JPS5781486A - Benzo(ij)quinolidine-2-carboxylic acid derivative - Google Patents

Benzo(ij)quinolidine-2-carboxylic acid derivative

Info

Publication number
JPS5781486A
JPS5781486A JP55158652A JP15865280A JPS5781486A JP S5781486 A JPS5781486 A JP S5781486A JP 55158652 A JP55158652 A JP 55158652A JP 15865280 A JP15865280 A JP 15865280A JP S5781486 A JPS5781486 A JP S5781486A
Authority
JP
Japan
Prior art keywords
compound
formula
bacteria
quinolidine
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55158652A
Other languages
English (en)
Other versions
JPS647996B2 (ja
Inventor
Hiroshi Ishikawa
Tetsuyuki Uno
Masanobu Kano
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP55158652A priority Critical patent/JPS5781486A/ja
Priority to NO813726A priority patent/NO156828C/no
Priority to AT0474881A priority patent/AT395150B/de
Priority to ZA817733A priority patent/ZA817733B/xx
Priority to FI813526A priority patent/FI71141C/fi
Priority to BE0/206483A priority patent/BE891046A/fr
Priority to DK495281A priority patent/DK160940C/da
Priority to SU813354800A priority patent/SU1366055A3/ru
Priority to IT49656/81A priority patent/IT1171646B/it
Priority to SE8106642A priority patent/SE448542B/sv
Priority to DE2000175035 priority patent/DE10075035I2/de
Priority to PT73957A priority patent/PT73957B/pt
Priority to DE19813144455 priority patent/DE3144455A1/de
Priority to ES507493A priority patent/ES8301981A1/es
Priority to MX785781A priority patent/MX155102A/es
Priority to FR8121100A priority patent/FR2493849A1/fr
Priority to NL8105075A priority patent/NL193457C/nl
Priority to GB8133890A priority patent/GB2086905B/en
Priority to AU77335/81A priority patent/AU546358B2/en
Priority to PH26477A priority patent/PH16685A/en
Priority to KR1019810004344A priority patent/KR880001625B1/ko
Priority to CA000389769A priority patent/CA1179341A/en
Priority to US06/320,027 priority patent/US4399134A/en
Priority to CH7200/81A priority patent/CH648845A5/de
Publication of JPS5781486A publication Critical patent/JPS5781486A/ja
Priority to ES516523A priority patent/ES516523A0/es
Priority to SU823527501A priority patent/SU1277896A3/ru
Priority to US06/497,914 priority patent/US4552879A/en
Publication of JPS647996B2 publication Critical patent/JPS647996B2/ja
Priority to AT2887/89A priority patent/AT393383B/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP55158652A 1980-11-10 1980-11-10 Benzo(ij)quinolidine-2-carboxylic acid derivative Granted JPS5781486A (en)

Priority Applications (28)

Application Number Priority Date Filing Date Title
JP55158652A JPS5781486A (en) 1980-11-10 1980-11-10 Benzo(ij)quinolidine-2-carboxylic acid derivative
NO813726A NO156828C (no) 1980-11-10 1981-11-04 Analogifremgangsm te for fremstilling av antibakterielt virksomme benzoheterocykliske forbindelser.
AT0474881A AT395150B (de) 1980-11-10 1981-11-05 Verfahren zur herstellung von neuen benzoheterozyklischen verbindungen
ZA817733A ZA817733B (en) 1980-11-10 1981-11-09 Piperazinylbenzoheterocyclic compounds and process for preparing same
FI813526A FI71141C (fi) 1980-11-10 1981-11-09 Foerfarande foer framstaellning av nya som antibakteriella aemnen anvaendbara 6,7-dihydro-1-oxo-benzo/ij/-kinolizin-2-karboxylsyror och 1,2-dihydro-6-oxo-pyrrolo/3,2,1-ij/-kinolin-5-karboxylsyror
BE0/206483A BE891046A (fr) 1980-11-10 1981-11-09 Composes benzoheterocycliques utiles comme medicaments antimicrobiens et procedes de leur preparation
DK495281A DK160940C (da) 1980-11-10 1981-11-09 Analogifremgangsmaade til fremstilling af benzoheterocycliske forbindelser eller farmaceutisk acceptable salte deraf
SU813354800A SU1366055A3 (ru) 1980-11-10 1981-11-09 Способ получения пиперазинилбензогетероциклических соединений
IT49656/81A IT1171646B (it) 1980-11-10 1981-11-09 Composti benzoeterociclici e procedimento per prepararli
SE8106642A SE448542B (sv) 1980-11-10 1981-11-09 Bensoheterocykliska foreningar, forfarande for deras framstellning och farmaceutisk komposition derav
DE2000175035 DE10075035I2 (de) 1980-11-10 1981-11-09 Benzo¬ij¾chinolizinderivate Verfahren zu deren Herstellung und bakteriostatische Mittel welche diese enthalten
PT73957A PT73957B (en) 1980-11-10 1981-11-09 Process for preparing piperazinylbenzoheterocyclic compounds
DE19813144455 DE3144455A1 (de) 1980-11-10 1981-11-09 Benzoheterozyklische verbindungen, verfahren zu deren herstellung und bakteriostatische mittel, welche diese enthalten
FR8121100A FR2493849A1 (fr) 1980-11-10 1981-11-10 Composes benzoheterocycliques utiles comme medicaments antimicrobiens et procedes de leur preparation
US06/320,027 US4399134A (en) 1980-11-10 1981-11-10 Pyrroloquinoline and benzoquinolizine compounds and antimicrobial compositions
ES507493A ES8301981A1 (es) 1980-11-10 1981-11-10 Procedimiento de preparar compuestos benzoheterociclicos.
NL8105075A NL193457C (nl) 1980-11-10 1981-11-10 Benzoheterocyclische verbindingen en farmaceutisch preparaat dat een dergelijke verbinding bevat.
GB8133890A GB2086905B (en) 1980-11-10 1981-11-10 Benzoheterocyclic compounds and process for preparing same
AU77335/81A AU546358B2 (en) 1980-11-10 1981-11-10 Piperazinylbenzoheterocyclic compounds
PH26477A PH16685A (en) 1980-11-10 1981-11-10 Benzoheterocyclic compounds and antibacterial composition containing same
KR1019810004344A KR880001625B1 (ko) 1980-11-10 1981-11-10 벤조헤테로사이클 화합물의 제조방법
CA000389769A CA1179341A (en) 1980-11-10 1981-11-10 Piperazinylbenzoheterocyclic compounds and process for preparing same
MX785781A MX155102A (es) 1980-11-10 1981-11-10 Procedimiento para preparar derivados del acido benzo(i j)-quinolizina-2-carboxilico y derivados del acido pirrolo-(3,2,1-i j)-quinolin-5-carboxilico
CH7200/81A CH648845A5 (de) 1980-11-10 1981-11-10 Benzoheterozyklische verbindungen, verfahren zu deren herstellung und bakteriostatische mittel, welche diese enthalten.
ES516523A ES516523A0 (es) 1980-11-10 1982-10-15 "metodo de preparar compuestos benzoheterociclicos".
SU823527501A SU1277896A3 (ru) 1980-11-10 1982-12-27 Способ получени производных тетрагидрохинолина или их фармацевтически приемлемых солей
US06/497,914 US4552879A (en) 1980-11-10 1983-05-25 Benzoheterocyclic compounds and pharmaceutical composition thereof
AT2887/89A AT393383B (de) 1980-11-10 1989-12-20 Verfahren zur herstellung von neuen benzoheterozyklischen verbindungen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55158652A JPS5781486A (en) 1980-11-10 1980-11-10 Benzo(ij)quinolidine-2-carboxylic acid derivative

Publications (2)

Publication Number Publication Date
JPS5781486A true JPS5781486A (en) 1982-05-21
JPS647996B2 JPS647996B2 (ja) 1989-02-10

Family

ID=15676382

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55158652A Granted JPS5781486A (en) 1980-11-10 1980-11-10 Benzo(ij)quinolidine-2-carboxylic acid derivative

Country Status (3)

Country Link
JP (1) JPS5781486A (ja)
BE (1) BE891046A (ja)
ZA (1) ZA817733B (ja)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02131483A (ja) * 1988-11-10 1990-05-21 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
WO1997044034A1 (fr) * 1996-05-20 1997-11-27 Otsuka Pharmaceutical Co., Ltd. Remede pour le traitement de l'acne rosacee
US6514986B2 (en) 2000-11-22 2003-02-04 Wockhardt Limited Chiral fluoroquinolone arginine salt forms
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
US6664267B1 (en) 2002-05-28 2003-12-16 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
US7164023B2 (en) 2003-09-04 2007-01-16 Wockhardt Limited Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
US7247642B2 (en) 1999-05-07 2007-07-24 Wockhardt Limited Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment
JP2014525420A (ja) * 2011-08-31 2014-09-29 大塚製薬株式会社 キノロン化合物

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02131483A (ja) * 1988-11-10 1990-05-21 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
WO1997044034A1 (fr) * 1996-05-20 1997-11-27 Otsuka Pharmaceutical Co., Ltd. Remede pour le traitement de l'acne rosacee
US7247642B2 (en) 1999-05-07 2007-07-24 Wockhardt Limited Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment
US6753333B2 (en) 1999-12-14 2004-06-22 Wockhardt Limited Chiral fluoroquinolone arginine salt forms
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
US6514986B2 (en) 2000-11-22 2003-02-04 Wockhardt Limited Chiral fluoroquinolone arginine salt forms
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US7393957B2 (en) 2001-04-25 2008-07-01 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US7626032B2 (en) 2001-04-25 2009-12-01 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US7132541B2 (en) 2002-05-28 2006-11-07 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
US6664267B1 (en) 2002-05-28 2003-12-16 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
US7164023B2 (en) 2003-09-04 2007-01-16 Wockhardt Limited Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
JP2014525420A (ja) * 2011-08-31 2014-09-29 大塚製薬株式会社 キノロン化合物

Also Published As

Publication number Publication date
JPS647996B2 (ja) 1989-02-10
ZA817733B (en) 1982-10-27
BE891046A (fr) 1982-03-01

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Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term