JPS5835144A - Ｍｂ−５３０ｂ誘導体およびその製造法 - Google Patents

Ｍｂ−５３０ｂ誘導体およびその製造法

Info

Publication number
JPS5835144A
JPS5835144A JP56134558A JP13455881A JPS5835144A JP S5835144 A JPS5835144 A JP S5835144A JP 56134558 A JP56134558 A JP 56134558A JP 13455881 A JP13455881 A JP 13455881A JP S5835144 A JPS5835144 A JP S5835144A
Authority
JP
Japan
Prior art keywords
genus
compound
lactone
pharmacologically acceptable
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56134558A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0371419B2 (enExample
Inventor
Akira Terahara
寺原　昭
Minoru Tanaka
実 田中
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP56134558A priority Critical patent/JPS5835144A/ja
Priority to US06/410,889 priority patent/US4517373A/en
Priority to DE8282304507T priority patent/DE3262998D1/de
Priority to CA000410212A priority patent/CA1197484A/en
Priority to AT82304507T priority patent/ATE12638T1/de
Priority to IE2061/82A priority patent/IE53740B1/en
Priority to EP82304507A priority patent/EP0074222B1/en
Publication of JPS5835144A publication Critical patent/JPS5835144A/ja
Priority to US06/908,969 priority patent/US4820865A/en
Publication of JPH0371419B2 publication Critical patent/JPH0371419B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP56134558A 1981-08-27 1981-08-27 Ｍｂ−５３０ｂ誘導体およびその製造法 Granted JPS5835144A (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP56134558A JPS5835144A (ja) 1981-08-27 1981-08-27 Ｍｂ−５３０ｂ誘導体およびその製造法
US06/410,889 US4517373A (en) 1981-08-27 1982-08-24 IsoMB-530B derivatives
DE8282304507T DE3262998D1 (en) 1981-08-27 1982-08-26 Mb-530b derivatives, their preparation and pharmaceutical compositions containing them
CA000410212A CA1197484A (en) 1981-08-27 1982-08-26 Mb-530b derivatives, their preparation and pharmaceutical compositions containing them
AT82304507T ATE12638T1 (de) 1981-08-27 1982-08-26 Mb-530b derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
IE2061/82A IE53740B1 (en) 1981-08-27 1982-08-26 Mb-530b derivatives, their preparation and pharmaceutical compositions containing them
EP82304507A EP0074222B1 (en) 1981-08-27 1982-08-26 Mb-530b derivatives, their preparation and pharmaceutical compositions containing them
US06/908,969 US4820865A (en) 1981-08-27 1986-09-17 MB-530B derivatives containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56134558A JPS5835144A (ja) 1981-08-27 1981-08-27 Ｍｂ−５３０ｂ誘導体およびその製造法

Publications (2)

Publication Number Publication Date
JPS5835144A true JPS5835144A (ja) 1983-03-01
JPH0371419B2 JPH0371419B2 (enExample) 1991-11-13

Family

ID=15131129

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56134558A Granted JPS5835144A (ja) 1981-08-27 1981-08-27 Ｍｂ−５３０ｂ誘導体およびその製造法

Country Status (7)

Country Link
US (2) US4517373A (enExample)
EP (1) EP0074222B1 (enExample)
JP (1) JPS5835144A (enExample)
AT (1) ATE12638T1 (enExample)
CA (1) CA1197484A (enExample)
DE (1) DE3262998D1 (enExample)
IE (1) IE53740B1 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5855443A (ja) * 1981-09-25 1983-04-01 Sankyo Co Ltd オクタヒドロナフタリン誘導体およびその製造法
US4472426A (en) * 1982-12-22 1984-09-18 Merck & Co., Inc. Antihypercholesterolemic compounds
US4668699A (en) * 1985-08-05 1987-05-26 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4766145A (en) * 1986-05-05 1988-08-23 Merck & Co., Inc. Antihypercholesterolemic compounds
US4661483A (en) * 1986-05-05 1987-04-28 Merck & Co., Inc. Antihypercholesterolemic lactone compounds, compositions and use
US4847306A (en) * 1986-05-05 1989-07-11 Merck & Co., Inc. Antihypercholesterolemic compounds
EP0245004A3 (en) * 1986-05-05 1989-07-26 Merck & Co. Inc. Antihypercholesterolemic compounds
EP0245003A3 (en) * 1986-05-05 1989-07-19 Merck & Co. Inc. Antihypercholesterolemic compounds
US4864038A (en) * 1986-05-05 1989-09-05 Merck & Co., Inc. Antihypercholesterolemic compounds
EP0245990A3 (en) * 1986-05-05 1989-07-19 Merck & Co. Inc. Antihypercholesterolemic compounds
US4771071A (en) * 1986-05-05 1988-09-13 Merck & Co., Inc. Antihypercholesterolemic compounds
PT85109A (en) * 1986-06-23 1987-07-01 Merck & Co Inc Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors
US4940727A (en) * 1986-06-23 1990-07-10 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
USRE36481E (en) * 1986-06-23 2000-01-04 Merck & Co., Inc. HMG-CoA reductase inhibitors
US5116870A (en) * 1986-06-23 1992-05-26 Merck & Co., Inc. HMG-CoA reductase inhibitors
US4678806A (en) * 1986-09-02 1987-07-07 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
US4736064A (en) * 1986-09-29 1988-04-05 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
US4833258A (en) * 1987-02-17 1989-05-23 Merck & Co., Inc. Intermediates useful in the preparation of HMG-COA reductase inhibitors
US4719229A (en) * 1987-05-13 1988-01-12 Merck & Co., Inc. Antihypercholesterolemic agents
US4782084A (en) * 1987-06-29 1988-11-01 Merck & Co., Inc. HMG-COA reductase inhibitors
EP0306263B1 (en) * 1987-09-02 1992-03-18 Merck & Co. Inc. Novel hmg-coa reductase inhibitors
US4857547A (en) * 1988-01-07 1989-08-15 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
DE68914495T2 (de) * 1988-03-02 1994-10-27 Merck & Co Inc Antihypercholesterolemisches Mittel.
US5021453A (en) * 1988-03-02 1991-06-04 Merck & Co., Inc. 3-keto HMG-CoA reductase inhibitors
EP0337548A3 (en) * 1988-04-15 1991-08-14 Merck & Co. Inc. HMG-COA reductase inhibitors produced by nocardia SP. (MA6455)(ATCC 53695)
US4997755A (en) * 1988-04-15 1991-03-05 Merck & Co., Inc. HMG-CoA reductase inhibitors produced by Nocardia sp. (MA 6455)
US4963538A (en) * 1988-06-29 1990-10-16 Merck & Co., Inc. 5-oxygenated HMG-CoA reductase inhibitors
JPH02245191A (ja) * 1989-02-01 1990-09-28 Merck & Co Inc ６―α―ヒドロキシメチルロバスタチン誘導体の製造方法
ATE135352T1 (de) * 1989-06-09 1996-03-15 Merck & Co Inc 3-keto-hmg-coa reduktase-inhibitoren
US5001241A (en) * 1989-06-09 1991-03-19 Merck & Co., Inc. 3-KETO HMG-CoA reductase inhibitors
US5041562A (en) * 1989-06-09 1991-08-20 Merck & Co., Inc. 3-keto HMG-CoA reductase inhibitors
US5010105A (en) * 1989-06-09 1991-04-23 Merck & Co., Inc. Antihypercholesterolemic compounds
US4937259A (en) * 1989-06-09 1990-06-26 Merck & Co., Inc. Antihypercholesterolemic compounds
US4997849A (en) * 1989-06-23 1991-03-05 Merck & Co., Inc. Microbial transformation of simvastatin
US4965200A (en) * 1989-06-23 1990-10-23 Merck & Co., Inc. Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs
US5112857A (en) * 1990-09-04 1992-05-12 Merck & Co., Inc. Hmg-coa reductase inhibitor metabolites
FR2709126B1 (fr) * 1993-08-18 1995-09-29 Adir Nouveaux dérivés de naphtalène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (enExample) * 1974-06-07 1981-03-18
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
IL60219A (en) * 1979-06-15 1985-05-31 Merck & Co Inc Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them
JPS56150037A (en) * 1980-04-22 1981-11-20 Sankyo Co Ltd Hydronaphthalene compound
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4450171A (en) * 1980-08-05 1984-05-22 Merck & Co., Inc. Antihypercholesterolemic compounds
JPS57185276A (en) * 1981-05-11 1982-11-15 Sankyo Co Ltd Dihydro-dum-4 and dihydro-isodum-4 and their derivative
US4499289A (en) * 1982-12-03 1985-02-12 G. D. Searle & Co. Octahydronapthalenes

Also Published As

Publication number Publication date
EP0074222B1 (en) 1985-04-10
US4517373A (en) 1985-05-14
CA1197484A (en) 1985-12-03
IE822061L (en) 1983-02-27
DE3262998D1 (en) 1985-05-15
EP0074222A1 (en) 1983-03-16
IE53740B1 (en) 1989-02-01
ATE12638T1 (de) 1985-04-15
JPH0371419B2 (enExample) 1991-11-13
US4820865A (en) 1989-04-11

Similar Documents

Publication Publication Date Title
JPS5835144A (ja) Ｍｂ−５３０ｂ誘導体およびその製造法
KR830002329B1 (ko) 모나콜린 k의 제조방법
JPH0371116B2 (enExample)
HU193579B (en) Process for preparing leucine derivative and pharmaceutical composition formed therefrom
JP2007291075A (ja) 新規化合物ステレニン及びその製造方法
JPH10287662A (ja) Ｆｏ−５６３７ａ物質及びｂ物質並びにそれらの製造法
US5142096A (en) 2,4-dihydroxy-3,5,6-trimethylbenzoic acid compounds
JPH06234693A (ja) 新規イソテトラセノン系物質及びその製造法
JP2811881B2 (ja) Ｗｓ７６２２ａ、ｂ、ｃおよびｄ物質、それらの誘導体、それらの製法ならびにそれらの用途
JP4351395B2 (ja) Ｗｋ−５３４４ａ物質及びｗｋ−５３４４ｂ物質並びにそれらの製造法
NL8204904A (nl) Dihydro- en tetrahydromonacolin l, metaalzouten en alkylesters daarvan, alsmede werkwijze voor het bereiden ervan.
JPS5815968A (ja) Ｍｌ−２３６ｂ誘導体およびその製法
US5151529A (en) Platelet activating factor antagonists, named "the phomactins" their preparation and use
JPH07278041A (ja) 抗腫瘍性物質ｂｅ−２４８１１及びその製造法
US4992570A (en) UCN-1028A and UCN-1028C and process for the production thereof
WO1993017991A1 (en) TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS
JP3435741B2 (ja) 新規物質及び該物質を生産する微生物
US5236929A (en) Compound uca1064-b
JPS5840475B2 (ja) 新生理活性物質ｍｌ−２３６ａおよびその製造法
JP3153959B2 (ja) 化合物ｔａｎ―１２５１、その誘導体、それらの製造法および用途
JP2928626B2 (ja) 血小板活性化因子拮抗物質フォマクチンｂ
US5223637A (en) KS-506 compounds
US5308867A (en) Platelet activating factor antagonists, named "the phomactins", their preparation and use
JP3046077B2 (ja) 脂肪族トリカルボン酸化合物及びその製造方法
JPS6113798B2 (enExample)