JPS57193457A - Amidinopiperidine derivative and its preparation - Google Patents
Amidinopiperidine derivative and its preparationInfo
- Publication number
- JPS57193457A JPS57193457A JP56078142A JP7814281A JPS57193457A JP S57193457 A JPS57193457 A JP S57193457A JP 56078142 A JP56078142 A JP 56078142A JP 7814281 A JP7814281 A JP 7814281A JP S57193457 A JPS57193457 A JP S57193457A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- amidinopiperidine
- formulai
- phenyl
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QUUYRYYUKNNNNS-UHFFFAOYSA-N piperidine-1-carboximidamide Chemical class NC(=N)N1CCCCC1 QUUYRYYUKNNNNS-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 108090000317 Chymotrypsin Proteins 0.000 abstract 1
- 108010028774 Complement C1 Proteins 0.000 abstract 1
- 102100025406 Complement C1s subcomponent Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 102000001399 Kallikrein Human genes 0.000 abstract 1
- 108060005987 Kallikrein Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical class OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 abstract 1
- 108090000631 Trypsin Proteins 0.000 abstract 1
- 102000004142 Trypsin Human genes 0.000 abstract 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 abstract 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 229960002376 chymotrypsin Drugs 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- VOHWDPXHUIOXIW-UHFFFAOYSA-N phenyl 1-carbamimidoylpiperidine-4-carboxylate;hydrochloride Chemical compound Cl.C1CN(C(=N)N)CCC1C(=O)OC1=CC=CC=C1 VOHWDPXHUIOXIW-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000012588 trypsin Substances 0.000 abstract 1
- 229960005356 urokinase Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56078142A JPS57193457A (en) | 1981-05-25 | 1981-05-25 | Amidinopiperidine derivative and its preparation |
| US06/379,714 US4433152A (en) | 1981-05-25 | 1982-05-19 | Amidinopiperidine derivatives |
| AR82289478A AR242560A1 (es) | 1981-05-25 | 1982-05-21 | Un procedimiento para producir derivados de acidos 1-amidin-piperidin-alcanoicos y sus sales farmaceuticamente aceptables. |
| CA000403483A CA1188302A (en) | 1981-05-25 | 1982-05-21 | Amidinopiperidine derivatives and a process for producing the same |
| GB08215069A GB2101125B (en) | 1981-05-25 | 1982-05-24 | Novel amidinopiperidine derivatives and processes for producing them |
| BE0/208163A BE893282A (fr) | 1981-05-25 | 1982-05-24 | Nouveaux derives d'amidinopiperidine et leur procede de production |
| CH3188/82A CH654298A5 (fr) | 1981-05-25 | 1982-05-24 | Derives de l'amidinopiperidine et leur procede de fabrication. |
| IT67668/82A IT1157014B (it) | 1981-05-25 | 1982-05-24 | Derivati dell'ammidinopiperidina particolarmente utili come medicamenti e procedimento per la loro produzione |
| NL8202109A NL8202109A (nl) | 1981-05-25 | 1982-05-24 | Nieuwe amidinopiperidinederivaten en werkwijzen voor het bereiden en toepassen van deze derivaten. |
| DE19823219614 DE3219614A1 (de) | 1981-05-25 | 1982-05-25 | Amidinopiperidinderivate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| BR8203060A BR8203060A (pt) | 1981-05-25 | 1982-05-25 | Processo para a producao de derivados de aminopiperidina |
| ES512519A ES512519A0 (es) | 1981-05-25 | 1982-05-25 | Proceso de fabricacion de los nuevos derivados de la amidinopiperadina. |
| FR8209056A FR2506306B1 (fr) | 1981-05-25 | 1982-05-25 | Nouveaux derives de l'amidinopiperidine, leur procede de preparation et leur application en therapeutique |
| KR8202310A KR880002273B1 (ko) | 1981-05-25 | 1982-05-25 | 아미디노 피페리딘 유도체의 제조방법 |
| MX192853A MX158198A (es) | 1981-05-25 | 1982-05-25 | Procedimiento para preparar derivados de amidinopiperidina |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56078142A JPS57193457A (en) | 1981-05-25 | 1981-05-25 | Amidinopiperidine derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57193457A true JPS57193457A (en) | 1982-11-27 |
| JPH0160020B2 JPH0160020B2 (enrdf_load_stackoverflow) | 1989-12-20 |
Family
ID=13653623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56078142A Granted JPS57193457A (en) | 1981-05-25 | 1981-05-25 | Amidinopiperidine derivative and its preparation |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS57193457A (enrdf_load_stackoverflow) |
| BE (1) | BE893282A (enrdf_load_stackoverflow) |
-
1981
- 1981-05-25 JP JP56078142A patent/JPS57193457A/ja active Granted
-
1982
- 1982-05-24 BE BE0/208163A patent/BE893282A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE893282A (fr) | 1982-09-16 |
| JPH0160020B2 (enrdf_load_stackoverflow) | 1989-12-20 |
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