JPS61140586A - 外部においてアルキル化された単環または二環の２‐第四級ヘテロアリールアルキル置換基を持つカルバペネム及び１‐メチルカルバペネム - Google Patents

外部においてアルキル化された単環または二環の２‐第四級ヘテロアリールアルキル置換基を持つカルバペネム及び１‐メチルカルバペネム

Info

Publication number
JPS61140586A
JPS61140586A JP60279379A JP27937985A JPS61140586A JP S61140586 A JPS61140586 A JP S61140586A JP 60279379 A JP60279379 A JP 60279379A JP 27937985 A JP27937985 A JP 27937985A JP S61140586 A JPS61140586 A JP S61140586A
Authority
JP
Japan
Prior art keywords
group
substituted
unsubstituted
alkyl
formulas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60279379A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0438754B2 (enExample
Inventor
バートン　ジー．クリステンセン
ロナルド　ダブリユ．ラトクリフ
ジエームス　ヴイ．ヘツク
トーマス　エヌ．ザルツマン
デイヴイツド　エツチ．シイー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS61140586A publication Critical patent/JPS61140586A/ja
Publication of JPH0438754B2 publication Critical patent/JPH0438754B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP60279379A 1984-12-13 1985-12-13 外部においてアルキル化された単環または二環の２‐第四級ヘテロアリールアルキル置換基を持つカルバペネム及び１‐メチルカルバペネム Granted JPS61140586A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US681179 1984-12-13
US06/681,179 US4729993A (en) 1984-12-13 1984-12-13 Carbapenems and 1-methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkyl substituent

Publications (2)

Publication Number Publication Date
JPS61140586A true JPS61140586A (ja) 1986-06-27
JPH0438754B2 JPH0438754B2 (enExample) 1992-06-25

Family

ID=24734167

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60279379A Granted JPS61140586A (ja) 1984-12-13 1985-12-13 外部においてアルキル化された単環または二環の２‐第四級ヘテロアリールアルキル置換基を持つカルバペネム及び１‐メチルカルバペネム

Country Status (3)

Country Link
US (1) US4729993A (enExample)
EP (1) EP0184843A1 (enExample)
JP (1) JPS61140586A (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04273876A (ja) * 1990-10-05 1992-09-30 Merck & Co Inc ２−（３−ピリジル）−カルバペネム抗菌剤

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978659A (en) * 1987-02-02 1990-12-18 Merck & Co., Inc. 2-(Heteroaryliumalkyl)phenyl carbapenem antibacterial agents
GB8804058D0 (en) * 1988-02-22 1988-03-23 Fujisawa Pharmaceutical Co 3-alkenyl-1-azabicyclo(3 2 0)hept-2-ene-2-carboxylic acid compounds
US5034385A (en) * 1990-06-26 1991-07-23 Merck & Co., Inc. 2-(heteroarylsubstituted)phenyl carbapenem antibacterial agents
CA2045847A1 (en) * 1990-06-29 1991-12-30 Frank P. Dininno Carbapenem antibacterial agents
CA2052730A1 (en) 1990-10-11 1992-04-12 Frank P. Dininno 2-(substituted-dibenzofuranyl and dibenzothienyl) carbapenem antibacterial agents
US5286721A (en) * 1990-10-15 1994-02-15 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
US5128335A (en) * 1990-10-15 1992-07-07 Merck & Co., Inc. 2-heteroarylphenyl-carbapenem antibacterial agents
GB9022309D0 (en) * 1990-10-15 1990-11-28 Fujisawa Pharmaceutical Co 1-azabicyclo(3.2.0.)hept-2-ene-2-carboxylic acid compounds
US5208328A (en) * 1991-04-16 1993-05-04 Merck & Co., Inc. 2-phenanthridonyl carbapenem intermediates
US5153185A (en) * 1991-04-16 1992-10-06 Merck & Co., Inc. 2-phenanthridonyl carbapenems
US5153186A (en) * 1991-05-24 1992-10-06 Merck & Co., Inc. 2-benzocoumarinyl-carbapenems
US5216146A (en) * 1991-05-24 1993-06-01 Merck & Co., Inc. 2-benzocoumarinyl-carbapenems
US5334590A (en) * 1991-10-17 1994-08-02 Merck & Co., Inc. MRSA active 2-phenyl-carbapenems
US5276149A (en) * 1991-10-17 1994-01-04 Merck & Co., Inc. 2-(N-imidazoliumphenyl)-carbapenems
US5256777A (en) * 1991-10-17 1993-10-26 Merck & Co., Inc. 2-phenyl-carbapenems
US5382575A (en) * 1991-10-17 1995-01-17 Merck & Co., Inc. (N-pyridiniumphenyl)-carbapenems
US5342933A (en) * 1992-08-28 1994-08-30 Merck & Co., Inc. Cationic-2-heteroarylphenyl-carbapenem antibacterial agents
US5292879A (en) * 1992-08-28 1994-03-08 Merck & Co., Inc. Intermediates for preparing cationic-2-heteroaryl-phenyl-carbapenem antibacterial agents
US5350746A (en) * 1993-04-14 1994-09-27 Merck & Co., Inc. Triazolyl and tetrazolyl phenyl substituted carbapenems, compositions containing such compounds and methods of use
US5496816A (en) * 1994-03-14 1996-03-05 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348320A (en) * 1976-11-19 1982-09-07 Merck & Co., Inc. Substituted azetidiones
US4218459A (en) * 1977-12-28 1980-08-19 Merck & Co., Inc. 6-Amido-1-carba-2-penem-3-carboxylic acid
US4189493A (en) * 1977-12-28 1980-02-19 Merck & Co., Inc. N-heterocyclic derivatives of thienamycin
US4465632A (en) * 1978-10-24 1984-08-14 Merck & Co., Inc. Process for preparing 1-6-and 2-substituted-1-carba-2-penem-3-carboxylic acids
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
JPS5660852A (en) * 1979-10-18 1981-05-26 Isuzu Motors Ltd Distributing type pump
US4262011A (en) * 1979-12-03 1981-04-14 Merck & Co., Inc. 1-1-Disubstituted-pen-2-em-3-carboxylic acids
US4262009A (en) * 1979-12-03 1981-04-14 Merck & Co., Inc. 6- And 1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acid
US4312871A (en) * 1979-12-03 1982-01-26 Merck & Co., Inc. 6-, 1- And 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4347355A (en) * 1980-02-21 1982-08-31 Abbott Laboratories Inhibitors of transpeptidase
JPS56122379A (en) * 1980-03-03 1981-09-25 Sankyo Co Ltd 1-carba-2-penem-3-carboxylic acid derivative
US4341706A (en) * 1980-10-10 1982-07-27 Merck & Co., Inc. Process for the preparation of carbapenem antibiotics
CA1179675A (en) * 1981-01-30 1984-12-18 Erwin Gotschi 7-oxo-1-azabicyclo ¬3,2,0| heptene-2-derivatives
JPS57145087A (en) * 1981-02-27 1982-09-07 Hitachi Metals Ltd Clad ceramic tool
JPS57145086A (en) * 1981-02-27 1982-09-07 Hitachi Metals Ltd Clad ceramic tool
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics
NZ205626A (en) * 1982-09-28 1986-12-05 Bristol Myers Co Carbapenem antibiotics
EP0109362A1 (de) * 1982-11-16 1984-05-23 Ciba-Geigy Ag Heterocyclylverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
US4680292A (en) * 1984-12-13 1987-07-14 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04273876A (ja) * 1990-10-05 1992-09-30 Merck & Co Inc ２−（３−ピリジル）−カルバペネム抗菌剤

Also Published As

Publication number Publication date
JPH0438754B2 (enExample) 1992-06-25
EP0184843A1 (en) 1986-06-18
US4729993A (en) 1988-03-08

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