JPS5998084A - イソキノリン化合物 - Google Patents

イソキノリン化合物

Info

Publication number
JPS5998084A
JPS5998084A JP58207303A JP20730383A JPS5998084A JP S5998084 A JPS5998084 A JP S5998084A JP 58207303 A JP58207303 A JP 58207303A JP 20730383 A JP20730383 A JP 20730383A JP S5998084 A JPS5998084 A JP S5998084A
Authority
JP
Japan
Prior art keywords
compound
microcrystalline
solvent
particle size
type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58207303A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6225668B2 (el
Inventor
スタンレ−・フレデリツク・ダイク
ゴ−ドン・ハンレ−・フイリツプス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of JPS5998084A publication Critical patent/JPS5998084A/ja
Publication of JPS6225668B2 publication Critical patent/JPS6225668B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP58207303A 1982-11-04 1983-11-04 イソキノリン化合物 Granted JPS5998084A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8231540 1982-11-04
GB8231540 1982-11-04

Publications (2)

Publication Number Publication Date
JPS5998084A true JPS5998084A (ja) 1984-06-06
JPS6225668B2 JPS6225668B2 (el) 1987-06-04

Family

ID=10534035

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58207303A Granted JPS5998084A (ja) 1982-11-04 1983-11-04 イソキノリン化合物

Country Status (20)

Country Link
US (1) US4831039A (el)
EP (1) EP0108620B1 (el)
JP (1) JPS5998084A (el)
KR (1) KR900008697B1 (el)
AT (1) ATE25256T1 (el)
AU (1) AU566898B2 (el)
CA (1) CA1272198A (el)
DE (1) DE3369515D1 (el)
DK (1) DK158666C (el)
ES (1) ES526995A0 (el)
FI (1) FI74003C (el)
GB (1) GB2129799B (el)
GR (1) GR78749B (el)
IE (1) IE56206B1 (el)
IL (1) IL70124A (el)
NO (1) NO159933C (el)
NZ (1) NZ206141A (el)
PH (1) PH19013A (el)
PT (1) PT77601B (el)
ZA (1) ZA838237B (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK158666C (da) * 1982-11-04 1990-11-19 Glaxo Group Ltd Analogifremgangsmaade til fremstilling af 5,14-dihydrobenz-oe5,6aa-isoindolooe2,1-baa-isoquinolin-8,13-dion
CA1268178A (en) * 1984-05-03 1990-04-24 Gordon H. Phillipps Isoquinoline derivatives
GB8513460D0 (en) * 1985-05-29 1985-07-03 Glaxo Group Ltd Chemical compounds
NO872963L (no) * 1986-07-29 1988-02-01 Glaxo Group Ltd Isokinolinderivater.
DK616087A (da) * 1986-11-27 1988-05-28 Glaxo Group Ltd Isoquinolinderivater og farmaceutiske praeparater indeholdende dem
GB8800312D0 (en) * 1988-01-07 1988-02-10 Glaxo Group Ltd Process

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1459137A (en) * 1973-05-30 1976-12-22 Sandoz Ltd Naphthoquinone derivatives
FR2387229A1 (fr) * 1977-04-13 1978-11-10 Anvar Dipyrido (4,3-b) (3,4-f) indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant
FR2436786A1 (fr) * 1978-09-21 1980-04-18 Anvar Nouveaux derives des pyrido (4,3-b) carbazoles (ellipticines), substitues en position 1 par une chaine polyaminee, leur obtention et leur application a titre de medicaments
DK158666C (da) * 1982-11-04 1990-11-19 Glaxo Group Ltd Analogifremgangsmaade til fremstilling af 5,14-dihydrobenz-oe5,6aa-isoindolooe2,1-baa-isoquinolin-8,13-dion
CA1268178A (en) * 1984-05-03 1990-04-24 Gordon H. Phillipps Isoquinoline derivatives

Also Published As

Publication number Publication date
EP0108620B1 (en) 1987-01-28
PT77601B (en) 1986-03-18
NZ206141A (en) 1986-09-10
IE56206B1 (en) 1991-05-22
AU2096683A (en) 1984-05-10
DK499583D0 (da) 1983-11-01
FI834045A0 (fi) 1983-11-03
IL70124A0 (en) 1984-02-29
NO159933C (no) 1989-02-22
NO159933B (no) 1988-11-14
GB8329342D0 (en) 1983-12-07
DK499583A (da) 1984-05-05
ES8504796A1 (es) 1985-04-16
FI74003B (fi) 1987-08-31
KR900008697B1 (ko) 1990-11-27
PT77601A (en) 1983-12-01
FI834045A (fi) 1984-05-05
IL70124A (en) 1986-11-30
ES526995A0 (es) 1985-04-16
GR78749B (el) 1984-10-02
DK158666C (da) 1990-11-19
PH19013A (en) 1985-12-03
US4831039A (en) 1989-05-16
IE832575L (en) 1984-05-04
DK158666B (da) 1990-07-02
EP0108620A1 (en) 1984-05-16
AU566898B2 (en) 1987-11-05
ATE25256T1 (de) 1987-02-15
JPS6225668B2 (el) 1987-06-04
GB2129799A (en) 1984-05-23
CA1272198A (en) 1990-07-31
NO834019L (no) 1984-05-07
ZA838237B (en) 1984-11-28
GB2129799B (en) 1986-02-26
DE3369515D1 (de) 1987-03-05
KR840006657A (ko) 1984-12-01
FI74003C (fi) 1987-12-10

Similar Documents

Publication Publication Date Title
JPS5920230A (ja) ピルプロフエン含有薬剤
EP0141300A2 (en) An occulusion compound of 2-nitroxymethyl-6-chloropyridine with beta-cyclodextrin and process for preparation thereof
DE3720493A1 (de) Arzneizubereitungen mit mikronisierten ebselen-kristallen
CN111135299A (zh) 光敏剂-低氧激活前药一体化前药自组装纳米粒的构建
JPH0662407B2 (ja) 安定化された３―オキシゲルミルプロピオン酸ポリマーを有効成分とする免疫調整剤
US5036103A (en) Method of treating cancer cells in humans
JPS5998084A (ja) イソキノリン化合物
TWI786579B (zh) 包含藥物二聚體的奈米粒子及其用途
CN108836937B (zh) 顺铂纳米药物制剂、制备方法和应用
CN115124420B (zh) 大黄酸与苦参碱共晶物水合物及制备方法和其组合物与用途
JPS63239292A (ja) 白金細胞毒性剤及びその製造方法
JPH0616556A (ja) 難溶性薬物含有製剤
DE2513693A1 (de) Theophyllinderivate, verfahren zu deren herstellung und arzneimittel
US3130126A (en) Oral pharmaceutical products prepared with carboxymethyl benzyl dextran having a low carboxymethyl d. s. of 0.15
CN113929898B (zh) 一种金属基纳米聚合物及其制备方法与应用
JP7386972B2 (ja) 実質的に増加した抗腫瘍効果を有する新規白金ｉｖ錯体
CN111643679B (zh) 一种壳寡糖修饰的白桦脂酸药物运输体系的制备方法及其应用
CN115212314A (zh) 一种白蛋白结合型抗肿瘤药及其纳米复合物、制备方法和应用
KR100344099B1 (ko) 신규한비페닐디카르복실산유도체와이의제조방법
DE2759916C2 (de) Bekämpfung maligner Neoplasien
RU2054286C1 (ru) Платиновый цитостатик и способ его получения
JPH01149723A (ja) 骨芽細胞活性化剤
DE10218312C1 (de) Tumorhemmende Siliziumverbindungen, diese enthaltende Arzneimittel und deren Verwendung
IE44187B1 (en) Pharmaceutical compositions containing eburnane derivatives
JPH04112833A (ja) 抗腫瘍剤