JPH05508652A - 26―(ジアルキルアミノアルキルスルホニル)プリスチナマイシンiibから誘導される新規な塩類 - Google Patents
26―(ジアルキルアミノアルキルスルホニル)プリスチナマイシンiibから誘導される新規な塩類Info
- Publication number
- JPH05508652A JPH05508652A JP91512548A JP51254891A JPH05508652A JP H05508652 A JPH05508652 A JP H05508652A JP 91512548 A JP91512548 A JP 91512548A JP 51254891 A JP51254891 A JP 51254891A JP H05508652 A JPH05508652 A JP H05508652A
- Authority
- JP
- Japan
- Prior art keywords
- pristinamycin
- tartrate
- iia
- acid
- diethylaminosulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06182—Dipeptides with the first amino acid being heterocyclic and Pristinamycin II; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Description
Claims (7)
- 1.ジ−p−トルイル酒石酸塩、ジ−t−ブチルアセチル酒石酸塩、ジ−ブチリ ル酒石酸塩およびジ−i−バレリル酒石酸塩から選択されることを特徴とする、 一般式: ▲数式、化学式、表等があります▼(I)[式中、 AIKは線状または分枝鎖状のアルキレン基を表し、そしてRは線状または分枝 鎖状のアルキル基を表し、これらの基の炭素数は1−10である]の26−[( 2−ジアルキルアミノアルキル)スルホニル]プリスチナマイシンIIa(26 S)の新規な塩類。
- 2.ジ−p−トルイル酒石酸26−[(2−ジエチルアミノスルホニル]プリス チナマイシンIIa(26S)。
- 3.ジ−t−ブチルアセチル酒石酸26−[(2−ジエチルアミノスルホニル] プリスチナマイシンIIa(26S)。
- 4.ジ−ブチリル酒石酸26−[(2−ジエチルアミノスルホニル]プリスチナ マイシンIIa(26S)。
- 5.ジ−i−バレリル酒石酸26−[(2−ジエチルアミノスルホニル]プリス チナマイシンIIa(26S)。
- 6.純粋状態の、或いは相容性であり且つ薬学的に許容可能な希釈剤もしくは佐 薬(adjuvant)および/またはプリスチナマイシンIA、、バージニア マイシンSまたはプリスチナマイシンIAもしくはバージニアマイシンSの可溶 性誘導体との組み合わせ物の形状の、請求の範囲1に記載の塩を含んでいること を特徴とする、薬学的組成物。
- 7.例えば請求の範囲1で定義されている如き26−[(2−ジアルキルアミノ アルキル)スルホニル]プリスチナマイシンIIB用の精製手段のための、請求 の範囲1−5のいずれかに記載の塩の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR909009037A FR2664600B1 (fr) | 1990-07-16 | 1990-07-16 | Nouveau sel derive de la dialcoylaminoalcoyl-sulfonyl-26 pristinamycine iib. |
FR90/09037 | 1990-07-16 | ||
PCT/FR1991/000582 WO1992001694A1 (fr) | 1990-07-16 | 1991-07-15 | Nouveaux sels derives de la dialcoylaminoalcoylsulfonyl-26 pristinamycine ii¿b? |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH05508652A true JPH05508652A (ja) | 1993-12-02 |
JP3345814B2 JP3345814B2 (ja) | 2002-11-18 |
Family
ID=9398755
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51254891A Expired - Lifetime JP3345814B2 (ja) | 1990-07-16 | 1991-07-15 | 26―(ジアルキルアミノアルキルスルホニル)プリスチナマイシンiibから誘導される新規な塩類 |
Country Status (20)
Country | Link |
---|---|
US (1) | US5326782A (ja) |
EP (1) | EP0539460B1 (ja) |
JP (1) | JP3345814B2 (ja) |
KR (1) | KR100199066B1 (ja) |
AT (1) | ATE112570T1 (ja) |
AU (1) | AU648097B2 (ja) |
CA (1) | CA2086925C (ja) |
DE (1) | DE69104485T2 (ja) |
DK (1) | DK0539460T3 (ja) |
ES (1) | ES2061259T3 (ja) |
FI (1) | FI100970B (ja) |
FR (1) | FR2664600B1 (ja) |
IE (1) | IE64068B1 (ja) |
IL (1) | IL98854A (ja) |
NZ (1) | NZ238949A (ja) |
PT (1) | PT98337B (ja) |
RU (1) | RU2081119C1 (ja) |
TW (1) | TW228523B (ja) |
WO (1) | WO1992001694A1 (ja) |
ZA (1) | ZA915445B (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2664598A1 (fr) * | 1990-07-16 | 1992-01-17 | Rhone Poulenc Rorer Sa | Procede de preparation de sulfinyl pristinamycine iib. |
FR2766489B1 (fr) | 1997-07-28 | 1999-08-27 | Rhone Poulenc Rorer Sa | Derives de streptogramines, leur preparation et les compositions qui les contiennent |
US6743812B1 (en) | 2000-07-14 | 2004-06-01 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
US6432954B1 (en) | 2000-07-14 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2576022B1 (fr) * | 1985-01-11 | 1987-09-11 | Rhone Poulenc Sante | Nouveaux derives de la pristinamycine ii b, leur preparation et les compositions pharmaceutiques qui les contiennent |
GB8616768D0 (en) * | 1986-07-09 | 1986-08-13 | May & Baker Ltd | Process |
EP0298177B1 (fr) * | 1987-07-07 | 1992-04-15 | Rhone-Poulenc Sante | Nouveau procédé de préparation de dérivés de la pristinamycine IIB |
US4931557A (en) * | 1988-10-17 | 1990-06-05 | Eli Lilly And Company | Method of resolving cis 3-amino-4-(2-furyl)vinyl)-1-methoxycarbonylmethyl-azetidin-2-one and di-p-toluoyl-tartaric acid salts thereof |
-
1990
- 1990-07-16 FR FR909009037A patent/FR2664600B1/fr not_active Expired - Fee Related
-
1991
- 1991-07-12 NZ NZ238949A patent/NZ238949A/xx not_active IP Right Cessation
- 1991-07-12 ZA ZA915445A patent/ZA915445B/xx unknown
- 1991-07-12 IE IE244891A patent/IE64068B1/en not_active IP Right Cessation
- 1991-07-15 AU AU82239/91A patent/AU648097B2/en not_active Expired
- 1991-07-15 IL IL9885491A patent/IL98854A/en not_active IP Right Cessation
- 1991-07-15 KR KR1019930700115A patent/KR100199066B1/ko not_active IP Right Cessation
- 1991-07-15 RU RU9192016553A patent/RU2081119C1/ru active
- 1991-07-15 DK DK91913376.9T patent/DK0539460T3/da active
- 1991-07-15 DE DE69104485T patent/DE69104485T2/de not_active Expired - Lifetime
- 1991-07-15 CA CA002086925A patent/CA2086925C/fr not_active Expired - Lifetime
- 1991-07-15 WO PCT/FR1991/000582 patent/WO1992001694A1/fr active IP Right Grant
- 1991-07-15 EP EP91913376A patent/EP0539460B1/fr not_active Expired - Lifetime
- 1991-07-15 AT AT91913376T patent/ATE112570T1/de not_active IP Right Cessation
- 1991-07-15 JP JP51254891A patent/JP3345814B2/ja not_active Expired - Lifetime
- 1991-07-15 US US07/961,925 patent/US5326782A/en not_active Expired - Lifetime
- 1991-07-15 ES ES91913376T patent/ES2061259T3/es not_active Expired - Lifetime
- 1991-07-16 PT PT98337A patent/PT98337B/pt not_active IP Right Cessation
- 1991-07-16 TW TW080105507A patent/TW228523B/zh not_active IP Right Cessation
-
1993
- 1993-01-15 FI FI930166A patent/FI100970B/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR930701451A (ko) | 1993-06-11 |
IE912448A1 (en) | 1992-01-29 |
IE64068B1 (en) | 1995-07-12 |
PT98337B (pt) | 1999-01-29 |
JP3345814B2 (ja) | 2002-11-18 |
ATE112570T1 (de) | 1994-10-15 |
FI930166A (fi) | 1993-01-15 |
DK0539460T3 (da) | 1994-11-07 |
DE69104485T2 (de) | 1995-02-23 |
FR2664600A1 (fr) | 1992-01-17 |
TW228523B (ja) | 1994-08-21 |
FI930166A0 (fi) | 1993-01-15 |
AU8223991A (en) | 1992-02-18 |
ZA915445B (en) | 1992-04-29 |
US5326782A (en) | 1994-07-05 |
IL98854A0 (en) | 1992-07-15 |
EP0539460A1 (fr) | 1993-05-05 |
IL98854A (en) | 1995-11-27 |
DE69104485D1 (de) | 1994-11-10 |
RU2081119C1 (ru) | 1997-06-10 |
KR100199066B1 (ko) | 1999-06-15 |
FR2664600B1 (fr) | 1994-09-02 |
AU648097B2 (en) | 1994-04-14 |
ES2061259T3 (es) | 1994-12-01 |
EP0539460B1 (fr) | 1994-10-05 |
NZ238949A (en) | 1992-09-25 |
WO1992001694A1 (fr) | 1992-02-06 |
FI100970B (fi) | 1998-03-31 |
CA2086925A1 (fr) | 1992-01-17 |
CA2086925C (fr) | 2002-12-10 |
PT98337A (pt) | 1992-05-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2022003052A (ja) | リファキシミン | |
SE510666C2 (sv) | Nya Kristallmodifikationer | |
JP3145715B2 (ja) | 無水7−([1α,5α,6α]−6−アミノ−3−アザビシクロ[3.1.0]ヘキサ−3−イル)−6−フルオロ−1−(2,4−ジフルオロフェニル)−1,4−ジヒドロ−4−オキソ−1,8−ナフチリディン−3−カルボン酸メタンスルホン酸塩の新規な結晶形態 | |
CZ471190A3 (cs) | Inhibitory retrovirálních proteáz | |
JPS638354A (ja) | ジアセチルライン塩及び関節炎の治療におけるそれらの使用 | |
IE912973A1 (en) | Codeine salt of a substituted carbonacid, process of its preparation, its use and pharmaceutical preparations | |
WO2012175002A1 (zh) | 10-甲氧基喜树碱衍生物、制备方法和用途 | |
CN103108865A (zh) | 方法和中间体 | |
JPH05508652A (ja) | 26―(ジアルキルアミノアルキルスルホニル)プリスチナマイシンiibから誘導される新規な塩類 | |
JP4277015B2 (ja) | ストレプトグラミン誘導体、その製造およびそれを含む製薬組成物 | |
CA2164296C (en) | Heterocyclic chemistry | |
CN104974221A (zh) | 二肽及三肽类蛋白酶体抑制剂及其制法和药物用途 | |
JPS606958B2 (ja) | 抗生物質の精製法 | |
US4072695A (en) | 3α,7α-Dihydroxy-cholanic acid derivatives | |
JP2001510849A (ja) | ストレプトグラミン類、それらの製造およびそれらを含有する組成物 | |
EP2789604A1 (en) | Daidzein derivative, pharmaceutically acceptable salt and preparation method thereof, and pharmaceutical composition containing same | |
EP1651661A1 (en) | Process for the preparation of finasteride form i | |
JPH08508258A (ja) | セフォニシドの結晶性ベンザチン塩およびその製造方法 | |
US3882127A (en) | 17-alkenyl-6{62 -azido-4,5{60 -epoxymorphinan-3-ols | |
US4014908A (en) | Chemical process | |
US3474115A (en) | Water soluble aldosterone like agents | |
JPH07504923A (ja) | 新規医薬活性フラビリウム化合物 | |
JPH11509188A (ja) | プロドラッグ6−n−(l−ala−l−ala)トロバフロキサシンの多形体 | |
JPS59101498A (ja) | 新規ボラン誘導体およびその製法 | |
JPH02138271A (ja) | 環状含硫黄化合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20080906 Year of fee payment: 6 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20080906 Year of fee payment: 6 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090906 Year of fee payment: 7 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100906 Year of fee payment: 8 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100906 Year of fee payment: 8 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110906 Year of fee payment: 9 |
|
EXPY | Cancellation because of completion of term |