JPS5911589B2 - ベンゾジアゼピン誘導体の製造法 - Google Patents

ベンゾジアゼピン誘導体の製造法

Info

Publication number
JPS5911589B2
JPS5911589B2 JP48093220A JP9322073A JPS5911589B2 JP S5911589 B2 JPS5911589 B2 JP S5911589B2 JP 48093220 A JP48093220 A JP 48093220A JP 9322073 A JP9322073 A JP 9322073A JP S5911589 B2 JPS5911589 B2 JP S5911589B2
Authority
JP
Japan
Prior art keywords
ammonia
formula
hexamethylenetetramine
reaction
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP48093220A
Other languages
English (en)
Japanese (ja)
Other versions
JPS4956992A (fr
Inventor
オズワルド チエ−ス ジヨ−ジ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JPS4956992A publication Critical patent/JPS4956992A/ja
Publication of JPS5911589B2 publication Critical patent/JPS5911589B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/30—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP48093220A 1972-08-21 1973-08-20 ベンゾジアゼピン誘導体の製造法 Expired JPS5911589B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28221772A 1972-08-21 1972-08-21
US282217 1972-08-21
US35981473A 1973-05-14 1973-05-14
US359814 1973-05-14

Publications (2)

Publication Number Publication Date
JPS4956992A JPS4956992A (fr) 1974-06-03
JPS5911589B2 true JPS5911589B2 (ja) 1984-03-16

Family

ID=26961312

Family Applications (1)

Application Number Title Priority Date Filing Date
JP48093220A Expired JPS5911589B2 (ja) 1972-08-21 1973-08-20 ベンゾジアゼピン誘導体の製造法

Country Status (24)

Country Link
JP (1) JPS5911589B2 (fr)
AR (1) AR198108A1 (fr)
AT (1) AT341527B (fr)
AU (1) AU472777B2 (fr)
CA (1) CA1012535A (fr)
CH (1) CH578544A5 (fr)
DD (1) DD107040A5 (fr)
DE (1) DE2340159A1 (fr)
DK (1) DK155326C (fr)
ES (1) ES418014A1 (fr)
FI (1) FI57939C (fr)
FR (1) FR2197003B1 (fr)
GB (1) GB1392681A (fr)
HU (1) HU170153B (fr)
IE (1) IE38091B1 (fr)
IL (1) IL42947A (fr)
LU (1) LU68269A1 (fr)
NL (1) NL179582C (fr)
NO (1) NO139481C (fr)
PH (1) PH13640A (fr)
PL (1) PL99162B1 (fr)
SE (1) SE408302B (fr)
SU (1) SU550980A3 (fr)
YU (1) YU219873A (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5334792A (en) * 1976-09-13 1978-03-31 Scherico Ltd Production of 1*44 benzodiazepines and 1*44 benzodiazepinee22ones
CN113149915B (zh) * 2021-03-01 2024-03-15 中国科学院成都有机化学有限公司 一种合成氯硝西泮化合物的方法
CN116023342B (zh) * 2021-10-26 2024-06-25 江苏昱林生物科技有限公司 一种高纯度氯硝西泮的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2016084A1 (de) * 1969-10-16 1971-04-29 CRC Compagnia dl Ricerca Chimica S A, Chiasso(Schweiz) Verfahren zur Herstellung von 1,4 Benzodiazepinen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1136709B (de) * 1959-12-10 1962-09-20 Hoffmann La Roche Verfahren zur Herstellung von 2-Oxo-1, 2-dihydro-1, 4-benzodiazepinen
BE785962A (fr) * 1971-07-08 1973-01-08 Hoffmann La Roche Procede pour la preparation de derives de benzodiazepine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2016084A1 (de) * 1969-10-16 1971-04-29 CRC Compagnia dl Ricerca Chimica S A, Chiasso(Schweiz) Verfahren zur Herstellung von 1,4 Benzodiazepinen

Also Published As

Publication number Publication date
GB1392681A (en) 1975-04-30
IL42947A0 (en) 1973-11-28
SU550980A3 (ru) 1977-03-15
CH578544A5 (fr) 1976-08-13
NL179582B (nl) 1986-05-01
CA1012535A (en) 1977-06-21
JPS4956992A (fr) 1974-06-03
NO139481B (no) 1978-12-11
NL179582C (nl) 1986-10-01
AU5918073A (en) 1975-02-13
PH13640A (en) 1980-08-18
DK155326C (da) 1989-08-14
DE2340159A1 (de) 1974-03-07
PL99162B1 (pl) 1978-06-30
NO139481C (no) 1979-03-21
HU170153B (fr) 1977-04-28
FR2197003B1 (fr) 1978-01-13
SE408302B (sv) 1979-06-05
IE38091L (en) 1974-02-21
DD107040A5 (fr) 1974-07-12
ES418014A1 (es) 1976-03-16
ATA720773A (de) 1977-06-15
FR2197003A1 (fr) 1974-03-22
LU68269A1 (fr) 1975-05-21
NL7311507A (fr) 1974-02-25
IE38091B1 (en) 1977-12-21
IL42947A (en) 1977-01-31
AU472777B2 (en) 1976-06-03
YU219873A (en) 1982-06-30
DE2340159C2 (fr) 1989-01-19
AR198108A1 (es) 1974-05-31
DK155326B (da) 1989-03-28
FI57939C (fi) 1980-11-10
FI57939B (fi) 1980-07-31
AT341527B (de) 1978-02-10

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