JPS59156349A - カプセル密封方法および装置 - Google Patents
カプセル密封方法および装置Info
- Publication number
- JPS59156349A JPS59156349A JP58200103A JP20010383A JPS59156349A JP S59156349 A JPS59156349 A JP S59156349A JP 58200103 A JP58200103 A JP 58200103A JP 20010383 A JP20010383 A JP 20010383A JP S59156349 A JPS59156349 A JP S59156349A
- Authority
- JP
- Japan
- Prior art keywords
- sealing
- capsule
- gelatin
- thermal energy
- capsules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 235000011852 gelatine desserts Nutrition 0.000 claims description 38
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- 229910052737 gold Inorganic materials 0.000 description 1
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 description 1
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- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
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- 150000002500 ions Chemical class 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 description 1
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- XRWKADIRZXTTLH-UHFFFAOYSA-N n,n-dimethylnitramide Chemical compound CN(C)[N+]([O-])=O XRWKADIRZXTTLH-UHFFFAOYSA-N 0.000 description 1
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- QWVGKYWNOKOFNN-UHFFFAOYSA-N o-cresol Chemical compound CC1=CC=CC=C1O QWVGKYWNOKOFNN-UHFFFAOYSA-N 0.000 description 1
- NMRPBPVERJPACX-UHFFFAOYSA-N octan-3-ol Chemical compound CCCCCC(O)CC NMRPBPVERJPACX-UHFFFAOYSA-N 0.000 description 1
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- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical compound O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 description 1
- XIPFMBOWZXULIA-UHFFFAOYSA-N pivalamide Chemical compound CC(C)(C)C(N)=O XIPFMBOWZXULIA-UHFFFAOYSA-N 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- MILWSGRFEGYSGM-UHFFFAOYSA-N propane-1,2-diol;propane-1,2,3-triol Chemical compound CC(O)CO.OCC(O)CO MILWSGRFEGYSGM-UHFFFAOYSA-N 0.000 description 1
- WYVAMUWZEOHJOQ-UHFFFAOYSA-N propionic anhydride Chemical compound CCC(=O)OC(=O)CC WYVAMUWZEOHJOQ-UHFFFAOYSA-N 0.000 description 1
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
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- LZOZLBFZGFLFBV-UHFFFAOYSA-N sulfene Chemical compound C=S(=O)=O LZOZLBFZGFLFBV-UHFFFAOYSA-N 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
- 239000002352 surface water Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4883—Capsule finishing, e.g. dyeing, aromatising, polishing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
- B29C65/4895—Solvent bonding, i.e. the surfaces of the parts to be joined being treated with solvents, swelling or softening agents, without adhesives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/01—General aspects dealing with the joint area or with the area to be joined
- B29C66/05—Particular design of joint configurations
- B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
- B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
- B29C66/112—Single lapped joints
- B29C66/1122—Single lap to lap joints, i.e. overlap joints
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
- B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
- B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
- B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
- B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
- B29C66/542—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles joining hollow covers or hollow bottoms to open ends of container bodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61G—TRANSPORT, PERSONAL CONVEYANCES, OR ACCOMMODATION SPECIALLY ADAPTED FOR PATIENTS OR DISABLED PERSONS; OPERATING TABLES OR CHAIRS; CHAIRS FOR DENTISTRY; FUNERAL DEVICES
- A61G2203/00—General characteristics of devices
- A61G2203/30—General characteristics of devices characterised by sensor means
- A61G2203/46—General characteristics of devices characterised by sensor means for temperature
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
- B29C65/52—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive
- B29C65/54—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive between pre-assembled parts
- B29C65/548—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive between pre-assembled parts by capillarity
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
- B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/712—Containers; Packaging elements or accessories, Packages
- B29L2031/7174—Capsules
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S220/00—Receptacles
- Y10S220/34—Anti-tamper pharmaceutical capsules, e.g. tamper indicating or resistant
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/17—Surface bonding means and/or assemblymeans with work feeding or handling means
- Y10T156/1798—Surface bonding means and/or assemblymeans with work feeding or handling means with liquid adhesive or adhesive activator applying means
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
- Closing Of Containers (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Formation And Processing Of Food Products (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US468022 | 1983-02-18 | ||
| US06/468,022 US4539060A (en) | 1983-02-18 | 1983-02-18 | Apparatus and method of sealing capsules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59156349A true JPS59156349A (ja) | 1984-09-05 |
| JPH0140627B2 JPH0140627B2 (enExample) | 1989-08-30 |
Family
ID=23858126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58200103A Granted JPS59156349A (ja) | 1983-02-18 | 1983-10-27 | カプセル密封方法および装置 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4539060A (enExample) |
| EP (1) | EP0116743B1 (enExample) |
| JP (1) | JPS59156349A (enExample) |
| KR (1) | KR890000206B1 (enExample) |
| AT (1) | ATE33346T1 (enExample) |
| AU (1) | AU559678B2 (enExample) |
| BR (1) | BR8306208A (enExample) |
| CA (1) | CA1255271A (enExample) |
| DE (1) | DE3376197D1 (enExample) |
| ES (1) | ES8501976A1 (enExample) |
| IE (1) | IE56363B1 (enExample) |
| IN (1) | IN160442B (enExample) |
| PH (1) | PH20191A (enExample) |
| SU (1) | SU1393309A3 (enExample) |
| YU (1) | YU44447B (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS602251A (ja) * | 1983-05-23 | 1985-01-08 | カプセルボンド・インコ−ポレイテツド | カプセルの接合方法 |
| JPS6024845A (ja) * | 1983-06-13 | 1985-02-07 | カプセルボンド・インコ−ポレイテツド | カプセルの接合装置 |
| JPS60176656A (ja) * | 1984-02-22 | 1985-09-10 | ワ−ナ−・ランバ−ト・カンパニ− | カプセルを封止するための装置および方法 |
| JP2018535708A (ja) * | 2015-11-16 | 2018-12-06 | カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップＣａｐｓｕｇｅｌ Ｂｅｌｇｉｕｍ ＮＶ | 開封防止剤形 |
| JP2018535709A (ja) * | 2015-11-16 | 2018-12-06 | カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップＣａｐｓｕｇｅｌ Ｂｅｌｇｉｕｍ ＮＶ | 開封防止剤形 |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59105455A (ja) * | 1982-11-23 | 1984-06-18 | ワ−ナ−・ランバ−ト・カンパニ− | カプセルを封止するための装置及び方法 |
| IE58468B1 (en) * | 1984-10-25 | 1993-09-22 | Warner Lambert Co | Method for sealing capsules and capsule |
| GB2172570B (en) * | 1985-03-21 | 1989-06-21 | Warner Lambert Co | Hard gelatin capsules. |
| CN1003578B (zh) * | 1984-10-25 | 1989-03-15 | 沃纳·兰伯特公司 | 改进的胶囊形状 |
| CH674800A5 (enExample) * | 1986-03-12 | 1990-07-31 | Warner Lambert Co | |
| CA1308357C (en) * | 1987-01-28 | 1992-10-06 | Tohru Chiba | Method for the preparation of a coated solid medicament |
| US4724019A (en) * | 1987-03-20 | 1988-02-09 | Warner-Lambert Company | Method and apparatus for sealing capsules |
| US4734149A (en) * | 1987-03-20 | 1988-03-29 | Warner-Lambert Company | Apparatus for heatsealing gelatin capsules containing a medicament |
| US4940499A (en) * | 1989-05-23 | 1990-07-10 | Warner-Lambert Company | Method and apparatus for sealing capsules containing medicaments |
| US5188688A (en) * | 1990-07-20 | 1993-02-23 | Minnesota Mining And Manufacturing Company | Method of sealing a gelatin capsule |
| GB9416902D0 (en) * | 1994-08-20 | 1994-10-12 | Scherer Corp R P | Hydrophilic controlled release device |
| EP1072245A1 (en) | 1999-07-30 | 2001-01-31 | Warner-Lambert Company | Method and apparatus for sealing capsules and capsules suitable for use in said method and apparatus |
| US6887916B2 (en) * | 2000-12-28 | 2005-05-03 | Kimberly-Clark Worldwide, Inc. | Materials having controlled shrinkage and patterns and methods of making same |
| EP1262174A1 (en) | 2001-06-01 | 2002-12-04 | Celanese Ventures GmbH | Two part hard shell capsule made of poly(1,4-alpha-D-glucane) and starch |
| WO2003016165A1 (en) | 2001-08-16 | 2003-02-27 | Warner-Lambert Company Llc | Water soluble packaging |
| CA2503510C (en) * | 2002-09-26 | 2014-12-02 | Probiohealth, Llc | Prebiotic and preservative uses of oil-emulsified probiotic encapsulations |
| US8895060B2 (en) | 2002-09-26 | 2014-11-25 | Vita-Herb Nutriceuticals, Inc. | Methods and apparatus for sealing capsules |
| EP1459725B1 (en) | 2003-03-21 | 2007-10-17 | Warner-Lambert Company LLC | Apparatus for and method of sealing capsules |
| GB2401345A (en) * | 2003-05-03 | 2004-11-10 | Reckitt Benckiser | Atomised aqueous composition sealing of water soluble members |
| US8377471B2 (en) * | 2005-08-09 | 2013-02-19 | Capsugel Belgium Nv | Container |
| US20070036830A1 (en) * | 2005-08-09 | 2007-02-15 | Stef Vanquickenborne | Container |
| US20070053972A1 (en) * | 2005-09-08 | 2007-03-08 | Cadbury Adams Usa Llc. | Gelatin capsules containing actives |
| EP1886657A1 (en) * | 2006-08-11 | 2008-02-13 | Pfizer Products Inc. | Method and apparatus for sealing capsules |
| US20080038334A1 (en) * | 2006-08-08 | 2008-02-14 | John Zazula | Method for producing and a system for cooling a hot-filled softgel capsule |
| RU2415068C2 (ru) * | 2006-10-24 | 2011-03-27 | Пфайзер Продактс Инк. | Транспортировочная линия |
| KR101170283B1 (ko) | 2006-10-27 | 2012-07-31 | 화이자 프로덕츠 인코포레이티드 | 하이드록시프로필 메틸 셀룰로스 경질 캡슐 및 이의 제조 방법 |
| ES2602571T3 (es) | 2007-02-15 | 2017-02-21 | Qualicaps Co., Ltd. | Elemento de sellado en banda para cápsulas duras que presentan PEG encapsulado en las mismas |
| PT103765A (pt) * | 2007-06-20 | 2008-12-22 | Inst Superior Tecnico | Síntese e aplicação de uma família de novos materiais resultantes do cruzamento entre gelatina e sais orgânicos |
| US8810259B2 (en) | 2009-11-13 | 2014-08-19 | Capsugel Belgium Nv | Method of inspection of sealed capsules with a process of determination of the quality of the seal and related equipment for in-line inspection |
| WO2012028702A1 (de) | 2010-09-02 | 2012-03-08 | Innogel Ag | Hartkapsel auf stärkebasis sowie tauchbeschichtungszusammensetzung, tauchbad und verfahren zur herstellung derselben |
| CN101953816B (zh) * | 2010-09-08 | 2015-01-07 | 浙江昂利康胶囊有限公司 | 药用空心胶囊、制备方法及其制造设备 |
| EP2720686A4 (en) * | 2011-06-15 | 2014-12-17 | Orient Pharma Co Ltd | MULTILAYER CAPSULE AND MANUFACTURING METHOD THEREFOR |
| MX363958B (es) * | 2011-10-06 | 2019-04-09 | Combocap Inc | Un metodo y aparato para fabricar una capsula. |
| CA2870033C (en) | 2012-05-02 | 2017-04-18 | Capsugel France SAS | Aqueous dispersions of controlled release polymers and shells and capsules thereof |
| WO2014197415A1 (en) | 2013-06-04 | 2014-12-11 | Monosol Llc | Water-soluble film sealing solutions, related methods, and related articles |
| US20160256399A1 (en) | 2013-11-04 | 2016-09-08 | Capsugel Belgium Nv | Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole |
| KR101706725B1 (ko) * | 2015-06-12 | 2017-02-16 | 주식회사 세종파마텍 | 정제 코팅 스프레이건 어셈블리 |
| CN106619128B (zh) * | 2015-11-04 | 2019-12-06 | 曹荣华 | 胶囊的封存组合物及其封存方法 |
| EP3167870B1 (en) * | 2015-11-16 | 2024-01-03 | Capsugel Belgium NV | Tamperproof oral dosage form |
| EP3167869B1 (en) * | 2015-11-16 | 2025-02-12 | Capsugel Belgium NV | Tamperproof oral dosage form |
| EP3199148B1 (en) | 2016-01-28 | 2020-12-02 | Capsugel Belgium NV | Compositions and resulting hard capsules comprising hydrophilic coloring foodstuff concentrates |
| EP3219300B1 (en) | 2016-03-15 | 2019-06-19 | Capsugel Belgium NV | Aseptic hard capsule sealing apparatus and methods |
| EP3272340A1 (en) | 2016-07-22 | 2018-01-24 | Capsugel Belgium NV | Acid resistant capsules |
| IL266695B (en) * | 2016-12-08 | 2022-09-01 | Scherer Technologies Llc R P | A method of damping stress in capsule shells to reduce the tendency to break |
| CA3059527A1 (en) | 2017-04-14 | 2018-10-18 | Capsugel Belgium Nv | Pullulan capsules |
| CN107157949B (zh) * | 2017-06-09 | 2021-01-15 | 厦门普罗康客科技有限公司 | 硬胶囊内部封口的方法及其应用 |
| EP3607931B1 (de) * | 2018-08-07 | 2023-03-29 | Harro Höfliger Verpackungsmaschinen GmbH | Kapselverschliesseinrichtung zum verschliessen zweiteiliger kapseln |
| WO2020230151A1 (en) * | 2019-05-15 | 2020-11-19 | Scitech Centre | Capsule sealing system and method therefor |
| EP4196073B1 (en) | 2020-10-02 | 2023-11-29 | Capsugel Belgium NV | Device for dispensing single droplets into a cap or body of a capsule |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5459312A (en) * | 1977-10-13 | 1979-05-12 | Chukyo Electric Co | Closing of hard capsule |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB617723A (en) * | 1945-10-31 | 1949-02-10 | Alfonso Mario Donofrio | Capsules and methods of manufacturing them |
| US2738827A (en) * | 1953-06-23 | 1956-03-20 | Edward R Dayton | Capsule sealing and marking apparatus |
| US3071513A (en) * | 1959-11-23 | 1963-01-01 | Upjohn Co | Process for sealing capsules |
| NL256671A (enExample) * | 1960-10-08 | 1965-02-15 | ||
| US3164508A (en) * | 1961-10-19 | 1965-01-05 | Ncr Co | Method for bonding plastic materials of the thermoplastic type |
| US3073087A (en) * | 1962-01-25 | 1963-01-15 | American Cyanamid Co | Method of sealing hard shell capsules |
| US3159546A (en) * | 1962-10-12 | 1964-12-01 | F G Okie Inc | Capsule sealing composition |
| US3394983A (en) * | 1963-06-14 | 1968-07-30 | American Cyanamid Co | Dip-dyeing capsules |
| US3466842A (en) * | 1967-05-10 | 1969-09-16 | Smithkline Corp | Machine for treating capsules |
| BE792903A (nl) * | 1971-12-30 | 1973-06-18 | American Can Co | Laserstraal-lassen van kunststoffen buizen |
| US3727022A (en) * | 1972-07-17 | 1973-04-10 | Procter & Gamble | Electromagnetic heating and sealing |
| GB1478759A (en) * | 1974-11-18 | 1977-07-06 | Alza Corp | Process for forming outlet passageways in pills using a laser |
| US4281763A (en) * | 1979-10-31 | 1981-08-04 | Pace Joseph A | Two-piece hardshell, soluble and digestible liquid containing gelatin capsule |
-
1983
- 1983-02-18 US US06/468,022 patent/US4539060A/en not_active Ceased
- 1983-09-13 EP EP83305330A patent/EP0116743B1/en not_active Expired
- 1983-09-13 AT AT83305330T patent/ATE33346T1/de not_active IP Right Cessation
- 1983-09-13 DE DE8383305330T patent/DE3376197D1/de not_active Expired
- 1983-09-15 IN IN639/DEL/83A patent/IN160442B/en unknown
- 1983-09-29 AU AU19773/83A patent/AU559678B2/en not_active Ceased
- 1983-10-04 ES ES526230A patent/ES8501976A1/es not_active Expired
- 1983-10-11 CA CA000438716A patent/CA1255271A/en not_active Expired
- 1983-10-14 KR KR1019830004869A patent/KR890000206B1/ko not_active Expired
- 1983-10-17 SU SU833655358A patent/SU1393309A3/ru active
- 1983-10-27 JP JP58200103A patent/JPS59156349A/ja active Granted
- 1983-11-04 YU YU2195/83A patent/YU44447B/xx unknown
- 1983-11-11 BR BR8306208A patent/BR8306208A/pt not_active IP Right Cessation
- 1983-11-28 PH PH29897A patent/PH20191A/en unknown
- 1983-11-30 IE IE2820/83A patent/IE56363B1/en not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5459312A (en) * | 1977-10-13 | 1979-05-12 | Chukyo Electric Co | Closing of hard capsule |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS602251A (ja) * | 1983-05-23 | 1985-01-08 | カプセルボンド・インコ−ポレイテツド | カプセルの接合方法 |
| JPS6024845A (ja) * | 1983-06-13 | 1985-02-07 | カプセルボンド・インコ−ポレイテツド | カプセルの接合装置 |
| JPS60176656A (ja) * | 1984-02-22 | 1985-09-10 | ワ−ナ−・ランバ−ト・カンパニ− | カプセルを封止するための装置および方法 |
| JP2018535708A (ja) * | 2015-11-16 | 2018-12-06 | カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップＣａｐｓｕｇｅｌ Ｂｅｌｇｉｕｍ ＮＶ | 開封防止剤形 |
| JP2018535709A (ja) * | 2015-11-16 | 2018-12-06 | カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップＣａｐｓｕｇｅｌ Ｂｅｌｇｉｕｍ ＮＶ | 開封防止剤形 |
Also Published As
| Publication number | Publication date |
|---|---|
| YU44447B (en) | 1990-08-31 |
| PH20191A (en) | 1986-10-16 |
| CA1255271A (en) | 1989-06-06 |
| YU219583A (en) | 1986-02-28 |
| DE3376197D1 (en) | 1988-05-11 |
| EP0116743B1 (en) | 1988-04-06 |
| AU1977383A (en) | 1984-08-23 |
| SU1393309A3 (ru) | 1988-04-30 |
| IE56363B1 (en) | 1991-07-03 |
| BR8306208A (pt) | 1984-11-13 |
| KR840007664A (ko) | 1984-12-20 |
| JPH0140627B2 (enExample) | 1989-08-30 |
| US4539060A (en) | 1985-09-03 |
| IE832820L (en) | 1984-08-18 |
| ES526230A0 (es) | 1984-12-16 |
| ES8501976A1 (es) | 1984-12-16 |
| ATE33346T1 (de) | 1988-04-15 |
| AU559678B2 (en) | 1987-03-19 |
| EP0116743A1 (en) | 1984-08-29 |
| IN160442B (enExample) | 1987-07-11 |
| KR890000206B1 (ko) | 1989-03-10 |
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