JPS61170471A - 骨補綴成形体 - Google Patents
骨補綴成形体Info
- Publication number
- JPS61170471A JPS61170471A JP60012123A JP1212385A JPS61170471A JP S61170471 A JPS61170471 A JP S61170471A JP 60012123 A JP60012123 A JP 60012123A JP 1212385 A JP1212385 A JP 1212385A JP S61170471 A JPS61170471 A JP S61170471A
- Authority
- JP
- Japan
- Prior art keywords
- bone
- bone prosthesis
- molded body
- calcium phosphate
- microns
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000988 bone and bone Anatomy 0.000 title claims description 246
- 239000001506 calcium phosphate Substances 0.000 claims description 57
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 56
- 235000011010 calcium phosphates Nutrition 0.000 claims description 56
- -1 calcium phosphate compound Chemical class 0.000 claims description 54
- 239000011148 porous material Substances 0.000 claims description 48
- 239000011800 void material Substances 0.000 claims description 20
- 230000007547 defect Effects 0.000 claims description 17
- 241001465754 Metazoa Species 0.000 claims description 12
- 239000011575 calcium Substances 0.000 claims description 9
- 208000018084 Bone neoplasm Diseases 0.000 claims description 7
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 6
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 6
- 208000010392 Bone Fractures Diseases 0.000 claims description 5
- 230000032683 aging Effects 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 229910052698 phosphorus Inorganic materials 0.000 claims description 2
- 239000011574 phosphorus Substances 0.000 claims description 2
- 239000002245 particle Substances 0.000 description 61
- 239000000843 powder Substances 0.000 description 42
- 239000000835 fiber Substances 0.000 description 40
- 239000000203 mixture Substances 0.000 description 27
- 239000000057 synthetic resin Substances 0.000 description 27
- 229920003002 synthetic resin Polymers 0.000 description 27
- 210000004027 cell Anatomy 0.000 description 18
- 238000000034 method Methods 0.000 description 18
- 238000010438 heat treatment Methods 0.000 description 16
- 102000008186 Collagen Human genes 0.000 description 14
- 108010035532 Collagen Proteins 0.000 description 14
- 229920001436 collagen Polymers 0.000 description 14
- 239000000126 substance Substances 0.000 description 14
- 239000000463 material Substances 0.000 description 11
- 210000002414 leg Anatomy 0.000 description 10
- 238000000465 moulding Methods 0.000 description 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 9
- 229910052760 oxygen Inorganic materials 0.000 description 9
- 239000001301 oxygen Substances 0.000 description 9
- 230000018109 developmental process Effects 0.000 description 8
- 238000005245 sintering Methods 0.000 description 8
- 239000007787 solid Substances 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 229910019142 PO4 Inorganic materials 0.000 description 7
- 239000002639 bone cement Substances 0.000 description 7
- 238000011049 filling Methods 0.000 description 7
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 6
- 241000723346 Cinnamomum camphora Species 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 6
- 229960000846 camphor Drugs 0.000 description 6
- 229930008380 camphor Natural products 0.000 description 6
- 238000005979 thermal decomposition reaction Methods 0.000 description 6
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 6
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 5
- 102000002322 Egg Proteins Human genes 0.000 description 5
- 108010000912 Egg Proteins Proteins 0.000 description 5
- 230000002950 deficient Effects 0.000 description 5
- 235000014103 egg white Nutrition 0.000 description 5
- 210000000969 egg white Anatomy 0.000 description 5
- 210000001621 ilium bone Anatomy 0.000 description 5
- 230000009545 invasion Effects 0.000 description 5
- 230000001172 regenerating effect Effects 0.000 description 5
- 239000011343 solid material Substances 0.000 description 5
- 241000282412 Homo Species 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 230000002159 abnormal effect Effects 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 210000003692 ilium Anatomy 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000011164 ossification Effects 0.000 description 4
- 239000006104 solid solution Substances 0.000 description 4
- 239000012798 spherical particle Substances 0.000 description 4
- 238000000859 sublimation Methods 0.000 description 4
- 230000008022 sublimation Effects 0.000 description 4
- 229920003043 Cellulose fiber Polymers 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000010478 bone regeneration Effects 0.000 description 3
- 229910010293 ceramic material Inorganic materials 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 229940075566 naphthalene Drugs 0.000 description 3
- 238000002271 resection Methods 0.000 description 3
- 210000004872 soft tissue Anatomy 0.000 description 3
- 239000012209 synthetic fiber Substances 0.000 description 3
- 229920002994 synthetic fiber Polymers 0.000 description 3
- 210000000115 thoracic cavity Anatomy 0.000 description 3
- 230000007306 turnover Effects 0.000 description 3
- 210000000689 upper leg Anatomy 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000003197 catalytic effect Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 239000004568 cement Substances 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 210000002758 humerus Anatomy 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000005304 joining Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 241001590997 Moolgarda engeli Species 0.000 description 1
- 206010039203 Road traffic accident Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 239000012237 artificial material Substances 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000037182 bone density Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 229940043430 calcium compound Drugs 0.000 description 1
- 150000001674 calcium compounds Chemical class 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 238000010000 carbonizing Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000003109 clavicle Anatomy 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000002297 emergency surgery Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000002082 fibula Anatomy 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 238000003980 solgel method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60012123A JPS61170471A (ja) | 1985-01-25 | 1985-01-25 | 骨補綴成形体 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60012123A JPS61170471A (ja) | 1985-01-25 | 1985-01-25 | 骨補綴成形体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61170471A true JPS61170471A (ja) | 1986-08-01 |
| JPH0526504B2 JPH0526504B2 (enrdf_load_stackoverflow) | 1993-04-16 |
Family
ID=11796760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60012123A Granted JPS61170471A (ja) | 1985-01-25 | 1985-01-25 | 骨補綴成形体 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61170471A (enrdf_load_stackoverflow) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63125259A (ja) * | 1986-11-14 | 1988-05-28 | 旭光学工業株式会社 | リン酸カルシウム系多孔質骨補填材 |
| JPS6456056A (en) * | 1987-08-26 | 1989-03-02 | Dental Chem Co Ltd | Hydroxyapatite bone filling material |
| JPH07299130A (ja) * | 1994-03-08 | 1995-11-14 | Shinichi Yoshino | 人工関節置換術用の骨補強材 |
| JP2001137328A (ja) * | 1999-11-11 | 2001-05-22 | Olympus Optical Co Ltd | 骨補填材 |
| JP2005046530A (ja) * | 2003-07-31 | 2005-02-24 | National Institute Of Advanced Industrial & Technology | 多孔質リン酸カルシウム硬化体、その製造方法及びそれを用いた人工骨及び薬剤徐放体 |
| JP2006263445A (ja) * | 2005-02-25 | 2006-10-05 | Yasuharu Noisshiki | 医用材料 |
| JP2008237937A (ja) * | 2008-06-26 | 2008-10-09 | Hiromi Matsuzaki | 骨補填材 |
| JP2010115412A (ja) * | 2008-11-14 | 2010-05-27 | Kobe Univ | 組織再生用の材料 |
| US8034117B2 (en) | 2003-12-09 | 2011-10-11 | Hoya Corporation | Bone replacement material |
| JP5166864B2 (ja) * | 2005-02-23 | 2013-03-21 | 株式会社ハイレックスコーポレーション | 人工歯根 |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53144194A (en) * | 1977-05-20 | 1978-12-15 | Kureha Chemical Ind Co Ltd | Compound implanted material and making method thereof |
| JPS5645814A (en) * | 1979-09-25 | 1981-04-25 | Kureha Chem Ind Co Ltd | Hydroxyapatite, its ceramic material and its manufacture |
| JPS5654841A (en) * | 1979-10-08 | 1981-05-15 | Mitsubishi Mining & Cement Co | Bone broken portion and filler for void portion and method of treating bone of animal using said filler |
| JPS56166843A (en) * | 1980-05-28 | 1981-12-22 | Mitsubishi Mining & Cement Co | Filler for bone broken section and void section |
| JPS5733057A (en) * | 1980-08-08 | 1982-02-23 | Aisin Seiki Co Ltd | Proportioning valve for car brake |
| JPS57119745A (en) * | 1981-01-17 | 1982-07-26 | Kyoto Ceramic | Bone prosthetic member |
| JPS59171545A (ja) * | 1983-03-18 | 1984-09-28 | 株式会社 吉田製作所 | リン酸カルシウム複合剤 |
| DE3425182A1 (de) * | 1983-07-09 | 1985-01-24 | Sumitomo Cement Co., Ltd., Tokio/Tokyo | Poroeses keramisches material und verfahren zu seiner herstellung |
| JPS6016879A (ja) * | 1983-07-09 | 1985-01-28 | 住友セメント株式会社 | 多孔質セラミツク材料 |
-
1985
- 1985-01-25 JP JP60012123A patent/JPS61170471A/ja active Granted
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53144194A (en) * | 1977-05-20 | 1978-12-15 | Kureha Chemical Ind Co Ltd | Compound implanted material and making method thereof |
| JPS5645814A (en) * | 1979-09-25 | 1981-04-25 | Kureha Chem Ind Co Ltd | Hydroxyapatite, its ceramic material and its manufacture |
| JPS5654841A (en) * | 1979-10-08 | 1981-05-15 | Mitsubishi Mining & Cement Co | Bone broken portion and filler for void portion and method of treating bone of animal using said filler |
| JPS56166843A (en) * | 1980-05-28 | 1981-12-22 | Mitsubishi Mining & Cement Co | Filler for bone broken section and void section |
| JPS5733057A (en) * | 1980-08-08 | 1982-02-23 | Aisin Seiki Co Ltd | Proportioning valve for car brake |
| JPS57119745A (en) * | 1981-01-17 | 1982-07-26 | Kyoto Ceramic | Bone prosthetic member |
| JPS59171545A (ja) * | 1983-03-18 | 1984-09-28 | 株式会社 吉田製作所 | リン酸カルシウム複合剤 |
| DE3425182A1 (de) * | 1983-07-09 | 1985-01-24 | Sumitomo Cement Co., Ltd., Tokio/Tokyo | Poroeses keramisches material und verfahren zu seiner herstellung |
| JPS6016879A (ja) * | 1983-07-09 | 1985-01-28 | 住友セメント株式会社 | 多孔質セラミツク材料 |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63125259A (ja) * | 1986-11-14 | 1988-05-28 | 旭光学工業株式会社 | リン酸カルシウム系多孔質骨補填材 |
| JPS6456056A (en) * | 1987-08-26 | 1989-03-02 | Dental Chem Co Ltd | Hydroxyapatite bone filling material |
| JPH07299130A (ja) * | 1994-03-08 | 1995-11-14 | Shinichi Yoshino | 人工関節置換術用の骨補強材 |
| JP2001137328A (ja) * | 1999-11-11 | 2001-05-22 | Olympus Optical Co Ltd | 骨補填材 |
| JP2005046530A (ja) * | 2003-07-31 | 2005-02-24 | National Institute Of Advanced Industrial & Technology | 多孔質リン酸カルシウム硬化体、その製造方法及びそれを用いた人工骨及び薬剤徐放体 |
| US8034117B2 (en) | 2003-12-09 | 2011-10-11 | Hoya Corporation | Bone replacement material |
| JP5166864B2 (ja) * | 2005-02-23 | 2013-03-21 | 株式会社ハイレックスコーポレーション | 人工歯根 |
| JP2006263445A (ja) * | 2005-02-25 | 2006-10-05 | Yasuharu Noisshiki | 医用材料 |
| JP2008237937A (ja) * | 2008-06-26 | 2008-10-09 | Hiromi Matsuzaki | 骨補填材 |
| JP2010115412A (ja) * | 2008-11-14 | 2010-05-27 | Kobe Univ | 組織再生用の材料 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0526504B2 (enrdf_load_stackoverflow) | 1993-04-16 |
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