JPS56127317A - Preparation of carcinostatic substance - Google Patents
Preparation of carcinostatic substanceInfo
- Publication number
- JPS56127317A JPS56127317A JP2980480A JP2980480A JPS56127317A JP S56127317 A JPS56127317 A JP S56127317A JP 2980480 A JP2980480 A JP 2980480A JP 2980480 A JP2980480 A JP 2980480A JP S56127317 A JPS56127317 A JP S56127317A
- Authority
- JP
- Japan
- Prior art keywords
- carcinostatic
- shinnamin
- edible
- precipitate
- ion exchange
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
PURPOSE: To obtain a carcinostatic substance shinnamin, by extracding the fruit body of edible Flammulina velutipes Sing., precipitating the extract with a solvent, and ultrafiltering and subjecting the precipitate and the supernatant liquid to the ion exchange treatment.
CONSTITUTION: The fruit body of edible Flammulina velutipes Sing. is extracted with hot water or dilute aqueous solution of an alkali, and the resultant extract is precipitated with acetone or a lower alcohol and separated into a precipitate and a suprenatant liquid. Both are then subjected to the ultrafiltration, ion exchange treatment and if necessary the conventional purifying step to give a plurality of fractions having a molecular weight of 300,000W50,000 and 50,000W6,000. The shinnamin components thus obtained are powdery substances consisting of saccharide components containing glucose, mannose, and galactose essentially. Tests on a mouse showed the higher carcinostatic acdivity than the carcinostatic substance derived from basidiomycetes against solid tumors by subcutaneous, abdominal and oral administration.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2980480A JPS56127317A (en) | 1980-03-11 | 1980-03-11 | Preparation of carcinostatic substance |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2980480A JPS56127317A (en) | 1980-03-11 | 1980-03-11 | Preparation of carcinostatic substance |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56127317A true JPS56127317A (en) | 1981-10-06 |
Family
ID=12286196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2980480A Pending JPS56127317A (en) | 1980-03-11 | 1980-03-11 | Preparation of carcinostatic substance |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56127317A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001051070A1 (en) * | 2000-01-12 | 2001-07-19 | Life Science Laboratories Co., Ltd. | Physiologically active substance eem-s originating in mushrooms, process for producing the same and drugs |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5244626A (en) * | 1975-10-06 | 1977-04-07 | Deutsch Res Lab | Device for detecting and closing keyboard switch |
JPS5279087A (en) * | 1975-12-25 | 1977-07-02 | Yamamoto Hisashige | Production of antiiulcer substance |
JPS53109920A (en) * | 1977-01-29 | 1978-09-26 | Kureha Chem Ind Co Ltd | Preparation of anti-tumor polysaccharides |
JPS5417187A (en) * | 1978-07-18 | 1979-02-08 | Yamamoto Hisashige | Production of cancer controlling substance |
JPS5459398A (en) * | 1977-10-19 | 1979-05-12 | Hirofumi Takahashi | Production of polysaccharide having antiicancer activity |
-
1980
- 1980-03-11 JP JP2980480A patent/JPS56127317A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5244626A (en) * | 1975-10-06 | 1977-04-07 | Deutsch Res Lab | Device for detecting and closing keyboard switch |
JPS5279087A (en) * | 1975-12-25 | 1977-07-02 | Yamamoto Hisashige | Production of antiiulcer substance |
JPS53109920A (en) * | 1977-01-29 | 1978-09-26 | Kureha Chem Ind Co Ltd | Preparation of anti-tumor polysaccharides |
JPS5459398A (en) * | 1977-10-19 | 1979-05-12 | Hirofumi Takahashi | Production of polysaccharide having antiicancer activity |
JPS5417187A (en) * | 1978-07-18 | 1979-02-08 | Yamamoto Hisashige | Production of cancer controlling substance |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001051070A1 (en) * | 2000-01-12 | 2001-07-19 | Life Science Laboratories Co., Ltd. | Physiologically active substance eem-s originating in mushrooms, process for producing the same and drugs |
US6783771B2 (en) | 2000-01-12 | 2004-08-31 | Life Science Laboratories Co., Ltd. | Physiologically active substance EEM-S originating in mushrooms, process for producing the same and drugs |
JP4728551B2 (en) * | 2000-01-12 | 2011-07-20 | 有限会社生命科学研究所 | Physiologically active substance EEM-S from persimmon, its production method and medicine |
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