JPS59205399A - ２１―クロロ―９β，１１β―エポキシ―１７―ヒドロキシ―１６β―メチルプレグナ―１，４―ジエン―３，２０―ジオンの１７―エステルおよびその製法 - Google Patents

２１―クロロ―９β，１１β―エポキシ―１７―ヒドロキシ―１６β―メチルプレグナ―１，４―ジエン―３，２０―ジオンの１７―エステルおよびその製法

Info

Publication number
JPS59205399A
JPS59205399A JP59015957A JP1595784A JPS59205399A JP S59205399 A JPS59205399 A JP S59205399A JP 59015957 A JP59015957 A JP 59015957A JP 1595784 A JP1595784 A JP 1595784A JP S59205399 A JPS59205399 A JP S59205399A
Authority
JP
Japan
Prior art keywords
dione
diene
epoxy
ester
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59015957A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6228160B2 (enrdf_load_stackoverflow
Inventor
ペーテル・マクドナルド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHIKOORU SOC ITARIAANA KORUCHI
SHIKOORU SOC ITARIAANA KORUCHIKOSUTEROIJI SpA
Original Assignee
SHIKOORU SOC ITARIAANA KORUCHI
SHIKOORU SOC ITARIAANA KORUCHIKOSUTEROIJI SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHIKOORU SOC ITARIAANA KORUCHI, SHIKOORU SOC ITARIAANA KORUCHIKOSUTEROIJI SpA filed Critical SHIKOORU SOC ITARIAANA KORUCHI
Publication of JPS59205399A publication Critical patent/JPS59205399A/ja
Publication of JPS6228160B2 publication Critical patent/JPS6228160B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP59015957A 1983-03-29 1984-01-31 ２１―クロロ―９β，１１β―エポキシ―１７―ヒドロキシ―１６β―メチルプレグナ―１，４―ジエン―３，２０―ジオンの１７―エステルおよびその製法 Granted JPS59205399A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT20334A/83 1983-03-29
IT20334/83A IT1194178B (it) 1983-03-29 1983-03-29 Processo per la preparazione di 17-esteri di clobetasolo e composti ottenuti

Publications (2)

Publication Number Publication Date
JPS59205399A true JPS59205399A (ja) 1984-11-20
JPS6228160B2 JPS6228160B2 (enrdf_load_stackoverflow) 1987-06-18

Family

ID=11165811

Family Applications (2)

Application Number Title Priority Date Filing Date
JP59015957A Granted JPS59205399A (ja) 1983-03-29 1984-01-31 ２１―クロロ―９β，１１β―エポキシ―１７―ヒドロキシ―１６β―メチルプレグナ―１，４―ジエン―３，２０―ジオンの１７―エステルおよびその製法
JP59015956A Pending JPS59205397A (ja) 1983-03-29 1984-01-31 クロベタゾ−ルの１７−エステルの製法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP59015956A Pending JPS59205397A (ja) 1983-03-29 1984-01-31 クロベタゾ−ルの１７−エステルの製法

Country Status (10)

Country Link
JP (2) JPS59205399A (enrdf_load_stackoverflow)
CA (1) CA1220468A (enrdf_load_stackoverflow)
CH (1) CH661930A5 (enrdf_load_stackoverflow)
DK (1) DK42884A (enrdf_load_stackoverflow)
FI (1) FI840344A7 (enrdf_load_stackoverflow)
IT (1) IT1194178B (enrdf_load_stackoverflow)
NL (1) NL8400910A (enrdf_load_stackoverflow)
NO (1) NO840065L (enrdf_load_stackoverflow)
SE (1) SE8400145L (enrdf_load_stackoverflow)
YU (1) YU54684A (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111944002A (zh) * 2020-07-29 2020-11-17 河南利华制药有限公司 一种倍氯米松二丙酸酯中间体及制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108727458A (zh) * 2018-05-10 2018-11-02 浙江仙居仙乐药业有限公司 一种17-丙酸酯的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1253831A (en) * 1968-01-19 1971-11-17 Glaxo Lab Ltd 9alpha,21-DIHALOPREGNANE COMPOUNDS
JPS51125372A (en) * 1975-03-31 1976-11-01 Taisho Pharmaceut Co Ltd Aprocess for preparing pregnane steroid-17-ester-21-halides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111944002A (zh) * 2020-07-29 2020-11-17 河南利华制药有限公司 一种倍氯米松二丙酸酯中间体及制备方法

Also Published As

Publication number Publication date
IT8320334A0 (it) 1983-03-29
DK42884A (da) 1984-09-30
NL8400910A (nl) 1984-10-16
DK42884D0 (da) 1984-01-31
FI840344L (fi) 1984-09-30
SE8400145D0 (sv) 1984-01-12
IT1194178B (it) 1988-09-14
CA1220468A (en) 1987-04-14
CH661930A5 (en) 1987-08-31
FI840344A7 (fi) 1984-09-30
SE8400145L (sv) 1984-09-30
JPS59205397A (ja) 1984-11-20
NO840065L (no) 1984-10-01
JPS6228160B2 (enrdf_load_stackoverflow) 1987-06-18
FI840344A0 (fi) 1984-01-27
YU54684A (en) 1986-10-31

Similar Documents

Publication Publication Date Title
US4041055A (en) Process for the preparation of 17α-hydroxyprogesterones and corticoids from androstenes
JPS6252759B2 (enrdf_load_stackoverflow)
US7718793B2 (en) Method for the preparation of 6-α fluoro corticosteroids
US4036831A (en) Trimethyl siloxane steroid intermediates
JPH01104095A (ja) アンドロスタ−１，４−ジエン−３，１７−ジオンのメチレン誘導体の製造方法
WO1995032989A1 (en) Process for preparing δ9,11 and 21-chloro corticosteroids
US4255331A (en) 3-Acetoxy-9β-11β-epoxy-dienes and the preparation of the corresponding 6α-halogen-4-ene-3-ones
JPH033680B2 (enrdf_load_stackoverflow)
US20170114088A1 (en) Process for the preparation of 17-desoxy-corticosteroids
JPS591720B2 (ja) ６−ハロ−プレグナン化合物の製造法
JP4095018B2 (ja) フルメタゾンおよびその１７−カルボキシルアンドロステン類似体の調製
JPS59205399A (ja) ２１―クロロ―９β，１１β―エポキシ―１７―ヒドロキシ―１６β―メチルプレグナ―１，４―ジエン―３，２０―ジオンの１７―エステルおよびその製法
EP0097328A2 (en) Process for preparation of steroids
JP2004534795A5 (enrdf_load_stackoverflow)
US4207235A (en) Selective epoxidation of steroidal bromohydrins
EP0027192A1 (en) A process for the preparation of 4,6-dien-3-one steroids
JPH01502818A (ja) １６α―メチル化方法
JP2000128897A (ja) ブデソニドの２２ｒエピマ―を調製する立体選択的な方法
DE2905674A1 (de) Steroidverbindungen und verfahren zu ihrer herstellung
US3980680A (en) Process for the preparation of 21-desoxy-17-acyloxy-4-pregnenes and of 21-iodo-21-desoxy-17-acyl oxy-4-pregnene intermediates useful therein
EP0071178B1 (en) Acyloxysteroids and process for producing same
KR820001643B1 (ko) 6-할로-프레그난류의 개량된 제조방법
JPS6153297A (ja) ９ａ―フルオル―又はクロル―コルチコステロイドエステル類の製造法
JPS6363555B2 (enrdf_load_stackoverflow)
JPS6360034B2 (enrdf_load_stackoverflow)