KR930701451A - 디알킬아미노알킬설포닐-26 프리스티나마이신 ii_b로부터 유도되는 신규한 염 - Google Patents

디알킬아미노알킬설포닐-26 프리스티나마이신 ii_b로부터 유도되는 신규한 염

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Publication number
KR930701451A
KR930701451A KR1019930700115A KR930700115A KR930701451A KR 930701451 A KR930701451 A KR 930701451A KR 1019930700115 A KR1019930700115 A KR 1019930700115A KR 930700115 A KR930700115 A KR 930700115A KR 930701451 A KR930701451 A KR 930701451A
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KR
South Korea
Prior art keywords
pristinamycin
tartrate
diethylaminosulfonyl
pct
novel salts
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KR1019930700115A
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English (en)
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KR100199066B1 (ko
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배리에르 장-끌로드
빠리 장-마아끄
라디송 그자비에
코르베 장-삐에르
Original Assignee
프랑소와즈 로브쥬이
로오느-푸우랜크 로레르 소시에테 아노님
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06182—Dipeptides with the first amino acid being heterocyclic and Pristinamycin II; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

하기 일반식(Ⅰ)을 가지는(디알킬아미노-2 알킬)설포닐-26 프리스티나마이신 ⅡB의 디-p-툴루오일 주석산염, 디-t-부틸 아세틸 주석산염, 디-부티릴 주석산염 및 디-i-발레릴 주석산염 :
상기식에서, Alk는 선형 또는 분지 알킬렌 라디칼을 나타내고, R은 선형 또는 분지 알킬 라디칼을 나타내며, 상기 라디칼은 1-10 탄소원자를 가진다.

Description

디알킬아미노알킬설포닐-26 프리스티나마이신 ⅡB로부터 유도되는 신규한 염
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 디-P-톨루오일주석산염, 디-t-부틸아세틸 주석산염, 디-부티릴주석산 염 및 디-i-발레릴주석산염 중에서 선택되는 것을 특징으로 하는, 하기 일반식의 26-[(2-디알킬아미노알킬)설포닐] 프리스티나마이신 ⅡB(26S)의 신규한 염 :
  3. 상기식에서, Alk는 선형 또는 분지 알킬렌 라더칼을 나타내고, R은 선형 또는 분지 알킬 라디칼을 나타내며, 이들 라디칼은 1-10 탄소원자를 함유한다.
  4. 26-[(2-디에틸아미노설포닐] 프리스티나마이신 ⅡB(26S)디-P-툴루일주석산염.
  5. 26-[(2-디에틸아미노설포닐] 프리스티나마이신 ⅡB(26S)디-t-부틸아세틸주석산 염.
  6. 26-[(2-디에틸아미노설포닐] 프리스티나마이신 ⅡB(26S)디-부틸릴주석산염.
  7. 26-[(2-디에틸아미노설포닐] 프리스티나마이신 ⅡB(26S)디-i-발레릴주석산염.
  8. 순수한 형태로, 또는 임의 양립 가능하고 제약학적으로 허용 가능한 희석제 또는 보조제와, 및/또는 프리스티나마이신 IA, 버어지니아마이신 S 또는 프리스티나마이신 IA의 또는 버어지니아마이신 S의 가용성 유도체와의 조합물 형태로의, 제1항에 따른 염으로 구성되는 것을 특징으로 하는 제약학적 조성물.
  9. 제1항에 정의된 바와 같은 26-[(2-디알킬아미노알킬)설포닐] 프리스티나마아신 ⅡB에 대한 정제 방법에 의한 제1-5항중 어느 하나에 따른 염의 사용.
  10. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930700115A 1990-07-16 1991-07-15 26-(디알킬아미노알킬설포닐)프리스티나마이신 iib로 부터 유도되는 신규한 염 KR100199066B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR90-09037 1990-07-16
FR909009037A FR2664600B1 (fr) 1990-07-16 1990-07-16 Nouveau sel derive de la dialcoylaminoalcoyl-sulfonyl-26 pristinamycine iib.
PCT/FR1991/000582 WO1992001694A1 (fr) 1990-07-16 1991-07-15 Nouveaux sels derives de la dialcoylaminoalcoylsulfonyl-26 pristinamycine ii¿b?

Publications (2)

Publication Number Publication Date
KR930701451A true KR930701451A (ko) 1993-06-11
KR100199066B1 KR100199066B1 (ko) 1999-06-15

Family

ID=9398755

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930700115A KR100199066B1 (ko) 1990-07-16 1991-07-15 26-(디알킬아미노알킬설포닐)프리스티나마이신 iib로 부터 유도되는 신규한 염

Country Status (20)

Country Link
US (1) US5326782A (ko)
EP (1) EP0539460B1 (ko)
JP (1) JP3345814B2 (ko)
KR (1) KR100199066B1 (ko)
AT (1) ATE112570T1 (ko)
AU (1) AU648097B2 (ko)
CA (1) CA2086925C (ko)
DE (1) DE69104485T2 (ko)
DK (1) DK0539460T3 (ko)
ES (1) ES2061259T3 (ko)
FI (1) FI100970B (ko)
FR (1) FR2664600B1 (ko)
IE (1) IE64068B1 (ko)
IL (1) IL98854A (ko)
NZ (1) NZ238949A (ko)
PT (1) PT98337B (ko)
RU (1) RU2081119C1 (ko)
TW (1) TW228523B (ko)
WO (1) WO1992001694A1 (ko)
ZA (1) ZA915445B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2664598A1 (fr) * 1990-07-16 1992-01-17 Rhone Poulenc Rorer Sa Procede de preparation de sulfinyl pristinamycine iib.
FR2766489B1 (fr) 1997-07-28 1999-08-27 Rhone Poulenc Rorer Sa Derives de streptogramines, leur preparation et les compositions qui les contiennent
US6432954B1 (en) 2000-07-14 2002-08-13 Targacept, Inc. Pharmaceutical compositions and methods for use
US6743812B1 (en) 2000-07-14 2004-06-01 Targacept, Inc. Pharmaceutical compositions and methods for use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2576022B1 (fr) * 1985-01-11 1987-09-11 Rhone Poulenc Sante Nouveaux derives de la pristinamycine ii b, leur preparation et les compositions pharmaceutiques qui les contiennent
GB8616768D0 (en) * 1986-07-09 1986-08-13 May & Baker Ltd Process
DE3778359D1 (de) * 1987-07-07 1992-05-21 Rhone Poulenc Sante Verfahren zur herstellung von derivaten von pristinamycin iib.
US4931557A (en) * 1988-10-17 1990-06-05 Eli Lilly And Company Method of resolving cis 3-amino-4-(2-furyl)vinyl)-1-methoxycarbonylmethyl-azetidin-2-one and di-p-toluoyl-tartaric acid salts thereof

Also Published As

Publication number Publication date
DE69104485T2 (de) 1995-02-23
IE912448A1 (en) 1992-01-29
PT98337A (pt) 1992-05-29
NZ238949A (en) 1992-09-25
ATE112570T1 (de) 1994-10-15
IL98854A (en) 1995-11-27
DE69104485D1 (de) 1994-11-10
EP0539460A1 (fr) 1993-05-05
FI930166A (fi) 1993-01-15
FR2664600A1 (fr) 1992-01-17
FI930166A0 (fi) 1993-01-15
FR2664600B1 (fr) 1994-09-02
FI100970B (fi) 1998-03-31
AU8223991A (en) 1992-02-18
PT98337B (pt) 1999-01-29
JPH05508652A (ja) 1993-12-02
TW228523B (ko) 1994-08-21
EP0539460B1 (fr) 1994-10-05
KR100199066B1 (ko) 1999-06-15
US5326782A (en) 1994-07-05
ZA915445B (en) 1992-04-29
DK0539460T3 (da) 1994-11-07
JP3345814B2 (ja) 2002-11-18
WO1992001694A1 (fr) 1992-02-06
AU648097B2 (en) 1994-04-14
IL98854A0 (en) 1992-07-15
RU2081119C1 (ru) 1997-06-10
ES2061259T3 (es) 1994-12-01
IE64068B1 (en) 1995-07-12
CA2086925C (fr) 2002-12-10
CA2086925A1 (fr) 1992-01-17

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