JPS6056982A - ３，６−ジ置換トリアゾロ〔３，４−ａ〕フタラジン誘導体、その製法および製薬学的組成物 - Google Patents

３，６−ジ置換トリアゾロ〔３，４−ａ〕フタラジン誘導体、その製法および製薬学的組成物

Info

Publication number
JPS6056982A
JPS6056982A JP59141573A JP14157384A JPS6056982A JP S6056982 A JPS6056982 A JP S6056982A JP 59141573 A JP59141573 A JP 59141573A JP 14157384 A JP14157384 A JP 14157384A JP S6056982 A JPS6056982 A JP S6056982A
Authority
JP
Japan
Prior art keywords
formula
phenyl
alkyl
substituted
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59141573A
Other languages
English (en)
Japanese (ja)
Other versions
JPH051267B2 (Direct
Inventor
エミリオ・オツチエルリ
ジヨルジヨ・タルジーア
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Gruppo Lepetit SpA
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit SpA, Lepetit SpA filed Critical Gruppo Lepetit SpA
Publication of JPS6056982A publication Critical patent/JPS6056982A/ja
Publication of JPH051267B2 publication Critical patent/JPH051267B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP59141573A 1983-07-12 1984-07-10 ３，６−ジ置換トリアゾロ〔３，４−ａ〕フタラジン誘導体、その製法および製薬学的組成物 Granted JPS6056982A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22014A/83 1983-07-12
IT22014/83A IT1194310B (it) 1983-07-12 1983-07-12 Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti

Publications (2)

Publication Number Publication Date
JPS6056982A true JPS6056982A (ja) 1985-04-02
JPH051267B2 JPH051267B2 (Direct) 1993-01-07

Family

ID=11190206

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59141573A Granted JPS6056982A (ja) 1983-07-12 1984-07-10 ３，６−ジ置換トリアゾロ〔３，４−ａ〕フタラジン誘導体、その製法および製薬学的組成物

Country Status (9)

Country Link
US (1) US4783461A (Direct)
EP (1) EP0134946B1 (Direct)
JP (1) JPS6056982A (Direct)
AT (1) ATE28874T1 (Direct)
AU (1) AU560726B2 (Direct)
CA (1) CA1234114A (Direct)
DE (1) DE3465309D1 (Direct)
DK (1) DK164704C (Direct)
IT (1) IT1194310B (Direct)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001525802A (ja) * 1997-05-08 2001-12-11 メルク シヤープ エンド ドーム リミテツド ＧＡＢＡα５リガンドとしての置換１，２，４−トリアゾロ［３，４−ａ］フタラジン誘導体
JP2008526717A (ja) * 2005-01-05 2008-07-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング トリアゾロフタラジン
JP2008526716A (ja) * 2005-01-05 2008-07-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング トリアゾロフタラジン

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9710729A (pt) * 1996-07-25 1999-08-17 Merck Sharp & Dohme Composto composi-Æo farmac-utica utiliza-Æo de um composto e processo para o tratamento e/ou a preven-Æo da ansiedade e de convuls{es para a triagem de compostos ansioliticos nÆo-sedativos e para a prepara-Æo de um composto
JP2000515851A (ja) 1996-07-25 2000-11-28 メルク シヤープ エンド ドーム リミテツド ＧＡＢＡ▲下Ａα５▼レセプターサブタイプの逆アゴニストとしての置換のあるトリアゾロピリダジン誘導体
GB9715977D0 (en) 1997-07-29 1997-10-01 Merck Sharp & Dohme Therapeutic agents
GB9726699D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9723999D0 (en) 1997-11-13 1998-01-14 Merck Sharp & Dohme Therapeutic use
GB9726702D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9726701D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
US6110915A (en) * 1997-12-18 2000-08-29 Merck & Co., Inc. Antiemetic use of triazolo-pyridazine derivatives
JP2002509150A (ja) 1998-01-14 2002-03-26 メルク シャープ エンド ドーム リミテッド Ｇａｂａ受容体のリガンドとしてのトリアゾロピリダジン誘導体
GB9801202D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801234D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801208D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
HRP20000492A2 (en) * 1998-01-21 2000-12-31 Merck Sharp & Dohme Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801210D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801397D0 (en) 1998-01-22 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801538D0 (en) 1998-01-23 1998-03-25 Merck Sharp & Dohme Pharmaceutical product
US6448249B1 (en) 1998-02-25 2002-09-10 Merck Sharp & Dohme Ltd. Substituted 1,2,4-triazolo[3,4-A]phthalazine derivatives as GABAα5 ligands
IT1303272B1 (it) * 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
WO2000027849A2 (en) 1998-11-12 2000-05-18 Merck & Co., Inc. Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
GB9824897D0 (en) 1998-11-12 1999-01-06 Merck Sharp & Dohme Therapeutic compounds
ATE236158T1 (de) * 1999-11-12 2003-04-15 Neurogen Corp Bicyclische und tricyclische heteroaromatische verbindungen
GB0028583D0 (en) 2000-11-23 2001-01-10 Merck Sharp & Dohme Therapeutic compounds
RU2531197C2 (ru) 2009-01-29 2014-10-20 Басф Се Абсорбент для извлечения кислых газов, содержащий аминокислоту и кислый промотор

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB629177A (en) * 1945-12-21 1949-09-14 Ciba Ltd Manufacture of new hydrazine compounds and derivatives thereof
US2484029A (en) * 1945-12-21 1949-10-11 Ciba Pharm Prod Inc Hydrazine derivatives of pyridazine compounds
US3711481A (en) * 1970-04-24 1973-01-16 G Hardtmann 6-aryl-imidazo(2,1-a)phthalazines
US3694442A (en) * 1970-07-28 1972-09-26 William J Houlihan SUBSTITUTED TETRAHYDRO-1H-PYRAZOLO{8 1,2-b{9 PHTHALAZINES
US3704300A (en) * 1971-04-09 1972-11-28 Sandoz Ag Imidazo(2,1-a)phthalazines
JPS603080B2 (ja) * 1976-08-10 1985-01-25 三菱化学株式会社 Ｓ―トリアゾロ〔３，４ ―α〕〔５，６，７，８〕テトラヒドロ フタラジン類
GR70309B (Direct) * 1979-10-29 1982-09-08 Dow Chemical Co
PH21834A (en) * 1982-01-18 1988-03-17 Lepetit Spa New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
US4391807A (en) * 1982-07-12 1983-07-05 The Dow Chemical Company 6-Substituted tetrahydroimidazo[2,1-a]phthalazines and use as bronchodilators
US4485106A (en) * 1982-07-12 1984-11-27 The Dow Chemical Company Substituted tetrahydrotetrazolo[5,1-a]phthalazines
US4487930A (en) * 1982-09-07 1984-12-11 The Dow Chemical Company 6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001525802A (ja) * 1997-05-08 2001-12-11 メルク シヤープ エンド ドーム リミテツド ＧＡＢＡα５リガンドとしての置換１，２，４−トリアゾロ［３，４−ａ］フタラジン誘導体
JP2008526717A (ja) * 2005-01-05 2008-07-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング トリアゾロフタラジン
JP2008526716A (ja) * 2005-01-05 2008-07-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング トリアゾロフタラジン

Also Published As

Publication number Publication date
AU560726B2 (en) 1987-04-16
DK331884D0 (da) 1984-07-06
US4783461A (en) 1988-11-08
EP0134946A1 (en) 1985-03-27
IT1194310B (it) 1988-09-14
DE3465309D1 (de) 1987-09-17
EP0134946B1 (en) 1987-08-12
DK331884A (da) 1985-01-13
IT8322014A0 (it) 1983-07-12
DK164704C (da) 1992-12-21
AU3022484A (en) 1985-01-17
DK164704B (da) 1992-08-03
ATE28874T1 (de) 1987-08-15
CA1234114A (en) 1988-03-15
JPH051267B2 (Direct) 1993-01-07

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