ES8504938A1 - Un metodo de producir una proteina interferon inmune humano - Google Patents
Un metodo de producir una proteina interferon inmune humanoInfo
- Publication number
- ES8504938A1 ES8504938A1 ES527414A ES527414A ES8504938A1 ES 8504938 A1 ES8504938 A1 ES 8504938A1 ES 527414 A ES527414 A ES 527414A ES 527414 A ES527414 A ES 527414A ES 8504938 A1 ES8504938 A1 ES 8504938A1
- Authority
- ES
- Spain
- Prior art keywords
- human immune
- immune interferon
- interferon protein
- production
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/249—Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
METODO DE PRODUCCION DE UNA PROTEINA INTERFERON HUMANO.SE REALIZA DESARROLLANDO UN TRANSFORMANTE CON ADN QUE CONTIENE UNA SECUENCIA BASICA QUE CODIFICA INTERFERON INMUNE HUMANO, PURIFICANDO EL LIQUIDO OBTENIDO CON ANTICUERPO MONOCLONAL CAPAZ DE UNIRSE A INTERFERON INMUNE HUMANO. EL ADN QUE CODIFICA I-IF HUMANO PUEDE PRODUCIRSE CULTIVANDO CELULAS SECRETORAS DE I-IF HUMANO, TALES COMO LINFOCITOS SANGUINEOS PERIFERICOS HUMANOS. EL INDUCTOR DE I-IF PUEDE SELECCIONARSE DE ENTRE FITOHEMAGLUTININA (PHA), CONCANAVALINA (CONA), ENTEROTOXINA DE ESTAFILOCOCO A (SEA), NEURAMINIDASA-GALACTOSA OXIDASA (NAGO) Y 12-O-TETRADECANOILFORBOL-13-ACETATO (TPA).DE APLICACION COMO SUSTANCIAS ANTIVIRICAS Y ANTITUMORES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP1982/000445 WO1984002129A1 (en) | 1982-11-22 | 1982-11-22 | Human immune interferon protein and process for its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8504938A1 true ES8504938A1 (es) | 1985-04-16 |
ES527414A0 ES527414A0 (es) | 1985-04-16 |
Family
ID=13762365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES527414A Granted ES527414A0 (es) | 1982-11-22 | 1983-11-21 | Un metodo de producir una proteina interferon inmune humano |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0110044A1 (es) |
JP (4) | JPS59186995A (es) |
KR (1) | KR920001377B1 (es) |
AU (1) | AU570219B2 (es) |
DK (1) | DK164063C (es) |
ES (1) | ES527414A0 (es) |
FI (1) | FI81832C (es) |
GR (1) | GR79035B (es) |
HU (1) | HU209152B (es) |
IE (1) | IE57053B1 (es) |
IL (1) | IL69791A (es) |
MC (1) | MC1553A1 (es) |
NO (1) | NO169725C (es) |
NZ (1) | NZ205667A (es) |
PH (1) | PH20024A (es) |
PT (1) | PT77573B (es) |
WO (1) | WO1984002129A1 (es) |
ZA (1) | ZA837057B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5582824A (en) * | 1981-10-19 | 1996-12-10 | Genentech, Inc. | Recombinant DES-CYS-TYR-CYS human immune interferon |
WO1984002129A1 (en) * | 1982-11-22 | 1984-06-07 | Takeda Chemical Industries Ltd | Human immune interferon protein and process for its preparation |
JPS6034919A (ja) * | 1983-08-04 | 1985-02-22 | Green Cross Corp:The | ガンマ・インタ−フェロン組成物 |
DE3484374D1 (de) * | 1983-08-04 | 1991-05-08 | Green Cross Corp | Gamma-interferonzusammensetzung. |
ZA846554B (en) * | 1983-09-20 | 1985-04-24 | Hoffmann La Roche | Immune interferon and method for its purification |
FR2556365B1 (fr) * | 1983-12-09 | 1987-07-31 | Transgene Sa | Vecteurs de clonage et d'expression de l'interferon-g, bacteries transformees et procede de preparation de l'interferon-g |
MX9203641A (es) * | 1983-12-16 | 1992-07-01 | Genentech Inc | Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion. |
US4855238A (en) | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
US4499014A (en) * | 1984-02-07 | 1985-02-12 | Interferon Sciences, Inc. | Method for purifying gamma-interferon |
DE3426077A1 (de) * | 1984-07-14 | 1986-01-23 | Dr. Karl Thomae Gmbh, 7950 Biberach | Monoklonale antikoerper gegen humanes ifn-(gamma), diese antikoerper produzierende hybridzellinien, verwendung der neuen antikoerper und verfahren zu deren herstellung |
DE3432196A1 (de) * | 1984-09-01 | 1986-03-06 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Neues mechanisches aufschlussverfahren von bakterienzellen zur isolierung von rekombinant hergestellten peptiden |
JPH0653067B2 (ja) * | 1984-09-11 | 1994-07-20 | 武田薬品工業株式会社 | 新規ハイブリドーマおよびその製造法 |
GB2164650A (en) * | 1984-09-25 | 1986-03-26 | Fujisawa Pharmaceutical Co | Process for production of y-interferon |
US4946674A (en) * | 1984-10-05 | 1990-08-07 | Bioferon Biochemische Substanzen Gmbh & Co. | Process for treatment of rheumatic diseases |
US4873312A (en) * | 1985-04-25 | 1989-10-10 | Amgen | Method for purifying interferon and composition of matter produced thereby |
US4828830A (en) * | 1986-01-24 | 1989-05-09 | Genentech, Inc. | Method and composition for prophylaxis and treatment of viral infections |
GB8719108D0 (en) * | 1987-08-12 | 1987-09-16 | Natural Environment Res | Expression vectors |
DE3829180A1 (de) * | 1988-08-29 | 1990-03-08 | Boehringer Ingelheim Int | Neues arzneimittel zur vorbeugung und behandlung von durch primaere immundefekte verursachte krankheiten |
PL356007A1 (en) | 1999-11-12 | 2004-05-31 | Maxygen Holdings Ltd | Interferon gamma conjugates |
YU32402A (sh) | 1999-11-12 | 2005-03-15 | Maxygen Holdings Ltd. | Konjugati gama interferona |
US6958388B2 (en) | 2001-04-06 | 2005-10-25 | Maxygen, Aps | Interferon gamma polypeptide variants |
US7038015B2 (en) | 2001-04-06 | 2006-05-02 | Maxygen Holdings, Ltd. | Interferon gamma polypeptide variants |
AU2003239774A1 (en) | 2002-07-03 | 2004-01-23 | Maxygen Holdings Ltd. | Full-length interferon gamma polypeptide variants |
ES2388068T3 (es) | 2004-12-23 | 2012-10-08 | Molmed Spa | Producto de conjugación |
CN103554215B (zh) | 2007-10-30 | 2016-06-15 | 健泰科生物技术公司 | 通过阳离子交换层析进行的抗体纯化 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4376821A (en) * | 1981-04-17 | 1983-03-15 | Meloy Laboratories, Inc. | Production of human IFN-gamma (immune) interferon |
IL65475A0 (en) * | 1981-04-17 | 1982-07-30 | Meloy Lab | Production of immune interferon and its mrna |
AU561343B2 (en) * | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
JPS58110548U (ja) * | 1982-01-22 | 1983-07-28 | 株式会社東海理化電機製作所 | 自動車用ミラ−の駆動装置 |
ZA831094B (en) * | 1982-02-22 | 1983-11-30 | Biogen Nv | Dna sequences,recombinant dna molecules and processes for producing human immune interferon-like polypeptides |
IL68100A0 (en) * | 1982-03-24 | 1983-06-15 | Takeda Chemical Industries Ltd | Novel dna and use thereof |
JPH0787797B2 (ja) * | 1982-05-20 | 1995-09-27 | サントリー株式会社 | ヒト・ガンマ・インタ−フエロン様ポリペプチドの製造法 |
US4681848A (en) * | 1982-09-22 | 1987-07-21 | Takeda Chemical Industries, Ltd. | Novel peptide and use thereof |
WO1984002129A1 (en) * | 1982-11-22 | 1984-06-07 | Takeda Chemical Industries Ltd | Human immune interferon protein and process for its preparation |
JP2526750B2 (ja) * | 1991-07-30 | 1996-08-21 | 株式会社ユアサコーポレーション | リチウム二次電池 |
-
1982
- 1982-11-22 WO PCT/JP1982/000445 patent/WO1984002129A1/ja unknown
-
1983
- 1983-09-21 NZ NZ205667A patent/NZ205667A/en unknown
- 1983-09-21 PH PH29570A patent/PH20024A/en unknown
- 1983-09-21 DK DK430683A patent/DK164063C/da not_active IP Right Cessation
- 1983-09-21 IE IE2216/83A patent/IE57053B1/en not_active IP Right Cessation
- 1983-09-21 AU AU19346/83A patent/AU570219B2/en not_active Ceased
- 1983-09-21 EP EP83109403A patent/EP0110044A1/en not_active Withdrawn
- 1983-09-21 IL IL6979183A patent/IL69791A/en not_active IP Right Cessation
- 1983-09-22 JP JP58176090A patent/JPS59186995A/ja active Granted
- 1983-09-22 ZA ZA837057A patent/ZA837057B/xx unknown
- 1983-09-22 KR KR1019830004437A patent/KR920001377B1/ko not_active IP Right Cessation
- 1983-09-29 FI FI833525A patent/FI81832C/fi not_active IP Right Cessation
- 1983-10-07 NO NO833659A patent/NO169725C/no unknown
- 1983-10-27 PT PT77573A patent/PT77573B/pt not_active IP Right Cessation
- 1983-11-10 GR GR72942A patent/GR79035B/el unknown
- 1983-11-21 MC MC831664A patent/MC1553A1/xx unknown
- 1983-11-21 HU HU834044A patent/HU209152B/hu not_active IP Right Cessation
- 1983-11-21 ES ES527414A patent/ES527414A0/es active Granted
-
1984
- 1984-03-21 JP JP59052243A patent/JPS59220190A/ja active Pending
-
1987
- 1987-10-08 JP JP62255867A patent/JPS63211240A/ja active Granted
-
1994
- 1994-04-25 JP JP6086570A patent/JPH06316532A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0110044A1 (en) | 1984-06-13 |
PT77573A (en) | 1983-11-01 |
NO833659L (no) | 1984-05-23 |
AU1934683A (en) | 1984-06-28 |
JPS59186995A (ja) | 1984-10-23 |
JPH0536414B2 (es) | 1993-05-31 |
JPS6411639B2 (es) | 1989-02-27 |
JPH06316532A (ja) | 1994-11-15 |
KR920001377B1 (ko) | 1992-02-11 |
IL69791A (en) | 1994-05-30 |
DK430683A (da) | 1984-05-23 |
KR840006676A (ko) | 1984-12-01 |
JPS59220190A (ja) | 1984-12-11 |
GR79035B (es) | 1984-10-02 |
NO169725B (no) | 1992-04-21 |
PT77573B (en) | 1986-03-18 |
NZ205667A (en) | 1987-01-23 |
DK164063B (da) | 1992-05-04 |
IE832216L (en) | 1984-05-22 |
ZA837057B (en) | 1984-04-25 |
WO1984002129A1 (en) | 1984-06-07 |
FI81832B (fi) | 1990-08-31 |
DK430683D0 (da) | 1983-09-21 |
FI833525A (fi) | 1984-05-23 |
NO169725C (no) | 1992-07-29 |
JPS63211240A (ja) | 1988-09-02 |
ES527414A0 (es) | 1985-04-16 |
DK164063C (da) | 1992-09-28 |
HU209152B (en) | 1994-03-28 |
FI833525A0 (fi) | 1983-09-29 |
IE57053B1 (en) | 1992-04-08 |
FI81832C (fi) | 1990-12-10 |
MC1553A1 (fr) | 1984-08-31 |
PH20024A (en) | 1986-09-01 |
AU570219B2 (en) | 1988-03-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20011110 |