JPS59186995A - ヒト免疫インターフェロン蛋白質およびその製造法 - Google Patents

ヒト免疫インターフェロン蛋白質およびその製造法

Info

Publication number
JPS59186995A
JPS59186995A JP58176090A JP17609083A JPS59186995A JP S59186995 A JPS59186995 A JP S59186995A JP 58176090 A JP58176090 A JP 58176090A JP 17609083 A JP17609083 A JP 17609083A JP S59186995 A JPS59186995 A JP S59186995A
Authority
JP
Japan
Prior art keywords
protein
arg
human immune
immune interferon
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58176090A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6411639B2 (enExample
Inventor
Masakazu Kikuchi
正和 菊池
Kyozo Tsukamoto
塚本　恭造
Tsutomu Kurokawa
勉 黒川
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of JPS59186995A publication Critical patent/JPS59186995A/ja
Publication of JPS6411639B2 publication Critical patent/JPS6411639B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/249—Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP58176090A 1982-11-22 1983-09-22 ヒト免疫インターフェロン蛋白質およびその製造法 Granted JPS59186995A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP1982/000445 WO1984002129A1 (fr) 1982-11-22 1982-11-22 Proteine de l'interferon immun humain et son procede de preparation
MC82/445 1982-11-22

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP59052243A Division JPS59220190A (ja) 1982-11-22 1984-03-21 形質転換体
JP62255867A Division JPS63211240A (ja) 1982-11-22 1987-10-08 ヒト免疫インターフェロン蛋白質含有薬剤

Publications (2)

Publication Number Publication Date
JPS59186995A true JPS59186995A (ja) 1984-10-23
JPS6411639B2 JPS6411639B2 (enExample) 1989-02-27

Family

ID=13762365

Family Applications (4)

Application Number Title Priority Date Filing Date
JP58176090A Granted JPS59186995A (ja) 1982-11-22 1983-09-22 ヒト免疫インターフェロン蛋白質およびその製造法
JP59052243A Pending JPS59220190A (ja) 1982-11-22 1984-03-21 形質転換体
JP62255867A Granted JPS63211240A (ja) 1982-11-22 1987-10-08 ヒト免疫インターフェロン蛋白質含有薬剤
JP6086570A Pending JPH06316532A (ja) 1982-11-22 1994-04-25 ヒト免疫インターフェロン蛋白質含有薬剤

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP59052243A Pending JPS59220190A (ja) 1982-11-22 1984-03-21 形質転換体
JP62255867A Granted JPS63211240A (ja) 1982-11-22 1987-10-08 ヒト免疫インターフェロン蛋白質含有薬剤
JP6086570A Pending JPH06316532A (ja) 1982-11-22 1994-04-25 ヒト免疫インターフェロン蛋白質含有薬剤

Country Status (18)

Country Link
EP (1) EP0110044A1 (enExample)
JP (4) JPS59186995A (enExample)
KR (1) KR920001377B1 (enExample)
AU (1) AU570219B2 (enExample)
DK (1) DK164063C (enExample)
ES (1) ES8504938A1 (enExample)
FI (1) FI81832C (enExample)
GR (1) GR79035B (enExample)
HU (1) HU209152B (enExample)
IE (1) IE57053B1 (enExample)
IL (1) IL69791A (enExample)
MC (1) MC1553A1 (enExample)
NO (1) NO169725C (enExample)
NZ (1) NZ205667A (enExample)
PH (1) PH20024A (enExample)
PT (1) PT77573B (enExample)
WO (1) WO1984002129A1 (enExample)
ZA (1) ZA837057B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6034919A (ja) * 1983-08-04 1985-02-22 Green Cross Corp:The ガンマ・インタ−フェロン組成物

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5582824A (en) * 1981-10-19 1996-12-10 Genentech, Inc. Recombinant DES-CYS-TYR-CYS human immune interferon
WO1984002129A1 (fr) * 1982-11-22 1984-06-07 Takeda Chemical Industries Ltd Proteine de l'interferon immun humain et son procede de preparation
DE3484374D1 (de) * 1983-08-04 1991-05-08 Green Cross Corp Gamma-interferonzusammensetzung.
ZA846554B (en) * 1983-09-20 1985-04-24 Hoffmann La Roche Immune interferon and method for its purification
FR2556365B1 (fr) * 1983-12-09 1987-07-31 Transgene Sa Vecteurs de clonage et d'expression de l'interferon-g, bacteries transformees et procede de preparation de l'interferon-g
US4855238A (en) * 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
MX9203641A (es) * 1983-12-16 1992-07-01 Genentech Inc Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion.
US4499014A (en) * 1984-02-07 1985-02-12 Interferon Sciences, Inc. Method for purifying gamma-interferon
DE3426077A1 (de) * 1984-07-14 1986-01-23 Dr. Karl Thomae Gmbh, 7950 Biberach Monoklonale antikoerper gegen humanes ifn-(gamma), diese antikoerper produzierende hybridzellinien, verwendung der neuen antikoerper und verfahren zu deren herstellung
DE3432196A1 (de) * 1984-09-01 1986-03-06 Boehringer Ingelheim International GmbH, 6507 Ingelheim Neues mechanisches aufschlussverfahren von bakterienzellen zur isolierung von rekombinant hergestellten peptiden
JPH0653067B2 (ja) * 1984-09-11 1994-07-20 武田薬品工業株式会社 新規ハイブリドーマおよびその製造法
GB2164650A (en) * 1984-09-25 1986-03-26 Fujisawa Pharmaceutical Co Process for production of y-interferon
US4946674A (en) * 1984-10-05 1990-08-07 Bioferon Biochemische Substanzen Gmbh & Co. Process for treatment of rheumatic diseases
US4873312A (en) * 1985-04-25 1989-10-10 Amgen Method for purifying interferon and composition of matter produced thereby
US4828830A (en) * 1986-01-24 1989-05-09 Genentech, Inc. Method and composition for prophylaxis and treatment of viral infections
GB8719108D0 (en) * 1987-08-12 1987-09-16 Natural Environment Res Expression vectors
DE3829180A1 (de) * 1988-08-29 1990-03-08 Boehringer Ingelheim Int Neues arzneimittel zur vorbeugung und behandlung von durch primaere immundefekte verursachte krankheiten
US7230081B1 (en) 1999-11-12 2007-06-12 Maxygen Holdings, Ltd. Interferon gamma conjugates
JP2003513681A (ja) 1999-11-12 2003-04-15 マキシゲン・ホールディングス・リミテッド インターフェロンガンマ・コンジュゲート
US6958388B2 (en) 2001-04-06 2005-10-25 Maxygen, Aps Interferon gamma polypeptide variants
US7038015B2 (en) 2001-04-06 2006-05-02 Maxygen Holdings, Ltd. Interferon gamma polypeptide variants
WO2004005341A2 (en) 2002-07-03 2004-01-15 Maxygen Holdings Ltd. Full-length interferon gamma polypeptide variants
EP1831254B1 (en) 2004-12-23 2012-06-06 Molmed SpA Conjugation product
HUE024877T2 (en) 2007-10-30 2016-02-29 Genentech Inc Antibody purification by cation exchange chromatography

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376821A (en) * 1981-04-17 1983-03-15 Meloy Laboratories, Inc. Production of human IFN-gamma (immune) interferon
IL65475A0 (en) * 1981-04-17 1982-07-30 Meloy Lab Production of immune interferon and its mrna
AU561343B2 (en) * 1981-10-19 1987-05-07 Genentech Inc. Human immune interferon by recombinant dna
JPS58110548U (ja) * 1982-01-22 1983-07-28 株式会社東海理化電機製作所 自動車用ミラ−の駆動装置
EP0088540A3 (en) * 1982-02-22 1984-10-17 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing human immune interferon-like polypeptides
IL68100A0 (en) * 1982-03-24 1983-06-15 Takeda Chemical Industries Ltd Novel dna and use thereof
JPH0787797B2 (ja) * 1982-05-20 1995-09-27 サントリー株式会社 ヒト・ガンマ・インタ−フエロン様ポリペプチドの製造法
US4681848A (en) * 1982-09-22 1987-07-21 Takeda Chemical Industries, Ltd. Novel peptide and use thereof
WO1984002129A1 (fr) * 1982-11-22 1984-06-07 Takeda Chemical Industries Ltd Proteine de l'interferon immun humain et son procede de preparation
JP2526750B2 (ja) * 1991-07-30 1996-08-21 株式会社ユアサコーポレーション リチウム二次電池

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6034919A (ja) * 1983-08-04 1985-02-22 Green Cross Corp:The ガンマ・インタ−フェロン組成物

Also Published As

Publication number Publication date
WO1984002129A1 (fr) 1984-06-07
IL69791A (en) 1994-05-30
KR920001377B1 (ko) 1992-02-11
FI81832C (fi) 1990-12-10
PH20024A (en) 1986-09-01
DK430683D0 (da) 1983-09-21
PT77573B (en) 1986-03-18
EP0110044A1 (en) 1984-06-13
JPH0536414B2 (enExample) 1993-05-31
FI833525A0 (fi) 1983-09-29
AU570219B2 (en) 1988-03-10
JPH06316532A (ja) 1994-11-15
KR840006676A (ko) 1984-12-01
GR79035B (enExample) 1984-10-02
FI833525L (fi) 1984-05-23
IE832216L (en) 1984-05-22
NO833659L (no) 1984-05-23
DK164063B (da) 1992-05-04
DK430683A (da) 1984-05-23
NO169725B (no) 1992-04-21
NZ205667A (en) 1987-01-23
FI81832B (fi) 1990-08-31
ZA837057B (en) 1984-04-25
JPS59220190A (ja) 1984-12-11
DK164063C (da) 1992-09-28
JPS6411639B2 (enExample) 1989-02-27
ES527414A0 (es) 1985-04-16
HU209152B (en) 1994-03-28
ES8504938A1 (es) 1985-04-16
IE57053B1 (en) 1992-04-08
MC1553A1 (fr) 1984-08-31
JPS63211240A (ja) 1988-09-02
NO169725C (no) 1992-07-29
AU1934683A (en) 1984-06-28
PT77573A (en) 1983-11-01

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