NO139481C - Fremgangsmaate ved fremstilling av benzodiazepin-derivater - Google Patents

Fremgangsmaate ved fremstilling av benzodiazepin-derivater

Info

Publication number
NO139481C
NO139481C NO3285/73A NO328573A NO139481C NO 139481 C NO139481 C NO 139481C NO 3285/73 A NO3285/73 A NO 3285/73A NO 328573 A NO328573 A NO 328573A NO 139481 C NO139481 C NO 139481C
Authority
NO
Norway
Prior art keywords
procedures
preparation
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
NO3285/73A
Other languages
English (en)
Norwegian (no)
Other versions
NO139481B (no
Inventor
George Oswald Chase
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO139481B publication Critical patent/NO139481B/no
Publication of NO139481C publication Critical patent/NO139481C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • C07D243/28Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • C07D243/30Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO3285/73A 1972-08-21 1973-08-20 Fremgangsmaate ved fremstilling av benzodiazepin-derivater NO139481C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28221772A 1972-08-21 1972-08-21
US35981473A 1973-05-14 1973-05-14

Publications (2)

Publication Number Publication Date
NO139481B NO139481B (no) 1978-12-11
NO139481C true NO139481C (no) 1979-03-21

Family

ID=26961312

Family Applications (1)

Application Number Title Priority Date Filing Date
NO3285/73A NO139481C (no) 1972-08-21 1973-08-20 Fremgangsmaate ved fremstilling av benzodiazepin-derivater

Country Status (24)

Country Link
JP (1) JPS5911589B2 (da)
AR (1) AR198108A1 (da)
AT (1) AT341527B (da)
AU (1) AU472777B2 (da)
CA (1) CA1012535A (da)
CH (1) CH578544A5 (da)
DD (1) DD107040A5 (da)
DE (1) DE2340159A1 (da)
DK (1) DK155326C (da)
ES (1) ES418014A1 (da)
FI (1) FI57939C (da)
FR (1) FR2197003B1 (da)
GB (1) GB1392681A (da)
HU (1) HU170153B (da)
IE (1) IE38091B1 (da)
IL (1) IL42947A (da)
LU (1) LU68269A1 (da)
NL (1) NL179582C (da)
NO (1) NO139481C (da)
PH (1) PH13640A (da)
PL (1) PL99162B1 (da)
SE (1) SE408302B (da)
SU (1) SU550980A3 (da)
YU (1) YU219873A (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5334792A (en) * 1976-09-13 1978-03-31 Scherico Ltd Production of 1*44 benzodiazepines and 1*44 benzodiazepinee22ones
CN113149915B (zh) * 2021-03-01 2024-03-15 中国科学院成都有机化学有限公司 一种合成氯硝西泮化合物的方法
CN116023342B (zh) * 2021-10-26 2024-06-25 江苏昱林生物科技有限公司 一种高纯度氯硝西泮的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1136709B (de) * 1959-12-10 1962-09-20 Hoffmann La Roche Verfahren zur Herstellung von 2-Oxo-1, 2-dihydro-1, 4-benzodiazepinen
CH537393A (de) * 1969-10-16 1973-05-31 Hoffmann La Roche Verfahren zur Herstellung von 1,4-Benzodiazepin-derivaten
BE785962A (fr) * 1971-07-08 1973-01-08 Hoffmann La Roche Procede pour la preparation de derives de benzodiazepine

Also Published As

Publication number Publication date
IE38091B1 (en) 1977-12-21
DE2340159A1 (de) 1974-03-07
FR2197003B1 (da) 1978-01-13
NO139481B (no) 1978-12-11
FR2197003A1 (da) 1974-03-22
NL179582C (nl) 1986-10-01
PL99162B1 (pl) 1978-06-30
DE2340159C2 (da) 1989-01-19
CA1012535A (en) 1977-06-21
JPS4956992A (da) 1974-06-03
AU5918073A (en) 1975-02-13
SE408302B (sv) 1979-06-05
IE38091L (en) 1974-02-21
NL7311507A (da) 1974-02-25
ES418014A1 (es) 1976-03-16
ATA720773A (de) 1977-06-15
NL179582B (nl) 1986-05-01
DD107040A5 (da) 1974-07-12
IL42947A0 (en) 1973-11-28
GB1392681A (en) 1975-04-30
PH13640A (en) 1980-08-18
FI57939C (fi) 1980-11-10
HU170153B (da) 1977-04-28
AT341527B (de) 1978-02-10
JPS5911589B2 (ja) 1984-03-16
LU68269A1 (da) 1975-05-21
SU550980A3 (ru) 1977-03-15
IL42947A (en) 1977-01-31
YU219873A (en) 1982-06-30
CH578544A5 (da) 1976-08-13
DK155326B (da) 1989-03-28
FI57939B (fi) 1980-07-31
DK155326C (da) 1989-08-14
AU472777B2 (en) 1976-06-03
AR198108A1 (es) 1974-05-31

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