JPS60174792A - メチレンジホスホン酸誘導体、その製造方法および抗リウマチ用薬剤組成物 - Google Patents

メチレンジホスホン酸誘導体、その製造方法および抗リウマチ用薬剤組成物

Info

Publication number
JPS60174792A
JPS60174792A JP60012348A JP1234885A JPS60174792A JP S60174792 A JPS60174792 A JP S60174792A JP 60012348 A JP60012348 A JP 60012348A JP 1234885 A JP1234885 A JP 1234885A JP S60174792 A JPS60174792 A JP S60174792A
Authority
JP
Japan
Prior art keywords
group
alk
alkyl group
formula
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60012348A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0455436B2 (enExample
Inventor
アラン・バルビエ
ジヤン‐クロード・ブレリエール
ジヨルジユ・ガルシア
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of JPS60174792A publication Critical patent/JPS60174792A/ja
Priority to US06/824,426 priority Critical patent/US4677693A/en
Publication of JPH0455436B2 publication Critical patent/JPH0455436B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Dental Preparations (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Steroid Compounds (AREA)
  • External Artificial Organs (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Fireproofing Substances (AREA)
JP60012348A 1984-01-26 1985-01-25 メチレンジホスホン酸誘導体、その製造方法および抗リウマチ用薬剤組成物 Granted JPS60174792A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US06/824,426 US4677693A (en) 1985-01-25 1986-01-31 Frequency conversion circuit

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8401214A FR2558837B1 (fr) 1984-01-26 1984-01-26 Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
FR8401214 1984-01-26

Publications (2)

Publication Number Publication Date
JPS60174792A true JPS60174792A (ja) 1985-09-09
JPH0455436B2 JPH0455436B2 (enExample) 1992-09-03

Family

ID=9300506

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60012348A Granted JPS60174792A (ja) 1984-01-26 1985-01-25 メチレンジホスホン酸誘導体、その製造方法および抗リウマチ用薬剤組成物

Country Status (30)

Country Link
US (1) US4876247A (enExample)
EP (1) EP0151072B1 (enExample)
JP (1) JPS60174792A (enExample)
KR (1) KR850005449A (enExample)
AT (1) ATE32900T1 (enExample)
AU (1) AU570764B2 (enExample)
CA (1) CA1263397A (enExample)
CS (2) CS247192B2 (enExample)
DD (1) DD233847A5 (enExample)
DE (1) DE3561819D1 (enExample)
DK (1) DK168573B1 (enExample)
EG (1) EG16903A (enExample)
ES (1) ES8602028A1 (enExample)
FI (1) FI77664C (enExample)
FR (1) FR2558837B1 (enExample)
GR (1) GR850160B (enExample)
HU (1) HU192664B (enExample)
IE (1) IE57971B1 (enExample)
IL (1) IL74117A (enExample)
MA (1) MA20331A1 (enExample)
NO (1) NO161678C (enExample)
NZ (1) NZ210945A (enExample)
OA (1) OA07941A (enExample)
PH (1) PH20913A (enExample)
PL (3) PL144353B1 (enExample)
PT (1) PT79859B (enExample)
SG (1) SG43289G (enExample)
SU (3) SU1382402A3 (enExample)
YU (2) YU11785A (enExample)
ZA (1) ZA85390B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902679A (en) * 1985-12-13 1990-02-20 Norwich Eaton Pharmaceuticals, Inc. Methods of treating diseases with certain geminal diphosphonates
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
IE912115A1 (en) * 1990-06-25 1992-01-01 Takeda Chemical Industries Ltd Bisphosphonic acid derivatives, their production and use
EP0491374B1 (en) * 1990-12-19 1996-01-31 Takeda Chemical Industries, Ltd. Bisphosphonic acid derivatives, their production and use
ATE165603T1 (de) * 1991-09-05 1998-05-15 Toray Industries Methandiphosphonsäurederivat, herstellung davon und verwendung davon als arzneimittel
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
US5391743A (en) * 1992-05-29 1995-02-21 Procter & Gamble Pharmaceuticals, Inc. Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
ES2118967T3 (es) * 1992-05-29 1998-10-01 Procter & Gamble Pharma Compuestos de fosfonato que contienen nitrogeno cuaternario para tratar un metabolismo anormal del calcio y fosfato asi como el calculo y la placa dentales.
EP0642521A1 (en) * 1992-05-29 1995-03-15 Procter & Gamble Pharmaceuticals Thio-substituted nitrogen-containing heterocyclic phosphonate compounds for treating abnormal calcium and phosphate metabolism
US5763611A (en) * 1992-05-29 1998-06-09 The Procter & Gamble Company Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
US5753634A (en) * 1992-05-29 1998-05-19 The Procter & Gamble Company Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
HUT69699A (en) * 1992-05-29 1995-09-28 Procter & Gamble Pharma Sulfur-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism
NZ253631A (en) * 1992-06-30 1997-02-24 Procter & Gamble Pharma Phosphonate or nsaid pharmaceutical compositions for treating arthritis
EP0603401B1 (en) * 1992-07-10 2001-04-11 Toray Industries, Inc. Methanediphosphonate derivative, production thereof, and pharmaceutical use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1958123C3 (de) * 1969-11-19 1978-09-28 Henkel Kgaa, 4000 Duesseldorf Verfahren zur Herstellung von 1 -Aminoalkan-1,1 -diphosphonsäuren oder deren Salzen
DE2115737C3 (de) * 1971-03-31 1979-11-08 Henkel Kgaa, 4000 Duesseldorf Verfahren zur Herstellung von 1 - Aminoalkan-1,1 -diphosphonsäuren
DE2405254C2 (de) * 1974-02-04 1982-05-27 Henkel KGaA, 4000 Düsseldorf Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper
US4100167A (en) * 1977-05-09 1978-07-11 Nalco Chemical Company Production of 1-aminoalkane-1, 1-diphosphonic acids using phosphorous acid and nitriles in a non-aqueous system
DE2754821C3 (de) * 1977-12-09 1981-08-13 Benckiser-Knapsack Gmbh, 6802 Ladenburg Verfahren zur Herstellung von 1-Aminoalkan-1,1-diphosphonsäuren
GB2043072B (en) * 1979-02-13 1983-11-23 Symphar Sa Diphosphonate compounds
DE3225469A1 (de) * 1982-07-05 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation

Also Published As

Publication number Publication date
DE3561819D1 (en) 1988-04-14
PL148892B1 (en) 1989-12-30
FR2558837A1 (fr) 1985-08-02
ZA85390B (en) 1985-08-28
PT79859A (fr) 1985-02-01
DK168573B1 (da) 1994-04-25
EP0151072B1 (fr) 1988-03-09
EG16903A (en) 1989-06-30
PT79859B (fr) 1986-10-23
FI77664B (fi) 1988-12-30
YU113787A (en) 1988-04-30
FI850319L (fi) 1985-07-27
IE57971B1 (en) 1993-06-02
NZ210945A (en) 1987-06-30
ES539833A0 (es) 1985-11-16
SG43289G (en) 1989-12-22
PL144353B1 (en) 1988-05-31
IL74117A (en) 1989-02-28
EP0151072A2 (fr) 1985-08-07
YU11785A (en) 1987-12-31
SU1382402A3 (ru) 1988-03-15
US4876247A (en) 1989-10-24
DK29285D0 (da) 1985-01-22
SU1419520A3 (ru) 1988-08-23
PL142493B1 (en) 1987-10-31
HU192664B (en) 1987-06-29
NO161678C (no) 1989-09-13
JPH0455436B2 (enExample) 1992-09-03
CS247199B2 (en) 1986-12-18
CS247192B2 (en) 1986-12-18
MA20331A1 (fr) 1985-10-01
ES8602028A1 (es) 1985-11-16
NO161678B (no) 1989-06-05
FI850319A0 (fi) 1985-01-24
EP0151072A3 (en) 1985-08-21
PL251700A1 (en) 1985-09-10
DK29285A (da) 1985-07-27
AU570764B2 (en) 1988-03-24
AU3794085A (en) 1985-08-01
CA1263397A (en) 1989-11-28
OA07941A (fr) 1987-01-31
GR850160B (enExample) 1985-05-23
FR2558837B1 (fr) 1986-06-27
ATE32900T1 (de) 1988-03-15
IE850140L (en) 1985-07-26
NO850315L (no) 1985-07-29
KR850005449A (ko) 1985-08-26
HUT38362A (en) 1986-05-28
PH20913A (en) 1987-05-28
SU1410865A3 (ru) 1988-07-15
DD233847A5 (de) 1986-03-12
IL74117A0 (en) 1985-04-30
FI77664C (fi) 1989-04-10

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