DK155326C - Fremgangsmaade til fremstilling af 1,4-benzodiazepin-2-on-derivater - Google Patents

Fremgangsmaade til fremstilling af 1,4-benzodiazepin-2-on-derivater

Info

Publication number
DK155326C
DK155326C DK457773A DK457773A DK155326C DK 155326 C DK155326 C DK 155326C DK 457773 A DK457773 A DK 457773A DK 457773 A DK457773 A DK 457773A DK 155326 C DK155326 C DK 155326C
Authority
DK
Denmark
Prior art keywords
benzodiazepin
derivatives
preparing
Prior art date
Application number
DK457773A
Other languages
English (en)
Other versions
DK155326B (da
Inventor
George Oswald Chase
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK155326B publication Critical patent/DK155326B/da
Application granted granted Critical
Publication of DK155326C publication Critical patent/DK155326C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • C07D243/28Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • C07D243/30Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK457773A 1972-08-21 1973-08-20 Fremgangsmaade til fremstilling af 1,4-benzodiazepin-2-on-derivater DK155326C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28221772A 1972-08-21 1972-08-21
US28221772 1972-08-21
US35981473A 1973-05-14 1973-05-14
US35981473 1973-05-14

Publications (2)

Publication Number Publication Date
DK155326B DK155326B (da) 1989-03-28
DK155326C true DK155326C (da) 1989-08-14

Family

ID=26961312

Family Applications (1)

Application Number Title Priority Date Filing Date
DK457773A DK155326C (da) 1972-08-21 1973-08-20 Fremgangsmaade til fremstilling af 1,4-benzodiazepin-2-on-derivater

Country Status (24)

Country Link
JP (1) JPS5911589B2 (da)
AR (1) AR198108A1 (da)
AT (1) AT341527B (da)
AU (1) AU472777B2 (da)
CA (1) CA1012535A (da)
CH (1) CH578544A5 (da)
DD (1) DD107040A5 (da)
DE (1) DE2340159A1 (da)
DK (1) DK155326C (da)
ES (1) ES418014A1 (da)
FI (1) FI57939C (da)
FR (1) FR2197003B1 (da)
GB (1) GB1392681A (da)
HU (1) HU170153B (da)
IE (1) IE38091B1 (da)
IL (1) IL42947A (da)
LU (1) LU68269A1 (da)
NL (1) NL179582C (da)
NO (1) NO139481C (da)
PH (1) PH13640A (da)
PL (1) PL99162B1 (da)
SE (1) SE408302B (da)
SU (1) SU550980A3 (da)
YU (1) YU219873A (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5334792A (en) * 1976-09-13 1978-03-31 Scherico Ltd Production of 1*44 benzodiazepines and 1*44 benzodiazepinee22ones
CN113149915B (zh) * 2021-03-01 2024-03-15 中国科学院成都有机化学有限公司 一种合成氯硝西泮化合物的方法
CN116023342A (zh) * 2021-10-26 2023-04-28 江苏昱林生物科技有限公司 一种高纯度氯硝西泮的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1136709B (de) * 1959-12-10 1962-09-20 Hoffmann La Roche Verfahren zur Herstellung von 2-Oxo-1, 2-dihydro-1, 4-benzodiazepinen
CH537393A (de) * 1969-10-16 1973-05-31 Hoffmann La Roche Verfahren zur Herstellung von 1,4-Benzodiazepin-derivaten
BE785962A (fr) * 1971-07-08 1973-01-08 Hoffmann La Roche Procede pour la preparation de derives de benzodiazepine

Also Published As

Publication number Publication date
NO139481B (no) 1978-12-11
CA1012535A (en) 1977-06-21
NL179582C (nl) 1986-10-01
ES418014A1 (es) 1976-03-16
CH578544A5 (da) 1976-08-13
ATA720773A (de) 1977-06-15
FI57939B (fi) 1980-07-31
FR2197003A1 (da) 1974-03-22
IL42947A (en) 1977-01-31
AR198108A1 (es) 1974-05-31
PH13640A (en) 1980-08-18
NL179582B (nl) 1986-05-01
FI57939C (fi) 1980-11-10
DE2340159C2 (da) 1989-01-19
IE38091B1 (en) 1977-12-21
AT341527B (de) 1978-02-10
AU5918073A (en) 1975-02-13
FR2197003B1 (da) 1978-01-13
NO139481C (no) 1979-03-21
SE408302B (sv) 1979-06-05
JPS4956992A (da) 1974-06-03
IL42947A0 (en) 1973-11-28
HU170153B (da) 1977-04-28
DE2340159A1 (de) 1974-03-07
JPS5911589B2 (ja) 1984-03-16
LU68269A1 (da) 1975-05-21
DD107040A5 (da) 1974-07-12
SU550980A3 (ru) 1977-03-15
DK155326B (da) 1989-03-28
PL99162B1 (pl) 1978-06-30
YU219873A (en) 1982-06-30
NL7311507A (da) 1974-02-25
AU472777B2 (en) 1976-06-03
GB1392681A (en) 1975-04-30
IE38091L (en) 1974-02-21

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Legal Events

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PBP Patent lapsed