ES8504816A1 - Un procedimiento de preparacion de un derivado de cefalosporina - Google Patents

Un procedimiento de preparacion de un derivado de cefalosporina

Info

Publication number
ES8504816A1
ES8504816A1 ES528898A ES528898A ES8504816A1 ES 8504816 A1 ES8504816 A1 ES 8504816A1 ES 528898 A ES528898 A ES 528898A ES 528898 A ES528898 A ES 528898A ES 8504816 A1 ES8504816 A1 ES 8504816A1
Authority
ES
Spain
Prior art keywords
compounds
hydrogen atom
cephalosporin antibiotics
toxic
vitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528898A
Other languages
English (en)
Other versions
ES528898A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8504816A1 publication Critical patent/ES8504816A1/es
Publication of ES528898A0 publication Critical patent/ES528898A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE UN DERIVADO DE CEFALOSPORINA.CONSISTENTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE PIRIDINA DE FORMULA (III), PARA OBTENER DERIVADOS DE CEFALOSPORINA DE FORMULA (I), DONDE RA Y RB SON H, METILO O ETILO; R ES AMINO PROTEGIDO; R ES 3 O 4 CARBAMOILO O H; B ES FS O FS9O; LA LINEA DE TRAZOS INDICA QUE ES COMPUESTO DE CEF-2-EM O CEF-3-EM; R ES H O UN GRUPO BLOQUEANTE CARBOXILO; Y X ES UN RADICAL NUCLEOFILO.SON ESPECIALMENTE UTILES EN EL TRATAMIENTO DE ENFERMEDADES RESISTENTES A OTROS ANTIBIOTICOS (PENICILINA) O EN PACIENTES SENSIBLES A LA PENICILINA.
ES528898A 1982-05-20 1984-01-16 Un procedimiento de preparacion de un derivado de cefalosporina Granted ES528898A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8214774 1982-05-20

Publications (2)

Publication Number Publication Date
ES8504816A1 true ES8504816A1 (es) 1985-05-01
ES528898A0 ES528898A0 (es) 1985-05-01

Family

ID=10530504

Family Applications (2)

Application Number Title Priority Date Filing Date
ES522549A Granted ES522549A0 (es) 1982-05-20 1983-05-19 Un procedimiento para la preparacion de un derivado de cefalosporina.
ES528898A Granted ES528898A0 (es) 1982-05-20 1984-01-16 Un procedimiento de preparacion de un derivado de cefalosporina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES522549A Granted ES522549A0 (es) 1982-05-20 1983-05-19 Un procedimiento para la preparacion de un derivado de cefalosporina.

Country Status (6)

Country Link
EP (1) EP0095329A3 (es)
JP (1) JPS58210093A (es)
AU (1) AU1468783A (es)
DK (1) DK223583A (es)
ES (2) ES522549A0 (es)
ZA (1) ZA833616B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4690921A (en) * 1983-10-11 1987-09-01 Yamanouchi Pharmaceutical Co., Ltd. Cephalosporin compounds and salts thereof
JPS60231682A (ja) * 1984-05-02 1985-11-18 Meiji Seika Kaisha Ltd 新規セフアロスポリン系抗菌性化合物及びその製造法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2384782A1 (fr) * 1977-03-25 1978-10-20 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-acetoxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
JPS609719B2 (ja) * 1977-08-06 1985-03-12 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
AU538653B2 (en) * 1979-10-02 1984-08-23 Glaxo Group Limited 7-(2-(2-amino thiazol-4-yl)-2-(carboxymethoxyimino) acetamioo)-3-(1-pyridiniammethyl)-ceph-3-em-4-carboxylate

Also Published As

Publication number Publication date
ES8407057A1 (es) 1984-08-16
JPS58210093A (ja) 1983-12-07
DK223583A (da) 1983-11-21
AU1468783A (en) 1983-11-24
DK223583D0 (da) 1983-05-19
EP0095329A2 (en) 1983-11-30
ZA833616B (en) 1984-06-27
ES528898A0 (es) 1985-05-01
EP0095329A3 (en) 1984-11-28
ES522549A0 (es) 1984-08-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001