JPS59219270A - テトラゾリウム塩を含有する溶液の安定化方法 - Google Patents
テトラゾリウム塩を含有する溶液の安定化方法Info
- Publication number
- JPS59219270A JPS59219270A JP58095185A JP9518583A JPS59219270A JP S59219270 A JPS59219270 A JP S59219270A JP 58095185 A JP58095185 A JP 58095185A JP 9518583 A JP9518583 A JP 9518583A JP S59219270 A JPS59219270 A JP S59219270A
- Authority
- JP
- Japan
- Prior art keywords
- cyclodextrin
- oxidase
- salt
- monotetrazolium
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000858 Cyclodextrin Polymers 0.000 title claims abstract description 79
- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 64
- 125000003831 tetrazolyl group Chemical group 0.000 title claims abstract description 47
- 238000000034 method Methods 0.000 title claims description 49
- 230000006641 stabilisation Effects 0.000 title claims description 28
- 238000011105 stabilization Methods 0.000 title claims description 28
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title description 7
- -1 thiol compound Chemical class 0.000 claims abstract description 41
- 150000003839 salts Chemical class 0.000 claims abstract description 40
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims abstract description 36
- 229960004853 betadex Drugs 0.000 claims abstract description 36
- 239000001116 FEMA 4028 Substances 0.000 claims abstract description 35
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims abstract description 35
- 230000000087 stabilizing effect Effects 0.000 claims abstract description 34
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims abstract description 33
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims abstract description 33
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 48
- 239000000243 solution Substances 0.000 claims description 38
- 235000012000 cholesterol Nutrition 0.000 claims description 24
- 239000000758 substrate Substances 0.000 claims description 22
- 108090000854 Oxidoreductases Proteins 0.000 claims description 15
- 102000004316 Oxidoreductases Human genes 0.000 claims description 15
- 239000004480 active ingredient Substances 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 102000004190 Enzymes Human genes 0.000 claims description 8
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 229940088598 enzyme Drugs 0.000 claims description 8
- 230000001590 oxidative effect Effects 0.000 claims description 8
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 claims description 8
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- 125000002252 acyl group Chemical group 0.000 claims description 5
- 239000012266 salt solution Substances 0.000 claims description 5
- 238000012360 testing method Methods 0.000 claims description 5
- 108010000659 Choline oxidase Proteins 0.000 claims description 4
- 108010015776 Glucose oxidase Proteins 0.000 claims description 4
- 239000004366 Glucose oxidase Substances 0.000 claims description 4
- 108010073450 Lactate 2-monooxygenase Proteins 0.000 claims description 4
- 108010042687 Pyruvate Oxidase Proteins 0.000 claims description 4
- 108010092464 Urate Oxidase Proteins 0.000 claims description 4
- 108010093894 Xanthine oxidase Proteins 0.000 claims description 4
- 102100033220 Xanthine oxidase Human genes 0.000 claims description 4
- 210000001124 body fluid Anatomy 0.000 claims description 4
- 239000010839 body fluid Substances 0.000 claims description 4
- UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 claims description 4
- 229940116332 glucose oxidase Drugs 0.000 claims description 4
- 235000019420 glucose oxidase Nutrition 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 229960003151 mercaptamine Drugs 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- ACTRVOBWPAIOHC-UHFFFAOYSA-N succimer Chemical compound OC(=O)C(S)C(S)C(O)=O ACTRVOBWPAIOHC-UHFFFAOYSA-N 0.000 claims description 4
- NBOMNTLFRHMDEZ-UHFFFAOYSA-N thiosalicylic acid Chemical compound OC(=O)C1=CC=CC=C1S NBOMNTLFRHMDEZ-UHFFFAOYSA-N 0.000 claims description 4
- 229940103494 thiosalicylic acid Drugs 0.000 claims description 4
- 108010089254 Cholesterol oxidase Proteins 0.000 claims description 3
- 108010024636 Glutathione Proteins 0.000 claims description 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 3
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims description 3
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims description 3
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims description 3
- 229960001231 choline Drugs 0.000 claims description 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 3
- 235000018417 cysteine Nutrition 0.000 claims description 3
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 claims description 3
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 3
- 108010090622 glycerol oxidase Proteins 0.000 claims description 3
- 229960000448 lactic acid Drugs 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- 239000004310 lactic acid Substances 0.000 claims description 3
- 229940116269 uric acid Drugs 0.000 claims description 3
- 229940075420 xanthine Drugs 0.000 claims description 3
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- XYZZKVRWGOWVGO-UHFFFAOYSA-N Glycerol-phosphate Chemical compound OP(O)(O)=O.OCC(O)CO XYZZKVRWGOWVGO-UHFFFAOYSA-N 0.000 claims description 2
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims description 2
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 229940076788 pyruvate Drugs 0.000 claims description 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 claims 2
- 229960002433 cysteine Drugs 0.000 claims 2
- 150000002500 ions Chemical class 0.000 claims 1
- 229940107700 pyruvic acid Drugs 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 abstract description 26
- 229920000159 gelatin Polymers 0.000 abstract description 26
- 235000019322 gelatine Nutrition 0.000 abstract description 26
- 235000011852 gelatine desserts Nutrition 0.000 abstract description 26
- 239000008273 gelatin Substances 0.000 abstract description 25
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 abstract description 14
- 239000011521 glass Substances 0.000 abstract description 11
- 150000001875 compounds Chemical class 0.000 abstract description 5
- 238000004043 dyeing Methods 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 3
- 238000004737 colorimetric analysis Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 238000004040 coloring Methods 0.000 description 24
- 210000002966 serum Anatomy 0.000 description 22
- 238000005259 measurement Methods 0.000 description 18
- 238000010186 staining Methods 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 8
- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical class N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 6
- 238000006722 reduction reaction Methods 0.000 description 6
- 239000012086 standard solution Substances 0.000 description 6
- 238000002835 absorbance Methods 0.000 description 5
- 239000012085 test solution Substances 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000006911 enzymatic reaction Methods 0.000 description 4
- 239000004744 fabric Substances 0.000 description 4
- 238000011161 development Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- 102000004539 Acyl-CoA Oxidase Human genes 0.000 description 1
- 108020001558 Acyl-CoA oxidase Proteins 0.000 description 1
- 241000006479 Cyme Species 0.000 description 1
- 108020005199 Dehydrogenases Proteins 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 108010008604 L-alpha-glycerol-phosphate oxidase Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000918728 Monotes Species 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 238000011481 absorbance measurement Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001687 destabilization Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910003002 lithium salt Inorganic materials 0.000 description 1
- 159000000002 lithium salts Chemical class 0.000 description 1
- FSVCQIDHPKZJSO-UHFFFAOYSA-L nitro blue tetrazolium dichloride Chemical compound [Cl-].[Cl-].COC1=CC(C=2C=C(OC)C(=CC=2)[N+]=2N(N=C(N=2)C=2C=CC=CC=2)C=2C=CC(=CC=2)[N+]([O-])=O)=CC=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=C([N+]([O-])=O)C=C1 FSVCQIDHPKZJSO-UHFFFAOYSA-L 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- AHKZTVQIVOEVFO-UHFFFAOYSA-N oxide(2-) Chemical compound [O-2] AHKZTVQIVOEVFO-UHFFFAOYSA-N 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B50/00—Formazane dyes; Tetrazolium dyes
- C09B50/02—Tetrazolium dyes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58095185A JPS59219270A (ja) | 1983-05-30 | 1983-05-30 | テトラゾリウム塩を含有する溶液の安定化方法 |
| DE8484106143T DE3467755D1 (en) | 1983-05-30 | 1984-05-29 | Stabilization of tetrazolium salt with cyclodextrin |
| AT84106143T ATE31060T1 (de) | 1983-05-30 | 1984-05-29 | Stabilisierung von tetrazoliumsalzen mit cyclodextrin. |
| EP84106143A EP0127179B1 (en) | 1983-05-30 | 1984-05-29 | Stabilization of tetrazolium salt with cyclodextrin |
| US06/930,094 US4837331A (en) | 1983-05-30 | 1986-11-13 | Stabilization of tetrazolium salts with cyclodextrins |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58095185A JPS59219270A (ja) | 1983-05-30 | 1983-05-30 | テトラゾリウム塩を含有する溶液の安定化方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59219270A true JPS59219270A (ja) | 1984-12-10 |
| JPH0416470B2 JPH0416470B2 (OSRAM) | 1992-03-24 |
Family
ID=14130688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58095185A Granted JPS59219270A (ja) | 1983-05-30 | 1983-05-30 | テトラゾリウム塩を含有する溶液の安定化方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4837331A (OSRAM) |
| EP (1) | EP0127179B1 (OSRAM) |
| JP (1) | JPS59219270A (OSRAM) |
| AT (1) | ATE31060T1 (OSRAM) |
| DE (1) | DE3467755D1 (OSRAM) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62249979A (ja) * | 1986-04-04 | 1987-10-30 | ベ−リンガ−・マンハイム・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | 基質又は酵素活性を測定するための方法及び試薬 |
| JPS63279800A (ja) * | 1987-05-13 | 1988-11-16 | Oriental Yeast Co Ltd | 分析感度及び分析精度を向上させる方法 |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60162957A (ja) * | 1984-02-03 | 1985-08-24 | Kyowa Medetsukusu Kk | セルロプラスミン活性の測定法 |
| US5196314A (en) * | 1986-04-04 | 1993-03-23 | Boehringer Mannheim Gmbh | Process and reagent for the determination of substrates or enzyme activities |
| US5300280A (en) * | 1992-02-14 | 1994-04-05 | Mallinckrodt Medical, Inc. | Stabilized radiopharmaceutical kits |
| US5733693A (en) | 1993-08-05 | 1998-03-31 | Kimberly-Clark Worldwide, Inc. | Method for improving the readability of data processing forms |
| US6211383B1 (en) | 1993-08-05 | 2001-04-03 | Kimberly-Clark Worldwide, Inc. | Nohr-McDonald elimination reaction |
| US5773182A (en) | 1993-08-05 | 1998-06-30 | Kimberly-Clark Worldwide, Inc. | Method of light stabilizing a colorant |
| US6017471A (en) | 1993-08-05 | 2000-01-25 | Kimberly-Clark Worldwide, Inc. | Colorants and colorant modifiers |
| US5645964A (en) | 1993-08-05 | 1997-07-08 | Kimberly-Clark Corporation | Digital information recording media and method of using same |
| US5643356A (en) | 1993-08-05 | 1997-07-01 | Kimberly-Clark Corporation | Ink for ink jet printers |
| US5721287A (en) | 1993-08-05 | 1998-02-24 | Kimberly-Clark Worldwide, Inc. | Method of mutating a colorant by irradiation |
| US5865471A (en) | 1993-08-05 | 1999-02-02 | Kimberly-Clark Worldwide, Inc. | Photo-erasable data processing forms |
| US5700850A (en) | 1993-08-05 | 1997-12-23 | Kimberly-Clark Worldwide | Colorant compositions and colorant stabilizers |
| US5681380A (en) | 1995-06-05 | 1997-10-28 | Kimberly-Clark Worldwide, Inc. | Ink for ink jet printers |
| US6017661A (en) | 1994-11-09 | 2000-01-25 | Kimberly-Clark Corporation | Temporary marking using photoerasable colorants |
| CA2120838A1 (en) | 1993-08-05 | 1995-02-06 | Ronald Sinclair Nohr | Solid colored composition mutable by ultraviolet radiation |
| US6071979A (en) | 1994-06-30 | 2000-06-06 | Kimberly-Clark Worldwide, Inc. | Photoreactor composition method of generating a reactive species and applications therefor |
| US5685754A (en) | 1994-06-30 | 1997-11-11 | Kimberly-Clark Corporation | Method of generating a reactive species and polymer coating applications therefor |
| US6242057B1 (en) | 1994-06-30 | 2001-06-05 | Kimberly-Clark Worldwide, Inc. | Photoreactor composition and applications therefor |
| US5739175A (en) | 1995-06-05 | 1998-04-14 | Kimberly-Clark Worldwide, Inc. | Photoreactor composition containing an arylketoalkene wavelength-specific sensitizer |
| US6008268A (en) | 1994-10-21 | 1999-12-28 | Kimberly-Clark Worldwide, Inc. | Photoreactor composition, method of generating a reactive species, and applications therefor |
| US5849411A (en) | 1995-06-05 | 1998-12-15 | Kimberly-Clark Worldwide, Inc. | Polymer film, nonwoven web and fibers containing a photoreactor composition |
| RU2170943C2 (ru) | 1995-06-05 | 2001-07-20 | Кимберли-Кларк Уорлдвайд, Инк. | Новые прекрасители |
| US5786132A (en) | 1995-06-05 | 1998-07-28 | Kimberly-Clark Corporation | Pre-dyes, mutable dye compositions, and methods of developing a color |
| US5798015A (en) | 1995-06-05 | 1998-08-25 | Kimberly-Clark Worldwide, Inc. | Method of laminating a structure with adhesive containing a photoreactor composition |
| US5811199A (en) | 1995-06-05 | 1998-09-22 | Kimberly-Clark Worldwide, Inc. | Adhesive compositions containing a photoreactor composition |
| US5747550A (en) | 1995-06-05 | 1998-05-05 | Kimberly-Clark Worldwide, Inc. | Method of generating a reactive species and polymerizing an unsaturated polymerizable material |
| ES2161357T3 (es) | 1995-06-28 | 2001-12-01 | Kimberly Clark Co | Composicion estabilizante de colorantes. |
| US6099628A (en) | 1996-03-29 | 2000-08-08 | Kimberly-Clark Worldwide, Inc. | Colorant stabilizers |
| US5855655A (en) | 1996-03-29 | 1999-01-05 | Kimberly-Clark Worldwide, Inc. | Colorant stabilizers |
| US5782963A (en) | 1996-03-29 | 1998-07-21 | Kimberly-Clark Worldwide, Inc. | Colorant stabilizers |
| WO1997020000A2 (en) | 1995-11-28 | 1997-06-05 | Kimberly-Clark Worldwide, Inc. | Improved colorant stabilizers |
| US5891229A (en) | 1996-03-29 | 1999-04-06 | Kimberly-Clark Worldwide, Inc. | Colorant stabilizers |
| US6524379B2 (en) | 1997-08-15 | 2003-02-25 | Kimberly-Clark Worldwide, Inc. | Colorants, colorant stabilizers, ink compositions, and improved methods of making the same |
| KR20010022593A (ko) | 1998-06-03 | 2001-03-26 | 로날드 디. 맥크레이 | 신규 광개시제 및 그 이용 |
| AU4320799A (en) | 1998-06-03 | 1999-12-20 | Kimberly-Clark Worldwide, Inc. | Neonanoplasts and microemulsion technology for inks and ink jet printing |
| CA2336641A1 (en) | 1998-07-20 | 2000-01-27 | Kimberly-Clark Worldwide, Inc. | Improved ink jet ink compositions |
| US6265458B1 (en) | 1998-09-28 | 2001-07-24 | Kimberly-Clark Worldwide, Inc. | Photoinitiators and applications therefor |
| ES2195869T3 (es) | 1999-01-19 | 2003-12-16 | Kimberly Clark Co | Nuevos colorantes, estabilizantes de colorantes, compuestos de tinta y metodos mejorados para su fabricacion. |
| US6331056B1 (en) | 1999-02-25 | 2001-12-18 | Kimberly-Clark Worldwide, Inc. | Printing apparatus and applications therefor |
| US6294698B1 (en) | 1999-04-16 | 2001-09-25 | Kimberly-Clark Worldwide, Inc. | Photoinitiators and applications therefor |
| US6368395B1 (en) | 1999-05-24 | 2002-04-09 | Kimberly-Clark Worldwide, Inc. | Subphthalocyanine colorants, ink compositions, and method of making the same |
| DE10032290C2 (de) * | 2000-07-03 | 2002-05-08 | Roche Diagnostics Gmbh | Adsorptionsmittelhaltige Kontrollflüssigkeit |
| US7153666B2 (en) * | 2003-07-17 | 2006-12-26 | General Atomics | Methods and compositions for determination of glycated proteins |
| JP5131955B2 (ja) * | 2004-08-05 | 2013-01-30 | 旭化成ファーマ株式会社 | プロテアーゼ反応促進剤及び／又は色素の安定化剤を含む試薬 |
| EP2044444B1 (en) * | 2006-07-25 | 2013-03-20 | General Atomics | Methods for assaying percentage of glycated hemoglobin |
| US7943385B2 (en) * | 2006-07-25 | 2011-05-17 | General Atomics | Methods for assaying percentage of glycated hemoglobin |
| JP4697809B2 (ja) * | 2007-02-22 | 2011-06-08 | 旭化成ファーマ株式会社 | ロイコ色素の安定化方法 |
| JP5424904B2 (ja) | 2007-03-15 | 2014-02-26 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | 安定化されたヘマトキシリン |
| WO2009140343A1 (en) * | 2008-05-13 | 2009-11-19 | General Atomics | Electrochemical biosensor for direct determination of percentage of glycated hemoglobin |
| GB201017547D0 (en) * | 2010-10-18 | 2010-12-01 | Univ Cardiff | Method and device for the detection of sulphur containing species |
| US11808708B2 (en) | 2020-08-12 | 2023-11-07 | F.A.T. Stats LLC | Method for maintaining the health of a diabetic patient by preventing the occurrence of diabetic ketoacidosis |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2059792A1 (de) * | 1970-12-04 | 1972-06-15 | Xerox Corp | Indikatorzubereitung fuer eine Verwendung zur quantitativen Bestimmung von Amylase in Koerperfluessigkeiten |
| US3954787A (en) * | 1974-06-18 | 1976-05-04 | Pfizer Inc. | Stabilized E-series prostaglandins |
| DE2537499A1 (de) * | 1974-10-04 | 1976-04-15 | Warner Lambert Co | Farbiger vergleichsstandard zur diagnostischen bestimmung von enzymatischen reaktionen und verfahren zu seiner herstellung |
| US4451563A (en) * | 1981-08-28 | 1984-05-29 | Kaufman Richard A | Method for increasing the sensitivity of assays |
| EP0100217B1 (en) * | 1982-07-23 | 1987-10-07 | Wako Pure Chemical Industries, Ltd. | Process for quantitative determination of substrate treated with oxidase |
-
1983
- 1983-05-30 JP JP58095185A patent/JPS59219270A/ja active Granted
-
1984
- 1984-05-29 EP EP84106143A patent/EP0127179B1/en not_active Expired
- 1984-05-29 AT AT84106143T patent/ATE31060T1/de not_active IP Right Cessation
- 1984-05-29 DE DE8484106143T patent/DE3467755D1/de not_active Expired
-
1986
- 1986-11-13 US US06/930,094 patent/US4837331A/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62249979A (ja) * | 1986-04-04 | 1987-10-30 | ベ−リンガ−・マンハイム・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | 基質又は酵素活性を測定するための方法及び試薬 |
| JPS63279800A (ja) * | 1987-05-13 | 1988-11-16 | Oriental Yeast Co Ltd | 分析感度及び分析精度を向上させる方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0127179A1 (en) | 1984-12-05 |
| DE3467755D1 (en) | 1988-01-07 |
| JPH0416470B2 (OSRAM) | 1992-03-24 |
| US4837331A (en) | 1989-06-06 |
| EP0127179B1 (en) | 1987-11-25 |
| ATE31060T1 (de) | 1987-12-15 |
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