en) 1979-06-21
DK557277A (da) 1978-06-15
IE46278B1 (en) 1983-04-20
DK147421C (da) 1985-02-11
ES473815A1 (es) 1979-05-01
DE2755752C2 (en, 2012) 1991-12-05
FI69839C (fi) 1986-05-26
IT1093045B (it) 1985-07-19
ES473816A1 (es) 1979-04-16
YU295877A (en) 1983-01-21
US4265894A (en) 1981-05-05
BE861853A (fr) 1978-06-14
FI773786A7 (fi) 1978-06-15
ES473814A1 (es) 1979-04-16
IL53597A0 (en) 1978-03-10
AU516920B2 (en) 1981-07-02
ES473818A1 (es) 1979-04-16
HU177999B (en) 1982-02-27
ES473817A1 (es) 1979-04-16
JPS5382789A (en) 1978-07-21
PT67400A (en) 1978-01-01
FI69839B (fi) 1985-12-31
NO774307L (no) 1978-06-15
PT67400B (en) 1979-05-21
DK147421B (da) 1984-07-30
GB1545094A (en) 1979-05-02

Similar Documents

Publication Publication Date Title
JPS6215546B2 (en, 2012)
CA1317300C (en) Process for the preparation of 2-¬2-¬4-¬(4-chlorophenyl) phenylmethyl|-1-piperazinyl|ethoxy|-acetic acid and its dihydrochloride
US6143769A (en) Phenylacetic acid benzylamides
EP0434561B1 (fr) Dérivés de la napht-1-yl pipérazine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
US4234595A (en) 3-Indolyl-tertiary butylaminopropanols
CA2046495A1 (fr) Derives de la piperidine, de la tetrahydropyridine et de la pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA1202971A (en) Theophylline derivatives and process for their production
US5001134A (en) Piperidines, processes of preparation and medications containing them
JPS62230767A (ja) アセトアミド誘導体、その製造方法およびその医薬への応用
JPH0473432B2 (en, 2012)
US4528194A (en) 2-(4-Diphenylmethylpiperazinyl)-1-phenyl alkanol or their salts, a process for their production and a cerebral circulation-improving drug
US5308840A (en) Substituted or unsubstituted benzhydryl heteroalkyl-substituted aminophenol compounds and pharmaceutical compositions thereof
JPS60112778A (ja) モルホリン誘導体，それらの製法及びそれらを含有する医薬組成物
JPS6047255B2 (ja) ２−アミノ−５−スルフアモイル−安息香酸アミドの製法
FR2522000A1 (fr) Nouvelles thiopyrannopyrimidines, utiles notamment comme agents hypoglycemiants, et leur fabrication
HU185432B (en) Process for producing indene derivatives
JP4444492B2 (ja) ２−｛３−［４−（２−ｔ−ブチル−６−トリフルオロメチルピリジン−４−イル）ピペラジン−１−イル］プロピルメルカプト｝ピリミジン−４−オル−フマレート
WO1984001945A1 (en) Phenoxyaminopropanol derivatives
WO1994020466A1 (fr) Nouveaux derives de la phenoxy-2 ethylamine, leur preparation et leur application en therapeutique
JPH0660135B2 (ja) シクロブテン誘導体
JPS6317071B2 (en, 2012)
JPS5839832B2 (ja) 新規ピラジン化合物の製法
JPS5922708B2 (ja) インダゾ−ル誘導体の製法
JPS625982A (ja) チアゾリジン誘導体
JPS62178585A (ja) １−〔３−（２−ヒドロキシ−３−アルキルアミノプロポキシ）−２−チエニル〕−３−フエニル−１−プロパノン及びそれらの酸付加塩並びにそれらの製造法及びそれらを含む薬学的組成物