JPS56127317A - Preparation of carcinostatic substance - Google Patents

Preparation of carcinostatic substance

Info

Publication number
JPS56127317A
JPS56127317A JP2980480A JP2980480A JPS56127317A JP S56127317 A JPS56127317 A JP S56127317A JP 2980480 A JP2980480 A JP 2980480A JP 2980480 A JP2980480 A JP 2980480A JP S56127317 A JPS56127317 A JP S56127317A
Authority
JP
Japan
Prior art keywords
carcinostatic
shinnamin
edible
precipitate
ion exchange
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2980480A
Other languages
Japanese (ja)
Inventor
Koichi Iwadare
Tetsuo Ikegawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Priority to JP2980480A priority Critical patent/JPS56127317A/en
Publication of JPS56127317A publication Critical patent/JPS56127317A/en
Pending legal-status Critical Current

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  • Medicines Containing Plant Substances (AREA)

Abstract

PURPOSE: To obtain a carcinostatic substance shinnamin, by extracding the fruit body of edible Flammulina velutipes Sing., precipitating the extract with a solvent, and ultrafiltering and subjecting the precipitate and the supernatant liquid to the ion exchange treatment.
CONSTITUTION: The fruit body of edible Flammulina velutipes Sing. is extracted with hot water or dilute aqueous solution of an alkali, and the resultant extract is precipitated with acetone or a lower alcohol and separated into a precipitate and a suprenatant liquid. Both are then subjected to the ultrafiltration, ion exchange treatment and if necessary the conventional purifying step to give a plurality of fractions having a molecular weight of 300,000W50,000 and 50,000W6,000. The shinnamin components thus obtained are powdery substances consisting of saccharide components containing glucose, mannose, and galactose essentially. Tests on a mouse showed the higher carcinostatic acdivity than the carcinostatic substance derived from basidiomycetes against solid tumors by subcutaneous, abdominal and oral administration.
COPYRIGHT: (C)1981,JPO&Japio
JP2980480A 1980-03-11 1980-03-11 Preparation of carcinostatic substance Pending JPS56127317A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2980480A JPS56127317A (en) 1980-03-11 1980-03-11 Preparation of carcinostatic substance

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2980480A JPS56127317A (en) 1980-03-11 1980-03-11 Preparation of carcinostatic substance

Publications (1)

Publication Number Publication Date
JPS56127317A true JPS56127317A (en) 1981-10-06

Family

ID=12286196

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2980480A Pending JPS56127317A (en) 1980-03-11 1980-03-11 Preparation of carcinostatic substance

Country Status (1)

Country Link
JP (1) JPS56127317A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001051070A1 (en) * 2000-01-12 2001-07-19 Life Science Laboratories Co., Ltd. Physiologically active substance eem-s originating in mushrooms, process for producing the same and drugs

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5244626A (en) * 1975-10-06 1977-04-07 Deutsch Res Lab Device for detecting and closing keyboard switch
JPS5279087A (en) * 1975-12-25 1977-07-02 Yamamoto Hisashige Production of antiiulcer substance
JPS53109920A (en) * 1977-01-29 1978-09-26 Kureha Chem Ind Co Ltd Preparation of anti-tumor polysaccharides
JPS5417187A (en) * 1978-07-18 1979-02-08 Yamamoto Hisashige Production of cancer controlling substance
JPS5459398A (en) * 1977-10-19 1979-05-12 Hirofumi Takahashi Production of polysaccharide having antiicancer activity

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5244626A (en) * 1975-10-06 1977-04-07 Deutsch Res Lab Device for detecting and closing keyboard switch
JPS5279087A (en) * 1975-12-25 1977-07-02 Yamamoto Hisashige Production of antiiulcer substance
JPS53109920A (en) * 1977-01-29 1978-09-26 Kureha Chem Ind Co Ltd Preparation of anti-tumor polysaccharides
JPS5459398A (en) * 1977-10-19 1979-05-12 Hirofumi Takahashi Production of polysaccharide having antiicancer activity
JPS5417187A (en) * 1978-07-18 1979-02-08 Yamamoto Hisashige Production of cancer controlling substance

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001051070A1 (en) * 2000-01-12 2001-07-19 Life Science Laboratories Co., Ltd. Physiologically active substance eem-s originating in mushrooms, process for producing the same and drugs
US6783771B2 (en) 2000-01-12 2004-08-31 Life Science Laboratories Co., Ltd. Physiologically active substance EEM-S originating in mushrooms, process for producing the same and drugs
JP4728551B2 (en) * 2000-01-12 2011-07-20 有限会社生命科学研究所 Physiologically active substance EEM-S from persimmon, its production method and medicine

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