SU1264559A1 - Method of synthesis of penicillin or cephalosporin derivatives or their salts with alkaline metals - Google Patents

Method of synthesis of penicillin or cephalosporin derivatives or their salts with alkaline metals

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Publication number
SU1264559A1
SU1264559A1 SU3765567/04A SU3765567A SU1264559A1 SU 1264559 A1 SU1264559 A1 SU 1264559A1 SU 3765567/04 A SU3765567/04 A SU 3765567/04A SU 3765567 A SU3765567 A SU 3765567A SU 1264559 A1 SU1264559 A1 SU 1264559A1
Authority
SU
USSR - Soviet Union
Prior art keywords
hydrogen
synthesis
acid
formulawhere
penicillin
Prior art date
Application number
SU3765567/04A
Other languages
Russian (ru)
Inventor
Е.Я. Зинченко
З.И. Лесовая
Л.В. Клочкова
А.С. Мезенцев
Д.Н. Маслин
Original Assignee
Всесоюзный научно-исследовательский институт антибиотиков
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Всесоюзный научно-исследовательский институт антибиотиков filed Critical Всесоюзный научно-исследовательский институт антибиотиков
Priority to SU3765567/04A priority Critical patent/SU1264559A1/en
Application granted granted Critical
Publication of SU1264559A1 publication Critical patent/SU1264559A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

FIELD: antibiotics. SUBSTANCE: method involves the synthesis of derivatives of penicillin or cephalosporin of the formulawhere R- hydrogen or hydroxy-group; R- hydrogen or alkaline metal; R- hydrogen or lower alkyl; X - the group of the formulaorwhere R- hydrogen or acetoxy-group; n = 1 or 2, or their salts with alkaline metals by acylation of N,O-(trialkylsilyl)-derivative of (2-amino-2-phenylacetamido)-β-lactamcarboxylic acid with heterocyclyl-N-carboxylic acid chloroanhydride in medium of anhydrous organic base. The end product is isolated as free acid or its salt with alkaline metal. The source of N,O-bis-(trialkylsilyl)-derivative of (2-amino-2-phenylacetamido)-b-lactamcarboxylic acid is the compound of the formulawhere Rand X have values indicated above, and chloroanhydride is heterocyclyl-N-carboxylic acid and acylation is carried out with compound of the formulawhere Rand n have indicated values. EFFECT: improved method of synthesis.
SU3765567/04A 1984-07-04 1984-07-04 Method of synthesis of penicillin or cephalosporin derivatives or their salts with alkaline metals SU1264559A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU3765567/04A SU1264559A1 (en) 1984-07-04 1984-07-04 Method of synthesis of penicillin or cephalosporin derivatives or their salts with alkaline metals

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU3765567/04A SU1264559A1 (en) 1984-07-04 1984-07-04 Method of synthesis of penicillin or cephalosporin derivatives or their salts with alkaline metals

Publications (1)

Publication Number Publication Date
SU1264559A1 true SU1264559A1 (en) 1996-10-10

Family

ID=60539816

Family Applications (1)

Application Number Title Priority Date Filing Date
SU3765567/04A SU1264559A1 (en) 1984-07-04 1984-07-04 Method of synthesis of penicillin or cephalosporin derivatives or their salts with alkaline metals

Country Status (1)

Country Link
SU (1) SU1264559A1 (en)

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