SU1264559A1 - Method of synthesis of penicillin or cephalosporin derivatives or their salts with alkaline metals - Google Patents
Method of synthesis of penicillin or cephalosporin derivatives or their salts with alkaline metalsInfo
- Publication number
- SU1264559A1 SU1264559A1 SU3765567/04A SU3765567A SU1264559A1 SU 1264559 A1 SU1264559 A1 SU 1264559A1 SU 3765567/04 A SU3765567/04 A SU 3765567/04A SU 3765567 A SU3765567 A SU 3765567A SU 1264559 A1 SU1264559 A1 SU 1264559A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- hydrogen
- synthesis
- acid
- formulawhere
- penicillin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
FIELD: antibiotics. SUBSTANCE: method involves the synthesis of derivatives of penicillin or cephalosporin of the formulawhere R- hydrogen or hydroxy-group; R- hydrogen or alkaline metal; R- hydrogen or lower alkyl; X - the group of the formulaorwhere R- hydrogen or acetoxy-group; n = 1 or 2, or their salts with alkaline metals by acylation of N,O-(trialkylsilyl)-derivative of (2-amino-2-phenylacetamido)-β-lactamcarboxylic acid with heterocyclyl-N-carboxylic acid chloroanhydride in medium of anhydrous organic base. The end product is isolated as free acid or its salt with alkaline metal. The source of N,O-bis-(trialkylsilyl)-derivative of (2-amino-2-phenylacetamido)-b-lactamcarboxylic acid is the compound of the formulawhere Rand X have values indicated above, and chloroanhydride is heterocyclyl-N-carboxylic acid and acylation is carried out with compound of the formulawhere Rand n have indicated values. EFFECT: improved method of synthesis.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU3765567/04A SU1264559A1 (en) | 1984-07-04 | 1984-07-04 | Method of synthesis of penicillin or cephalosporin derivatives or their salts with alkaline metals |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU3765567/04A SU1264559A1 (en) | 1984-07-04 | 1984-07-04 | Method of synthesis of penicillin or cephalosporin derivatives or their salts with alkaline metals |
Publications (1)
Publication Number | Publication Date |
---|---|
SU1264559A1 true SU1264559A1 (en) | 1996-10-10 |
Family
ID=60539816
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU3765567/04A SU1264559A1 (en) | 1984-07-04 | 1984-07-04 | Method of synthesis of penicillin or cephalosporin derivatives or their salts with alkaline metals |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU1264559A1 (en) |
-
1984
- 1984-07-04 SU SU3765567/04A patent/SU1264559A1/en active
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