JPS6116391B2 - - Google Patents
Info
- Publication number
- JPS6116391B2 JPS6116391B2 JP57033252A JP3325282A JPS6116391B2 JP S6116391 B2 JPS6116391 B2 JP S6116391B2 JP 57033252 A JP57033252 A JP 57033252A JP 3325282 A JP3325282 A JP 3325282A JP S6116391 B2 JPS6116391 B2 JP S6116391B2
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- fluorouracil
- solvent
- fluoro
- uracil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 5-fluoro-1-(2-trifluoromethylpropionyl)uracil Chemical compound 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 description 9
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
- 229960002949 fluorouracil Drugs 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical class FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 1
- DQOGDQIDOONUSK-UHFFFAOYSA-N 3,3,3-trifluoro-2-methylpropanoic acid Chemical compound OC(=O)C(C)C(F)(F)F DQOGDQIDOONUSK-UHFFFAOYSA-N 0.000 description 1
- NDLGCTJYADULQO-UHFFFAOYSA-N 3,3,3-trifluoro-2-methylpropanoyl chloride Chemical compound ClC(=O)C(C)C(F)(F)F NDLGCTJYADULQO-UHFFFAOYSA-N 0.000 description 1
- WADSJYLPJPTMLN-UHFFFAOYSA-N 3-(cycloundecen-1-yl)-1,2-diazacycloundec-2-ene Chemical compound C1CCCCCCCCC=C1C1=NNCCCCCCCC1 WADSJYLPJPTMLN-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57033252A JPS58150572A (ja) | 1982-03-03 | 1982-03-03 | ５−フルオロ−１−（２−トリフルオロメチルプロピオニル）ウラシル |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57033252A JPS58150572A (ja) | 1982-03-03 | 1982-03-03 | ５−フルオロ−１−（２−トリフルオロメチルプロピオニル）ウラシル |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58150572A JPS58150572A (ja) | 1983-09-07 |
| JPS6116391B2 true JPS6116391B2 (enrdf_load_stackoverflow) | 1986-04-30 |
Family
ID=12381299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57033252A Granted JPS58150572A (ja) | 1982-03-03 | 1982-03-03 | ５−フルオロ−１−（２−トリフルオロメチルプロピオニル）ウラシル |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58150572A (enrdf_load_stackoverflow) |
-
1982
- 1982-03-03 JP JP57033252A patent/JPS58150572A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS58150572A (ja) | 1983-09-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2018088527A1 (ja) | 新規トリチル保護剤 | |
| JP7227925B2 (ja) | １－［５－（２－フルオロフェニル）－１－（ピリジン－３－イルスルホニル）－１ｈ－ピロ－ル－３－イル］－ｎ－メチルメタンアミンモノフマル酸塩の製造法 | |
| JPS6116391B2 (enrdf_load_stackoverflow) | ||
| JP2787343B2 (ja) | アゾ化合物 | |
| JPS6353991B2 (enrdf_load_stackoverflow) | ||
| JP2805155B2 (ja) | オキサゾリジン―２―オン誘導体の製造法 | |
| JP3038380B1 (ja) | ケテンイミン化合物の製造方法 | |
| JPH10287650A (ja) | １−クロロカルボニル−４−ピペリジノピペリジンまたはその塩酸塩の製造方法 | |
| JP4004082B2 (ja) | 環状ニトログアニジン誘導体の製造法 | |
| JPS5817751B2 (ja) | イソオキサゾ−ル誘導体の製造法 | |
| JPS60181075A (ja) | ピリミジン類，その製法およびその利用法 | |
| JPS6249276B2 (enrdf_load_stackoverflow) | ||
| JP4168184B2 (ja) | Ｎ−アシル（メタ）アクリルアミド誘導体の製造方法 | |
| JPH06228149A (ja) | 新規な５環性ヘテロ環化合物、製造中間体とそれらの製造方法 | |
| JP2979134B2 (ja) | ２，４−ジケトオキサゾリジン骨格化合物の製造方法及び２，４−ジケトメタオキサジン骨格化合物の製造方法 | |
| JPS5916879A (ja) | Ｎ−置換イミダゾ−ル類の製造法 | |
| JP2000053645A (ja) | ヒドラジン誘導体の製造方法、その中間体および中間体の製造方法 | |
| JPS637557B2 (enrdf_load_stackoverflow) | ||
| JPS6360023B2 (enrdf_load_stackoverflow) | ||
| JPH0623141B2 (ja) | アミノシクロペンテノン誘導体およびその製造法 | |
| JPH0827148A (ja) | ジチアゾリウム塩の製造方法 | |
| IL37124A (en) | Chlorocarbonyl history of penicillin and their preparation | |
| JPH0812658A (ja) | シドノン類の製造法 | |
| JPH06234725A (ja) | カルボジイミド類の製造法 | |
| JP2000226390A (ja) | ２−ｎ−（ｎ−メチルピロリジン−２−イリデン）−６−クロロプリン及びその製造法 |