JPS6052130B2 - 医療および美容用コラ−ゲン物質の製造法 - Google Patents
医療および美容用コラ−ゲン物質の製造法Info
- Publication number
- JPS6052130B2 JPS6052130B2 JP55502079A JP50207980A JPS6052130B2 JP S6052130 B2 JPS6052130 B2 JP S6052130B2 JP 55502079 A JP55502079 A JP 55502079A JP 50207980 A JP50207980 A JP 50207980A JP S6052130 B2 JPS6052130 B2 JP S6052130B2
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- weight
- solution
- freeze
- slurry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000008186 Collagen Human genes 0.000 title claims description 87
- 108010035532 Collagen Proteins 0.000 title claims description 87
- 229920001436 collagen Polymers 0.000 title claims description 74
- 239000002537 cosmetic Substances 0.000 title claims description 7
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 239000000126 substance Substances 0.000 title claims description 4
- 239000000463 material Substances 0.000 claims description 48
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 28
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 20
- 239000002002 slurry Substances 0.000 claims description 18
- 239000011780 sodium chloride Substances 0.000 claims description 14
- 239000000725 suspension Substances 0.000 claims description 11
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
- 241001465754 Metazoa Species 0.000 claims description 8
- 230000001954 sterilising effect Effects 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 claims description 6
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims description 6
- 229910000041 hydrogen chloride Inorganic materials 0.000 claims description 6
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 102000057297 Pepsin A Human genes 0.000 claims description 4
- 108090000284 Pepsin A Proteins 0.000 claims description 4
- 239000012153 distilled water Substances 0.000 claims description 4
- 238000004108 freeze drying Methods 0.000 claims description 4
- 229940111202 pepsin Drugs 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 4
- 239000000080 wetting agent Substances 0.000 claims description 4
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 238000000502 dialysis Methods 0.000 claims description 3
- 235000019441 ethanol Nutrition 0.000 claims description 3
- 235000019253 formic acid Nutrition 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 229910000039 hydrogen halide Inorganic materials 0.000 claims description 3
- 239000012433 hydrogen halide Substances 0.000 claims description 3
- 150000007524 organic acids Chemical class 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- 230000002335 preservative effect Effects 0.000 claims description 3
- 241000283690 Bos taurus Species 0.000 claims description 2
- 238000000108 ultra-filtration Methods 0.000 claims description 2
- 238000005238 degreasing Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
- 239000000243 solution Substances 0.000 description 19
- 210000001519 tissue Anatomy 0.000 description 14
- 238000010521 absorption reaction Methods 0.000 description 8
- 230000000704 physical effect Effects 0.000 description 6
- 239000003814 drug Substances 0.000 description 4
- -1 hydrogen halides Chemical class 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 101710137510 Saimiri transformation-associated protein Proteins 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 150000001540 azides Chemical class 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
- 239000010802 sludge Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
- C08H1/06—Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09H—PREPARATION OF GLUE OR GELATINE
- C09H1/00—Pretreatment of collagen-containing raw materials for the manufacture of glue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/08—Collagen
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH9030/79-0 | 1979-10-08 | ||
| CH903079 | 1979-10-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56501282A JPS56501282A (show.php) | 1981-09-10 |
| JPS6052130B2 true JPS6052130B2 (ja) | 1985-11-18 |
Family
ID=4347549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55502079A Expired JPS6052130B2 (ja) | 1979-10-08 | 1980-09-17 | 医療および美容用コラ−ゲン物質の製造法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4389487A (show.php) |
| EP (1) | EP0036415B1 (show.php) |
| JP (1) | JPS6052130B2 (show.php) |
| CH (1) | CH645271A5 (show.php) |
| DE (1) | DE3049932C1 (show.php) |
| GB (1) | GB2072193B (show.php) |
| WO (1) | WO1981000963A1 (show.php) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3248188A1 (de) * | 1982-12-27 | 1984-06-28 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung eines kollagen-vlieses |
| IT1181737B (it) * | 1985-11-26 | 1987-09-30 | Pierfrancesco Morganti | Supproto di collagene biologicamente attivo per uso cosmetico e farmaceutico e metodo per prepararlo |
| IT1214505B (it) * | 1987-03-12 | 1990-01-18 | Gentili Ist Spa | Procedimento per la preparazione di collageno e prodotti cosi'ottenuto. |
| US5036056A (en) * | 1987-07-08 | 1991-07-30 | Martin Kludas | Methods for treating damaged corneal, uterine, or cartilage tissue |
| US5055298A (en) * | 1987-12-01 | 1991-10-08 | Chemisches Laboratorium Dr. Kurt Richter Gmbh | Cosmetic composition comprising an extracellular connective tissue matrix |
| US5147343B1 (en) * | 1988-04-21 | 1998-03-17 | Kimberly Clark Co | Absorbent products containing hydrogels with ability to swell against pressure |
| US4948540A (en) * | 1988-08-01 | 1990-08-14 | Semex Medical, Inc. | Method of preparing collagen dressing sheet material |
| US5149335A (en) * | 1990-02-23 | 1992-09-22 | Kimberly-Clark Corporation | Absorbent structure |
| DE4028622C2 (de) * | 1990-09-08 | 1994-01-27 | Suwelack Nachf Dr Otto | Verfahren zum Herstellen von Kollagenschwämmen |
| SE9100999L (sv) * | 1991-04-05 | 1992-09-07 | Collagen Casing Einar Sjoeland | Foerfarande foer framstaellning av kollagen och kollagen framstaellt genom foerfarandet samt anvaendning av kollagen |
| US5437287A (en) * | 1992-08-17 | 1995-08-01 | Carbomedics, Inc. | Sterilization of tissue implants using iodine |
| CA2114815C (en) | 1993-02-24 | 2005-06-14 | Mark Kevin Melius | Absorbent composite |
| DE4312977C2 (de) * | 1993-04-21 | 2001-03-15 | Becker & Co Naturinwerk | Biologisch abbaubare Sammel- oder Transportbehältnisse |
| US5711853A (en) * | 1993-06-16 | 1998-01-27 | Ranpak Corp. | Paper strengthened with solubilized collagen and method |
| US5316942A (en) * | 1993-06-16 | 1994-05-31 | Battelle Memorial Institute | Process for the production of low-cost soluble high-molecular weight collagen |
| US5700353A (en) * | 1993-06-16 | 1997-12-23 | Ranpak Corporation | Paper strengthened with solubilized collagen and method |
| US5700354A (en) * | 1993-06-16 | 1997-12-23 | Ranpak Corp. | Paper strengthened with solubilized collagen and method |
| DE4404625C2 (de) * | 1994-02-14 | 1996-10-17 | Ludwig Dr Baumgartner | Verfahren zur Inaktivierung thermolabiler Viren in biologischem Material unter Beibehaltung der kollagenen Eigenschaften |
| US6451326B2 (en) | 1996-05-02 | 2002-09-17 | Burt D. Ensley | Cosmetic compositions |
| US6196768B1 (en) | 1996-11-15 | 2001-03-06 | Shell Oil Company | Spar fairing |
| US6179524B1 (en) | 1996-11-15 | 2001-01-30 | Shell Oil Company | Staggered fairing system for suppressing vortex-induced-vibration |
| JP5105216B2 (ja) * | 1997-02-13 | 2012-12-26 | ジンマー オーソバイオロジックス，インコーポレーテッド | 移植可能なパテ状材料 |
| US6679918B1 (en) | 1997-02-13 | 2004-01-20 | Centerpulse Biologics Inc. | Implantable putty material |
| EP1844798A1 (en) * | 1997-02-13 | 2007-10-17 | Zimmer Orthobiologics, Inc. | Implantable putty material |
| US6067922A (en) * | 1997-05-08 | 2000-05-30 | Shell Oil Company | Copper protected fairings |
| US20040081704A1 (en) * | 1998-02-13 | 2004-04-29 | Centerpulse Biologics Inc. | Implantable putty material |
| US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
| US6838440B2 (en) * | 2001-01-24 | 2005-01-04 | Collagen Nutraceuticals, Inc. | Kolla2-desiccated avian sternal cartilage powder |
| KR100465015B1 (ko) * | 2002-03-04 | 2005-01-13 | 이재관 | 유기용매를 이용한 가용성 콜라겐의 제조방법 |
| US7166133B2 (en) | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
| US7622562B2 (en) | 2002-06-26 | 2009-11-24 | Zimmer Orthobiologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
| US7718616B2 (en) | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
| AU2011329054B2 (en) | 2010-11-15 | 2015-05-28 | Zimmer Orthobiologics, Inc. | Bone void fillers |
| WO2013120143A1 (en) * | 2012-02-17 | 2013-08-22 | Commonwealth Scientific And Industrial Research Organisation | Method of promoting the formation of cross-links between coiled coil silk proteins |
| US11060122B2 (en) * | 2017-05-10 | 2021-07-13 | Robert den Hoed | Method of producing jellyfish collagen extract |
| MX2020014328A (es) | 2020-12-18 | 2022-06-20 | Top Health S A P I De C V | Proceso para producir estructuras de colageno humano con caracteristicas controladas. |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA585232A (en) * | 1959-10-20 | Burton Donald | Process and compositions for the enzymatic treatment of hides and skins | |
| CA665262A (en) * | 1963-06-18 | Nishihara Tomio | Method of promotion of the solubilization of insoluble collagen fibers | |
| DE673203C (de) | 1933-01-03 | 1939-07-03 | Wolfgang Grassmann Dr | Verfahren zur Gewinnung wasserunloeslicher, verdaulicher Abbauprodukte von Keratinen |
| DE1692548U (de) | 1954-11-19 | 1955-02-03 | Metallgesellschaft Ag | Gas-mischeinrichtung von dem gaseintritt in eiektrofilter. |
| GB1144552A (en) * | 1965-03-01 | 1969-03-05 | Fmc Corp | Method of producing fibrous bodies and fibrous bodies produced thereby |
| US3303038A (en) * | 1965-07-29 | 1967-02-07 | Ethicon Inc | Process of forming collagen articles and dispersions |
| DE1692548A1 (de) * | 1966-12-22 | 1971-08-05 | Charier Vadrot Pierre | Verfahren zur Herstellung von Speisegelatine aus Kollagenen animalischen Ursprungs |
| US3664844A (en) * | 1970-02-10 | 1972-05-23 | Devro Inc | Edible collagen film |
| US3742955A (en) * | 1970-09-29 | 1973-07-03 | Fmc Corp | Fibrous collagen derived product having hemostatic and wound binding properties |
| CH627078A5 (en) | 1975-06-05 | 1981-12-31 | Pentapharm Ag | Process for the preparation of a sterile collagen product with felt-like or web-like fibre structure |
| US4066083A (en) * | 1976-06-03 | 1978-01-03 | Pentapharm A.G. | Sterile surgical collagen product |
| JPS5832576B2 (ja) | 1976-10-28 | 1983-07-14 | 協和醗酵工業株式会社 | ゼラチンの改質法 |
-
1980
- 1980-09-17 WO PCT/CH1980/000107 patent/WO1981000963A1/de not_active Ceased
- 1980-09-17 JP JP55502079A patent/JPS6052130B2/ja not_active Expired
- 1980-09-17 US US06/269,023 patent/US4389487A/en not_active Expired - Fee Related
- 1980-09-17 DE DE3049932A patent/DE3049932C1/de not_active Expired
- 1980-09-17 GB GB8116255A patent/GB2072193B/en not_active Expired
- 1980-09-17 CH CH365181A patent/CH645271A5/de not_active IP Right Cessation
-
1981
- 1981-04-21 EP EP80901717A patent/EP0036415B1/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE3049932C1 (de) | 1984-11-29 |
| WO1981000963A1 (fr) | 1981-04-16 |
| US4389487A (en) | 1983-06-21 |
| EP0036415B1 (de) | 1984-07-04 |
| GB2072193B (en) | 1983-06-15 |
| DE3049932D2 (en) | 1982-04-01 |
| EP0036415A1 (fr) | 1981-09-30 |
| JPS56501282A (show.php) | 1981-09-10 |
| GB2072193A (en) | 1981-09-30 |
| CH645271A5 (de) | 1984-09-28 |
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