JPS6048934A - 錠剤用粉粒体組成物 - Google Patents
錠剤用粉粒体組成物Info
- Publication number
- JPS6048934A JPS6048934A JP15874183A JP15874183A JPS6048934A JP S6048934 A JPS6048934 A JP S6048934A JP 15874183 A JP15874183 A JP 15874183A JP 15874183 A JP15874183 A JP 15874183A JP S6048934 A JPS6048934 A JP S6048934A
- Authority
- JP
- Japan
- Prior art keywords
- disintegrant
- powder
- cellulose glycolate
- powdery composition
- tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 16
- 239000000843 powder Substances 0.000 claims abstract description 24
- 239000007884 disintegrant Substances 0.000 claims abstract description 15
- 239000001913 cellulose Substances 0.000 claims abstract description 14
- 229920002678 cellulose Polymers 0.000 claims abstract description 14
- 239000000654 additive Substances 0.000 claims abstract 3
- 230000000996 additive effect Effects 0.000 claims abstract 2
- 239000002253 acid Substances 0.000 claims description 13
- 230000005484 gravity Effects 0.000 claims description 13
- 239000004615 ingredient Substances 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 5
- 229910052791 calcium Inorganic materials 0.000 abstract description 4
- 239000011575 calcium Substances 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 3
- AEMRFAOFKBGASW-UHFFFAOYSA-M Glycolate Chemical compound OCC([O-])=O AEMRFAOFKBGASW-UHFFFAOYSA-M 0.000 abstract 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 3
- 239000003085 diluting agent Substances 0.000 abstract 2
- 238000013329 compounding Methods 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000000465 moulding Methods 0.000 description 4
- 238000006386 neutralization reaction Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 230000001079 digestive effect Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 235000008597 Diospyros kaki Nutrition 0.000 description 1
- 244000236655 Diospyros kaki Species 0.000 description 1
- 241000212342 Sium Species 0.000 description 1
- 206010049040 Weight fluctuation Diseases 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007907 direct compression Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000008202 granule composition Substances 0.000 description 1
- 238000007542 hardness measurement Methods 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15874183A JPS6048934A (ja) | 1983-08-29 | 1983-08-29 | 錠剤用粉粒体組成物 |
| US06/643,648 US4508893A (en) | 1983-08-25 | 1984-08-23 | Process for the preparation of a powdery calcium cellulose glycolate |
| DE3431227A DE3431227C2 (de) | 1983-08-25 | 1984-08-24 | Verfahren zur Herstellung von pulverförmigem Calciumcelluloseglycolat |
| KR1019840005131A KR900004699B1 (ko) | 1983-08-25 | 1984-08-24 | 분말상 섬유소 글리코올 칼슘의 제조법 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15874183A JPS6048934A (ja) | 1983-08-29 | 1983-08-29 | 錠剤用粉粒体組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6048934A true JPS6048934A (ja) | 1985-03-16 |
| JPH0465813B2 JPH0465813B2 (https=) | 1992-10-21 |
Family
ID=15678318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15874183A Granted JPS6048934A (ja) | 1983-08-25 | 1983-08-29 | 錠剤用粉粒体組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6048934A (https=) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53127553A (en) * | 1977-04-13 | 1978-11-07 | Asahi Chem Ind Co Ltd | Vehicle |
| JPS59176217A (ja) * | 1983-03-28 | 1984-10-05 | Daicel Chem Ind Ltd | 固形薬剤用粉粒体組成物 |
| JPH043413A (ja) * | 1990-04-20 | 1992-01-08 | Hitachi Ltd | アライメント装置 |
-
1983
- 1983-08-29 JP JP15874183A patent/JPS6048934A/ja active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53127553A (en) * | 1977-04-13 | 1978-11-07 | Asahi Chem Ind Co Ltd | Vehicle |
| JPS59176217A (ja) * | 1983-03-28 | 1984-10-05 | Daicel Chem Ind Ltd | 固形薬剤用粉粒体組成物 |
| JPH043413A (ja) * | 1990-04-20 | 1992-01-08 | Hitachi Ltd | アライメント装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0465813B2 (https=) | 1992-10-21 |
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