JPS58134090A - （３ｓ）−３−置換アミノ−２−オキソ−１−アゼチジンスルホン酸および４−置換誘導体の製造法 - Google Patents

（３ｓ）−３−置換アミノ−２−オキソ−１−アゼチジンスルホン酸および４−置換誘導体の製造法

Info

Publication number
JPS58134090A
JPS58134090A JP58013621A JP1362183A JPS58134090A JP S58134090 A JPS58134090 A JP S58134090A JP 58013621 A JP58013621 A JP 58013621A JP 1362183 A JP1362183 A JP 1362183A JP S58134090 A JPS58134090 A JP S58134090A
Authority
JP
Japan
Prior art keywords
acid
amino
solution
formula
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58013621A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0312065B2 (en, 2012
Inventor
クリストフア−・エム・シマラステイ
リタ・テイ・フオツクス
アラン・ダブリユ−・フリツツ
ウイリアム・エイチ・コスタ−
ジエロ−ム・エル・モニオツト
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of JPS58134090A publication Critical patent/JPS58134090A/ja
Publication of JPH0312065B2 publication Critical patent/JPH0312065B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP58013621A 1982-02-01 1983-01-29 （３ｓ）−３−置換アミノ−２−オキソ−１−アゼチジンスルホン酸および４−置換誘導体の製造法 Granted JPS58134090A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/344,895 US4443374A (en) 1982-02-01 1982-02-01 Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]amino]-2-oxo-1-azetidinesulfonic acid, and 4-substituted derivatives
US344895 1982-02-01

Publications (2)

Publication Number Publication Date
JPS58134090A true JPS58134090A (ja) 1983-08-10
JPH0312065B2 JPH0312065B2 (en, 2012) 1991-02-19

Family

ID=23352540

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58013621A Granted JPS58134090A (ja) 1982-02-01 1983-01-29 （３ｓ）−３−置換アミノ−２−オキソ−１−アゼチジンスルホン酸および４−置換誘導体の製造法

Country Status (7)

Country Link
US (1) US4443374A (en, 2012)
EP (1) EP0086556B1 (en, 2012)
JP (1) JPS58134090A (en, 2012)
AT (1) ATE19631T1 (en, 2012)
CA (1) CA1196335A (en, 2012)
DE (1) DE3363312D1 (en, 2012)
IE (1) IE54430B1 (en, 2012)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58210061A (ja) * 1982-05-31 1983-12-07 Takeda Chem Ind Ltd １−スルホ−２−オキソアゼチジン誘導体、その製造法および用途
JP2008505189A (ja) * 2005-05-09 2008-02-21 シコール インコーポレイティド アズトレオナムの製造方法
JP2020529398A (ja) * 2017-08-02 2020-10-08 ノバルティス アーゲー モノバクタム系抗生物質およびその中間体を製造するための化学的方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704457A (en) * 1982-06-21 1987-11-03 E. R. Squibb & Sons, Inc. Process for the preparation of (3S)-3-[[[2-(protected amino)-4-thiazolyl]-oxoacetyl]amino]-2-oxo-1-azetidinesulfonic acid and 4-substituted derivatives thereof
US4596777A (en) * 1983-08-10 1986-06-24 E. R. Squibb & Sons, Inc. Process for preparing (3S)-3-[[[2-(protected or unprotected amino)-4-thiazolyl]acetyl]amino]-2-oxo-1-azetidinesulfonic acid and 4-substituted derivatives thereof
AT381944B (de) * 1984-04-10 1986-12-10 Biochemie Gmbh Verfahren zur herstellung von cephalosporinantibiotika
US4675398A (en) * 1985-08-16 1987-06-23 E. R. Squibb & Sons, Inc. Copper-mediated oximation reaction
US4684722A (en) * 1986-01-06 1987-08-04 E. R. Squibb & Sons, Inc. Monosulfactams
RU2126398C1 (ru) * 1993-02-05 1999-02-20 Плива, Фармацеутска, Кемийска, Прехрамбена и Козметичка Индустрия Дионичко Друштво Загреб Производные аминоаскорбиновой кислоты, способы их получения и производные галоидаскорбиновой кислоты
KR100472048B1 (ko) * 2002-07-11 2005-03-08 종근당바이오 주식회사 아즈트레오남의 신규제조방법
CN103570707B (zh) * 2012-07-21 2016-03-09 重庆圣华曦药业股份有限公司 一种改进的氨曲南的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1389194A (en) * 1971-01-29 1975-04-03 Glaxo Lab Ltd Antibiotics
US4024133A (en) * 1971-05-14 1977-05-17 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(thienyl-,furyl- or pyridylacetamido)]cephalosporins
US4191762A (en) * 1974-03-14 1980-03-04 Fujisawa Pharmaceutical Co., Ltd. 2-Lower alkyl-7-substituted amino-2 or 3-cephem-4-carboxylic acid compounds
US4152433A (en) * 1976-03-12 1979-05-01 Fujisawa Pharmaceutical Co., Ltd. 2-Lower alkyl-7-substituted-2 or 3-cephem-4-carboxylic acid compounds and pharmaceutical compositions
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
FI771866A7 (en, 2012) * 1976-06-28 1977-12-29 Fujisawa Pharmaceutical Co
DE2710902A1 (de) * 1977-03-12 1978-09-21 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
DE2818263A1 (de) * 1978-04-26 1979-11-08 Bayer Ag Beta-lactamantibiotika
DE2822861A1 (de) * 1978-05-26 1979-11-29 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
NZ205240A (en) * 1980-02-07 1984-07-31 Squibb & Sons Inc Sulphonamide derivatives,being starting materials for producing beta-lactams
FR2515182B1 (fr) * 1981-10-23 1986-05-09 Roussel Uclaf Nouveaux produits derives de l'acide 3-amino 2-oxo azetidine 1-sulfamique, leur procede de preparation, leur application comme medicaments et les produits intermediaires necessaires a leur preparation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58210061A (ja) * 1982-05-31 1983-12-07 Takeda Chem Ind Ltd １−スルホ−２−オキソアゼチジン誘導体、その製造法および用途
JP2008505189A (ja) * 2005-05-09 2008-02-21 シコール インコーポレイティド アズトレオナムの製造方法
JP2020529398A (ja) * 2017-08-02 2020-10-08 ノバルティス アーゲー モノバクタム系抗生物質およびその中間体を製造するための化学的方法

Also Published As

Publication number Publication date
US4443374A (en) 1984-04-17
JPH0312065B2 (en, 2012) 1991-02-19
CA1196335A (en) 1985-11-05
IE830166L (en) 1983-08-01
EP0086556B1 (en) 1986-05-07
ATE19631T1 (de) 1986-05-15
DE3363312D1 (en) 1986-06-12
IE54430B1 (en) 1989-10-11
EP0086556A1 (en) 1983-08-24

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