JPS5714534A - Protein rbf-pm - Google Patents
Protein rbf-pmInfo
- Publication number
- JPS5714534A JPS5714534A JP8875680A JP8875680A JPS5714534A JP S5714534 A JPS5714534 A JP S5714534A JP 8875680 A JP8875680 A JP 8875680A JP 8875680 A JP8875680 A JP 8875680A JP S5714534 A JPS5714534 A JP S5714534A
- Authority
- JP
- Japan
- Prior art keywords
- rbf
- insoluble
- fraction
- organic solvent
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:Protein RBF-PM, its cystine content: less than 0.1%, nitrogen content: ranging from 12% to 15%; isoelectric point: ranging in pH from 3 to 6; solubility: insoluble in dilute sodium chloride solution and dilute acid, soluble in dilute alkali.
USE: Antitumor agent: it is a protein of less cystine content and obtained as a fraction insoluble in a polar organic solvent of RBF-P. It remarkably supresses mouce tumors.
PREPARATION: The hot water-soluble fraction is removed from rice bran and the bran is extracted with a basic aqueous solution such as 1W10wt% sodium hydroxide aqueous solution. The extract is mixed with an organic solvent such as ethanol or acetone and the insoluble fraction is removed. Then, an acid such as hydrochloric or phosphoric acid is added to precipitate RBF-P. The resultant RBF-P is treated with a polar organic solvent such as methanol or acetone and the insoluble fraction is collected by filtration as RBF-PM.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55088756A JPS5936965B2 (en) | 1980-06-30 | 1980-06-30 | Protein RBF-PM |
DE8080104847T DE3064701D1 (en) | 1979-08-17 | 1980-08-14 | Antitumor substance and its production |
EP80104847A EP0027514B1 (en) | 1979-08-17 | 1980-08-14 | Antitumor substance and its production |
US06/377,490 US4457863A (en) | 1979-08-17 | 1982-05-12 | Antitumor substance |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55088756A JPS5936965B2 (en) | 1980-06-30 | 1980-06-30 | Protein RBF-PM |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5714534A true JPS5714534A (en) | 1982-01-25 |
JPS5936965B2 JPS5936965B2 (en) | 1984-09-06 |
Family
ID=13951725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP55088756A Expired JPS5936965B2 (en) | 1979-08-17 | 1980-06-30 | Protein RBF-PM |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5936965B2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6290838A (en) * | 1985-10-17 | 1987-04-25 | Ise Electronics Corp | Base plate for fluorescent display tube |
JP2018532398A (en) * | 2015-09-21 | 2018-11-08 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | Nutritional treatment for cancer |
-
1980
- 1980-06-30 JP JP55088756A patent/JPS5936965B2/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6290838A (en) * | 1985-10-17 | 1987-04-25 | Ise Electronics Corp | Base plate for fluorescent display tube |
JP2018532398A (en) * | 2015-09-21 | 2018-11-08 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | Nutritional treatment for cancer |
Also Published As
Publication number | Publication date |
---|---|
JPS5936965B2 (en) | 1984-09-06 |
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