JPS5630927A - Stabilization of guaiazulene and its derivative - Google Patents

Stabilization of guaiazulene and its derivative

Info

Publication number
JPS5630927A
JPS5630927A JP10776579A JP10776579A JPS5630927A JP S5630927 A JPS5630927 A JP S5630927A JP 10776579 A JP10776579 A JP 10776579A JP 10776579 A JP10776579 A JP 10776579A JP S5630927 A JPS5630927 A JP S5630927A
Authority
JP
Japan
Prior art keywords
guaiazulene
water
derivative
cyclodextrin
isopropylazulene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10776579A
Other languages
Japanese (ja)
Inventor
Yasuo Yonezawa
Shigekazu Maruyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ZERIA SHINYAKU KOGYO KK
Zeria Pharmaceutical Co Ltd
Original Assignee
ZERIA SHINYAKU KOGYO KK
Zeria Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ZERIA SHINYAKU KOGYO KK, Zeria Pharmaceutical Co Ltd filed Critical ZERIA SHINYAKU KOGYO KK
Priority to JP10776579A priority Critical patent/JPS5630927A/en
Publication of JPS5630927A publication Critical patent/JPS5630927A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To increase the light stability of the titled substance, useful as a medicine, having anti-inflammatory, antiallergic and tissue regenerating actions on higher animals and prevent the reduction in the effectiveness with time, by reacting a guaiazulene with a cyclodextrin.
CONSTITUTION: A water-insoluble guaiazulene (1,4-dimethyl-7-isopropylazulene) or a water-soluble azulene which is a derivative thereof (sodium 1,4-dimethyl-7-isopropylazulene-3-sulfonate) in a solvent is reacted with β-cyclodextrin consisting of 7 glucose units or γ-cyclodextrin consisting of 8 glucose units dissolved in water to give the aimed compound stable to light.
COPYRIGHT: (C)1981,JPO&Japio
JP10776579A 1979-08-24 1979-08-24 Stabilization of guaiazulene and its derivative Pending JPS5630927A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10776579A JPS5630927A (en) 1979-08-24 1979-08-24 Stabilization of guaiazulene and its derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10776579A JPS5630927A (en) 1979-08-24 1979-08-24 Stabilization of guaiazulene and its derivative

Publications (1)

Publication Number Publication Date
JPS5630927A true JPS5630927A (en) 1981-03-28

Family

ID=14467422

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10776579A Pending JPS5630927A (en) 1979-08-24 1979-08-24 Stabilization of guaiazulene and its derivative

Country Status (1)

Country Link
JP (1) JPS5630927A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58154548A (en) * 1982-03-09 1983-09-14 Nippon Shinyaku Co Ltd Stabilization of azulene derivative
JPS58154547A (en) * 1982-03-09 1983-09-14 Nippon Shinyaku Co Ltd Stabilization of azulene derivative
JP2002535253A (en) * 1999-01-21 2002-10-22 ブリストル−マイヤーズ スクイブ カンパニー Complex of ras farnesyltransferase inhibitor and sulfobutylether-7-β-cyclodextrin or 2-hydroxypropyl-β-cyclodextrin, and method for producing the same

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58154548A (en) * 1982-03-09 1983-09-14 Nippon Shinyaku Co Ltd Stabilization of azulene derivative
JPS58154547A (en) * 1982-03-09 1983-09-14 Nippon Shinyaku Co Ltd Stabilization of azulene derivative
JPH0150226B2 (en) * 1982-03-09 1989-10-27 Nippon Shinyaku Co Ltd
JPH0150225B2 (en) * 1982-03-09 1989-10-27 Nippon Shinyaku Co Ltd
JP2002535253A (en) * 1999-01-21 2002-10-22 ブリストル−マイヤーズ スクイブ カンパニー Complex of ras farnesyltransferase inhibitor and sulfobutylether-7-β-cyclodextrin or 2-hydroxypropyl-β-cyclodextrin, and method for producing the same

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