JPS56156219A - Extract from plant of genus epimedium, its preparation and immunological enhancer containing the same as active constituent - Google Patents
Extract from plant of genus epimedium, its preparation and immunological enhancer containing the same as active constituentInfo
- Publication number
- JPS56156219A JPS56156219A JP5742480A JP5742480A JPS56156219A JP S56156219 A JPS56156219 A JP S56156219A JP 5742480 A JP5742480 A JP 5742480A JP 5742480 A JP5742480 A JP 5742480A JP S56156219 A JPS56156219 A JP S56156219A
- Authority
- JP
- Japan
- Prior art keywords
- water
- extract
- plant
- reaction
- miscible
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
NEW MATERIAL:An extract extracted from a plant of the genus Epimedium with either of water or a mixed solvent of a water-miscible organic solvent with water, capable of forming a precipitate on mixing the resultant aqueous extract with an organic solvent freely miscible with water, positive to any of the anthrone-sulfuric acid reaction, ferric chloride reaction, Molisch reaction and skatole reaction, and having a λmax (nm) of 280 and 325 (shoulder) in the ultraviolet absorption spectrum. Brown powder, and pH of aqueous solution: about 6.5. Soluble in water and insoluble in a lower alchol, ketone, etc.
USE: An immunological enhancer, useful for a patient with reduced immune ability, e.g. the use togehter with an anticancer agent in a cancerous patient, and the prevention and inhibition of infectious diseases, and administered orally or by injection (subcutaneous or intramuscular route).
PROCESS: A plant of the genus Epimedium is extracted with a mixed solvent of a water-miscible organic solvent with water or water, and the resultant extract is then precipitated with a water-miscible solvent to give the aimed extract.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5742480A JPS56156219A (en) | 1980-04-30 | 1980-04-30 | Extract from plant of genus epimedium, its preparation and immunological enhancer containing the same as active constituent |
DE3116695A DE3116695C2 (en) | 1980-04-30 | 1981-04-28 | New plant extract, process for its preparation and a medicinal product containing it |
NL8102073A NL8102073A (en) | 1980-04-30 | 1981-04-28 | NEW EXTRACT FROM A PLANT OF THE GENDER EPIMEDIUM SP., PROCESS FOR PREPARING THE EXTRACT, IMMUNITY STIMULATOR, INCLUDING THE EXTRACT AS AN EFFECTIVE COMPONENT AND IMMUNOTHERAPY USING THE EXTRACT. |
CA000376500A CA1153696A (en) | 1980-04-30 | 1981-04-29 | Extract from plant of genus epimedium sp., process for preparation of said extract, immunostimulating agent comprising said extract as effective component and immunotherapy by using said extract |
IT21484/81A IT1136593B (en) | 1980-04-30 | 1981-04-30 | EXTRACT FROM PLANTS OF THE GENRE EPIMEDIUM, PROCEDURE FOR THE PREPARATION OF THAT EXTRACT, IMMUNOSTIMULATING AGENT THAT INCLUDES THE EXTRACT AS AN EFFECTIVE COMPONENT AND IMMUNOTHERAPY THROUGH THE USE OF THE EXTRACT |
FR8108748A FR2481704A1 (en) | 1980-04-30 | 1981-04-30 | PLANT EXTRACT OF THE GENUS EPIMADIUM SP PROCESS FOR PREPARING THE EXTRACT, IMMUNOSTIMULATING AGENT COMPRISING THE EXTRACT AS AN ACTIVE COMPONENT AND IMMUNOTHERAPY OBTAINED USING THE EXTRACT |
CH2842/81A CH652028A5 (en) | 1980-04-30 | 1981-04-30 | EXTRACT FROM PLANTS OF THE GENUS EPIMEDIUM SP., METHOD FOR THE PRODUCTION OF THIS EXTRACT AND USE OF THE EXTRACT AS AN EFFECTIVE COMPONENT IN AN IMMUNTIMULATING AGENT. |
GB8113312A GB2076002B (en) | 1980-04-30 | 1981-04-30 | Extract and process for extraction from plant of genus epimedium sp immunostimulating agent comprising said extract and extract for use in immunotherapy |
BE2/59137A BE888635A (en) | 1980-04-30 | 1981-04-30 | NOVEL PLANT EXTRACT, PREPARATION METHOD, IMMUNOSTIMULATING AGENT COMPRISING THIS EXTRACT AS AN EFFECTIVE COMPONENT AND IMMUNOTHERAPY THEREOF, |
US06/520,760 US4501736A (en) | 1980-04-30 | 1983-08-08 | Extract from barrenwort |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5742480A JPS56156219A (en) | 1980-04-30 | 1980-04-30 | Extract from plant of genus epimedium, its preparation and immunological enhancer containing the same as active constituent |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56156219A true JPS56156219A (en) | 1981-12-02 |
JPH0144719B2 JPH0144719B2 (en) | 1989-09-29 |
Family
ID=13055266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5742480A Granted JPS56156219A (en) | 1980-04-30 | 1980-04-30 | Extract from plant of genus epimedium, its preparation and immunological enhancer containing the same as active constituent |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPS56156219A (en) |
BE (1) | BE888635A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013541625A (en) * | 2010-11-05 | 2013-11-14 | インスティテュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー.エル.エー.チャイナ | Epimedium polysaccharide, its fractions, and its use as a vaccine adjuvant |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2918569B1 (en) * | 2007-07-09 | 2012-09-28 | Engelhard Lyon | SUBSTANCES INHIBITING GLYCATION OF PROTEINS. |
-
1980
- 1980-04-30 JP JP5742480A patent/JPS56156219A/en active Granted
-
1981
- 1981-04-30 BE BE2/59137A patent/BE888635A/en not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013541625A (en) * | 2010-11-05 | 2013-11-14 | インスティテュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー.エル.エー.チャイナ | Epimedium polysaccharide, its fractions, and its use as a vaccine adjuvant |
Also Published As
Publication number | Publication date |
---|---|
JPH0144719B2 (en) | 1989-09-29 |
BE888635A (en) | 1981-08-17 |
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