ES8504938A1 - Un metodo de producir una proteina interferon inmune humano - Google Patents

Un metodo de producir una proteina interferon inmune humano

Info

Publication number
ES8504938A1
ES8504938A1 ES527414A ES527414A ES8504938A1 ES 8504938 A1 ES8504938 A1 ES 8504938A1 ES 527414 A ES527414 A ES 527414A ES 527414 A ES527414 A ES 527414A ES 8504938 A1 ES8504938 A1 ES 8504938A1
Authority
ES
Spain
Prior art keywords
human immune
immune interferon
interferon protein
production
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527414A
Other languages
English (en)
Other versions
ES527414A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES8504938A1 publication Critical patent/ES8504938A1/es
Publication of ES527414A0 publication Critical patent/ES527414A0/es
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/249Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/57IFN-gamma
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • C12N15/71Expression systems using regulatory sequences derived from the trp-operon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

METODO DE PRODUCCION DE UNA PROTEINA INTERFERON HUMANO.SE REALIZA DESARROLLANDO UN TRANSFORMANTE CON ADN QUE CONTIENE UNA SECUENCIA BASICA QUE CODIFICA INTERFERON INMUNE HUMANO, PURIFICANDO EL LIQUIDO OBTENIDO CON ANTICUERPO MONOCLONAL CAPAZ DE UNIRSE A INTERFERON INMUNE HUMANO. EL ADN QUE CODIFICA I-IF HUMANO PUEDE PRODUCIRSE CULTIVANDO CELULAS SECRETORAS DE I-IF HUMANO, TALES COMO LINFOCITOS SANGUINEOS PERIFERICOS HUMANOS. EL INDUCTOR DE I-IF PUEDE SELECCIONARSE DE ENTRE FITOHEMAGLUTININA (PHA), CONCANAVALINA (CONA), ENTEROTOXINA DE ESTAFILOCOCO A (SEA), NEURAMINIDASA-GALACTOSA OXIDASA (NAGO) Y 12-O-TETRADECANOILFORBOL-13-ACETATO (TPA).DE APLICACION COMO SUSTANCIAS ANTIVIRICAS Y ANTITUMORES.
ES527414A 1982-11-22 1983-11-21 Un metodo de producir una proteina interferon inmune humano Granted ES527414A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1982/000445 WO1984002129A1 (en) 1982-11-22 1982-11-22 Human immune interferon protein and process for its preparation

Publications (2)

Publication Number Publication Date
ES8504938A1 true ES8504938A1 (es) 1985-04-16
ES527414A0 ES527414A0 (es) 1985-04-16

Family

ID=13762365

Family Applications (1)

Application Number Title Priority Date Filing Date
ES527414A Granted ES527414A0 (es) 1982-11-22 1983-11-21 Un metodo de producir una proteina interferon inmune humano

Country Status (18)

Country Link
EP (1) EP0110044A1 (es)
JP (4) JPS59186995A (es)
KR (1) KR920001377B1 (es)
AU (1) AU570219B2 (es)
DK (1) DK164063C (es)
ES (1) ES527414A0 (es)
FI (1) FI81832C (es)
GR (1) GR79035B (es)
HU (1) HU209152B (es)
IE (1) IE57053B1 (es)
IL (1) IL69791A (es)
MC (1) MC1553A1 (es)
NO (1) NO169725C (es)
NZ (1) NZ205667A (es)
PH (1) PH20024A (es)
PT (1) PT77573B (es)
WO (1) WO1984002129A1 (es)
ZA (1) ZA837057B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5582824A (en) * 1981-10-19 1996-12-10 Genentech, Inc. Recombinant DES-CYS-TYR-CYS human immune interferon
WO1984002129A1 (en) * 1982-11-22 1984-06-07 Takeda Chemical Industries Ltd Human immune interferon protein and process for its preparation
JPS6034919A (ja) * 1983-08-04 1985-02-22 Green Cross Corp:The ガンマ・インタ−フェロン組成物
DE3484374D1 (de) * 1983-08-04 1991-05-08 Green Cross Corp Gamma-interferonzusammensetzung.
ZA846554B (en) * 1983-09-20 1985-04-24 Hoffmann La Roche Immune interferon and method for its purification
FR2556365B1 (fr) * 1983-12-09 1987-07-31 Transgene Sa Vecteurs de clonage et d'expression de l'interferon-g, bacteries transformees et procede de preparation de l'interferon-g
MX9203641A (es) * 1983-12-16 1992-07-01 Genentech Inc Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion.
US4855238A (en) 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
US4499014A (en) * 1984-02-07 1985-02-12 Interferon Sciences, Inc. Method for purifying gamma-interferon
DE3426077A1 (de) * 1984-07-14 1986-01-23 Dr. Karl Thomae Gmbh, 7950 Biberach Monoklonale antikoerper gegen humanes ifn-(gamma), diese antikoerper produzierende hybridzellinien, verwendung der neuen antikoerper und verfahren zu deren herstellung
DE3432196A1 (de) * 1984-09-01 1986-03-06 Boehringer Ingelheim International GmbH, 6507 Ingelheim Neues mechanisches aufschlussverfahren von bakterienzellen zur isolierung von rekombinant hergestellten peptiden
JPH0653067B2 (ja) * 1984-09-11 1994-07-20 武田薬品工業株式会社 新規ハイブリドーマおよびその製造法
GB2164650A (en) * 1984-09-25 1986-03-26 Fujisawa Pharmaceutical Co Process for production of y-interferon
US4946674A (en) * 1984-10-05 1990-08-07 Bioferon Biochemische Substanzen Gmbh & Co. Process for treatment of rheumatic diseases
US4873312A (en) * 1985-04-25 1989-10-10 Amgen Method for purifying interferon and composition of matter produced thereby
US4828830A (en) * 1986-01-24 1989-05-09 Genentech, Inc. Method and composition for prophylaxis and treatment of viral infections
GB8719108D0 (en) * 1987-08-12 1987-09-16 Natural Environment Res Expression vectors
DE3829180A1 (de) * 1988-08-29 1990-03-08 Boehringer Ingelheim Int Neues arzneimittel zur vorbeugung und behandlung von durch primaere immundefekte verursachte krankheiten
PL356007A1 (en) 1999-11-12 2004-05-31 Maxygen Holdings Ltd Interferon gamma conjugates
YU32402A (sh) 1999-11-12 2005-03-15 Maxygen Holdings Ltd. Konjugati gama interferona
US6958388B2 (en) 2001-04-06 2005-10-25 Maxygen, Aps Interferon gamma polypeptide variants
US7038015B2 (en) 2001-04-06 2006-05-02 Maxygen Holdings, Ltd. Interferon gamma polypeptide variants
AU2003239774A1 (en) 2002-07-03 2004-01-23 Maxygen Holdings Ltd. Full-length interferon gamma polypeptide variants
ES2388068T3 (es) 2004-12-23 2012-10-08 Molmed Spa Producto de conjugación
CN103554215B (zh) 2007-10-30 2016-06-15 健泰科生物技术公司 通过阳离子交换层析进行的抗体纯化

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376821A (en) * 1981-04-17 1983-03-15 Meloy Laboratories, Inc. Production of human IFN-gamma (immune) interferon
IL65475A0 (en) * 1981-04-17 1982-07-30 Meloy Lab Production of immune interferon and its mrna
AU561343B2 (en) * 1981-10-19 1987-05-07 Genentech Inc. Human immune interferon by recombinant dna
JPS58110548U (ja) * 1982-01-22 1983-07-28 株式会社東海理化電機製作所 自動車用ミラ−の駆動装置
ZA831094B (en) * 1982-02-22 1983-11-30 Biogen Nv Dna sequences,recombinant dna molecules and processes for producing human immune interferon-like polypeptides
IL68100A0 (en) * 1982-03-24 1983-06-15 Takeda Chemical Industries Ltd Novel dna and use thereof
JPH0787797B2 (ja) * 1982-05-20 1995-09-27 サントリー株式会社 ヒト・ガンマ・インタ−フエロン様ポリペプチドの製造法
US4681848A (en) * 1982-09-22 1987-07-21 Takeda Chemical Industries, Ltd. Novel peptide and use thereof
WO1984002129A1 (en) * 1982-11-22 1984-06-07 Takeda Chemical Industries Ltd Human immune interferon protein and process for its preparation
JP2526750B2 (ja) * 1991-07-30 1996-08-21 株式会社ユアサコーポレーション リチウム二次電池

Also Published As

Publication number Publication date
EP0110044A1 (en) 1984-06-13
PT77573A (en) 1983-11-01
NO833659L (no) 1984-05-23
AU1934683A (en) 1984-06-28
JPS59186995A (ja) 1984-10-23
JPH0536414B2 (es) 1993-05-31
JPS6411639B2 (es) 1989-02-27
JPH06316532A (ja) 1994-11-15
KR920001377B1 (ko) 1992-02-11
IL69791A (en) 1994-05-30
DK430683A (da) 1984-05-23
KR840006676A (ko) 1984-12-01
JPS59220190A (ja) 1984-12-11
GR79035B (es) 1984-10-02
NO169725B (no) 1992-04-21
PT77573B (en) 1986-03-18
NZ205667A (en) 1987-01-23
DK164063B (da) 1992-05-04
IE832216L (en) 1984-05-22
ZA837057B (en) 1984-04-25
WO1984002129A1 (en) 1984-06-07
FI81832B (fi) 1990-08-31
DK430683D0 (da) 1983-09-21
FI833525A (fi) 1984-05-23
NO169725C (no) 1992-07-29
JPS63211240A (ja) 1988-09-02
ES527414A0 (es) 1985-04-16
DK164063C (da) 1992-09-28
HU209152B (en) 1994-03-28
FI833525A0 (fi) 1983-09-29
IE57053B1 (en) 1992-04-08
FI81832C (fi) 1990-12-10
MC1553A1 (fr) 1984-08-31
PH20024A (en) 1986-09-01
AU570219B2 (en) 1988-03-10

Similar Documents

Publication Publication Date Title
ES8504938A1 (es) Un metodo de producir una proteina interferon inmune humano
OA08947A (en) Mammalian interleukin-4.
ES2006941A6 (es) Un metodo de producir un peptido o una proteina relacionados con un epitope de virus asociado a linfoadenopatiasnvirus de leucemia de celulas t humanas (lavnhtlv-iii).
CA2095852A1 (en) Proteins with changed epitopes and methods for the production thereof
HUT61591A (en) Process for producing haemoglobin and its analogs
DE3650322D1 (de) Fusionsproteine aus Interleukin-2 und Hirudin.
EP0120551A3 (en) Yeast expression systems with vectors having gapdh or pyk promoters, and synthesis of foreign proteins
ES8500996A1 (es) Meotod de producir un polipeptido.
EP0097518A3 (en) Monoclonal antibody
MY104673A (en) Binding proteins for insulin-like growth factors.
HK206196A (en) Acid-labile subunit (ALS) of insulin-like-growth factor (IGF) binding protein complex
NZ216737A (en) Dna sequence, transformed cells and expressed proteins antigenic to anti-bovine diarrhea virus antibodies
GB2153364B (en) Lymphokine, monoclonal antibody specific to the lymphokine, and their production and uses
ES2056753A6 (es) Un procedimiento para la produccion de un polipeptido que tiene actividad de factor quemotactico de monocitos humanos.
IL92685A0 (en) Dna encoding lymphokine/cytokine like proteins,cells transformed thereby and production of said proteins and antibodies against them
EP0149241A3 (en) Dna base sequence containing regions involved in the production and secretion of a protein, recombinant dna including the whole or a part of the dna base sequence, and method of producing proteins by use of the recombinant dna
NZ222006A (en) Monoclonal antibodies specific to omega-ifn
EP0343132A3 (en) Methods and systems for producing hiv antigens
NZ209588A (en) Production of human immune interferon and pharmaceutical composition
JPS6427495A (en) Novel physiologically active polypeptide
ES8703928A1 (es) Un metodo para preparar la proteina factor de estimulacion de colonias (csf-1)recombinante

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20011110