CA1255271A - Apparatus and method for sealing capsules - Google Patents
Apparatus and method for sealing capsulesInfo
- Publication number
- CA1255271A CA1255271A CA000438716A CA438716A CA1255271A CA 1255271 A CA1255271 A CA 1255271A CA 000438716 A CA000438716 A CA 000438716A CA 438716 A CA438716 A CA 438716A CA 1255271 A CA1255271 A CA 1255271A
- Authority
- CA
- Canada
- Prior art keywords
- gelatin
- capsule
- sealing
- sealing fluid
- capsules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 186
- 238000007789 sealing Methods 0.000 title claims abstract description 135
- 238000000034 method Methods 0.000 title claims abstract description 24
- 239000012530 fluid Substances 0.000 claims abstract description 115
- 239000007903 gelatin capsule Substances 0.000 claims abstract description 24
- 108010010803 Gelatin Proteins 0.000 claims description 51
- 239000008273 gelatin Substances 0.000 claims description 51
- 229920000159 gelatin Polymers 0.000 claims description 51
- 235000019322 gelatine Nutrition 0.000 claims description 51
- 235000011852 gelatine desserts Nutrition 0.000 claims description 51
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 238000002844 melting Methods 0.000 claims description 22
- 230000008018 melting Effects 0.000 claims description 22
- 238000010438 heat treatment Methods 0.000 claims description 12
- 239000000243 solution Substances 0.000 claims description 12
- 238000005507 spraying Methods 0.000 claims description 11
- 239000003960 organic solvent Substances 0.000 claims description 10
- 229920000642 polymer Polymers 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 238000007598 dipping method Methods 0.000 claims description 9
- 230000009477 glass transition Effects 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 6
- 239000000839 emulsion Substances 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 150000007513 acids Chemical class 0.000 claims description 4
- 230000009471 action Effects 0.000 claims description 4
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- 239000000463 material Substances 0.000 description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 11
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 11
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- 230000000694 effects Effects 0.000 description 8
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- 229910052751 metal Inorganic materials 0.000 description 7
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
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- 230000015572 biosynthetic process Effects 0.000 description 5
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- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
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- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
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- 239000007789 gas Substances 0.000 description 3
- 238000005304 joining Methods 0.000 description 3
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- 235000004977 Brassica sinapistrum Nutrition 0.000 description 2
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- NIQCNGHVCWTJSM-UHFFFAOYSA-N Dimethyl phthalate Chemical compound COC(=O)C1=CC=CC=C1C(=O)OC NIQCNGHVCWTJSM-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
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- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 2
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 2
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- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
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Classifications
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- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4883—Capsule finishing, e.g. dyeing, aromatising, polishing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
- B29C65/4895—Solvent bonding, i.e. the surfaces of the parts to be joined being treated with solvents, swelling or softening agents, without adhesives
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/01—General aspects dealing with the joint area or with the area to be joined
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
- B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
- B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
- B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
- B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
- B29C66/542—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles joining hollow covers or hollow bottoms to open ends of container bodies
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- A61G2203/00—General characteristics of devices
- A61G2203/30—General characteristics of devices characterised by sensor means
- A61G2203/46—General characteristics of devices characterised by sensor means for temperature
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
- B29C65/52—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive
- B29C65/54—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive between pre-assembled parts
- B29C65/548—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive between pre-assembled parts by capillarity
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
- B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/712—Containers; Packaging elements or accessories, Packages
- B29L2031/7174—Capsules
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S220/00—Receptacles
- Y10S220/34—Anti-tamper pharmaceutical capsules, e.g. tamper indicating or resistant
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/17—Surface bonding means and/or assemblymeans with work feeding or handling means
- Y10T156/1798—Surface bonding means and/or assemblymeans with work feeding or handling means with liquid adhesive or adhesive activator applying means
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
- Closing Of Containers (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Formation And Processing Of Food Products (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000501422A CA1219214A (en) | 1983-02-18 | 1986-02-07 | Sealed capsule |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US468,022 | 1983-02-18 | ||
| US06/468,022 US4539060A (en) | 1983-02-18 | 1983-02-18 | Apparatus and method of sealing capsules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000501422A Division CA1219214A (en) | 1983-02-18 | 1986-02-07 | Sealed capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1255271A true CA1255271A (en) | 1989-06-06 |
Family
ID=23858126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000438716A Expired CA1255271A (en) | 1983-02-18 | 1983-10-11 | Apparatus and method for sealing capsules |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4539060A (enExample) |
| EP (1) | EP0116743B1 (enExample) |
| JP (1) | JPS59156349A (enExample) |
| KR (1) | KR890000206B1 (enExample) |
| AT (1) | ATE33346T1 (enExample) |
| AU (1) | AU559678B2 (enExample) |
| BR (1) | BR8306208A (enExample) |
| CA (1) | CA1255271A (enExample) |
| DE (1) | DE3376197D1 (enExample) |
| ES (1) | ES526230A0 (enExample) |
| IE (1) | IE56363B1 (enExample) |
| IN (1) | IN160442B (enExample) |
| PH (1) | PH20191A (enExample) |
| SU (1) | SU1393309A3 (enExample) |
| YU (1) | YU44447B (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59105455A (ja) * | 1982-11-23 | 1984-06-18 | ワ−ナ−・ランバ−ト・カンパニ− | カプセルを封止するための装置及び方法 |
| US4656066A (en) * | 1982-12-20 | 1987-04-07 | Warner-Lambert Company | Apparatus and method for sealing capsules |
| US4820364A (en) * | 1983-05-23 | 1989-04-11 | Capsulbond Incorporated | Method for sealing capsules |
| DE3469408D1 (en) * | 1983-06-13 | 1988-03-31 | Capsulbond Inc | Apparatus for sealing capsules |
| GB2172570B (en) * | 1985-03-21 | 1989-06-21 | Warner Lambert Co | Hard gelatin capsules. |
| CN1003578B (zh) * | 1984-10-25 | 1989-03-15 | 沃纳·兰伯特公司 | 改进的胶囊形状 |
| IE58468B1 (en) * | 1984-10-25 | 1993-09-22 | Warner Lambert Co | Method for sealing capsules and capsule |
| CH674800A5 (enExample) * | 1986-03-12 | 1990-07-31 | Warner Lambert Co | |
| CA1308357C (en) * | 1987-01-28 | 1992-10-06 | Tohru Chiba | Method for the preparation of a coated solid medicament |
| US4724019A (en) * | 1987-03-20 | 1988-02-09 | Warner-Lambert Company | Method and apparatus for sealing capsules |
| US4734149A (en) * | 1987-03-20 | 1988-03-29 | Warner-Lambert Company | Apparatus for heatsealing gelatin capsules containing a medicament |
| US4940499A (en) * | 1989-05-23 | 1990-07-10 | Warner-Lambert Company | Method and apparatus for sealing capsules containing medicaments |
| US5188688A (en) * | 1990-07-20 | 1993-02-23 | Minnesota Mining And Manufacturing Company | Method of sealing a gelatin capsule |
| GB9416902D0 (en) * | 1994-08-20 | 1994-10-12 | Scherer Corp R P | Hydrophilic controlled release device |
| EP1072245A1 (en) | 1999-07-30 | 2001-01-31 | Warner-Lambert Company | Method and apparatus for sealing capsules and capsules suitable for use in said method and apparatus |
| US6887916B2 (en) * | 2000-12-28 | 2005-05-03 | Kimberly-Clark Worldwide, Inc. | Materials having controlled shrinkage and patterns and methods of making same |
| EP1262174A1 (en) | 2001-06-01 | 2002-12-04 | Celanese Ventures GmbH | Two part hard shell capsule made of poly(1,4-alpha-D-glucane) and starch |
| DE60223691T3 (de) | 2001-08-16 | 2012-07-19 | Capsugel Belgium Nv | Wasserlösliche verpackung |
| US8895060B2 (en) | 2002-09-26 | 2014-11-25 | Vita-Herb Nutriceuticals, Inc. | Methods and apparatus for sealing capsules |
| JP2006501281A (ja) * | 2002-09-26 | 2006-01-12 | プロバイオヘルス・エルエルシー | 油乳化プロバイオティックカプセル封入物のプレバイオティックおよび保存的使用 |
| EP1459725B1 (en) | 2003-03-21 | 2007-10-17 | Warner-Lambert Company LLC | Apparatus for and method of sealing capsules |
| GB2401345A (en) * | 2003-05-03 | 2004-11-10 | Reckitt Benckiser | Atomised aqueous composition sealing of water soluble members |
| US20070036830A1 (en) * | 2005-08-09 | 2007-02-15 | Stef Vanquickenborne | Container |
| US8377471B2 (en) * | 2005-08-09 | 2013-02-19 | Capsugel Belgium Nv | Container |
| US20070053972A1 (en) * | 2005-09-08 | 2007-03-08 | Cadbury Adams Usa Llc. | Gelatin capsules containing actives |
| EP1886657A1 (en) * | 2006-08-11 | 2008-02-13 | Pfizer Products Inc. | Method and apparatus for sealing capsules |
| US20080038334A1 (en) * | 2006-08-08 | 2008-02-14 | John Zazula | Method for producing and a system for cooling a hot-filled softgel capsule |
| US8671650B2 (en) | 2006-10-24 | 2014-03-18 | Capsugel Belgium Nv | Transfer line |
| CN101595133B (zh) | 2006-10-27 | 2012-11-14 | 比利时胶囊公司 | 羟丙基甲基纤维素硬胶囊及制备方法 |
| JP5489471B2 (ja) * | 2007-02-15 | 2014-05-14 | クオリカプス株式会社 | Ｐｅｇ充填硬質カプセル剤のバンドシール |
| PT103765A (pt) * | 2007-06-20 | 2008-12-22 | Inst Superior Tecnico | Síntese e aplicação de uma família de novos materiais resultantes do cruzamento entre gelatina e sais orgânicos |
| EA201290317A1 (ru) | 2009-11-13 | 2012-10-30 | Кэпсьюджел Белджиум Нв | Способ контроля герметичных капсул с использованием процесса определения качества герметичности, а также соответствующее оборудование для контроля на производственной линии |
| WO2012028702A1 (de) | 2010-09-02 | 2012-03-08 | Innogel Ag | Hartkapsel auf stärkebasis sowie tauchbeschichtungszusammensetzung, tauchbad und verfahren zur herstellung derselben |
| CN101953816B (zh) * | 2010-09-08 | 2015-01-07 | 浙江昂利康胶囊有限公司 | 药用空心胶囊、制备方法及其制造设备 |
| KR101793771B1 (ko) * | 2011-06-15 | 2017-11-03 | 오리엔트 파마 컴퍼니 리미티드 | 다층 캡슐 및 이의 제조 방법 |
| CN103987357B (zh) * | 2011-10-06 | 2017-12-12 | 康宝卡普股份有限公司 | 胶囊的制造方法和装置 |
| EP3446713A3 (en) | 2012-05-02 | 2019-05-15 | Capsugel Belgium NV | Aqueous dispersions of controlled release polymers and shells and capsules thereof |
| CN105377965B (zh) | 2013-06-04 | 2019-05-10 | 蒙诺苏尔有限公司 | 水溶性膜密封溶液、相关方法和相关物品 |
| US20160256399A1 (en) | 2013-11-04 | 2016-09-08 | Capsugel Belgium Nv | Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole |
| KR101706725B1 (ko) * | 2015-06-12 | 2017-02-16 | 주식회사 세종파마텍 | 정제 코팅 스프레이건 어셈블리 |
| CN106619128B (zh) * | 2015-11-04 | 2019-12-06 | 曹荣华 | 胶囊的封存组合物及其封存方法 |
| EP3167869B1 (en) * | 2015-11-16 | 2025-02-12 | Capsugel Belgium NV | Tamperproof oral dosage form |
| EP3167868A1 (en) * | 2015-11-16 | 2017-05-17 | Capsugel Belgium NV | Tamperproof dosage form |
| EP3167870B1 (en) * | 2015-11-16 | 2024-01-03 | Capsugel Belgium NV | Tamperproof oral dosage form |
| EP3167867A1 (en) * | 2015-11-16 | 2017-05-17 | Capsugel Belgium NV | Tamperproof dosage form |
| ES2845688T3 (es) | 2016-01-28 | 2021-07-27 | Capsugel Belgium Nv | Composiciones y cápsulas duras resultantes que comprenden concentrados alimentarios colorantes hidrófilos |
| EP3219300B1 (en) | 2016-03-15 | 2019-06-19 | Capsugel Belgium NV | Aseptic hard capsule sealing apparatus and methods |
| EP3272340A1 (en) | 2016-07-22 | 2018-01-24 | Capsugel Belgium NV | Acid resistant capsules |
| AU2017371180B2 (en) * | 2016-12-08 | 2023-05-11 | R.P. Scherer Technologies, Llc | A method to relieve stress in capsule shells to reduce propensity to break |
| CN110678170A (zh) | 2017-04-14 | 2020-01-10 | 比利时胶囊公司 | 普鲁兰多糖胶囊 |
| CN107157949B (zh) * | 2017-06-09 | 2021-01-15 | 厦门普罗康客科技有限公司 | 硬胶囊内部封口的方法及其应用 |
| EP3607931B1 (de) * | 2018-08-07 | 2023-03-29 | Harro Höfliger Verpackungsmaschinen GmbH | Kapselverschliesseinrichtung zum verschliessen zweiteiliger kapseln |
| US12138227B2 (en) * | 2019-05-15 | 2024-11-12 | ACG PAM Pharma Technologies Pvt. Ltd. | Capsule sealing system and method therefor |
| JP7756156B2 (ja) | 2020-10-02 | 2025-10-17 | キャプシュゲル・ベルジウム・エヌ・ヴィ | 単一液滴をカプセルのキャップ又は本体に吐出するための装置 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB617723A (en) * | 1945-10-31 | 1949-02-10 | Alfonso Mario Donofrio | Capsules and methods of manufacturing them |
| US2738827A (en) * | 1953-06-23 | 1956-03-20 | Edward R Dayton | Capsule sealing and marking apparatus |
| US3071513A (en) * | 1959-11-23 | 1963-01-01 | Upjohn Co | Process for sealing capsules |
| NL256671A (enExample) * | 1960-10-08 | 1965-02-15 | ||
| US3164508A (en) * | 1961-10-19 | 1965-01-05 | Ncr Co | Method for bonding plastic materials of the thermoplastic type |
| US3073087A (en) * | 1962-01-25 | 1963-01-15 | American Cyanamid Co | Method of sealing hard shell capsules |
| US3159546A (en) * | 1962-10-12 | 1964-12-01 | F G Okie Inc | Capsule sealing composition |
| US3394983A (en) * | 1963-06-14 | 1968-07-30 | American Cyanamid Co | Dip-dyeing capsules |
| US3466842A (en) * | 1967-05-10 | 1969-09-16 | Smithkline Corp | Machine for treating capsules |
| BE792903A (nl) * | 1971-12-30 | 1973-06-18 | American Can Co | Laserstraal-lassen van kunststoffen buizen |
| US3727022A (en) * | 1972-07-17 | 1973-04-10 | Procter & Gamble | Electromagnetic heating and sealing |
| GB1478759A (en) * | 1974-11-18 | 1977-07-06 | Alza Corp | Process for forming outlet passageways in pills using a laser |
| JPS5459312A (en) * | 1977-10-13 | 1979-05-12 | Chukyo Electric Co | Closing of hard capsule |
| US4281763A (en) * | 1979-10-31 | 1981-08-04 | Pace Joseph A | Two-piece hardshell, soluble and digestible liquid containing gelatin capsule |
-
1983
- 1983-02-18 US US06/468,022 patent/US4539060A/en not_active Ceased
- 1983-09-13 DE DE8383305330T patent/DE3376197D1/de not_active Expired
- 1983-09-13 AT AT83305330T patent/ATE33346T1/de not_active IP Right Cessation
- 1983-09-13 EP EP83305330A patent/EP0116743B1/en not_active Expired
- 1983-09-15 IN IN639/DEL/83A patent/IN160442B/en unknown
- 1983-09-29 AU AU19773/83A patent/AU559678B2/en not_active Ceased
- 1983-10-04 ES ES526230A patent/ES526230A0/es active Granted
- 1983-10-11 CA CA000438716A patent/CA1255271A/en not_active Expired
- 1983-10-14 KR KR1019830004869A patent/KR890000206B1/ko not_active Expired
- 1983-10-17 SU SU833655358A patent/SU1393309A3/ru active
- 1983-10-27 JP JP58200103A patent/JPS59156349A/ja active Granted
- 1983-11-04 YU YU2195/83A patent/YU44447B/xx unknown
- 1983-11-11 BR BR8306208A patent/BR8306208A/pt not_active IP Right Cessation
- 1983-11-28 PH PH29897A patent/PH20191A/en unknown
- 1983-11-30 IE IE2820/83A patent/IE56363B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU559678B2 (en) | 1987-03-19 |
| KR890000206B1 (ko) | 1989-03-10 |
| ES8501976A1 (es) | 1984-12-16 |
| BR8306208A (pt) | 1984-11-13 |
| SU1393309A3 (ru) | 1988-04-30 |
| IE832820L (en) | 1984-08-18 |
| IE56363B1 (en) | 1991-07-03 |
| EP0116743B1 (en) | 1988-04-06 |
| YU44447B (en) | 1990-08-31 |
| DE3376197D1 (en) | 1988-05-11 |
| ATE33346T1 (de) | 1988-04-15 |
| YU219583A (en) | 1986-02-28 |
| EP0116743A1 (en) | 1984-08-29 |
| JPH0140627B2 (enExample) | 1989-08-30 |
| ES526230A0 (es) | 1984-12-16 |
| JPS59156349A (ja) | 1984-09-05 |
| US4539060A (en) | 1985-09-03 |
| KR840007664A (ko) | 1984-12-20 |
| AU1977383A (en) | 1984-08-23 |
| PH20191A (en) | 1986-10-16 |
| IN160442B (enExample) | 1987-07-11 |
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| MKEX | Expiry |