JPS59205399A - ２１―クロロ―９β，１１β―エポキシ―１７―ヒドロキシ―１６β―メチルプレグナ―１，４―ジエン―３，２０―ジオンの１７―エステルおよびその製法 - Google Patents

２１―クロロ―９β，１１β―エポキシ―１７―ヒドロキシ―１６β―メチルプレグナ―１，４―ジエン―３，２０―ジオンの１７―エステルおよびその製法

Info

Publication number
JPS59205399A
JPS59205399A JP59015957A JP1595784A JPS59205399A JP S59205399 A JPS59205399 A JP S59205399A JP 59015957 A JP59015957 A JP 59015957A JP 1595784 A JP1595784 A JP 1595784A JP S59205399 A JPS59205399 A JP S59205399A
Authority
JP
Japan
Prior art keywords
dione
diene
epoxy
ester
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59015957A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6228160B2 (enrdf_load_stackoverflow
Inventor
ペーテル・マクドナルド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHIKOORU SOC ITARIAANA KORUCHI
SHIKOORU SOC ITARIAANA KORUCHIKOSUTEROIJI SpA
Original Assignee
SHIKOORU SOC ITARIAANA KORUCHI
SHIKOORU SOC ITARIAANA KORUCHIKOSUTEROIJI SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHIKOORU SOC ITARIAANA KORUCHI, SHIKOORU SOC ITARIAANA KORUCHIKOSUTEROIJI SpA filed Critical SHIKOORU SOC ITARIAANA KORUCHI
Publication of JPS59205399A publication Critical patent/JPS59205399A/ja
Publication of JPS6228160B2 publication Critical patent/JPS6228160B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP59015957A 1983-03-29 1984-01-31 ２１―クロロ―９β，１１β―エポキシ―１７―ヒドロキシ―１６β―メチルプレグナ―１，４―ジエン―３，２０―ジオンの１７―エステルおよびその製法 Granted JPS59205399A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT20334/83A IT1194178B (it) 1983-03-29 1983-03-29 Processo per la preparazione di 17-esteri di clobetasolo e composti ottenuti
IT20334A/83 1983-03-29

Publications (2)

Publication Number Publication Date
JPS59205399A true JPS59205399A (ja) 1984-11-20
JPS6228160B2 JPS6228160B2 (enrdf_load_stackoverflow) 1987-06-18

Family

ID=11165811

Family Applications (2)

Application Number Title Priority Date Filing Date
JP59015956A Pending JPS59205397A (ja) 1983-03-29 1984-01-31 クロベタゾ−ルの１７−エステルの製法
JP59015957A Granted JPS59205399A (ja) 1983-03-29 1984-01-31 ２１―クロロ―９β，１１β―エポキシ―１７―ヒドロキシ―１６β―メチルプレグナ―１，４―ジエン―３，２０―ジオンの１７―エステルおよびその製法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP59015956A Pending JPS59205397A (ja) 1983-03-29 1984-01-31 クロベタゾ−ルの１７−エステルの製法

Country Status (10)

Country Link
JP (2) JPS59205397A (enrdf_load_stackoverflow)
CA (1) CA1220468A (enrdf_load_stackoverflow)
CH (1) CH661930A5 (enrdf_load_stackoverflow)
DK (1) DK42884A (enrdf_load_stackoverflow)
FI (1) FI840344A7 (enrdf_load_stackoverflow)
IT (1) IT1194178B (enrdf_load_stackoverflow)
NL (1) NL8400910A (enrdf_load_stackoverflow)
NO (1) NO840065L (enrdf_load_stackoverflow)
SE (1) SE8400145L (enrdf_load_stackoverflow)
YU (1) YU54684A (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111944002A (zh) * 2020-07-29 2020-11-17 河南利华制药有限公司 一种倍氯米松二丙酸酯中间体及制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108727458A (zh) * 2018-05-10 2018-11-02 浙江仙居仙乐药业有限公司 一种17-丙酸酯的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1253831A (en) * 1968-01-19 1971-11-17 Glaxo Lab Ltd 9alpha,21-DIHALOPREGNANE COMPOUNDS
JPS51125372A (en) * 1975-03-31 1976-11-01 Taisho Pharmaceut Co Ltd Aprocess for preparing pregnane steroid-17-ester-21-halides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111944002A (zh) * 2020-07-29 2020-11-17 河南利华制药有限公司 一种倍氯米松二丙酸酯中间体及制备方法

Also Published As

Publication number Publication date
FI840344L (fi) 1984-09-30
IT8320334A0 (it) 1983-03-29
FI840344A7 (fi) 1984-09-30
NL8400910A (nl) 1984-10-16
SE8400145L (sv) 1984-09-30
NO840065L (no) 1984-10-01
CH661930A5 (en) 1987-08-31
YU54684A (en) 1986-10-31
JPS59205397A (ja) 1984-11-20
IT1194178B (it) 1988-09-14
DK42884A (da) 1984-09-30
SE8400145D0 (sv) 1984-01-12
FI840344A0 (fi) 1984-01-27
DK42884D0 (da) 1984-01-31
CA1220468A (en) 1987-04-14
JPS6228160B2 (enrdf_load_stackoverflow) 1987-06-18

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