JPS6112676A - アロマターゼ阻害剤 - Google Patents

アロマターゼ阻害剤

Info

Publication number
JPS6112676A
JPS6112676A JP60135224A JP13522485A JPS6112676A JP S6112676 A JPS6112676 A JP S6112676A JP 60135224 A JP60135224 A JP 60135224A JP 13522485 A JP13522485 A JP 13522485A JP S6112676 A JPS6112676 A JP S6112676A
Authority
JP
Japan
Prior art keywords
methyl
chlorophenyl
item
tetrazole
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60135224A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0548228B2 (enExample
Inventor
ケネス・ステイーブン・ハーシ
チヤールズ・デビツド・ジヨンズ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPS6112676A publication Critical patent/JPS6112676A/ja
Publication of JPH0548228B2 publication Critical patent/JPH0548228B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP60135224A 1984-06-18 1985-06-18 アロマターゼ阻害剤 Granted JPS6112676A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US621582 1984-06-18
US06/621,582 US4801594A (en) 1984-06-18 1984-06-18 Aromatase inhibitors

Publications (2)

Publication Number Publication Date
JPS6112676A true JPS6112676A (ja) 1986-01-21
JPH0548228B2 JPH0548228B2 (enExample) 1993-07-20

Family

ID=24490764

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60135224A Granted JPS6112676A (ja) 1984-06-18 1985-06-18 アロマターゼ阻害剤

Country Status (6)

Country Link
US (1) US4801594A (enExample)
EP (1) EP0165778B1 (enExample)
JP (1) JPS6112676A (enExample)
AT (1) ATE40822T1 (enExample)
CA (1) CA1270835A (enExample)
DE (1) DE3568275D1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773240A (en) * 1994-06-13 1998-06-30 Mitsubishi Rayon Co., Ltd. Optically active α-substituted carboxylic acid derivatives and method for producing the same

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112845A (en) * 1986-03-07 1992-05-12 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US4749713A (en) * 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
US4937250A (en) * 1988-03-07 1990-06-26 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US5352795A (en) * 1986-03-07 1994-10-04 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
NZ224714A (en) * 1987-06-01 1990-03-27 Janssen Pharmaceutica Nv Substituted benzotriazole derivatives and pharmaceutical compositions
GB8714013D0 (en) * 1987-06-16 1987-07-22 Ici Plc (substituted-aralkyl)heterocyclic compounds
GB8716651D0 (en) * 1987-07-15 1987-08-19 Ici Plc 2-propanol derivatives
GB8818561D0 (en) * 1988-08-04 1988-09-07 Ici Plc Diphenylethane derivatives
IE892812L (en) * 1988-09-12 1990-03-12 Brendan Coleman Tricyclic aromatase inhibitors
DE59010171D1 (de) * 1989-07-14 1996-04-11 Ciba Geigy Ag Substituierte Benzonitrile
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
JPH07247274A (ja) * 1994-03-10 1995-09-26 Wakamoto Pharmaceut Co Ltd ピバル酸 テトラゾリルフェニルエステル誘導体、それらを有効成分として含有するエラスターゼ阻害剤及び肺障害治療剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2407305C2 (de) * 1974-02-15 1984-06-28 Bayer Ag, 5090 Leverkusen Triphenyl-1,2,3-triazol-1-yl-methane, Verfahren zu ihrer Herstellung und ihre Verwendung als Fungizide
IL50699A0 (en) * 1975-10-28 1976-12-31 Ici America Inc Triazole derivatives
US4094881A (en) * 1976-03-10 1978-06-13 Smithkline Corporation Process for preparing triazolethiols
GB1511195A (en) * 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4227004A (en) * 1979-01-02 1980-10-07 Ici Americas Inc. Synthesis of substituted 1-aralkyl-1H-v-triazoles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773240A (en) * 1994-06-13 1998-06-30 Mitsubishi Rayon Co., Ltd. Optically active α-substituted carboxylic acid derivatives and method for producing the same

Also Published As

Publication number Publication date
ATE40822T1 (de) 1989-03-15
EP0165778A1 (en) 1985-12-27
DE3568275D1 (en) 1989-03-23
EP0165778B1 (en) 1989-02-15
US4801594A (en) 1989-01-31
CA1270835A (en) 1990-06-26
JPH0548228B2 (enExample) 1993-07-20

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