JPS6115881A - 無水の安定したプラゾシン塩酸塩のδ型結晶体および該δ型結晶体の製造法 - Google Patents

無水の安定したプラゾシン塩酸塩のδ型結晶体および該δ型結晶体の製造法

Info

Publication number
JPS6115881A
JPS6115881A JP59227640A JP22764084A JPS6115881A JP S6115881 A JPS6115881 A JP S6115881A JP 59227640 A JP59227640 A JP 59227640A JP 22764084 A JP22764084 A JP 22764084A JP S6115881 A JPS6115881 A JP S6115881A
Authority
JP
Japan
Prior art keywords
prazosin hydrochloride
organic solvent
anhydrous
stable
prazosin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59227640A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0481993B2 (OSRAM
Inventor
スチグ・オロフ・エンゲルベルト・リンドホルム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtyma Oy filed Critical Orion Yhtyma Oy
Publication of JPS6115881A publication Critical patent/JPS6115881A/ja
Publication of JPH0481993B2 publication Critical patent/JPH0481993B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP59227640A 1984-06-25 1984-10-29 無水の安定したプラゾシン塩酸塩のδ型結晶体および該δ型結晶体の製造法 Granted JPS6115881A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI842544 1984-06-25
FI842544A FI79107C (fi) 1984-06-25 1984-06-25 Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid.

Publications (2)

Publication Number Publication Date
JPS6115881A true JPS6115881A (ja) 1986-01-23
JPH0481993B2 JPH0481993B2 (OSRAM) 1992-12-25

Family

ID=8519293

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59227640A Granted JPS6115881A (ja) 1984-06-25 1984-10-29 無水の安定したプラゾシン塩酸塩のδ型結晶体および該δ型結晶体の製造法

Country Status (17)

Country Link
US (2) US4739055A (OSRAM)
JP (1) JPS6115881A (OSRAM)
AT (1) AT389117B (OSRAM)
AU (1) AU566814B2 (OSRAM)
BE (1) BE900925A (OSRAM)
CH (1) CH661045A5 (OSRAM)
DE (1) DE3429415A1 (OSRAM)
FI (1) FI79107C (OSRAM)
FR (1) FR2567124B1 (OSRAM)
GB (1) GB2160861B (OSRAM)
IL (1) IL73267A (OSRAM)
IT (1) IT1224142B (OSRAM)
LU (1) LU85616A1 (OSRAM)
NL (1) NL8403250A (OSRAM)
NZ (1) NZ209962A (OSRAM)
PT (1) PT79411B (OSRAM)
ZA (1) ZA85910B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03206088A (ja) * 1989-12-28 1991-09-09 Yodogawa Seiyaku Kk 無水のε型結晶体２―〔４―（２―フロイル）ピペラジン―１―イル〕―４―アミノ―６，７―ジメトキシキナゾリン塩酸塩及びその製造方法

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EP0237608B1 (de) * 1986-03-21 1992-01-29 HEUMANN PHARMA GMBH & CO Kristalline, wasserfreie Sigma -Form von 2-[4-(2-Furoyl-(2-piperazin)-1-yl]-4-amino-6,7-dimethoxychinazolinhydrochlorid und Verfahren zu ihrer Herstellung
JPH07206857A (ja) * 1993-12-28 1995-08-08 Synthelabo Sa アルフゾシン塩酸塩の二水和物
EP1368349B1 (de) * 2001-02-24 2007-02-14 Boehringer Ingelheim Pharma GmbH & Co.KG Xanthinderivate, deren herstellung und deren verwendung als arzneimittel
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7501426B2 (en) * 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
EP2540725A1 (de) 2006-05-04 2013-01-02 Boehringer Ingelheim International GmbH Polymorphe von 1-((4-Methyl-chinazolin-2-yl)methyl)-3-methyl-7-(2-butin-1-yl)-8-(3-(R)-amino-piperidin-1-yl)xanthin
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP1852108A1 (en) * 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
WO2009024542A2 (en) * 2007-08-17 2009-02-26 Boehringer Ingelheim International Gmbh Purin derivatives for use in the treatment of fab-related diseases
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
NZ604091A (en) * 2008-08-15 2014-08-29 Boehringer Ingelheim Int Purin derivatives for use in the treatment of fab-related diseases
CN102149407A (zh) 2008-09-10 2011-08-10 贝林格尔.英格海姆国际有限公司 治疗糖尿病和相关病症的组合疗法
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CN102256976A (zh) 2008-12-23 2011-11-23 贝林格尔.英格海姆国际有限公司 有机化合物的盐形式
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
KR20240090632A (ko) 2009-11-27 2024-06-21 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
CN102946875A (zh) 2010-05-05 2013-02-27 贝林格尔.英格海姆国际有限公司 组合疗法
WO2011161161A1 (en) 2010-06-24 2011-12-29 Boehringer Ingelheim International Gmbh Diabetes therapy
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
US8883800B2 (en) 2011-07-15 2014-11-11 Boehringer Ingelheim International Gmbh Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
JP6218811B2 (ja) 2012-05-14 2017-10-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｓｉｒｓ及び／又は敗血症の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
JP6224084B2 (ja) 2012-05-14 2017-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
EP3110449B1 (en) 2014-02-28 2023-06-28 Boehringer Ingelheim International GmbH Medical use of a dpp-4 inhibitor
CN109310697A (zh) 2016-06-10 2019-02-05 勃林格殷格翰国际有限公司 利格列汀和二甲双胍的组合

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52105206A (en) * 1976-03-01 1977-09-03 Pfizer Novel crystal form of 22*44*22froyl*piperazinee11il**44aminoo6* 77dimethoxychinazolin hydrochloride

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
US2969375A (en) * 1961-01-24 Certification of correction
DE156532C (OSRAM) *
NL54420C (OSRAM) * 1937-05-25
GB1156973A (en) * 1965-07-06 1969-07-02 Quinazoline Derivatives
US3433788A (en) * 1966-04-27 1969-03-18 Union Carbide Corp Process for recovery of amines from aqueous solutions by solvent treatment and distillation
US3421983A (en) * 1967-03-07 1969-01-14 Lummus Co Azeotropic distillation of aqueous toluene diamine
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3743672A (en) * 1970-05-27 1973-07-03 Halcon International Inc Separation of water in alkylene glycol mono and diester purification by azeotropic distillation
GB1308718A (en) * 1970-07-01 1973-03-07 Sir Soc Italiana Resine Spa Method of separating vinyl acetate from liquid mixtures
IT956765B (it) * 1972-06-22 1973-10-10 Montedison Spa Procedimento per la purificazione di 1 3 diossolano
US3935213A (en) * 1973-12-05 1976-01-27 Pfizer Inc. Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4001237A (en) * 1976-02-18 1977-01-04 Bristol-Myers Company Oxazole, isoxazole, thiazole and isothiazole amides
FI67699C (fi) * 1979-01-31 1985-05-10 Orion Yhtymae Oy Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan
FI64367C (fi) * 1980-02-26 1986-08-05 Orion Yhtymae Oy Foerfarande foer framstaellning av alfa-form av prazosinhydroklorid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52105206A (en) * 1976-03-01 1977-09-03 Pfizer Novel crystal form of 22*44*22froyl*piperazinee11il**44aminoo6* 77dimethoxychinazolin hydrochloride

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03206088A (ja) * 1989-12-28 1991-09-09 Yodogawa Seiyaku Kk 無水のε型結晶体２―〔４―（２―フロイル）ピペラジン―１―イル〕―４―アミノ―６，７―ジメトキシキナゾリン塩酸塩及びその製造方法

Also Published As

Publication number Publication date
US4739055A (en) 1988-04-19
IT1224142B (it) 1990-09-26
ZA85910B (en) 1985-09-25
DE3429415C2 (OSRAM) 1990-05-03
GB2160861A (en) 1986-01-02
JPH0481993B2 (OSRAM) 1992-12-25
NZ209962A (en) 1987-06-30
FR2567124B1 (fr) 1990-09-21
DE3429415A1 (de) 1986-01-02
FR2567124A1 (fr) 1986-01-10
FI79107B (fi) 1989-07-31
PT79411A (en) 1984-11-01
IL73267A (en) 1988-06-30
AU566814B2 (en) 1987-10-29
FI79107C (fi) 1989-11-10
AT389117B (de) 1989-10-25
US4873330A (en) 1989-10-10
AU3451084A (en) 1986-01-02
FI842544L (fi) 1985-12-26
BE900925A (fr) 1985-02-15
GB2160861B (en) 1987-11-18
FI842544A0 (fi) 1984-06-25
IL73267A0 (en) 1985-01-31
LU85616A1 (fr) 1985-06-04
PT79411B (en) 1986-09-15
GB8424999D0 (en) 1984-11-07
CH661045A5 (de) 1987-06-30
NL8403250A (nl) 1986-01-16
ATA344184A (de) 1989-03-15
IT8423292A0 (it) 1984-10-24

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