JPS6157589A - 純粋な結晶の形態のＤ‐６‐｛α‐［（２‐オキソ‐３‐フルフリリデン‐アミノ‐イミダゾリジン‐１‐イル）‐カルボニルアミノ］‐２‐チエニルアセタミド｝‐ペニシラン酸のナトリウム塩、その製造方法およびその薬物における使用 - Google Patents

純粋な結晶の形態のＤ‐６‐｛α‐［（２‐オキソ‐３‐フルフリリデン‐アミノ‐イミダゾリジン‐１‐イル）‐カルボニルアミノ］‐２‐チエニルアセタミド｝‐ペニシラン酸のナトリウム塩、その製造方法およびその薬物における使用

Info

Publication number
JPS6157589A
JPS6157589A JP60185652A JP18565285A JPS6157589A JP S6157589 A JPS6157589 A JP S6157589A JP 60185652 A JP60185652 A JP 60185652A JP 18565285 A JP18565285 A JP 18565285A JP S6157589 A JPS6157589 A JP S6157589A
Authority
JP
Japan
Prior art keywords
sodium salt
penicillanic acid
formula
ethanol
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP60185652A
Other languages
English (en)
Japanese (ja)
Inventor
ハンス‐ボド・ケーニツヒ
カルル・ゲオルク・メツツガー
ビルフリート・シユレツク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of JPS6157589A publication Critical patent/JPS6157589A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/70—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with hetero rings as additional substituents on the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP60185652A 1984-08-25 1985-08-23 純粋な結晶の形態のＤ‐６‐｛α‐［（２‐オキソ‐３‐フルフリリデン‐アミノ‐イミダゾリジン‐１‐イル）‐カルボニルアミノ］‐２‐チエニルアセタミド｝‐ペニシラン酸のナトリウム塩、その製造方法およびその薬物における使用 Pending JPS6157589A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19843431273 DE3431273A1 (de) 1984-08-25 1984-08-25 Kristallines natriumsalz der d-6-((alpha)-(2-oxo-3-furfuryl-iden-amino-imidazolidin-1-yl)-carbonylamino)-thienyl-2-acetamido)-penicillansaeure, verfahren zur herstellung und seine verwendung in arzneimitteln
DE3431273.0 1984-08-25
CN85106479A CN85106479B (zh) 1984-08-25 1985-08-29 晶状的右旋-6-{α-[(2-氧代-3-亚糠基-氨基-咪唑烷-1-基)碳酰氨基]-2-噻吩基乙酰氨基}-青霉烷酸钠盐制备方法

Publications (1)

Publication Number Publication Date
JPS6157589A true JPS6157589A (ja) 1986-03-24

Family

ID=25741999

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60185652A Pending JPS6157589A (ja) 1984-08-25 1985-08-23 純粋な結晶の形態のＤ‐６‐｛α‐［（２‐オキソ‐３‐フルフリリデン‐アミノ‐イミダゾリジン‐１‐イル）‐カルボニルアミノ］‐２‐チエニルアセタミド｝‐ペニシラン酸のナトリウム塩、その製造方法およびその薬物における使用

Country Status (18)

Country Link
EP (1) EP0176716B1 (OSRAM)
JP (1) JPS6157589A (OSRAM)
KR (1) KR860001818A (OSRAM)
CN (1) CN85106479B (OSRAM)
AT (1) ATE34576T1 (OSRAM)
AU (1) AU559040B2 (OSRAM)
DE (2) DE3431273A1 (OSRAM)
DK (1) DK385085A (OSRAM)
ES (1) ES8609340A1 (OSRAM)
FI (1) FI853211L (OSRAM)
GR (1) GR852047B (OSRAM)
HU (1) HU194893B (OSRAM)
IL (1) IL76164A0 (OSRAM)
NO (1) NO853188L (OSRAM)
NZ (1) NZ213198A (OSRAM)
PH (1) PH21842A (OSRAM)
PT (1) PT81014B (OSRAM)
ZA (1) ZA856413B (OSRAM)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW347383B (en) * 1995-10-26 1998-12-11 Biochemie Gmbh A process for the production of a crystalline sodium salt of amoxicillin in ethanol as solvent
US9844374B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL85039B1 (pl) * 1972-02-17 1977-02-26 Tarchomińskie Zakłady Farmaceutyczne Sposób wytwarzania soli sodowej a-ftminobenzylopeiiicylmy
PL87153B1 (pl) * 1973-07-13 1976-12-15 Tarchomińskie Zakłady Farmaceutyczne Sposób otrzymywania krystalicznej soli dwusodowej penicyliny a-karboksybenzylowej
DE2732283A1 (de) * 1977-07-16 1979-01-25 Bayer Ag Beta-lactam-verbindungen
DE2732323A1 (de) * 1977-07-16 1979-01-25 Bayer Ag Beta-lactam-verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung
JPS5940727A (ja) * 1982-07-28 1984-03-06 Fujitsu Ltd 自動等化方式

Also Published As

Publication number Publication date
IL76164A0 (en) 1985-12-31
HUT38354A (en) 1986-05-28
ATE34576T1 (de) 1988-06-15
HU194893B (en) 1988-03-28
DE3562918D1 (en) 1988-06-30
ES546379A0 (es) 1986-07-16
NO853188L (no) 1986-02-26
FI853211A0 (fi) 1985-08-21
EP0176716B1 (de) 1988-05-25
PH21842A (en) 1988-03-17
CN85106479A (zh) 1987-03-18
PT81014A (en) 1985-09-01
KR860001818A (ko) 1986-03-22
EP0176716A1 (de) 1986-04-09
FI853211A7 (fi) 1986-02-26
NZ213198A (en) 1989-02-24
AU4657785A (en) 1986-02-27
PT81014B (pt) 1987-12-30
DE3431273A1 (de) 1986-03-06
AU559040B2 (en) 1987-02-19
DK385085A (da) 1986-02-26
DK385085D0 (da) 1985-08-23
ZA856413B (en) 1986-04-30
CN85106479B (zh) 1988-07-27
ES8609340A1 (es) 1986-07-16
FI853211L (fi) 1986-02-26
GR852047B (OSRAM) 1985-12-20

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