NZ206619A - Production of spiro-linked tricyclic heterocyclic compounds - Google Patents

Production of spiro-linked tricyclic heterocyclic compounds

Info

Publication number
NZ206619A
NZ206619A NZ206619A NZ20661983A NZ206619A NZ 206619 A NZ206619 A NZ 206619A NZ 206619 A NZ206619 A NZ 206619A NZ 20661983 A NZ20661983 A NZ 20661983A NZ 206619 A NZ206619 A NZ 206619A
Authority
NZ
New Zealand
Prior art keywords
compound
mixture
process according
formula
benzyl
Prior art date
Application number
NZ206619A
Other languages
English (en)
Inventor
G R Bedford
D R Brittain
R Platt
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Plc filed Critical Ici Plc
Publication of NZ206619A publication Critical patent/NZ206619A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/38Oxygen atoms in positions 2 and 3, e.g. isatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
  • Storage Of Web-Like Or Filamentary Materials (AREA)
  • Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
  • Indole Compounds (AREA)
NZ206619A 1982-12-20 1983-12-19 Production of spiro-linked tricyclic heterocyclic compounds NZ206619A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8236969 1982-12-20

Publications (1)

Publication Number Publication Date
NZ206619A true NZ206619A (en) 1986-09-10

Family

ID=10535286

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ206619A NZ206619A (en) 1982-12-20 1983-12-19 Production of spiro-linked tricyclic heterocyclic compounds

Country Status (21)

Country Link
EP (1) EP0115679B1 (https=)
JP (1) JPS59118787A (https=)
KR (1) KR840007407A (https=)
AT (1) ATE30233T1 (https=)
AU (1) AU567312B2 (https=)
CA (1) CA1209148A (https=)
CS (1) CS240986B2 (https=)
DD (1) DD216935A5 (https=)
DE (1) DE3374060D1 (https=)
DK (1) DK579283A (https=)
ES (1) ES8600298A1 (https=)
FI (1) FI834637A7 (https=)
GB (1) GB8331194D0 (https=)
GR (1) GR79707B (https=)
HU (1) HU189824B (https=)
IE (1) IE56288B1 (https=)
NO (1) NO834687L (https=)
NZ (1) NZ206619A (https=)
PL (1) PL245203A1 (https=)
PT (1) PT77848B (https=)
ZA (1) ZA838930B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8415635D0 (en) * 1984-06-19 1984-07-25 Ici Plc Cyclic amides
CN101415713A (zh) * 2006-02-07 2009-04-22 阿斯利康(瑞典)有限公司 用于治疗香草素受体1相关病症的新螺[咪唑烷-4,3’-吲哚]-2,2’,5(1’h)-三酮
TW200801011A (en) 2006-02-07 2008-01-01 Astrazeneca Ab New compounds II

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3024231A (en) * 1959-02-11 1962-03-06 Spencer Chem Co Racemization of d- and l-isomers of alpha-amino-epsilon-carprolactam
GB1569486A (en) * 1976-12-22 1980-06-18 Merck & Co Inc Racemisationof 6-oxo-2-piperidine-carboxylic acid entantiomers
AU532110B2 (en) * 1979-11-13 1983-09-15 Ici Ltd. Spiro(imidazolidine-4,3:-indoline)-2,2:5-trione derivatives
IE53102B1 (en) * 1981-05-12 1988-06-22 Ici Plc Pharmaceutical spiro-succinimide derivatives
GB8312379D0 (en) * 1983-05-05 1983-06-08 Ici Plc Heterocyclic compounds

Also Published As

Publication number Publication date
JPS59118787A (ja) 1984-07-09
PL245203A1 (en) 1985-03-12
GB8331194D0 (en) 1983-12-29
HU189824B (en) 1986-08-28
ZA838930B (en) 1985-04-24
DD216935A5 (de) 1985-01-02
ES528173A0 (es) 1985-10-01
IE832808L (en) 1984-06-20
CA1209148A (en) 1986-08-05
EP0115679B1 (en) 1987-10-14
CS240986B2 (en) 1986-03-13
KR840007407A (ko) 1984-12-07
ATE30233T1 (de) 1987-10-15
DK579283D0 (da) 1983-12-15
DK579283A (da) 1984-06-21
FI834637A7 (fi) 1984-06-21
CS961283A2 (en) 1985-06-13
AU2185283A (en) 1984-06-28
EP0115679A1 (en) 1984-08-15
AU567312B2 (en) 1987-11-19
IE56288B1 (en) 1991-06-05
FI834637A0 (fi) 1983-12-16
PT77848A (en) 1984-01-01
GR79707B (https=) 1984-10-31
DE3374060D1 (en) 1987-11-19
PT77848B (en) 1986-07-11
ES8600298A1 (es) 1985-10-01
NO834687L (no) 1984-06-21

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