JPS60112766A - ４−ピリジルチオ酢酸の製造法 - Google Patents
４−ピリジルチオ酢酸の製造法Info
- Publication number
- JPS60112766A JPS60112766A JP21843283A JP21843283A JPS60112766A JP S60112766 A JPS60112766 A JP S60112766A JP 21843283 A JP21843283 A JP 21843283A JP 21843283 A JP21843283 A JP 21843283A JP S60112766 A JPS60112766 A JP S60112766A
- Authority
- JP
- Japan
- Prior art keywords
- alcohol
- acid
- solvent
- compound
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PGUPJAPHYIEKLT-UHFFFAOYSA-N 2-pyridin-4-ylsulfanylacetic acid Chemical compound OC(=O)CSC1=CC=NC=C1 PGUPJAPHYIEKLT-UHFFFAOYSA-N 0.000 title claims description 11
- 238000004519 manufacturing process Methods 0.000 title description 4
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 claims abstract description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 150000001875 compounds Chemical class 0.000 claims abstract description 16
- 239000002904 solvent Substances 0.000 claims abstract description 16
- 239000002253 acid Substances 0.000 claims abstract description 8
- 150000003839 salts Chemical class 0.000 claims abstract description 8
- -1 1-(4- pyridyl)pyridinium halide Chemical class 0.000 claims abstract description 4
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 7
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
- 239000000460 chlorine Substances 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 239000012320 chlorinating reagent Substances 0.000 claims description 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 238000003763 carbonization Methods 0.000 claims 1
- 238000004821 distillation Methods 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract description 12
- 239000002994 raw material Substances 0.000 abstract description 6
- 238000010992 reflux Methods 0.000 abstract description 5
- 229930186147 Cephalosporin Natural products 0.000 abstract description 2
- 125000003158 alcohol group Chemical group 0.000 abstract description 2
- 230000001476 alcoholic effect Effects 0.000 abstract description 2
- 229910052794 bromium Inorganic materials 0.000 abstract description 2
- 229940124587 cephalosporin Drugs 0.000 abstract description 2
- 150000001780 cephalosporins Chemical class 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 2
- DFOUTGGPUPHEMO-UHFFFAOYSA-N 2-pyridin-1-ium-4-ylpyridine;chloride Chemical compound Cl.N1=CC=CC=C1C1=CC=NC=C1 DFOUTGGPUPHEMO-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pyridine Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21843283A JPS60112766A (ja) | 1983-11-18 | 1983-11-18 | ４−ピリジルチオ酢酸の製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21843283A JPS60112766A (ja) | 1983-11-18 | 1983-11-18 | ４−ピリジルチオ酢酸の製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60112766A true JPS60112766A (ja) | 1985-06-19 |
| JPS6210507B2 JPS6210507B2 (enExample) | 1987-03-06 |
Family
ID=16719813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP21843283A Granted JPS60112766A (ja) | 1983-11-18 | 1983-11-18 | ４−ピリジルチオ酢酸の製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60112766A (enExample) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5466684A (en) * | 1977-11-01 | 1979-05-29 | Nippon Soda Co Ltd | Preparation of 4- piperidinopyridine |
| JPS551253A (en) * | 1978-06-20 | 1980-01-08 | Katsuji Takayama | Rack for elevated rail |
-
1983
- 1983-11-18 JP JP21843283A patent/JPS60112766A/ja active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5466684A (en) * | 1977-11-01 | 1979-05-29 | Nippon Soda Co Ltd | Preparation of 4- piperidinopyridine |
| JPS551253A (en) * | 1978-06-20 | 1980-01-08 | Katsuji Takayama | Rack for elevated rail |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6210507B2 (enExample) | 1987-03-06 |
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