JPS61103890A - ６−０−メチルエリスロマイシンａ誘導体 - Google Patents

６−０−メチルエリスロマイシンａ誘導体

Info

Publication number
JPS61103890A
JPS61103890A JP59225543A JP22554384A JPS61103890A JP S61103890 A JPS61103890 A JP S61103890A JP 59225543 A JP59225543 A JP 59225543A JP 22554384 A JP22554384 A JP 22554384A JP S61103890 A JPS61103890 A JP S61103890A
Authority
JP
Japan
Prior art keywords
compound
oxime
methyl
acid
ethyl acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59225543A
Other languages
English (en)
Japanese (ja)
Other versions
JPH053476B2 (enExample
Inventor
Shigeo Morimoto
森本　繁夫
Takashi Adachi
孝 安達
Toshibumi Asaga
俊文 朝賀
Yoshiaki Watanabe
渡辺　慶昭
Kaoru Soda
曾田　馨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16830937&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS61103890(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Priority to JP59225543A priority Critical patent/JPS61103890A/ja
Priority to US06/789,771 priority patent/US4680386A/en
Priority to AU48973/85A priority patent/AU574233B2/en
Priority to EP85307680A priority patent/EP0180415B1/en
Priority to DE8585307680T priority patent/DE3575729D1/de
Priority to DK198504905A priority patent/DK172636B1/da
Priority to ZA858212A priority patent/ZA858212B/xx
Publication of JPS61103890A publication Critical patent/JPS61103890A/ja
Publication of JPH053476B2 publication Critical patent/JPH053476B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP59225543A 1984-10-26 1984-10-26 ６−０−メチルエリスロマイシンａ誘導体 Granted JPS61103890A (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP59225543A JPS61103890A (ja) 1984-10-26 1984-10-26 ６−０−メチルエリスロマイシンａ誘導体
US06/789,771 US4680386A (en) 1984-10-26 1985-10-21 6-O-methylerythromycin a derivative
AU48973/85A AU574233B2 (en) 1984-10-26 1985-10-23 6-0-methyl erythromycin a derivative
EP85307680A EP0180415B1 (en) 1984-10-26 1985-10-24 A 6-0-methylerythromycin A derivative
DE8585307680T DE3575729D1 (en) 1984-10-26 1985-10-24 6-o-methylerythromycin a derivative
DK198504905A DK172636B1 (en) 1984-10-26 1985-10-25 6-o-methylerythromycin a derivative
ZA858212A ZA858212B (en) 1984-10-26 1985-10-25 6-o-methylerythromycin a derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59225543A JPS61103890A (ja) 1984-10-26 1984-10-26 ６−０−メチルエリスロマイシンａ誘導体

Publications (2)

Publication Number Publication Date
JPS61103890A true JPS61103890A (ja) 1986-05-22
JPH053476B2 JPH053476B2 (enExample) 1993-01-14

Family

ID=16830937

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59225543A Granted JPS61103890A (ja) 1984-10-26 1984-10-26 ６−０−メチルエリスロマイシンａ誘導体

Country Status (7)

Country Link
US (1) US4680386A (enExample)
EP (1) EP0180415B1 (enExample)
JP (1) JPS61103890A (enExample)
AU (1) AU574233B2 (enExample)
DE (1) DE3575729D1 (enExample)
DK (1) DK172636B1 (enExample)
ZA (1) ZA858212B (enExample)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8506380D0 (en) * 1985-03-12 1985-04-11 Beecham Group Plc Chemical compounds
US4670549A (en) * 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives
JPS63107994A (ja) * 1986-05-02 1988-05-12 Taisho Pharmaceut Co Ltd エリスロマイシン誘導体
DE3782994T2 (de) 1986-09-18 1993-04-08 Taisho Pharma Co Ltd Erythromycin-a-derivate und verfahren zu ihrer herstellung.
EP0284203A3 (en) * 1987-02-24 1989-11-02 Beecham Group Plc Erythromycin derivatives, process for their preparation and their pharmaceutical use
YU45033B (en) * 1987-04-14 1991-06-30 Pliva Zagreb Process for preparing 10,11,12,13-tetrahydro derivative
US4808411A (en) * 1987-06-05 1989-02-28 Abbott Laboratories Antibiotic-polymer compositions
GB8721165D0 (en) * 1987-09-09 1987-10-14 Beecham Group Plc Chemical compounds
US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
SI9010556B (sl) * 1990-03-21 1998-10-31 Pliva Oleandomicin oksimi in postopek za njihovo pripravo
SI9011409A (en) * 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
CA2062932A1 (en) * 1991-03-15 1992-09-16 Robert R. Wilkening 9-deoxo-9(z)-hydroxyiminoerythromycin a and o-derivatives thereof
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
US5872229A (en) 1995-11-21 1999-02-16 Abbott Laboratories Process for 6-O-alkylation of erythromycin derivatives
US5858986A (en) 1996-07-29 1999-01-12 Abbott Laboratories Crystal form I of clarithromycin
CA2261732C (en) 1996-07-29 2001-07-24 Abbott Laboratories Preparation of crystal form ii of clarithromycin
HRP960509A2 (en) * 1996-10-30 1998-06-30 Pliva Pharm & Chem Works Novel polyhydro tylosin derivatives and a process for the preparation thereof
US5945405A (en) 1997-01-17 1999-08-31 Abbott Laboratories Crystal form O of clarithromycin
US5864023A (en) * 1997-02-13 1999-01-26 Abbott Laboratories 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
US5929219A (en) * 1997-09-10 1999-07-27 Abbott Laboratories 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same
US5852180A (en) * 1997-11-17 1998-12-22 Abbott Laboratories Chemical synthesis of 6-O-alkyl erythromycin A
US5932710A (en) * 1997-12-01 1999-08-03 Abbott Laboratories Process for preparing 6-O-alkyl-9-oxime erythromycin B
IL135792A0 (en) * 1997-12-01 2001-05-20 Abbott Lab 6-o-alkyl derivatives of erythronolide b
US5892008A (en) * 1997-12-16 1999-04-06 Abbott Laboratories Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
GB9827355D0 (en) 1998-12-11 1999-02-03 Biochemie Sa Organic compounds
CA2292359C (en) 1999-01-28 2004-09-28 Pfizer Products Inc. Novel azalides and methods of making same
KR20020016799A (ko) * 1999-05-24 2002-03-06 데이비드 존 우드 13-메틸-에리트로마이신 유도체
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
KR20010008496A (ko) * 1999-07-01 2001-02-05 유충식 6-오-메틸 에리트로마이신의 제조방법
CN1666991A (zh) 1999-12-16 2005-09-14 特瓦制药工业有限公司 克拉霉素多晶型物的制备方法和新的多晶型物ⅳ
CN1450903A (zh) 2000-01-11 2003-10-22 特瓦制药工业有限公司 克拉霉素多晶型物的制备方法
US6565882B2 (en) 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
CA2401571A1 (en) * 2000-02-29 2001-09-07 Ilya Avrutov Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
US6605707B1 (en) 2000-03-23 2003-08-12 Abbott Laboratories Process for the preparation of 6-O-propargyl erythromycin derivatives
AU6381201A (en) * 2000-03-28 2001-10-08 Biochemie Gmbh Granulated particles with masked taste
US6541014B2 (en) 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6843854B2 (en) 2002-05-31 2005-01-18 Purdue Research Foundation Method and apparatus for separating a component from a mixture
JP2006528185A (ja) 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
WO2005009368A2 (en) 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
EP1648415A4 (en) 2003-07-21 2011-11-16 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
CA2535177A1 (en) 2003-08-11 2005-02-24 Advancis Pharmaceutical Corporation Robust pellet
CA2535398C (en) 2003-08-12 2013-11-12 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
WO2005023184A2 (en) 2003-08-29 2005-03-17 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
AU2004273830B2 (en) 2003-09-15 2011-03-24 Shionogi, Inc. Antibiotic product, use and formulation thereof
EP1771158A4 (en) 2004-07-02 2008-03-12 Advancis Pharmaceutical Corp TABLET FOR PULSE DISTRIBUTION
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8299052B2 (en) * 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
WO2009023191A2 (en) * 2007-08-09 2009-02-19 Teva Pharmaceutical Industries Ltd. An improved process for the preparation of clarithromycin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2473525A1 (fr) * 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
JPS5896097A (ja) * 1981-12-01 1983-06-07 Taisho Pharmaceut Co Ltd エリスロマイシンｂ誘導体
JPS60214796A (ja) * 1984-04-06 1985-10-28 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシン類の製法
US4670549A (en) * 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives

Also Published As

Publication number Publication date
ZA858212B (en) 1986-07-30
DK490585D0 (en) 1985-10-25
EP0180415A3 (en) 1986-10-29
US4680386A (en) 1987-07-14
AU574233B2 (en) 1988-06-30
EP0180415B1 (en) 1990-01-31
JPH053476B2 (enExample) 1993-01-14
DE3575729D1 (en) 1990-03-08
EP0180415A2 (en) 1986-05-07
DK172636B1 (en) 1999-03-22
DK490585A (en) 1986-04-27
AU4897385A (en) 1986-05-01

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Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term