JPS5993054A - イソキノリンスルホン酸アミド誘導体 - Google Patents

イソキノリンスルホン酸アミド誘導体

Info

Publication number
JPS5993054A
JPS5993054A JP57201085A JP20108582A JPS5993054A JP S5993054 A JPS5993054 A JP S5993054A JP 57201085 A JP57201085 A JP 57201085A JP 20108582 A JP20108582 A JP 20108582A JP S5993054 A JPS5993054 A JP S5993054A
Authority
JP
Japan
Prior art keywords
group
acid amide
compound according
formula
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57201085A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0428698B2 (OSRAM
Inventor
Hiroyoshi Hidaka
弘義 日高
Takanori Sone
孝範 曽根
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Priority to JP57201085A priority Critical patent/JPS5993054A/ja
Priority to US06/548,722 priority patent/US4634770A/en
Priority to AT83111095T priority patent/ATE26112T1/de
Priority to DE8383111095T priority patent/DE3370478D1/de
Priority to EP83111095A priority patent/EP0109023B1/en
Publication of JPS5993054A publication Critical patent/JPS5993054A/ja
Priority to US06/919,774 priority patent/US4709032A/en
Publication of JPH0428698B2 publication Critical patent/JPH0428698B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
JP57201085A 1982-11-18 1982-11-18 イソキノリンスルホン酸アミド誘導体 Granted JPS5993054A (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP57201085A JPS5993054A (ja) 1982-11-18 1982-11-18 イソキノリンスルホン酸アミド誘導体
US06/548,722 US4634770A (en) 1982-11-18 1983-11-04 Isoquinolinesulfonamide derivatives
AT83111095T ATE26112T1 (de) 1982-11-18 1983-11-07 Isochinolin-sulfonamidderivate und verfahren fuer ihre herstellung.
DE8383111095T DE3370478D1 (en) 1982-11-18 1983-11-07 Isoquinolinesulfonamide derivatives and process for the preparation thereof
EP83111095A EP0109023B1 (en) 1982-11-18 1983-11-07 Isoquinolinesulfonamide derivatives and process for the preparation thereof
US06/919,774 US4709032A (en) 1982-11-18 1986-10-17 Isoquinolinesulfonamide derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57201085A JPS5993054A (ja) 1982-11-18 1982-11-18 イソキノリンスルホン酸アミド誘導体

Publications (2)

Publication Number Publication Date
JPS5993054A true JPS5993054A (ja) 1984-05-29
JPH0428698B2 JPH0428698B2 (OSRAM) 1992-05-15

Family

ID=16435138

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57201085A Granted JPS5993054A (ja) 1982-11-18 1982-11-18 イソキノリンスルホン酸アミド誘導体

Country Status (5)

Country Link
US (2) US4634770A (OSRAM)
EP (1) EP0109023B1 (OSRAM)
JP (1) JPS5993054A (OSRAM)
AT (1) ATE26112T1 (OSRAM)
DE (1) DE3370478D1 (OSRAM)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678783A (en) * 1983-11-04 1987-07-07 Asahi Kasei Kogyo Kabushiki Kaisha Substituted isoquinolinesulfonyl compounds
JPH0656668A (ja) * 1992-08-10 1994-03-01 Asahi Chem Ind Co Ltd 心臓保護剤
WO1998006433A1 (en) 1996-08-12 1998-02-19 Yoshitomi Pharmaceutical Industries, Ltd. MEDICINES COMPRISING Rho KINASE INHIBITOR

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61227581A (ja) * 1985-04-02 1986-10-09 Asahi Chem Ind Co Ltd 血管拡張剤
DE3438694A1 (de) * 1984-10-23 1986-04-24 Basf Ag, 6700 Ludwigshafen Neue amidoalkylmelamine und aminoalkylmelamine und verfahren zu ihrer herstellung
DE3583287D1 (de) * 1984-12-27 1991-07-25 Asahi Chemical Ind Substituierte isochinolinsulfonyl-verbindungen.
JPH0667926B2 (ja) * 1985-11-12 1994-08-31 旭化成工業株式会社 環状のイソキノリンスルホンアミド誘導体
US4857301A (en) * 1987-09-25 1989-08-15 Schering Corporation Sulfonamide compounds, compositions and method of use
JPH0215067A (ja) * 1988-07-04 1990-01-18 Hokuriku Seiyaku Co Ltd イソキノリンスルホンアミド誘導体
CA2005741C (en) * 1988-12-26 1998-06-02 Hiroyoshi Hidaka Quinoline sulfonoamino compounds having vessel smooth muscle relaxation activity
DE3942114C2 (de) * 1988-12-26 1997-09-04 Hiroyoshi Hidaka Verbindungen mit einer Wirkung für eine gleichmäßige Gefäßmuskelentspannung und pharmazeutische Zusammensetzung, die diese enthält
US5245034A (en) * 1988-12-26 1993-09-14 Kiroyoshi Hidaka Compound having vessel smooth muscle relaxation activity
US5340811A (en) * 1990-03-08 1994-08-23 Asahi Kasei Kogyo Kabushiki Kaisha Isoquinoline-or quinoline-sulfonamide derivative and a pharmaceutical composition comprising the same
WO1992014712A1 (en) * 1991-02-13 1992-09-03 Asahi Kasei Kogyo Kabushiki Kaisha Substituted sulfonamide derivative or pharmaceutical composition containing the same
SI0656348T1 (en) * 1993-12-03 2000-08-31 F. Hoffmann-La Roche Ag Aceric acid derivatives as medicaments
ES2205166T3 (es) * 1996-02-02 2004-05-01 D. Western Therapeutics Institute Derivados de isoquinolina y medicamento.
DE19934272A1 (de) * 1999-07-21 2001-01-25 Bayer Ag Neue antivirale Mittel
EP1479386A1 (en) * 2003-04-30 2004-11-24 Switch Biotech Aktiengesellschaft Use of isoquinoline-derivatives for treating and preventing pigmentary disorders
JP4257383B2 (ja) * 2005-04-25 2009-04-22 株式会社デ・ウエスタン・セラピテクス研究所 高選択的Ｒｈｏキナーゼ阻害剤
WO2007120955A2 (en) * 2006-01-27 2007-10-25 Translational Genomics Research Institute Genes affecting human memory performance
WO2008019395A2 (en) * 2006-08-10 2008-02-14 Translational Genomics Research Institute Compounds for improving learning and memory
JP5235887B2 (ja) 2006-09-20 2013-07-10 アエリー ファーマシューティカルズ インコーポレイテッド Ｒｈｏキナーゼ阻害剤
US20090036465A1 (en) * 2006-10-18 2009-02-05 United Therapeutics Corporation Combination therapy for pulmonary arterial hypertension
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8455514B2 (en) * 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
US8394826B2 (en) 2009-05-01 2013-03-12 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
HUE028684T2 (en) 2009-06-19 2016-12-28 D Western Therapeutics Inst Inc Substituted isoquinoline derivatives
US8258341B2 (en) * 2009-07-10 2012-09-04 E.I. Du Pont De Nemours And Company Polyfluorosulfonamido amine and intermediate
EP4335507A3 (en) 2013-03-15 2024-06-05 Aerie Pharmaceuticals, Inc. Combination therapy
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
JP6832946B2 (ja) 2015-11-17 2021-02-24 アエリエ ファーマシューティカルズ インコーポレイテッド キナーゼ阻害剤およびその中間体の調製方法
BR112019003945A2 (pt) 2016-08-31 2019-05-21 Aerie Pharmaceuticals, Inc. composições oftálmicas
MX2019011784A (es) 2017-03-31 2019-11-18 Aerie Pharmaceuticals Inc Compuestos de aril ciclopropil-amino-isoquinolinil amida.
CA3112391A1 (en) 2018-09-14 2020-03-19 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097472A (en) * 1974-11-08 1978-06-27 Mitsubishi Chemical Industries Limited N2 -arylsulfonyl-l-argininamides and the pharmaceutically acceptable salts thereof
US4097591A (en) * 1974-11-08 1978-06-27 Mitsubishi Chemical Industries Limited N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
IE48623B1 (en) * 1978-08-31 1985-03-20 Mitsubishi Chem Ind Alpha-(n-arylsulfonyl-l-argininamides,processes for their preparation and pharmaceutical compositions containing these substances
US4369320A (en) * 1980-11-03 1983-01-18 E. I. Du Pont De Nemours And Company N-[Heterocyclicaminocarbonyl]-8-quinolinesulfonamides
US4456757A (en) * 1981-03-20 1984-06-26 Asahi Kasei Kogyo Kabushiki Kaisha Isoquinolinesulfonyl derivatives and process for the preparation thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678783A (en) * 1983-11-04 1987-07-07 Asahi Kasei Kogyo Kabushiki Kaisha Substituted isoquinolinesulfonyl compounds
JPH0656668A (ja) * 1992-08-10 1994-03-01 Asahi Chem Ind Co Ltd 心臓保護剤
WO1998006433A1 (en) 1996-08-12 1998-02-19 Yoshitomi Pharmaceutical Industries, Ltd. MEDICINES COMPRISING Rho KINASE INHIBITOR

Also Published As

Publication number Publication date
EP0109023A1 (en) 1984-05-23
ATE26112T1 (de) 1987-04-15
DE3370478D1 (en) 1987-04-30
EP0109023B1 (en) 1987-03-25
US4709032A (en) 1987-11-24
US4634770A (en) 1987-01-06
JPH0428698B2 (OSRAM) 1992-05-15

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