DE3562918D1 - Crystalline sodium salt of d-6-(alpha-û(2-oxo-3-furfurylidene-amino-imidazolidin-1-yl)carbonylamine¨-thienyl-2-acetamido)-penicillanic acid, process for its preparation and its use in pharmaceutical compounds - Google Patents

Crystalline sodium salt of d-6-(alpha-û(2-oxo-3-furfurylidene-amino-imidazolidin-1-yl)carbonylamine¨-thienyl-2-acetamido)-penicillanic acid, process for its preparation and its use in pharmaceutical compounds

Info

Publication number
DE3562918D1
DE3562918D1 DE8585110189T DE3562918T DE3562918D1 DE 3562918 D1 DE3562918 D1 DE 3562918D1 DE 8585110189 T DE8585110189 T DE 8585110189T DE 3562918 T DE3562918 T DE 3562918T DE 3562918 D1 DE3562918 D1 DE 3562918D1
Authority
DE
Germany
Prior art keywords
imidazolidin
oxo
alpha
sodium salt
carbonylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8585110189T
Other languages
German (de)
Inventor
Hans-Bodo Dr Konig
Karl Georg Dr Metzger
Wilfried Dr Schrock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE8585110189T priority Critical patent/DE3562918D1/en
Application granted granted Critical
Publication of DE3562918D1 publication Critical patent/DE3562918D1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/70—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with hetero rings as additional substituents on the carbon chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1. Sodium salt of D-6-{alpha-[(2-oxo-3- furfurylideneamino-imidazolidin-1-yl)-carbonylamino]-2- thienylacetamido}-penicillanic acid of the formula (I) see diagramm : EP0176716,P8,F2 in pure crystalline form, characterized by the following NMR signals : delta = 9.36 (1H), 9.23 (1H), 7.8 (2H), 7.5 (1H), 7.25 (1H), 7.05 (1H), 6.89 (1H), 6.62 (1H), 6.2 (1H), 5.74 (1H), 5.56 (1H), 4.35 (1H), 3.92 (4H), 1.6 (3H) and 1,5 ppm (3H) (in DMF-d7 ).
DE8585110189T 1984-08-25 1985-08-14 Crystalline sodium salt of d-6-(alpha-û(2-oxo-3-furfurylidene-amino-imidazolidin-1-yl)carbonylamine¨-thienyl-2-acetamido)-penicillanic acid, process for its preparation and its use in pharmaceutical compounds Expired DE3562918D1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE8585110189T DE3562918D1 (en) 1984-08-25 1985-08-14 Crystalline sodium salt of d-6-(alpha-û(2-oxo-3-furfurylidene-amino-imidazolidin-1-yl)carbonylamine¨-thienyl-2-acetamido)-penicillanic acid, process for its preparation and its use in pharmaceutical compounds

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19843431273 DE3431273A1 (en) 1984-08-25 1984-08-25 CRYSTALLINE SODIUM SALT OF THE D-6 - ((ALPHA) - (2-OXO-3-FURFURYL-IDEN-AMINO-IMIDAZOLIDIN-1-YL) -CARBONYLAMINO) -THIENYL-2-ACETAMIDO) -PENICILLANIC ACID, METHODS OF PROCESSING IN MEDICINAL PRODUCTS
DE8585110189T DE3562918D1 (en) 1984-08-25 1985-08-14 Crystalline sodium salt of d-6-(alpha-û(2-oxo-3-furfurylidene-amino-imidazolidin-1-yl)carbonylamine¨-thienyl-2-acetamido)-penicillanic acid, process for its preparation and its use in pharmaceutical compounds
CN85106479A CN85106479B (en) 1984-08-25 1985-08-29 Crystalline D-6 {alpha-[(2-aldo-3-furfurylidene-amino-1-imidazolidinyl) carbonyl amino]-2 thienylacetamido}-penicillanic acid salt with sodium, process thereof and use as medicine

Publications (1)

Publication Number Publication Date
DE3562918D1 true DE3562918D1 (en) 1988-06-30

Family

ID=25741999

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19843431273 Withdrawn DE3431273A1 (en) 1984-08-25 1984-08-25 CRYSTALLINE SODIUM SALT OF THE D-6 - ((ALPHA) - (2-OXO-3-FURFURYL-IDEN-AMINO-IMIDAZOLIDIN-1-YL) -CARBONYLAMINO) -THIENYL-2-ACETAMIDO) -PENICILLANIC ACID, METHODS OF PROCESSING IN MEDICINAL PRODUCTS
DE8585110189T Expired DE3562918D1 (en) 1984-08-25 1985-08-14 Crystalline sodium salt of d-6-(alpha-û(2-oxo-3-furfurylidene-amino-imidazolidin-1-yl)carbonylamine¨-thienyl-2-acetamido)-penicillanic acid, process for its preparation and its use in pharmaceutical compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19843431273 Withdrawn DE3431273A1 (en) 1984-08-25 1984-08-25 CRYSTALLINE SODIUM SALT OF THE D-6 - ((ALPHA) - (2-OXO-3-FURFURYL-IDEN-AMINO-IMIDAZOLIDIN-1-YL) -CARBONYLAMINO) -THIENYL-2-ACETAMIDO) -PENICILLANIC ACID, METHODS OF PROCESSING IN MEDICINAL PRODUCTS

Country Status (18)

Country Link
EP (1) EP0176716B1 (en)
JP (1) JPS6157589A (en)
KR (1) KR860001818A (en)
CN (1) CN85106479B (en)
AT (1) ATE34576T1 (en)
AU (1) AU559040B2 (en)
DE (2) DE3431273A1 (en)
DK (1) DK385085A (en)
ES (1) ES8609340A1 (en)
FI (1) FI853211L (en)
GR (1) GR852047B (en)
HU (1) HU194893B (en)
IL (1) IL76164A0 (en)
NO (1) NO853188L (en)
NZ (1) NZ213198A (en)
PH (1) PH21842A (en)
PT (1) PT81014B (en)
ZA (1) ZA856413B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW347383B (en) * 1995-10-26 1998-12-11 Biochemie Gmbh A process for the production of a crystalline sodium salt of amoxicillin in ethanol as solvent
US9844374B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL85039B1 (en) * 1972-02-17 1977-02-26 Tarchomińskie Zakłady Farmaceutyczne Method for the preparation of sodium salt of α-ftminobenzylopeiiicylmy
PL87153B1 (en) * 1973-07-13 1976-12-15 Tarchomińskie Zakłady Farmaceutyczne Method of obtaining crystalline penicillin disodium salt of α-carboxybenzyl
DE2732323A1 (en) * 1977-07-16 1979-01-25 Bayer Ag BETA-LACTAM COMPOUNDS, THE PROCESS FOR THEIR PRODUCTION AND THEIR USE
DE2732283A1 (en) * 1977-07-16 1979-01-25 Bayer Ag BETA-LACTAM COMPOUNDS
JPS5940727A (en) * 1982-07-28 1984-03-06 Fujitsu Ltd Automatic equalization system

Also Published As

Publication number Publication date
EP0176716A1 (en) 1986-04-09
PT81014A (en) 1985-09-01
AU559040B2 (en) 1987-02-19
PH21842A (en) 1988-03-17
EP0176716B1 (en) 1988-05-25
ES8609340A1 (en) 1986-07-16
FI853211A0 (en) 1985-08-21
JPS6157589A (en) 1986-03-24
FI853211L (en) 1986-02-26
ZA856413B (en) 1986-04-30
ATE34576T1 (en) 1988-06-15
DE3431273A1 (en) 1986-03-06
KR860001818A (en) 1986-03-22
PT81014B (en) 1987-12-30
DK385085D0 (en) 1985-08-23
CN85106479A (en) 1987-03-18
DK385085A (en) 1986-02-26
ES546379A0 (en) 1986-07-16
HU194893B (en) 1988-03-28
AU4657785A (en) 1986-02-27
CN85106479B (en) 1988-07-27
NZ213198A (en) 1989-02-24
IL76164A0 (en) 1985-12-31
HUT38354A (en) 1986-05-28
NO853188L (en) 1986-02-26
GR852047B (en) 1985-12-20

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