JPS59118787A - スピロ結合三環複素環化合物のラセミ体の製造方法 - Google Patents

スピロ結合三環複素環化合物のラセミ体の製造方法

Info

Publication number
JPS59118787A
JPS59118787A JP58239004A JP23900483A JPS59118787A JP S59118787 A JPS59118787 A JP S59118787A JP 58239004 A JP58239004 A JP 58239004A JP 23900483 A JP23900483 A JP 23900483A JP S59118787 A JPS59118787 A JP S59118787A
Authority
JP
Japan
Prior art keywords
group
compound
formula
enantiomer
optical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP58239004A
Other languages
English (en)
Japanese (ja)
Inventor
ジヨフリ−・ロバ−ト・ベドフオ−ド
デイヴイツド・ロバ−ト・ブリツテイン
ロナルド・プラツト
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of JPS59118787A publication Critical patent/JPS59118787A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
  • Storage Of Web-Like Or Filamentary Materials (AREA)
  • Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
  • Indole Compounds (AREA)
JP58239004A 1982-12-20 1983-12-20 スピロ結合三環複素環化合物のラセミ体の製造方法 Pending JPS59118787A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8236969 1982-12-20
GB8236969 1982-12-20

Publications (1)

Publication Number Publication Date
JPS59118787A true JPS59118787A (ja) 1984-07-09

Family

ID=10535286

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58239004A Pending JPS59118787A (ja) 1982-12-20 1983-12-20 スピロ結合三環複素環化合物のラセミ体の製造方法

Country Status (21)

Country Link
EP (1) EP0115679B1 (https=)
JP (1) JPS59118787A (https=)
KR (1) KR840007407A (https=)
AT (1) ATE30233T1 (https=)
AU (1) AU567312B2 (https=)
CA (1) CA1209148A (https=)
CS (1) CS240986B2 (https=)
DD (1) DD216935A5 (https=)
DE (1) DE3374060D1 (https=)
DK (1) DK579283A (https=)
ES (1) ES8600298A1 (https=)
FI (1) FI834637A7 (https=)
GB (1) GB8331194D0 (https=)
GR (1) GR79707B (https=)
HU (1) HU189824B (https=)
IE (1) IE56288B1 (https=)
NO (1) NO834687L (https=)
NZ (1) NZ206619A (https=)
PL (1) PL245203A1 (https=)
PT (1) PT77848B (https=)
ZA (1) ZA838930B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009526044A (ja) * 2006-02-07 2009-07-16 アストラゼネカ・アクチエボラーグ 新規な化合物ｉ

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8415635D0 (en) * 1984-06-19 1984-07-25 Ici Plc Cyclic amides
TW200801011A (en) 2006-02-07 2008-01-01 Astrazeneca Ab New compounds II

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3024231A (en) * 1959-02-11 1962-03-06 Spencer Chem Co Racemization of d- and l-isomers of alpha-amino-epsilon-carprolactam
GB1569486A (en) * 1976-12-22 1980-06-18 Merck & Co Inc Racemisationof 6-oxo-2-piperidine-carboxylic acid entantiomers
AU532110B2 (en) * 1979-11-13 1983-09-15 Ici Ltd. Spiro(imidazolidine-4,3:-indoline)-2,2:5-trione derivatives
IE53102B1 (en) * 1981-05-12 1988-06-22 Ici Plc Pharmaceutical spiro-succinimide derivatives
GB8312379D0 (en) * 1983-05-05 1983-06-08 Ici Plc Heterocyclic compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009526044A (ja) * 2006-02-07 2009-07-16 アストラゼネカ・アクチエボラーグ 新規な化合物ｉ

Also Published As

Publication number Publication date
PL245203A1 (en) 1985-03-12
GB8331194D0 (en) 1983-12-29
NZ206619A (en) 1986-09-10
HU189824B (en) 1986-08-28
ZA838930B (en) 1985-04-24
DD216935A5 (de) 1985-01-02
ES528173A0 (es) 1985-10-01
IE832808L (en) 1984-06-20
CA1209148A (en) 1986-08-05
EP0115679B1 (en) 1987-10-14
CS240986B2 (en) 1986-03-13
KR840007407A (ko) 1984-12-07
ATE30233T1 (de) 1987-10-15
DK579283D0 (da) 1983-12-15
DK579283A (da) 1984-06-21
FI834637A7 (fi) 1984-06-21
CS961283A2 (en) 1985-06-13
AU2185283A (en) 1984-06-28
EP0115679A1 (en) 1984-08-15
AU567312B2 (en) 1987-11-19
IE56288B1 (en) 1991-06-05
FI834637A0 (fi) 1983-12-16
PT77848A (en) 1984-01-01
GR79707B (https=) 1984-10-31
DE3374060D1 (en) 1987-11-19
PT77848B (en) 1986-07-11
ES8600298A1 (es) 1985-10-01
NO834687L (no) 1984-06-21

Similar Documents

Publication Publication Date Title
US4113731A (en) Fused isoquinoline derivatives
IE49170B1 (en) Analgesic 6-acylaminotetrahydro-1,3,5-triazine-2,4-dione derivatives,pharmaceutical compositions thereof,and process for their manufacture
SU862824A3 (ru) Способ получени фенилгидразинопиридазинов
SG175829A1 (en) Process for the preparation of [4-(2-chloro-4-methoxy-5-methylphenyl)-5-methyl-thiazolo-2-yl]-[2-cyclopropyl-1-(3-fluoro-4-methylphenyl)-ethyl]-amine
Dandia et al. Microwave assisted one pot synthesis of a series of trifluoromethyl substituted spiro [indole–triazoles]
SU474981A3 (ru) Способ получени 9(1-замещенный-4пиперидилиден)-тиоксантенов или их солей
JPS59118787A (ja) スピロ結合三環複素環化合物のラセミ体の製造方法
JPS60105680A (ja) 塩基性基によつて置換されたフルオラン化合物の製造方法
Michels et al. Chemotherapeutic Nitrofurans. IV. 1 Some Derivatives of 1-Amino-2-imidazolidinone, 1-Amino-2-pyrrolidinone and 3-Amino-2-thiazolidinone
US2650226A (en) Furo and thieno quinaldines and process for making same
US3534092A (en) Dispiropyran compounds having photochromic properties
Bakke et al. Substitution reactions of 5-nitropyridine-2-sulfonic acid. A new pathway to 2, 5-disubstituted pyridines
RU2295521C2 (ru) Фотохромные оксазиновые соединения и способы их производства
CN104140430B (zh) 一种异构体的消旋方法
US4611062A (en) Process for resolving certain spiro compounds
US4567278A (en) Process for racemizing certain spiro compounds
RU2425047C1 (ru) Способ получения замещенных 4-гидрокси-3-оксо-3,4-дигидро-2н-1,4-бензоксазин-6,7-дикарбонитрилов на основе 4-бром-5-нитрофталонитрила
JP4693261B2 (ja) ５−置換オキサゾール化合物の製造方法
US10807962B2 (en) Process for the synthesis of firocoxib
Sarbu et al. Synthesis of 2-Pyrrolydinyl-1, 3-Dithiolium Derivatives from Propiophenones
US2003596A (en) Producing azanthragene derivatives
SU1154281A1 (ru) 10-Алкилхиндолины в качестве промежуточных продуктов дл получени сенсибилизаторов электрофотографических слоев на основе поли- @ -эпоксипропилкарбазола и способ их получени
SU786886A3 (ru) Способ получени производных 2,6-динитроанилина
Samarov et al. Reactions of Quinazoline Alkaloids and their Derivatives with Electrophilic Reagents
SU973533A1 (ru) Способ получени 3-арил-5-алкил(арил) азо- @ -изоксазолинов