JPS58173465A - 抗原抗体反応の光学的測定方法 - Google Patents
抗原抗体反応の光学的測定方法Info
- Publication number
- JPS58173465A JPS58173465A JP5643382A JP5643382A JPS58173465A JP S58173465 A JPS58173465 A JP S58173465A JP 5643382 A JP5643382 A JP 5643382A JP 5643382 A JP5643382 A JP 5643382A JP S58173465 A JPS58173465 A JP S58173465A
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antibody
- reaction
- intensity
- light
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 34
- 239000000427 antigen Substances 0.000 title claims abstract description 25
- 102000036639 antigens Human genes 0.000 title claims abstract description 25
- 108091007433 antigens Proteins 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims abstract description 20
- 230000003287 optical effect Effects 0.000 title claims description 4
- 238000001514 detection method Methods 0.000 claims description 12
- 239000011541 reaction mixture Substances 0.000 claims description 5
- 238000000691 measurement method Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 abstract description 22
- 238000000149 argon plasma sintering Methods 0.000 abstract description 19
- 230000035945 sensitivity Effects 0.000 abstract description 6
- 238000011088 calibration curve Methods 0.000 abstract description 3
- 239000004065 semiconductor Substances 0.000 abstract description 2
- 230000001678 irradiating effect Effects 0.000 abstract 2
- 239000002131 composite material Substances 0.000 abstract 1
- 230000004907 flux Effects 0.000 abstract 1
- 238000003018 immunoassay Methods 0.000 description 12
- 238000010586 diagram Methods 0.000 description 7
- 238000012545 processing Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000002123 temporal effect Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 238000005755 formation reaction Methods 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- CPBQJMYROZQQJC-UHFFFAOYSA-N helium neon Chemical compound [He].[Ne] CPBQJMYROZQQJC-UHFFFAOYSA-N 0.000 description 1
- 229940098197 human immunoglobulin g Drugs 0.000 description 1
- 230000000951 immunodiffusion Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011896 sensitive detection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5643382A JPS58173465A (ja) | 1982-04-05 | 1982-04-05 | 抗原抗体反応の光学的測定方法 |
| US06/481,961 US4766083A (en) | 1982-04-04 | 1983-04-04 | Method for the photometric determination of biological agglutination |
| AT83103297T ATE58245T1 (de) | 1982-04-04 | 1983-04-05 | Verfahren zur photometrischen bestimmung biologischer agglutinaten. |
| EP83103297A EP0091636B1 (en) | 1982-04-04 | 1983-04-05 | Method for the photometric determination of biological agglutination |
| DE8383103297T DE3381979D1 (de) | 1982-04-04 | 1983-04-05 | Verfahren zur photometrischen bestimmung biologischer agglutinaten. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5643382A JPS58173465A (ja) | 1982-04-05 | 1982-04-05 | 抗原抗体反応の光学的測定方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58173465A true JPS58173465A (ja) | 1983-10-12 |
| JPH042906B2 JPH042906B2 (enrdf_load_stackoverflow) | 1992-01-21 |
Family
ID=13026949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5643382A Granted JPS58173465A (ja) | 1982-04-04 | 1982-04-05 | 抗原抗体反応の光学的測定方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58173465A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102333855A (zh) * | 2009-02-25 | 2012-01-25 | 亚历法克斯控股有限公司 | 分析生物样品的设备 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5313492A (en) * | 1976-06-02 | 1978-02-07 | Beckman Instruments Inc | Process and method for immunity nephelometry |
| JPS54151495A (en) * | 1978-05-19 | 1979-11-28 | Hitachi Ltd | Nephelometric immuno-assay method |
| JPS5694244A (en) * | 1979-12-27 | 1981-07-30 | Chugai Pharmaceut Co Ltd | Quantitative apparatus for determining reaction product of antigen antibody utilizing laser light |
-
1982
- 1982-04-05 JP JP5643382A patent/JPS58173465A/ja active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5313492A (en) * | 1976-06-02 | 1978-02-07 | Beckman Instruments Inc | Process and method for immunity nephelometry |
| JPS54151495A (en) * | 1978-05-19 | 1979-11-28 | Hitachi Ltd | Nephelometric immuno-assay method |
| JPS5694244A (en) * | 1979-12-27 | 1981-07-30 | Chugai Pharmaceut Co Ltd | Quantitative apparatus for determining reaction product of antigen antibody utilizing laser light |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102333855A (zh) * | 2009-02-25 | 2012-01-25 | 亚历法克斯控股有限公司 | 分析生物样品的设备 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH042906B2 (enrdf_load_stackoverflow) | 1992-01-21 |
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