JPS60231668A - 縮合７員環化合物およびそれを含有してなる高血圧症予防・治療剤 - Google Patents

縮合７員環化合物およびそれを含有してなる高血圧症予防・治療剤

Info

Publication number
JPS60231668A
JPS60231668A JP60012053A JP1205385A JPS60231668A JP S60231668 A JPS60231668 A JP S60231668A JP 60012053 A JP60012053 A JP 60012053A JP 1205385 A JP1205385 A JP 1205385A JP S60231668 A JPS60231668 A JP S60231668A
Authority
JP
Japan
Prior art keywords
add
water
acetic acid
oxo
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60012053A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0566389B2 (https=
Inventor
Hirosada Sugihara
杉原　弘貞
Kohei Nishikawa
浩平 西川
Katsumi Ito
克己 伊藤
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of JPS60231668A publication Critical patent/JPS60231668A/ja
Publication of JPH0566389B2 publication Critical patent/JPH0566389B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP60012053A 1984-03-22 1985-01-24 縮合７員環化合物およびそれを含有してなる高血圧症予防・治療剤 Granted JPS60231668A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
WO84/119 1984-03-22
PCT/JP1984/000119 WO1985004402A1 (fr) 1984-03-24 1984-03-24 Composes cycliques fusionnes a sept membres et leur procede de preparation
WO84/172 1984-04-06
WO84/363 1984-07-13
US599187 1996-02-09

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP1118070A Division JPH0215060A (ja) 1984-03-22 1989-05-10 ４―ピペリジン誘導体

Publications (2)

Publication Number Publication Date
JPS60231668A true JPS60231668A (ja) 1985-11-18
JPH0566389B2 JPH0566389B2 (https=) 1993-09-21

Family

ID=13818277

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60012053A Granted JPS60231668A (ja) 1984-03-22 1985-01-24 縮合７員環化合物およびそれを含有してなる高血圧症予防・治療剤

Country Status (5)

Country Link
JP (1) JPS60231668A (https=)
HU (1) HUT38631A (https=)
PH (1) PH24015A (https=)
WO (1) WO1985004402A1 (https=)
ZA (1) ZA851293B (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2607004A1 (fr) * 1986-11-20 1988-05-27 Synthelabo Compositions pharmaceutiques contenant du diltiazem et un inhibiteur de l'enzyme de conversion de l'angiotensine
JPH01199962A (ja) * 1987-05-25 1989-08-11 Yoshitomi Pharmaceut Ind Ltd ピペリジン化合物
JPH08507363A (ja) * 1993-07-02 1996-08-06 アプリカツィオーンス− ウント テヒニーク ツェントルム フュア エネルギーフェアファーレンス−、ウムヴェルト ウント シュトリュームングステヒニーク バーナー
WO1998035941A1 (en) * 1997-02-18 1998-08-20 Shionogi & Co., Ltd. New benzolactam derivatives and medicinal compositions containing the same
WO1998041510A1 (en) * 1997-03-14 1998-09-24 Shionogi & Co., Ltd. Novel benzolactam derivatives and medicinal compositions comprising the same

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2751981B1 (fr) * 1996-08-02 1998-09-11 Rhone Poulenc Chimie Fluide comprenant des microfibrilles de cellulose et son application pour l'exploitation de gisementss petroliers

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59167577A (ja) * 1983-02-28 1984-09-21 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド チアジンおよびチアゼピン環含有化合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58116477A (ja) * 1981-06-05 1983-07-11 メルク・エンド・カムパニ−・インコ−ポレ−テツド 抗高血圧剤としてのパ−ヒドロ−１，４−チアゼピン−５−オンおよびパ−ヒドロ−１，４−チアゾシン−５−オン誘導体

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59167577A (ja) * 1983-02-28 1984-09-21 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド チアジンおよびチアゼピン環含有化合物

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2607004A1 (fr) * 1986-11-20 1988-05-27 Synthelabo Compositions pharmaceutiques contenant du diltiazem et un inhibiteur de l'enzyme de conversion de l'angiotensine
JPH01199962A (ja) * 1987-05-25 1989-08-11 Yoshitomi Pharmaceut Ind Ltd ピペリジン化合物
JPH08507363A (ja) * 1993-07-02 1996-08-06 アプリカツィオーンス− ウント テヒニーク ツェントルム フュア エネルギーフェアファーレンス−、ウムヴェルト ウント シュトリュームングステヒニーク バーナー
WO1998035941A1 (en) * 1997-02-18 1998-08-20 Shionogi & Co., Ltd. New benzolactam derivatives and medicinal compositions containing the same
WO1998041510A1 (en) * 1997-03-14 1998-09-24 Shionogi & Co., Ltd. Novel benzolactam derivatives and medicinal compositions comprising the same

Also Published As

Publication number Publication date
JPH0566389B2 (https=) 1993-09-21
PH24015A (en) 1990-02-09
HUT38631A (en) 1986-06-30
ZA851293B (en) 1986-10-29
WO1985004402A1 (fr) 1985-10-10

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