JPS5630927A - Stabilization of guaiazulene and its derivative - Google Patents
Stabilization of guaiazulene and its derivativeInfo
- Publication number
- JPS5630927A JPS5630927A JP10776579A JP10776579A JPS5630927A JP S5630927 A JPS5630927 A JP S5630927A JP 10776579 A JP10776579 A JP 10776579A JP 10776579 A JP10776579 A JP 10776579A JP S5630927 A JPS5630927 A JP S5630927A
- Authority
- JP
- Japan
- Prior art keywords
- guaiazulene
- water
- derivative
- cyclodextrin
- isopropylazulene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To increase the light stability of the titled substance, useful as a medicine, having anti-inflammatory, antiallergic and tissue regenerating actions on higher animals and prevent the reduction in the effectiveness with time, by reacting a guaiazulene with a cyclodextrin.
CONSTITUTION: A water-insoluble guaiazulene (1,4-dimethyl-7-isopropylazulene) or a water-soluble azulene which is a derivative thereof (sodium 1,4-dimethyl-7-isopropylazulene-3-sulfonate) in a solvent is reacted with β-cyclodextrin consisting of 7 glucose units or γ-cyclodextrin consisting of 8 glucose units dissolved in water to give the aimed compound stable to light.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10776579A JPS5630927A (en) | 1979-08-24 | 1979-08-24 | Stabilization of guaiazulene and its derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10776579A JPS5630927A (en) | 1979-08-24 | 1979-08-24 | Stabilization of guaiazulene and its derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5630927A true JPS5630927A (en) | 1981-03-28 |
Family
ID=14467422
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10776579A Pending JPS5630927A (en) | 1979-08-24 | 1979-08-24 | Stabilization of guaiazulene and its derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5630927A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58154548A (en) * | 1982-03-09 | 1983-09-14 | Nippon Shinyaku Co Ltd | Stabilization of azulene derivative |
JPS58154547A (en) * | 1982-03-09 | 1983-09-14 | Nippon Shinyaku Co Ltd | Stabilization of azulene derivative |
JP2002535253A (en) * | 1999-01-21 | 2002-10-22 | ブリストル−マイヤーズ スクイブ カンパニー | Complex of ras farnesyltransferase inhibitor and sulfobutylether-7-β-cyclodextrin or 2-hydroxypropyl-β-cyclodextrin, and method for producing the same |
-
1979
- 1979-08-24 JP JP10776579A patent/JPS5630927A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58154548A (en) * | 1982-03-09 | 1983-09-14 | Nippon Shinyaku Co Ltd | Stabilization of azulene derivative |
JPS58154547A (en) * | 1982-03-09 | 1983-09-14 | Nippon Shinyaku Co Ltd | Stabilization of azulene derivative |
JPH0150226B2 (en) * | 1982-03-09 | 1989-10-27 | Nippon Shinyaku Co Ltd | |
JPH0150225B2 (en) * | 1982-03-09 | 1989-10-27 | Nippon Shinyaku Co Ltd | |
JP2002535253A (en) * | 1999-01-21 | 2002-10-22 | ブリストル−マイヤーズ スクイブ カンパニー | Complex of ras farnesyltransferase inhibitor and sulfobutylether-7-β-cyclodextrin or 2-hydroxypropyl-β-cyclodextrin, and method for producing the same |
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