JPS58194887A - １，８−ナフチリジンおよび１，５，８−アザナフチリジン誘導体類 - Google Patents

１，８−ナフチリジンおよび１，５，８−アザナフチリジン誘導体類

Info

Publication number
JPS58194887A
JPS58194887A JP58072779A JP7277983A JPS58194887A JP S58194887 A JPS58194887 A JP S58194887A JP 58072779 A JP58072779 A JP 58072779A JP 7277983 A JP7277983 A JP 7277983A JP S58194887 A JPS58194887 A JP S58194887A
Authority
JP
Japan
Prior art keywords
group
carbon atoms
hydrogen
compound
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58072779A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0568476B2 (enExample
Inventor
マ−ガレツト・エツチ・シヤ−ロツク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schering Plough Corp
Original Assignee
Schering Plough Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Plough Corp filed Critical Schering Plough Corp
Publication of JPS58194887A publication Critical patent/JPS58194887A/ja
Publication of JPH0568476B2 publication Critical patent/JPH0568476B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP58072779A 1982-04-26 1983-04-25 １，８−ナフチリジンおよび１，５，８−アザナフチリジン誘導体類 Granted JPS58194887A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/371,623 US4452800A (en) 1982-04-26 1982-04-26 Salts of 3(n-butyl)-4-hydroxy-1-phenyl-1,8-naphthyridine-2(1H)-one and their use in treating chronic obstructive lung diseases
US371623 1982-04-26
US438681 1982-11-03

Publications (2)

Publication Number Publication Date
JPS58194887A true JPS58194887A (ja) 1983-11-12
JPH0568476B2 JPH0568476B2 (enExample) 1993-09-29

Family

ID=23464718

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58072779A Granted JPS58194887A (ja) 1982-04-26 1983-04-25 １，８−ナフチリジンおよび１，５，８−アザナフチリジン誘導体類

Country Status (3)

Country Link
US (1) US4452800A (enExample)
JP (1) JPS58194887A (enExample)
ZA (1) ZA832903B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0794455B2 (ja) * 1985-07-29 1995-10-11 シェリング・コ−ポレ−ション 双性イオン性二環式化合物およびその塩、溶媒和物、水和物ならびにエステル
JPH07116187B2 (ja) * 1987-07-22 1995-12-13 シェリング・コーポレーション 二環式化合物、それらを薬剤として使用すること、それらの製法、およびそれらの製造に有用な中間体
WO2001042244A1 (en) * 1999-12-08 2001-06-14 Grelan Pharmaceutical Co., Ltd. Novel 1,8-naphthyridin-2(1h)-one derivatives

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4628055A (en) * 1982-11-03 1986-12-09 Schering Corporation Method for treating allergic reactions and compositions therefore
US4680298A (en) * 1983-05-31 1987-07-14 Schering Corporation Tricyclic anti-allergy and use as anti-inflammatory agents
US4680297A (en) * 1983-07-14 1987-07-14 Schering Corporation Tricyclic positive inotropic agents
US4666922A (en) * 1985-06-18 1987-05-19 Schering Corporation Method for modulating the immune response
US4760073A (en) * 1986-04-11 1988-07-26 Schering Corporation Aryl-substituted naphthyridine and pyridopyrazine derivatives, useful as anti-allergic agents
US5011860A (en) * 1986-04-11 1991-04-30 Schering Corporation Aryl-substituted naphthyridine and pyridopyrazine derivatives and their use in treating hyperproliferative skin diseases
US5037826A (en) * 1986-10-15 1991-08-06 Schering Corporation 1-substituted naphthyridine and pyridopyrazine derivatives
US4740511A (en) * 1987-02-18 1988-04-26 Schering Corporation Method of treating hyperproliferative skin disease
US4897487A (en) * 1988-04-06 1990-01-30 Schering Corporation Process for preparing intermediates for pharmaceutically useful bicyclic compounds
US5079360A (en) * 1988-04-06 1992-01-07 Schering Corporation Processes for preparing bicyclic compounds and intermediates thereof
US5180823A (en) * 1988-04-06 1993-01-19 Schering Corporation Processes for preparing bicyclic compounds
US5618842A (en) * 1991-12-31 1997-04-08 Lifegroup S.P.A. N-acyl derivatives of aminoalcohols with polycarboxylic acids able to modulate mast cells in inflammatory processes having neuroimmunogenic origin
US20030130288A1 (en) * 2001-09-17 2003-07-10 Henkel Timothy John Method of treatment
JP4294469B2 (ja) * 2001-06-12 2009-07-15 あすか製薬株式会社 Ｐｄｅｉｖ阻害剤

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4949993A (enExample) * 1972-06-16 1974-05-15
JPS5236694A (en) * 1975-08-15 1977-03-22 Sandoz Ag Production of 33nitroo44 hydroxyypyrid *2*33b* pyridinee2 *1h**ones
JPS52116495A (en) * 1976-03-25 1977-09-29 Hisamitsu Pharmaceut Co Inc Novel naphthyridine derivatives
US4128649A (en) * 1977-06-29 1978-12-05 Sandoz, Inc. 4-Hydroxy-pyrido[2,3-b]pyridine-2(1H)-one-3-carboxylic acids and esters

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4949993A (enExample) * 1972-06-16 1974-05-15
JPS5236694A (en) * 1975-08-15 1977-03-22 Sandoz Ag Production of 33nitroo44 hydroxyypyrid *2*33b* pyridinee2 *1h**ones
JPS52116495A (en) * 1976-03-25 1977-09-29 Hisamitsu Pharmaceut Co Inc Novel naphthyridine derivatives
US4128649A (en) * 1977-06-29 1978-12-05 Sandoz, Inc. 4-Hydroxy-pyrido[2,3-b]pyridine-2(1H)-one-3-carboxylic acids and esters

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0794455B2 (ja) * 1985-07-29 1995-10-11 シェリング・コ−ポレ−ション 双性イオン性二環式化合物およびその塩、溶媒和物、水和物ならびにエステル
JPH07116187B2 (ja) * 1987-07-22 1995-12-13 シェリング・コーポレーション 二環式化合物、それらを薬剤として使用すること、それらの製法、およびそれらの製造に有用な中間体
WO2001042244A1 (en) * 1999-12-08 2001-06-14 Grelan Pharmaceutical Co., Ltd. Novel 1,8-naphthyridin-2(1h)-one derivatives
US6642250B2 (en) 1999-12-08 2003-11-04 Grelan Pharmaceutical Co., Ltd. 1,8-naphthyridin-2(1H)-one derivatives
AU780053B2 (en) * 1999-12-08 2005-02-24 Grelan Pharmaceutical Co. Ltd. Novel 1,8-naphthyridin-2(1H)-one derivatives
JP4825387B2 (ja) * 1999-12-08 2011-11-30 あすか製薬株式会社 新規な１，８−ナフチリジン−２（１ｈ）−オン誘導体

Also Published As

Publication number Publication date
JPH0568476B2 (enExample) 1993-09-29
ZA832903B (en) 1984-01-25
US4452800A (en) 1984-06-05

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